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Generation of Reactive Oxygen Species, DNA Damage and Lipid Peroxidation in Liver by Structurally Dissimilar Pesticides

  • S. J. Stohs
  • D. Bagchi
  • M. Bagchi
  • E. A. Hassoun

Abstract

The structurally dissimilar polyhalogenated cyclic hydrocarbons (PCH), chlorinated acetamide herbicides (CAH) and organophosphate insecticides (OPS) are classified as pesticides or contaminants of pesticides, and/or environmental pollutants. PCH such as endrin and chlordane, and CAH such as alachlor are halogenated and lipophilic [1–3], while OPS as fenthion and chlorpyrifos are organic triesters of phosphoric acid and phosphorothioic acid and are also lipophilic and highly toxic [3].

Keywords

Lipid Peroxidation Liver Homogenate Single Strand Break Hepatic Lipid Peroxidation Oxidative Tissue Damage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • S. J. Stohs
    • 1
  • D. Bagchi
    • 1
  • M. Bagchi
    • 1
  • E. A. Hassoun
    • 1
  1. 1.Department of Pharmaceutical and Administrative SciencesCreighton UniversityOmahaUSA

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