Toxin Induced Mitochondrial Dysfunction and Neurodegeneration

  • Mohammad I. Sabri


Several pieces of evidence suggest a relationship between environmental toxin exposure and onset of neurodegenerative diseases. Epidemiological evidence strongly supports the hypothesis that environmental agents cause neurological diseases, but specific chemicals that produce neurodegenerative diseases have not been identified.1,2 The concern about environmental toxins causing neurological dysfunction (e.g., movement disorders, and memory loss) has increased interest in investigating their role in triggering Parkinson’s disease (PD), Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS), however, little is being done to avert the threat from environmental toxins. The magnitude of the threat from toxic chemicals is illustrated by the fact that about 70,000 chemicals are currently used in industry, most of which have not been tested for their neurotoxic properties.3 As a result, thousands of people are exposed to toxic levels of environmental agents every day. While the number of people affected with neurotoxic disorders is unknown, the Health Care Financing Administration of the U.S. Department of Health and Human Services reported that $23 billion were spent in 1980 alone for the care of people with neurological diseases. In many cases, these illnesses were due to accidental exposure to neurotoxicants.4


Amyotrophic Lateral Sclerosis Huntington Disease Domoic Acid Environmental Toxin Mitochondrial Toxin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Mohammad I. Sabri

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