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ts1 MoMuLV: A Murine Model of Neuroimmunodegeneration

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Neuroimmunodegeneration

Abstract

Replication-competent retrovirus infection results either in accel-erated cell proliferation leading to tumorigenesis or to degenerative cell death, particularly in the immune and nervous systems. The outcome depends on the virus, the cell type affected, and the stage of cell differentiation. The Moloney murine leukemia virus (MoMuLV) family is a good example of a retrovirus that can produce either outcome in the infected host. Although wild-type (WT) MoMuLV primarily causes T cell lymphoma, several temperature-sensitive (ts) mutants of MoMuLV have been shown to cause early and fatal degenerative disorders of the immune and nervous systems when administered to neonatal mice.1 One of these ts mutants, designated tsi MoMuLV, has been studied intensively. ts1 MoMuLV, isolated in 1973,2 was the first neuroimmunopathogenic retrovirus to be isolated in vitro from a nonneuroimmunovirulent MuLV.3 ts1 MoMuLV and its variants, however, are not the only murine retroviruses that induce neurological disorders. A large number of murine retroviruses, including CasBrE MuLV, an isolate of MuLV of wild mouse origin, are capable of inducing neurological disorders.4 Another murine retrovirus, LP-BM5, the virus which induces severe T and B cell deficiencies (murine AIDS), also induces a mild form of

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Authors
  1. Paul K. Y. Wong
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  2. William S. Lynn
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  3. Y. C. Lin
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  4. Wonkyu Choe
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  5. P. H. Yuen
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Editors and Affiliations

  1. M. D. Anderson Cancer Center, Science Park-Research Division, The University of Texas, Smithville, Texas, USA

    Paul K. Y. Wong  & William S. Lynn  & 

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© 1998 Springer-Verlag Berlin Heidelberg

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Wong, P.K.Y., Lynn, W.S., Lin, Y.C., Choe, W., Yuen, P.H. (1998). ts1 MoMuLV: A Murine Model of Neuroimmunodegeneration. In: Wong, P.K.Y., Lynn, W.S. (eds) Neuroimmunodegeneration. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12579-3_4

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  • DOI: https://doi.org/10.1007/978-3-662-12579-3_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-12581-6

  • Online ISBN: 978-3-662-12579-3

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