Epithelial Salivary Gland Tumors: Tumor Markers

  • Gerhard Seifert
  • Jorg Caselitz


THE MORPHOLOGICAL CLASSIFICATION of salivary gland tumors is based upon the publications of the WHO1 and the Armed Forces Institute of Pathology.2 The terminology has been applied by the Salivary Gland Registry of the University of Hamburg.3 The application of immunohistochemistry to these neoplasms has influenced our thinking about salivary gland tumors.4–14 In addition, new aspects of histogenesis and functional differentiation of tumors have been elucidated by the application of monoclonal antibodies.15–31


Salivary Gland Parotid Gland Myoepithelial Cell Adenoid Cystic Carcinoma Pleomorphic Adenoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Thackray AC, Sobin LH: Histological Typing of Salivary Gland Tumors. World Health Organization, Geneva, 1972.Google Scholar
  2. 2.
    Thackray AC, Lucas RB: Tumors of the major salivary glands. Atlas of Tumor Pathology, 2nd Series, Fascicle 10. Armed Forces Institute of Pathology, Washington, 1954.Google Scholar
  3. 3.
    Seifert G., Miehlke A, Haubrich J, et al: Diseases of the Salivary Glands. Pathology-Diagnosis-Treatment-Facial Nerve Surgery. Thieme, Stuttgart-New York, 1986.Google Scholar
  4. 4.
    DeLellis RA: Diagnostic Immunohistochemistry. Masson, New York, 1981.Google Scholar
  5. 5.
    Erlandson RA: Diagnostic immunohistochemistry of human tumors. An interim evaluation (editorial). Am J Surg Pathol 8:615–624, 1984.PubMedCrossRefGoogle Scholar
  6. 6.
    Falini B, Taylor CR: New developments in immunoperoxidase techniques and their application. Arch Pathol Lab Med 107:105–117, 1983.PubMedGoogle Scholar
  7. 7.
    Mukai K, Rosai J: Applications of immunoperoxidase techniques in surgical pathology, in Fenoglio CM and Wolff M (eds): Progress in Surgical Pathology, 1:15–59, Masson, New York.Google Scholar
  8. 8.
    Nagle RB, McDaniel KM, Clark VA, et al: The use of antikeratin antibodies in the diagnosis of human neoplasms. Am J Clin Pathol 79:458–466, 1983.PubMedGoogle Scholar
  9. 9.
    Pinkus GS: Diagnostic immunocytochemistry of paraffin-embedded tissues. Hum Pathol 13:411 – 415, 1982.PubMedCrossRefGoogle Scholar
  10. 10.
    Polak JM, VanNoorden S: Immunocytochemistry. Practical Applications in Pathology and Biology. Wright, Bristol-London-Boston, 1983.Google Scholar
  11. 11.
    Ramaekers FCS, Haag D, Kant A, et al: Co-expression of keratin and vimentin-type intermediate filaments in human metastatic carcinoma cells. Proc Natl Acad Sci 80:2618–2622, 1983.PubMedCrossRefGoogle Scholar
  12. 12.
    Seifert G, Denk H, Klein PJ, et al: Die Anwendung der Immunzytochemie in der praktischen Diagnostik des Pathologen. Anwendungsgebiete-Methoden- Kostenplanung, Pathologe 6:187–199, 1984.Google Scholar
  13. 13.
    Sternberger LA: Immunocytochemistry. 2nd Edition, Wiley, New York, 1979.Google Scholar
  14. 14.
    Taylor CR, Kledzik G: Immunohistological techniques in surgical pathology. A spectrum of “new” special stains. Hum Pathol 12:590–596, 1981.PubMedCrossRefGoogle Scholar
  15. 15.
    Borowitz MJ, Stein RB: Diagnostic applications of monoclonal antibodies to human cancer. Arch Pathol Lab Med 108:101–105, 1984.PubMedGoogle Scholar
  16. 16.
    Damjanov I, Knowles BB: Biology of disease. Monoclonal antibodies and tumor-associated antigens. Lab Invest 48:510–525, 1983.PubMedGoogle Scholar
  17. 17.
    Debus E, Moll R, Franke WW, et al: Immunohistochemical distinction of human carcinomas by cytokeratin typing with monoclonal antibodies. Am J Pathol 114:121–130, 1984.PubMedGoogle Scholar
  18. 18.
    Hellstrom KE, Hellstrom I, Brown JP: Human tumor-associated antigens identified by monoclonal antibodies. Springer Semin Immunop 5:127–146, 1982.Google Scholar
  19. 19.
    Moll R, Krepier R, Franke WW: Complex cytokeratin polypeptide pattern observed in certain human carcinomas. Differentiation 23:256–259, 1983.PubMedCrossRefGoogle Scholar
  20. 20.
    Neville AM, Foster Chr S, Moshakis V, et al: Monoclonal antibodies and human tumor pathology. Hum Pathol 13:1067–1081, 1982.PubMedCrossRefGoogle Scholar
  21. 21.
    vanMuijen GNP, Ruiter DJ, Ponec M, et al: Monoclonal antibodies with different specificities against cytokeratins. Am J Pathol 114:9–17, 1984.Google Scholar
  22. 22.
    Wright GL (ed.): Monoclonal Antibodies and Cancer. Marcel Dekker, New York-Basel, 1984.Google Scholar
  23. 23.
    Altmannsberger M, Osborn M, Schauer A, et al: Antibodies to different intermediate filament proteins. Cell type-specific markers on paraffin-embedded human tissue. Lab Invest 45:427–434, 1981.PubMedGoogle Scholar
  24. 24.
    Altmannsberger M, Osborn M, Weber K, et al: Expression of intermediate filaments in different human epithelial and mesenchymal tumors. Path Res Pract 175:227–237, 1982.PubMedCrossRefGoogle Scholar
  25. 25.
    Altmannsberger M, Weber K, Holscher A, et al: Antibodies to intermediate filaments as diagnostic tools. Lab Invest 46:520–526, 1982.PubMedGoogle Scholar
  26. 26.
    Denk H, Krepier R, Artlieb U, et al: Proteins of intermediate filaments. An immunohistochemical and biochemical approach to the classification of soft tissue tumors. Am J Pathol 110: 193–208, 1983.PubMedGoogle Scholar
  27. 27.
    Gabbiani G, Kapanci Y, Barazzone Ph., et al: Immunohistochemical identification of intermediate sized filaments in human neoplastic cells. A diagnostic aid for the surgical pathologists. Am J Pathol 104:206–216, 1981.PubMedGoogle Scholar
  28. 28.
    Gabbiani G, Kocher PO: Cytocontractile and cytoskeletal elements in pathologic processes. Arch Pathol Lab Med 107:622–625, 1983.PubMedGoogle Scholar
  29. 29.
    Miettinen M, Lehto VP, Badley RA, et al: Expression of intermediate filaments in soft-tissue sarcomas. Int J Cancer 30:541–546, 1982.PubMedCrossRefGoogle Scholar
  30. 30.
    Osborn M, Weber K: Biology of disease. Tumor diagnosis by intermediate filament typing: A novel tool for surgical pathology. Lab Invest 48:372–394, 1983.PubMedGoogle Scholar
  31. 31.
    Weber K, Osborn M: Cytoskeleton: Definition, structure and gene regulation. Pathol Res Pract 175:128–145, 1982.PubMedCrossRefGoogle Scholar
  32. 32.
    Caselitz J, Becker J, Seifert G, et al: Co-expression of keratin and vimentin filaments in adenoid cystic carcinomas of the salivary glands. Virchows Arch (Pathol Anat) 403: 337–344, 1984.CrossRefGoogle Scholar
  33. 33.
    Caselitz J, Seifert G, Jaup T: Tumor antigens in neoplasms of the parotid gland. J Oral Pathol 11:374–386, 1982.PubMedCrossRefGoogle Scholar
  34. 34.
    Loning Th.: Immunopathology of the oral mucosa. Oral immune system inflammatory reactions tumor “markers”. Virus identification, in, Progress in Pathology, Volume 121, Fischer, New York, 1984.Google Scholar
  35. 35.
    Loning Th., Viac J, Caselitz J, et al: Comparative investigations of keratin filaments in normal tissue and tumors of skin, oral mucosa, salivary glands and thymus. Pathol Res Pract 175:256–265, 1982.PubMedCrossRefGoogle Scholar
  36. 36.
    Seifert G: The importance of tumor markers in oral pathology. II. Cell membrane and cytoplasmic antigens as tumor markers. Path Res Pract 179:625–628, 1985.PubMedCrossRefGoogle Scholar
  37. 37.
    Seifert G, Caselitz J: Tumor markers in parotid gland carcinomas. Immunohistochemical investigations. Cancer Detection Prevention 6:119–130, 1983.Google Scholar
  38. 38.
    Seifert G, Caselitz J: Markers of oral and salivary gland tumors: immunocytochemical investigations. Cancer Detection Prevention 8:23–34, 1985.Google Scholar
  39. 39.
    Seifert G, Loning Th., Hoepfner I: Morphologische Diagnostik bei Virusinfektionen. Pathohistologie. Immunhistologie. Hybridisierungstechnik. Elektronenmikroskopie. Pathologe 5:326–342, 1984.PubMedGoogle Scholar
  40. 40.
    Sendler A, Caselitz J, Seifert G, et al: Reaction pattern of xenografted human salivary glands in nude mice. An immunohistological and autoradiographical study. Virchows Arch (Pathol Anat) 403:1–13, 1984.CrossRefGoogle Scholar
  41. 41.
    Yamamoto H, Caselitz J, Seifert G: Cystadeno-lymphoma: An immunohistochemical study with special reference to IgE and mastcells. Path Res Pract 180:364–368, 1985.PubMedCrossRefGoogle Scholar
  42. 42.
    Zimmer KP, Caselitz J, Seifert G: Immunoelectron microscopy of amylase in the human parotid gland. Ultrastructural localization by use of both the protein A-gold and the biotin-avidin-gold technique. Virchows Arch (Pathol Anat) 404: 187–196, 1984.CrossRefGoogle Scholar
  43. 43.
    Zimmer KP, Caselitz J, Seifert G: Subcellular localization of tissue polypeptide antigen and cytokeratins in epithelial cells (salivary and mammary glands). Combined use of the cryoultramicrotomy and the protein A-gold technique. Virchows Arch (Cell Pathol) 49:161–173, 1985.CrossRefGoogle Scholar
  44. 44.
    Caselitz J, Loning T, Staquet MJ, et al: Immunocytochemical demonstration of filametous structures in the parotid gland. Occurrence of keratin and actin in normal and tumoral parotid gland with special respect to the myoepithelial cells. J Cancer Res Clin Oncol 100:59–68, 1981.PubMedCrossRefGoogle Scholar
  45. 45.
    Caselitz J, Osborn M, Seifert G, et al: Intermediate sized proteins (prekeratin, vimentin, des-min) in the normal parotid gland and parotid gland tumors. Virchows Arch (Pathol Anat) 393: 273–286, 1981.Google Scholar
  46. 46.
    Caselitz J, Osborn M, Wustrow J, et al: The expression of different intermediate sized filaments in human salivary glands and their tumors. Path Res Pract 175:266–278, 1982.PubMedCrossRefGoogle Scholar
  47. 47.
    Dardick I, vanNostrand AWP, Philips JM: Histogenesis of salivary gland pleomorphic adenoma (mixed tumor) with an evaluation of the role of the myoepithelial cell. Hum Pathol 13:62–75, 1982.PubMedCrossRefGoogle Scholar
  48. 48.
    Erlandson RA, Cardon-Cardo C, Higgins PJ: Histogenesis of benign pleomorphic adenoma (mixed tumor) of the major salivary glands. An ultrastructural and immunohistochemical study. Am J Surg Pathol 8:803–820, 1984.PubMedCrossRefGoogle Scholar
  49. 49.
    Krepier E, Denk H, Artilier U, et al: Immuno-histochemistry of intermediate filament proteins present in pleomorphic adenomas of the human parotid gland: Characterization of different cell types in the same tumor. Differentiation 21:191–199, 1982.CrossRefGoogle Scholar
  50. 50.
    Luna MA, Ordonez NG, MacKay B, et al: Salivary epithelial myoepithelial carcinomas of intercalated ducts: An immunocytochemical study. Oral Surg 9:482–490, 1985.CrossRefGoogle Scholar
  51. 51.
    Nathrath WBJ, Wilson PD, Trejdosiewicz LK: Immunohistochemical localization of keratin and luminal epithelial antigen in myoepithelial and luminal epithelial cells of human mammary and salivary gland tumors. Pathol Res Pract 175:279–288, 1982.PubMedCrossRefGoogle Scholar
  52. 52.
    Palmer RM: Epithelial-myoepithelial carcinomas: An immunocytochemical study. Oral Surg 59:511–515, 1985.PubMedCrossRefGoogle Scholar
  53. 53.
    Saku T, Okabe H, Yagi Y, et al: A comparative study on the immunolocalization of keratin and myosin in salivary gland tumors. Acta Pathol Jap 34:1031–1040, 1984.Google Scholar
  54. 54.
    Nathrath WBJ, Heidenkummer P, Arnholdt H, et al: Distribution of tissue polypeptide antigen in normal and neoplastic human tissues. Protides Biol Fluids 31:437–440, 1984.Google Scholar
  55. 55.
    Caselitz J, Salfelder A, Seifert G: Adenolymphoma: An immunohistochemical study with monoclonal antibodies against lymphocytic antigens. J Oral Pathol 13:438–447, 1984.PubMedCrossRefGoogle Scholar
  56. 56.
    Caselitz J, Salfelder A, Seifert G: Mastcells in cystadenolymphomas. Klin Wschr 62:284–286, 1984.PubMedCrossRefGoogle Scholar
  57. 57.
    Caselitz J, Lunau U, Hamper K, et al: The pleomorphic adenoma of salivary glands transplanted on athymic mice. A light microscopical and immunohistochemical investigation. Virchows Arch (Pathol Anat) 408:191–209, 1985.CrossRefGoogle Scholar
  58. 58.
    Dardick I, vanNostrand AWP, Diane Jeans MT, et al: Pleomorphic adenoma: I. Ultrastructural organization of “epithelial” regions. II. Ultra-structural organization of “stromal” regions. Hum Pathol 14:780–809, 1983.PubMedCrossRefGoogle Scholar
  59. 59.
    Lane EB, Hogan BLM, Kurkinen M, et al: Co-expression of vimentin and cytokeratins in parietal endoderm cells of early mouse embryo. Nature 303:701–104, 1983.PubMedCrossRefGoogle Scholar
  60. 60.
    Lehtonen E, Lento VP, Paasivuo R, et al: Parietal and visceral endoderm differ in their expression of intermediate filaments. Eur Mol Biol Org J 2:1023–1028, 1983.Google Scholar
  61. 61.
    Ramaekers FCS, Puts JJG, Kant A, et al: Use of antibodies to intermediate filaments in the characterization of human tumors. Cold Spring Harbor Symp Quant Biol 46:331–339, 1981.CrossRefGoogle Scholar
  62. 62.
    Dardick I, Kahn HJ, vanNostrand AWP, et al: Salivary gland monomorphic adenoma. Ultra-structural, immunoperoxidase, and histogenetic aspects. Am J Pathol 115:334–348, 1984.PubMedGoogle Scholar
  63. 63.
    Gusterson BA, Lucas RB, Ormerod MG: Distribution of epithelial membrane antigen in benign and malignant lesions of the salivary glands. Virchows Arch (Pathol Anat) 397: 227–233, 1982.Google Scholar
  64. 64.
    Caselitz J, Seifert G, Bjorklund B, et al: Detection of tissue polypeptide antigen in salivary glands and salivary gland tumors. An immunohistochemical study. Applied Pathol 1:115–120, 1983.Google Scholar
  65. 64a.
    Weber K, Osborn M, Moll R, et al: Tissue polypeptide antigen (PTA) is related to the non-epidermal keratins 8,18 and 19 typical of simple and non-squamous epithelia: re-evaluation of a human tumor marker. EMBO J 2:2707–2714, 1984.Google Scholar
  66. 65.
    Bjorklund B: On the nature and clinical use of tissue polypeptide C antigen (TPA). Tumor Diagnostik 1:9–20, 1980.Google Scholar
  67. 66.
    Caselitz J, Seifert G, Jaup T: Presence of carci-noembryonic antigen (CEA) in the normal and inflamed human parotid gland. An immunohistochemical study of 31 cases. J Cancer Res Clin Oncol 1100:205–211, 1981.CrossRefGoogle Scholar
  68. 67.
    Caselitz J, Jaup T, Seifert G: Immunohistochemical detection of carcinoembryonic antigen (CEA) in parotid gland carcinomas. Analysis of 52 cases. Virchows Arch (Pathol Anat) 394: 49–60, 1981.Google Scholar
  69. 68.
    McDicken JW, Scott J: The presence and distribution of carcinoembryonic antigen in tumors of human minor salivary glands. J Oral Pathol 10:296–303, 1981.PubMedCrossRefGoogle Scholar
  70. 69.
    Tsukitani K, Kobayashi K, Murase N, et al: Characterization of cells in salivary gland lesions by immunohistochemical identification of carcinoembryonic antigens. Oral Surg 59:595–599, 1985.PubMedCrossRefGoogle Scholar
  71. 70.
    Kraus FW, Mestecky J: Immunohistochemical localization of amylase, lysozyme and immunoglobulins in the human parotid gland. Arch Oral Biol 16:781–789, 1971.PubMedCrossRefGoogle Scholar
  72. 71.
    Caselitz J, Seifert G, Grenner G, et al: Amylase as an additional marker of salivary gland neoplasms. An immunoperoxidase study. Path Res Pract 176:276–283, 1983.PubMedCrossRefGoogle Scholar
  73. 72.
    Morley DJ, Hodes JE, Calland J, et al: Immunohistochemical demonstration of ribonuclease and amylase in normal and neoplastic parotid glands. Hum Pathol 14:969–973, 1983.PubMedCrossRefGoogle Scholar
  74. 73.
    Takata T, Ogawa I, Nikai H, et al: Immunohistochemical studies on salivary gland tumors. I. Localization of various secretory epithelial markers in the normal human salivary gland tissue. Jpn J Oral Biol 26:1190–1199, 1984.CrossRefGoogle Scholar
  75. 74.
    Donath K, Seifert G, Lentrodt J: The embryonal carcinoma of the parotid gland. A rare example of an embryonal tumor. Virchows Arch (Pathol Anat) 403:425–440, 1984.CrossRefGoogle Scholar
  76. 75.
    Ogawa I, Takata T, Nikai H, et al: Immunohistochemical studies on salivary gland tumors. II. Localization of secretory epithelial markers in various benign tumors. Jpn J Oral Biol 26: 1200–1209, 1984.CrossRefGoogle Scholar
  77. 76.
    Korsrud FR, Brandtzaeg P: Immunofluorescence study of secretory epithelial markers in pleomorphic adenomas. Virchows Arch (Pathol Anat) 403:291–300, 1984.CrossRefGoogle Scholar
  78. 77.
    Masson PL, Heremans JF, Schonee E: Lactofer-rin, an iron-binding protein in neutrophilic leukocytes. J Exp Med 130:643–658, 1969.PubMedCrossRefGoogle Scholar
  79. 78.
    Caselitz J, Jaup T, Seifert G: Lactoferrin and lysozyme in carcinomas of the parotid gland. A comparative immunocytochemical study with the occurrence in normal and inflamed tissue. Virchows Arch (Pathol Anat) 394:61–73, 1981.CrossRefGoogle Scholar
  80. 79.
    Korsrud FR, Brandtzaeg P: Characterization of epithelial elements in human major salivary glands by functional markers: Localization of amylase, lactoferrin, lysozyme, secretory component, and secretory immunoglobulins by paired immunofluorescence staining. J Histochem Cytochem 30:657–666, 1982.PubMedCrossRefGoogle Scholar
  81. 80.
    Mason DY, Taylor CR: Distribution of transferrin, ferritin and lactoferrin in human tissues. J Clin Pathol 31:316–327, 1978.PubMedCrossRefGoogle Scholar
  82. 81.
    Nakamura T, Nagura H, Komatsu N, et al: Immunocytochemical and enzymecytochemical studies on the intracellular transport mechanism of secretory immunoglobulin A and lactoferrin in human salivary glands. Virchows Arch (Pathol Anat) 406:367–372, 1985.CrossRefGoogle Scholar
  83. 82.
    Reitamo S, Kontinnen YT, Segerber-Kontinnen M: Distribution of lactoferrin in human salivary glands. Histochemistry 66:285–291, 1980.PubMedCrossRefGoogle Scholar
  84. 83.
    Tourville DR, Adler RH, Bienenstock J, et al: The human secretory immunoglobulin system: Immunohistochemical localization of gamma A secretory piece and lactoferrin in normal tissue. J Exp Med 129:411–429, 1969.PubMedCrossRefGoogle Scholar
  85. 84.
    Sehested M, Barfoed C, Krogdahl A, et al: Immunohistochemical investigation of lysozyme, lactoferrin, alpha-1 antitrypsin, alpha-1 antichymotrypsin and ferritin in parotid gland tumors. J Oral Pathol 14:459–465, 1985.PubMedCrossRefGoogle Scholar
  86. 85.
    Moro I, Umemura S, Crago SS, et al: Immunohistochemical distribution of immunoglobulins, lactoferrin, and lysozyme in human minor salivary glands. J Oral Pathol 13:97–104, 1984.PubMedCrossRefGoogle Scholar
  87. 86.
    Spicer SS, Frayser R, Virella G, et al: Immunohistochemical localization of lysozymes in respiratory and other tissues. Lab Invest 36:282–295, 1977.PubMedGoogle Scholar
  88. 87.
    Reitamo S: Lysozyme antigenicity and tissue fixation. Histochemistry 55:197–207, 1978.PubMedCrossRefGoogle Scholar
  89. 88.
    Reitamo S, Klockars M, Raeste AM: Immunohistochemical identification of lysozyme in the minor salivary glands of man. Arch Oral Biol 22:515–519, 1977.PubMedCrossRefGoogle Scholar
  90. 89.
    Geboes K, Ray MB, Rutgeerts P, et al: Morphological identification of alpha-1 antitrypsin in the human small intestine. Histopathol 6:55–60, 1982.CrossRefGoogle Scholar
  91. 90.
    Harris JP, South MA: Secretory component. A glandular epithelial cell marker. Am J Pathol 105:47–53, 1981.PubMedGoogle Scholar
  92. 91.
    Brandtzaeg P: Transport models for secretory IgA and secretory IgM. Clin Exp Immunol 44:221–232, 1981.PubMedGoogle Scholar
  93. 92.
    Fantasia JE, Lally ET: Localization of free secretory component in pleomorphic adenomas of minor salivary gland origin. Cancer 53:1786–1789, 1984.PubMedCrossRefGoogle Scholar
  94. 93.
    Brandtzaeg P: Immunohistochemical characterization of intracellular J chain and binding site for secretory component (SC) in human immunoglobulin (Ig)-producing cells. Molec Immunol 20:941–966, 1983.CrossRefGoogle Scholar
  95. 94.
    Korsrud FR, Brandtzaeg P: Quantitative immunohistochemistry of immunoglobulin and J chain-producing cells in human parotid and submandibular glands. Immunology 39:129–140, 1980.PubMedGoogle Scholar
  96. 95.
    Brandtzaeg P: The oral immune system under normal and pathological conditions. Path Res Pract 179:619–621, 1985.PubMedCrossRefGoogle Scholar
  97. 96.
    Beckenkamp G: Das Verteilungsmuster des zellularen Immunosystems in den großen und kleinen Mündspeicheldrusen. Immunzytochemische Befunde HNO (Berl) 33:196–203, 1985.Google Scholar
  98. 97.
    Korsrud FR, Brandtzaeg P: Immunohistochemical characterization of cellular immunoglobulins and epithelial marker antigens in Warthin’s tumor. Hum Pathol 15:361–367, 1984.PubMedCrossRefGoogle Scholar
  99. 98.
    Cossmann J, Deegan MJ, Batsakis JG: Warthin’s tumor. B-lymphocytes within the lymphoid infiltrate. Arch Pathol Lab Med 101:354–356, 1977.Google Scholar
  100. 99.
    Diamond LW, Braylan RC: Cell surface markers on lymphoid cells from Warthin’s tumors. Cancer 44:580–583, 1979.PubMedCrossRefGoogle Scholar
  101. 100.
    Foulsham CK, Johnson G, Snyder GG, et al: Immunohistopathology of papillary cystadenoma lymphomatosum (Warthin’s tumor). Ann Clin Labor Sci 14:47–63, 1984.Google Scholar
  102. 101.
    Hsu SM, Hsu P, Nayak RN: Warthin’s tumor: An immunohistochemical study of its lymphoid stroma. Hum Pathol 12:251–257, 1981.PubMedCrossRefGoogle Scholar
  103. 102.
    Norrby K: Intradermal mast-cell secretion causing cutaneous mitogenesis. Virchows Arch (Cell Pathol) 42:263–269, 1983.Google Scholar
  104. 103.
    Caselitz J, Loning T, Seifert G: An approach to stain actin in parotid gland cells in paraffin-embedded material. Staining by human anti-actin antibodies using the indirect unlabeled immun-operoxidase technique. Virchows Arch (Pathol Anat) 387:300–305, 1980.Google Scholar
  105. 104.
    Line SE, Archer FL: The postnatal development of myoepithelial cells in the rat submandibular gland. Virchows Arch (Cell Pathol) 10:253–262, 1972.Google Scholar
  106. 105.
    Nilsen R, Donath K: Actin containing cells in normal human salivary glands. An immunohistochemical study. Virchows Arch (Pathol Anat) 381:315–322, 1981.Google Scholar
  107. 106.
    Caselitz J, Loning Th.: Specific demonstration of actin and keratin filaments in pleomorphic adenomas by means of immunoelectron microscopy. Virchows Arch (Pathol Anat) 393:153–158, 1981.CrossRefGoogle Scholar
  108. 107.
    Moore BW: A soluble protein characteristic of the nervous system. Biochem Biophys Res Commun 19:739–744, 1965.PubMedCrossRefGoogle Scholar
  109. 108.
    Hara K, Ito M, Takeuchi J, et al: Distribution of S-100b protein in normal salivary glands and salivary gland tumors. Virchows Arch (Pathol Anat) 401:237–249, 1983.CrossRefGoogle Scholar
  110. 109.
    Molin SO, Rosengren L, Haglid K, et al: Differential localization of “brain-specific” S-100 and its subunits in rat salivary glands. J Histochem Cytochem 32:805–814, 1984.PubMedCrossRefGoogle Scholar
  111. 110.
    Nakazato Y, Ishida Y, Takahashi K, et al: Immunohistochemical distribution of S-100 protein and glial fibrillary acidic protein in normal and neoplastic salivary glands. Virchows Arch (Pathol Anat) 405:299–310, 1985.CrossRefGoogle Scholar
  112. 111.
    Nakazato Y, Ishizeki J, Takahashi K, et al: Localization of S-100 protein and glial fibrillary acidic protein-related antigen in pleomorphic adenoma of the salivary glands. Lab Invest 46:621–626, 1982.PubMedGoogle Scholar
  113. 112.
    Cooper HS: Lectins as probes in histochemistry and immunohistochemistry: The peanut (Arachis hypogaea) lectin. Hum Pathol 15:904–906, 1984.PubMedCrossRefGoogle Scholar
  114. 113.
    Raedler A, Raedler E: The use of lectins to study normal differentiation and malignant transformation. J Cancer Res Clin Oncol 109:245–251, 1985.PubMedCrossRefGoogle Scholar
  115. 114.
    Born IA, Liewald F, Muller P: Lektin-Bindungsmuster in menschlichen Kopfspeicheldrusen. Berichte Pathol 100:252, 1984.Google Scholar
  116. 115.
    Hamper K, Caselitz J, Seifert G, et al: Die Verteilung des Thomsen-Friedenreich-Antigens in Speicheldrusentumoren. Verh Dtsch Ges Pathol 68:562, 1984.Google Scholar
  117. 116.
    Menghi G: Reactivity of peroxidase-labeled lectins in rabbit submandibular and sublingual glands. Acta Histochem (Jena) 75:27–35, 1984.PubMedCrossRefGoogle Scholar
  118. 117.
    Naito R, Takai Y, Tsukitani K, et al: Use of lectins for differential localization of secretory materials of granular convoluted tubules and ducts in the submandibular gland. Acta Histochem Cytochem (Kyoto) 16:483–493, 1983.CrossRefGoogle Scholar
  119. 118.
    Hosaka M, Takai Y, Murase N, et al: Histochemical observations of lectin-binding in experimental carcinomas in mouse submandibular glands. J Oral Pathol 13:585–594, 1984.PubMedCrossRefGoogle Scholar
  120. 119.
    Murase N, Takai Y, Hosaka M, et al: Lectin-binding in premalignant lesions during submandibular gland carcinogenesis. J Oral Pathol 13:505–515, 1984.PubMedCrossRefGoogle Scholar
  121. 120.
    Takai Y, Hyun KH, Hosaka N, et al: Histochemical studies on Concanavalin A-binding in experimental carcinoma of the mouse submandibular gland. J Oral Pathol 13:429–437, 1984.PubMedCrossRefGoogle Scholar
  122. 121.
    Caselitz J, Seifert G: Immunhistologische Untersuchungen zum Verteilungsmuster von intrazytoplasmatischen Antigenen und Lektinrezeptoren bei Parotiskarzinomen. Verh Dtsch Ges Path 65:378, 1981.Google Scholar
  123. 122.
    Dabelsteen E, Fulling HJ: A preliminary study of blood group substances A and B in oral epithelium exhibiting atypia. Scand J Dent Res 79:387–393, 1971.PubMedGoogle Scholar
  124. 123.
    Dabelsteen E, Daniels TE: Tumor associated antigens in oral cancer and premalignant lesions. Dtsch Z Mund Kiefer Gesichts Chir 7:87–92, 1983.Google Scholar
  125. 124.
    Hamper K, Caselitz J, Seifert G, et al: Blutgruppenantigene in Speicheldrusentumoren. Verh Dtsch Ges Path 69:435, 1985.Google Scholar
  126. 125.
    Woltering EA, Tuttle SE, James AG, et al: ABO (H) cell surface antigens in benign and malignant parotid neoplasms. J Surg Oncol 24:177–179, 1983.PubMedCrossRefGoogle Scholar
  127. 126.
    Caselitz J, Seifert G, Hamper K, et al: Thomsen-Friedenreich-Antigen and related antigens in salivary gland tumors. Cancer Detection Prevention 7:480, 1984.Google Scholar
  128. 127.
    Martinez-Hernandez A, Amenta PS: The basement membrane in pathology. Lab Invest 48:656–677, 1983.PubMedGoogle Scholar
  129. 128.
    Barsky S, Siegal GP, Jannotta F, et al: Loss of basement membrane components by invasive tumors but not their benign counterparts. Lab Invest 49:140–147, 1983.PubMedGoogle Scholar
  130. 129.
    Birembaut P, Caron Y, Adnet JJ, et al: Usefulness of basement membrane markers in tumoral pathology. J Pathol 145:283–296, 1985.PubMedCrossRefGoogle Scholar
  131. 130.
    Liotta LA: Tumor invasion and metastases: Role of the basement membrane. Warner-Lambert Parke-Davis award lecture. Amer J Pathol 117:339–348, 1984.Google Scholar
  132. 131.
    Liotta LA, Rao CN, Barsky SH: Tumor invasion and the extracellular matrix. Lab Invest 49:636–649, 1983.PubMedGoogle Scholar
  133. 132.
    Iozzo RV: Proteoglycans and neoplastic-mesenchymal cell interactions. Hum Pathol 15:2–10, 1984.PubMedCrossRefGoogle Scholar
  134. 133.
    Timpl R, Rohde H, Robey PG, et al: Laminin — a glycoprotein from basement membranes. J Biol Chem 254:9933–9937, 1979.PubMedGoogle Scholar
  135. 134.
    Toida M, Takeuchi J, Hara K, et al: Histochemical studies of intercellular components of salivary gland tumors with special reference to glycosaminoglycan, laminin and vascular elements. Virchows Arch (Pathol Anat) 403:15–26, 1984.CrossRefGoogle Scholar
  136. 135.
    D’Ardenne AJ, Burns J, Sykes BC, et al: Fibronectin and type III collagen in epithelial neoplasms of gastrointestinal tract and salivary glands. J Clin Pathol 36:756–763, 1983.PubMedCrossRefGoogle Scholar
  137. 136.
    Klar E, Heene DL: Fibronectin. Klin Wschr 62:963–974, 1984.PubMedCrossRefGoogle Scholar
  138. 137.
    Ruoslahti E: Fibronectin. J Oral Pathol 10:3–13, 1981.PubMedCrossRefGoogle Scholar
  139. 138.
    D’Ardenne AJ, McGee JOD: Fibronectin in disease. J Pathol 142:235–251, 1984.PubMedCrossRefGoogle Scholar
  140. 139.
    Linde A, Berghem LE, Hansson HA, et al: Ultrastructural localization of fibronectin in duct cells of human minor salivary glands and its immunochemical detection in minor salivary gland secretion. Arch Oral Biol 29:921–925, 1984.PubMedCrossRefGoogle Scholar
  141. 140.
    Rosenbloom J: Biology of disease. Elastin: Relation of protein and gene structure to disease. Lab Invest 51:605–623, 1984.PubMedGoogle Scholar
  142. 141.
    Adkins KF, Daley TJ: Elastic tissues in adenoid cystic carcinomas. Oral Surg 38:562–569, 1974.PubMedCrossRefGoogle Scholar
  143. 142.
    Azzopardi JG, Zayid I: Elastic tissue in tumors of salivary glands. J Pathol 107:149–156, 1972.PubMedCrossRefGoogle Scholar
  144. 143.
    David R, Buchner A: Elastosis in benign and malignant salivary gland tumors. Cancer 45:2301–2310, 1980.PubMedCrossRefGoogle Scholar
  145. 144.
    David R, Buchner A: Tannic acid-glutaraldehyde fixative and pleomorphic adenomas of the salivary gland: An ultrastructural study. J Oral Pathol 11:26–38, 1982.PubMedCrossRefGoogle Scholar
  146. 145.
    Nikai H, Ogawa I, Ijuchin N, et al: Ultrastructural cytochemical demonstration of elastin in the matrix of salivary gland tumors. Acta Pathol Jpn 32:1171–1181, 1983.Google Scholar
  147. 146.
    Abbey LM, Witorsch RJ: Prolactin binding in normal human minor salivary gland tissue: An immunohistochemical study. Oral Surg 58:682–687, 1984.PubMedCrossRefGoogle Scholar
  148. 147.
    Poulsen HS, Ozzello L, King WJ, et al: The use of monoclonal antibodies to estrogen receptors (ER) for immunoperoxidase detection of ER in paraffin sections of human breast cancer tissue. J Histochem Cytochem 33:87–92, 1985.PubMedCrossRefGoogle Scholar
  149. 148.
    Cantin M, Gutkowska J, Thibault G, et al: Immunocytochemical localization of atrial natriuretic factor in the heart and salivary glands. Histochemistry 80:113–127, 1984.PubMedCrossRefGoogle Scholar
  150. 149.
    Sahara N, Suzuki K: Ultrastructural localization of dipeptidyl peptidase IV in rat salivary glands by immunocytochemistry. Cell Tissue Res 235:427–432, 1984.PubMedCrossRefGoogle Scholar
  151. 150.
    Cohen S: Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. J Biol Chem 237:1555–1562, 1962.PubMedGoogle Scholar
  152. 151.
    Mori M, Hamada K, Naito R, et al: Immunohistochemical localization of epidermal growth factor in rodent submandibular glands. Acta Histochem Cytochem 16:36–54, 1983.CrossRefGoogle Scholar
  153. 152.
    Mori M, Takai Y, Naito R, et al: Immunohistochemical demonstration of epidermal growth factor and nerve growth factor in experimental carcinogenesis in the mouse submandibular gland. Virchows Arch (Cell Pathol) 45:431–441, 1984.CrossRefGoogle Scholar
  154. 153.
    Kasselberg AG, Orth DN, Gray ME, et al: Immunocytochemical localization of human epidermal growth factor/urogastrone in several human tissues. J Histochem Cytochem 33:315–322, 1985.PubMedCrossRefGoogle Scholar
  155. 154.
    Lamey JP, Waterhouse JP, Ferguson MM: Pleomorphic salivary adenoma. Virally induced pleomorphic adenoma in the CFLP mouse. Am J Pathol 108:129–132, 1982.Google Scholar
  156. 155.
    Seifert G: Virale Erkrankungen der Speicheldrüsen. Dtsch Z Mund Kiefer Gesichts Chir 8:187–194, 1984.Google Scholar
  157. 156.
    Morgan DG, Niederman JC, Miller G, et al: Site of Epstein-Barr virus replication in the oropharynx. Lancet 11:1154–1157, 1979.CrossRefGoogle Scholar
  158. 157.
    Niederman JC, Miller C, Pearson HA, et al: Infectious mononucleosis. Epstein-Barr virus shedding in saliva and the oropharynx. New Engl J Med 294:1355–1359, 1976.PubMedCrossRefGoogle Scholar
  159. 158.
    Wolf H, Bayliss GJ, Wilmes E: Biological properties in Epstein-Barr virus, in, (ed.) Grundmann E, Volume 5, Fischer, Stuttgart-New York, 1981.Google Scholar
  160. 159.
    Nielsen NH, Mikkelsen F, Hansen JPH: Incidence of salivary gland neoplasms in Greenland, with special reference to an anaplastic carcinoma. Acta Pathol Microbiol Immunol Scand A 86:185–193, 1978.Google Scholar
  161. 160.
    Saemunden AK, Albeck H, Hansen JPH, et al: Epstein-Barr virus in nasopharyngeal and salivary gland carcinomas of Greenland Eskimoes. Brit J Cancer 46:721–728, 1982.CrossRefGoogle Scholar
  162. 161.
    Stenman G, Dahlenfors R, Mark J, et al: Adenoid cystic carcinoma: A third type of human salivary gland neoplasm characterized cytogenetically by reciprocal translocation. Anticancer Res 2:11–16, 1982.PubMedGoogle Scholar
  163. 162.
    Stenman G, Mark J: Specificity of the involvement of chromosomes 8 and 12 in human mixed salivary gland tumors. J Oral Pathol 12:446–457, 1983a.PubMedCrossRefGoogle Scholar
  164. 163.
    Stenman G, Mark J: Loss of the Y-chromosome in a cultured human salivary gland adenocarcinoma. J Oral Pathol 12:458–464, 1983b.PubMedCrossRefGoogle Scholar
  165. 164.
    Mark J, Dahlenfors R, Ekedahl C: Chromosomal deviations and their specificity in human mixed salivary gland tumors. Anticancer Res 1:49–57, 1981.Google Scholar
  166. 165.
    Mark J, Dahlenfors R, Ekedahl C: Specificity and implications of ring chromosomes and dicentrics in benign mixed salivary gland tumors. Acta Pathol Microbiol Immunol Scand A 91:3397–3402, 1983a.Google Scholar
  167. 166.
    Mark J, Dahlenfors R, Ekedahl C: Cytogenetics of the human benign mixed salivary gland tumor. Hereditas 99:115–129, 1983b.PubMedCrossRefGoogle Scholar
  168. 167.
    Kahn HJ, Baumal R, Marks A, et al: Myoepithelial cells in salivary gland tumors. Arch Pathol Lab Med 109:190–195, 1985.PubMedGoogle Scholar
  169. 168.
    Palmer RM, Lucas RB, Knight J, Gusterson B: Immunocytochemical identification of cell types in pleomorphic adenomas, with particular reference to myoepithelial cells. J Pathol 146:213–220, 1985.PubMedCrossRefGoogle Scholar
  170. 169.
    Palmer RM: The identification of myoepithelial cells in human salivary glands. A review and comparison of light microscopical methods. J Oral Pathol 15:221–229, 1986.PubMedCrossRefGoogle Scholar
  171. 170.
    Caselitz J, Walther B, Wustrow J, et al: A monoclonal antibody that detects myoepithelial cells in exocrine glands, basal cells in other epithelial and basal and suprabasal cells in certain hyperplastic tissues. Virchows Arch (Pathol Anat) 409:725–738, 1986.CrossRefGoogle Scholar
  172. 171.
    Caselitz J, Osborn M, Hamper K, et al: Pleomorphic adenomas, adenoid cystic carcinomas and adenolymphomas of salivary glands analysed by a monoclonal antibody against myoepithelial/basal cells. An immunohistochemical study. Virchows Arch (Pathol Anat) 409:805–816, 1986.CrossRefGoogle Scholar
  173. 172.
    Geiger S, Geiger B, Leitner O, Marshak G: Cytokeratin polypeptides expression in different epithelial elements of human salivary glands. Virchows Arch (Pathol Anat) 410:403–414, 1987.CrossRefGoogle Scholar
  174. 173.
    Born IA, Schwechheimer K, Maier M, Otto HF: Cytokeratin expression in normal salivary glands and in cystadenolymphomas demonstrated by monoclonal antibodies against selective cytokeratin polypeptides. Virchows Arch (Pathol Anat) 411:583–589, 1987.CrossRefGoogle Scholar
  175. 174.
    Gustafsson H, Kjorell U, Carlsoo B: Cytoskeletal proteins in oncocytic tumors of the parotid gland. Arch Otolaryngol 111:99–105, 1985.PubMedCrossRefGoogle Scholar
  176. 175.
    Palmer RM: Epithelial-myoepithelial carcinoma: An immunocytochemical study. Oral Surg 59:511–515, 1985.PubMedCrossRefGoogle Scholar
  177. 176.
    Luna MA, Ordonez NG, Mackay B, et al: Salivary epithelial-myoepithelial carcinomas of intercalated ducts: A clinical, electron microscopic, and immunocytochemical study. Oral Surg 59:482–490, 1985.PubMedCrossRefGoogle Scholar
  178. 177.
    Sehested M, Barfoed C, Krogdahl A, et al: Immunohistochemical investigation of lysozyme, lactoferrin, alpha-1 antitrypsin, alpha-1 antichymotrypsin and ferritin in parotid gland tumors. J Oral Pathol 14:459–465, 1985.PubMedCrossRefGoogle Scholar
  179. 178.
    Toto PD, Hsu DJ: Product definition of pleomorphic adenoma of minor salivary glands. J Oral Pathol 14:459–465, 1985.CrossRefGoogle Scholar
  180. 179.
    Warner TFCS, Seo IS, Azen EA, et al: Immunocytochemistry of acinic cell carcinomas and mixed tumors of salivary glands. Cancer 56:2221–2227, 1985.PubMedCrossRefGoogle Scholar
  181. 180.
    Sumitomo S, Kumasa S, Tatemoto Y, et al: Immunohistochemical localization of amylase in sialoadenitis and salivary gland tumors. J Oral Pathol 15:381–385, 1986.PubMedCrossRefGoogle Scholar
  182. 181.
    Tsukitani K, Nakai M, Tatemoto Y, et al: Histochemical studies of obstructive adenitis in human submandibular salivary glands. 1. Immunohistochemical demonstration of lactoferrin, lysozyme and carcinoembryonic antigen. J Oral Pathol 14:631–638, 1985.PubMedCrossRefGoogle Scholar
  183. 182.
    Crocker J, Jenkins R, Campbell J, et al: Immunohistochemical demonstration of S-100 protein in salivary gland neoplasms. J Pathol 146:115–121, 1985.PubMedCrossRefGoogle Scholar
  184. 183.
    Mori M, Tsukitani K, Ninomiya T, Okada Y: Various expressions of modified myoepithelial cells in salivary pleomorphic adenomas. Immunohistochemical studies. Path Res Pract 182:632–646, 1987.PubMedCrossRefGoogle Scholar
  185. 184.
    Sumitomo S, Kumasa S, Mitani H, Mori M: Comparison of CEA distribution in lesions and tumors of salivary glands as determined with monoclonal and polyclonal antibodies. Virchows Arch B 53:133–139, 1987.PubMedCrossRefGoogle Scholar
  186. 185.
    Caselitz J, Schulze I, Seifert G: Adenoid cystic carcinom of the salivary glands: an immunohistochemical study. J Oral Pathol 15:308–318, 1986.PubMedCrossRefGoogle Scholar
  187. 186.
    Born IA, Zimmer K-P, Schwechheimer K, et al: Binding sites of Ulex europeuslectin I in human parotid gland. A light-microscopic and ultra-structural study using the immunoperoxidase technique and immunocryoultramicrotomy. Cell Tissue Res 248:455–461, 1987.PubMedCrossRefGoogle Scholar
  188. 187.
    Caselitz J, Gabius R, Hamper K, et al: Endogene Lektine in Speicheldrüsentumoren. Eine immunhistologische Studie. Verh Dtsch Ges Path 71:345, 1987.Google Scholar
  189. 188.
    Hamper K, Caselitz J, Seifert G, et al: The occurrence of blood group substances (A,B,H,Le-a,Le-b) in salivary glands and salivary gland tumors. An immunohistochemical investigation. J Oral Pathol 15:334–338, 1986.PubMedCrossRefGoogle Scholar
  190. 189.
    Lötterie J, Heine W-D: Expression of ABH and Lewis antigens in salivary glands—an immunohistochemical investigation. Verh Dtsch Ges Path 70:352–357, 1986.Google Scholar
  191. 190.
    Mori M, Naito R, Tsukitani K, et al: Immunohistochemical distribution of human epidermal growth factor in salivary gland tumours. Virchows Arch (Pathol Anat) 411:499–507, 1987.CrossRefGoogle Scholar
  192. 191.
    Caselitz J, Weber W, Seifert G: Morphological investigation on the epidermal growth factor receptor. Analysis of human tumors and tumor-transplants on athymic mice with special reference to salivary gland tumors. Verh Dtsch Ges Path 70:343–346, 1986.Google Scholar
  193. 192.
    Caselitz J, Seifert G: New developments in tumor markers and receptors in head and neck tumors. In: Cimino, Birkmayer, Klavins, et al: Human Tumor Markers, p 731–753. de Gruyter, Berlin-New York, 1987.Google Scholar
  194. 193.
    Hamper K, Caselitz J, Rauchfuss A, Seifert G: Zum Verhalten des Transferrin-Rezeptors in menschlichen Tumoren. Eine immunhistologische Studie. Verh Dtsch Ges Path 70:580, 1986.Google Scholar
  195. 194.
    Abbey LM, Witorsch RJ: Prolactin binding in minor salivary gland tumors. Oral Surg 60:44–49, 1985.PubMedCrossRefGoogle Scholar
  196. 195.
    Gerdes J, Lemke H, Baisch H, et al: Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133:1710–1715, 1984.PubMedGoogle Scholar
  197. 196.
    Hamper K, Caselitz J, Schreiber M, et al: Vergleichende Untersuchungen zum Proliferationsund Rezeptorverhalten von Speicheldrüsen- und Mammatumoren. Eine immunhistologische Studie. Verh Dtsch Ges Path 70:461, 1986.Google Scholar
  198. 196.
    Hamper K, Caselitz J, Schreiber M, et al: Vergleichende Untersuchungen zum Proliferationsund Rezeptorverhalten von Speicheldrüsen- und Mammatumoren. Eine immunhistologische Studie. Verh Dtsch Ges Path 70:461, 1986.Google Scholar
  199. 198.
    Seifert G (Ed): Morphological Tumor Markers. General Aspects and Diagnostic Relevance. Curr Top Pathol 77, 1–398. Springer, Berlin-Heidelberg-New York, 1987.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Gerhard Seifert
  • Jorg Caselitz

There are no affiliations available

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