Liver Injury and Serum Hyaluronan

  • Takato Ueno
  • Kyuichi Tanikawa


Hyaluronan (HA) (hyaluronic acid, hyaluronate), a glycosaminoglycan macromolecule, is one of the major non-structural elements of the extracellular matrix. The major biological roles of HA include the maintenance of water and protein homeostasis as well as the protection of cells from potentially harmful effects. In the liver, most HA is produced by Ito cells (fat-storing cells, lipocytes, stellate cells) located in the Disse’s spaces [1]. On the other hand, HA in the tissue enters the blood stream through the lymph, and is rapidly taken up via receptors into hepatic sinusoidal endothelial cells (SEC), where degradation follows [2, 3].


Chronic Hepatitis Hyaluronic Acid Liver Cirrhosis Liver Fibrosis Primary Biliary Cirrhosis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Takato Ueno
    • 1
  • Kyuichi Tanikawa
    • 1
  1. 1.Second Department of MedicineKurume University School of MedicineKurume 830Japan

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