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Lymph Node Biopsy in the Diagnosis of Persistent Lymphadenopathy Syndrome (LAS) and Acquired Immunodeficiency Syndrome Related Complex (ARC)

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Progress in Surgical Pathology

Abstract

In 1981, in the United States, the observation of an unusual association of Kaposi’s sarcoma with several different severe infectious diseases, particularly Pneumocystis carinii pneumonia and cytomegalovirus infections, defined a new syndrome.1–4 The Centers for Disease Control published the first clinical reports and noted that the syndrome occurred primarily in male homosexuals.1–3,5–8 This new syndrome was called acquired immunodeficiency syndrome (AIDS). It consisted of the occurrence of one or several opportunistic infections, and sometimes Kaposi’s sarcoma, developing in subjects below 60 years of age without any evident cause of immunodeficiency.9 The disease was first described in male homosexuals,6–8,10 drug abusers,11,12 subjects born or having lived in Haiti or certain African countries as Zaire,13 and individuals undergoing repeated transfusions for various reasons such as hemophilia.14 Cases were later described in heterosexual women and in children of infected women. Finally, more recently, cases transmitted by a single blood transfusion have been reported.

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Authors
  1. J. Diebold
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  2. J. Audouin
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  3. A. Le Tourneau
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  4. J. P. Aubert
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Editor information

Editors and Affiliations

  1. University of New Mexico, Albuquerque, New Mexico, USA

    Cecilia M. Fenoglio-Preiser M.D. (Professor of Pathology, Director of Laboratory Services) (Professor of Pathology, Director of Laboratory Services)

  2. Albuquerque Veterans Administration Medical Center, Albuquerque, New Mexico, USA

    Cecilia M. Fenoglio-Preiser M.D. (Professor of Pathology, Director of Laboratory Services) (Professor of Pathology, Director of Laboratory Services)

  3. Columbia University College of Physicians and Surgeons, Morristown, New Jersey, USA

    Marianne Wolff M.D. (Professor of Clinical Surgical Pathology) (Professor of Clinical Surgical Pathology)

  4. Department of Pathology, Memorial Hospital, Morristown, New Jersey, USA

    Marianne Wolff M.D. (Professor of Clinical Surgical Pathology) (Professor of Clinical Surgical Pathology)

  5. Division of Pathology and Cytology, The National Tumor Institute, Milan, Italy

    Franco Rilke M.D. (Director) (Director)

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Diebold, J., Audouin, J., Le Tourneau, A., Aubert, J.P. (1988). Lymph Node Biopsy in the Diagnosis of Persistent Lymphadenopathy Syndrome (LAS) and Acquired Immunodeficiency Syndrome Related Complex (ARC). In: Fenoglio-Preiser, C.M., Wolff, M., Rilke, F. (eds) Progress in Surgical Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12820-6_5

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