Diabetes and Ampullary Carcinoma: A Possible Relationship

  • Mary Bridge

Abstract

MOST CARCINOMAS ARE NOT KNOWN to have a relationship to diabetes mellitus with the exception of primary pancreatic carcinomas, which do appear to have a predilection for maturity onset diabetics, particularly in patients over the age of 40.1–5 When we were reviewing mucosal neoplasms of the small bowel, it appeared as if there might be a possible relationship between diabetes and the presence of ampullary carcinoma.6 Of 51 surgically treated patients with primary small intestinal adenomas, more than one-half contained an invasive carcinoma arising in the adenoma. Four of the 51 patients were diabetic, and two others had first-degree diabetic relatives. These six individuals all had carcinomas arising in ampullary adenomas.

Keywords

Obesity Carbohydrate Adenoma Neuropathy Hyperglycemia 

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References

  1. 1.
    Bell E.T.: Carcinoma of the pancreas: I. A clinical and pathologic study of 609 necropsied cases. I. The relation of carcinoma of the pancreas to diabetes mellitus. Am J Pathol 33:499–521, 1957.PubMedGoogle Scholar
  2. 2.
    Karmody A.J., Kyle J.: The association between carcinoma of the pancreas and diabetes mellitus. Br J Surg 56:362–364, 1969.PubMedCrossRefGoogle Scholar
  3. 3.
    Moldow R.E., Connelly R.R.: Epidemiology of pancreatic carcinoma in Connecticut. Gastroenterology 55:677–686, 1968.PubMedGoogle Scholar
  4. 4.
    Williams R.H. (ed): Textbook of Endocrinology, ed 5. Philadelphia, Saunders, 1974.Google Scholar
  5. 5.
    Wynder E.L., Mabuchi K., Manichi N., Fortner J.G.: Epidemiology of cancer of the pancreas. J Natl Cancer Inst 50:645–667, 1973.PubMedGoogle Scholar
  6. 6.
    Perzin K.H., Bridge M.F.: Adenomas of the small intestine: A clinico-pathologic review of 51 cases and a study of their relationship to carcinoma. Cancer 48:799–819, 1981.PubMedCrossRefGoogle Scholar
  7. 7.
    Edmondson H.A.: Tumors of the gallbladder and extrahepatic bile ducts. Atlas of Tumor Pathology, Section VII, Fascicle 26. Washington, D.C., Armed Forces Institute of Pathology, 1967.Google Scholar
  8. 8.
    Pridgen J.E., Mayo C.W., Dockerty M.B.: Carcinoma of the jejunum and ileum, exclusive of carcinoid tumors. Surg Gynecol Obstet, 90:513–524, 1950.PubMedGoogle Scholar
  9. 9.
    Malins J.: Clinical Diabetes Mellitus. London, Eyre and Spattiswoode, 1968.Google Scholar
  10. 10.
    Lynch H.T., Follett K.I., Lynch P.M., et al: Family history in an oncology clinic. Implications for cancer genetics. JAMA 242:1268–1272, 1979.PubMedCrossRefGoogle Scholar
  11. 11.
    Hill A.B.: A Short Textbook of Medical Statistics. London, Hodder and Stoughton, 1974.Google Scholar
  12. 12.
    Rimoin D.L.: Inheritance in diabetes mellitus, in Bondy P.K., Felig P. (eds): Symposium on diabetes mellitus. Med Clin N Am 55:807–819, 1971.Google Scholar
  13. 13.
    Bale G.S., Entmacher P.S.: Estimated life expectancy of diabetics. Diabetes 26:434–438, 1977.PubMedCrossRefGoogle Scholar
  14. 14.
    Diabetes Mellitus Coordinating Committee, First Annual Report to the Director, National Institute of Health, Education and Welfare, (DHEW Publication No. (NIH) 76–1017) 1976.Google Scholar
  15. 15.
    Feinlieb M., Fabsitz R., Sharrett A.R. (compilers): Mortality from Cardiovascular and Noncardiovascular Diseases for United States Cities, 1979. United States Department of Health, Education and Welfare, (DHEW Publication No. (NIH) 79–1453.Google Scholar
  16. 16.
    United States Department of Health, Education and Welfare, Public Health Service, Vital Statistics of the United States, 1951, 1960, 1970, 1974, 1976.Google Scholar
  17. 17.
    Spitz N.: Nerve disease in diabetes mellitus, in Podolsky S. (ed): Symposium on diabetes mellitus. Med Clin N Am 62:787–798, 1978.Google Scholar
  18. 18.
    Goyal R.K., Spiro H.M.: Gastrointestinal manifestations of diabetes mellitus, in Bondy P.K., Felig P. (eds): Symposium on diabetes mellitus. Med Clin N Am 55:1031–1044, 1971.Google Scholar
  19. 19.
    Lowenfels A.B.: Why are small bowel tumors so rare? Lancet 1:24–26, 1973.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Mary Bridge

There are no affiliations available

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