Abstract
Evidence has accumulated to indicate that the release of the neurohypophysial hormones occurs by exocytosis (emiocytosis, and reverse pinocytosis, are synonyms). During this process, the secretory granule-limiting membrane fuses with the plasma membrane, and an opening is formed which allows passage of the soluble content of the neurosecretory granules to the extracellular environment.
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References
Branton, D.: Fracture faces of frozen membranes. Proc. nat. Acad. Sci. (Wash.) 55, 1048–1056 (1966).
Bunt, A. H.: Formation of coated and “synaptic” vesicles within neurosecretory axon terminals of the crustacean sinus gland. J. Ultrastruct. Res. 28, 411–421 (1969).
Dempsey, G.P., Bullivant, S., Watkins, W.B.: Ultrastructure of the rat posterior pituitary gland and evidence of hormone release by exocytosis as revealed by freeze-fracturing. Z. Zellforsch., in press.
Douglas, W.W., Ishida, A. : The stimulant effect of cold on vasopressin release from the neurohypophysis in vitro. J. Physiol. (Lond.) 179, 185–191 (1965).
Douglas, W.W., Nagasawa, J., Schulz, R.: Electron microscopic studies on the mechanism of secretion of posterior pituitary hormones and significance of micro vesicles (“synaptic vesicles”) evidence of secretion by exocytosis and formation of micro vesicles as a byproduct of this process. In: Subcellular Organization and Function in Endocrine Tissues. Memoirs of the Society for Endocrinology, No. 19 (H. Heller, K. Lederis, Eds.), p. 353–377. Cambridge: University Press 1971a.
Douglas, W.W., Nagasawa, J., Schulz, R. : Coated microvesicles in neurosecretory terminals of posterior pituitary glands shed their coats to become smooth “synaptic” vesicles. Nature (Lond.) 232, 340–341 (1971b).
Dreifuss, J. J., Akert, K., Sandri, C, Moor, H. : The fine structure of freeze-fractured neurosecretory nerve endings in the neurohypophysis. Brain Res., in press.
Dreifuss, J. J., Grau, J.D., Bianchi, R.E.: Antagonism between Ca and Na ions at neurohypophysial nerve terminals. Experientia (Basel) 27, 1295–1296 (1971).
Dreifuss, J. J., Grau, J.D., Nordmann, J. J. : Effects on the isolated neurohypophysis of agents which affect the membrane permeability to calcium. J. Physiol. (Lond.) 231, 96–98P (1973).
Krisch, B., Becker, K., Bargmann, W. : Exocytose am Hinterlappen der Hypophyse. Z. Zellforsch. 123, 47–54 (1972).
Nagasawa, J., Douglas, W.W., Schulz, R.: Micropinocytotic origin of coated and smooth microvesicles (“synaptic vesicles”) in neurosecretory terminals of posterior pituitary glands demonstrated by incorporation of horseradish peroxidase. Nature (Lond.) 232, 341–342 (1971).
Nordmann, J. J., Dreifuss, J. J., Ravazzola, M., Malaisse-Lagae, F., Orci, L.: Secretion-dependent endocytosis in the rat neurohypophysis. Submitted for publication.
Norman, T.C.: The mechanism of hormone release from neurosecretory axon endings in the insect Calliphora erythrocephala. In: Aspects of Neuroendocrinology (W. Bargmann, B. Scharrer, Eds.), p. 30–42. Berlin-Heidelberg-New York: Springer 1970.
Norman, T. C, Duve, H.: Experimentally induced release of a neurohormone influencing hemolymph trehalose level in Calliphora erythrocephala (Diptera). Gen. comp. Endocr. 12, 449–459 (1969).
Pfenninger, K., Akert, K., Moor, H., Sandri, C. : The fine structure of freeze-fractured presynaptic membranes. J. Neurocytol. 1, 129–149 (1972).
Smith, U. : The origin of small vesicles in neurosecretory axons. Tissue and Cell 2, 427–433 (1970).
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Dreifuss, J.J., Nordmann, J.J., Akert, K., Sandri, C., Moor, H. (1974). Exo-Endocytosis in the Neurohypophysis as Revealed by Freeze-Fracturing. In: Knowles, F., Vollrath, L. (eds) Neurosecretion — The Final Neuroendocrine Pathway. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12587-8_4
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DOI: https://doi.org/10.1007/978-3-662-12587-8_4
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