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Undifferentiated Gene Expression as the Entity of Liver Injuries

  • Kazuhisa Taketa

Abstract

In a series of studies analyzing enzyme activities of carbohydrate and related metabolism in injured livers as well as serum levels of α-fetoprotein (AFP) and its sugar chain in acute liver injury, undifferentiated phenotypes were noted as a common feature of hepatic injuries of different etiologies [1–8].

Keywords

Liver Injury Hepatocyte Growth Factor Carbon Tetrachloride Partial Hepatectomy Hepatic Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Taketa, K. (1973). Electrophoretic multiplicity of phosphofructokinase in rat liver and other tissues and effect of carbon tetrachloride intoxication, Acta Med Okayama, Vol. 27, pp. 205–209.PubMedGoogle Scholar
  2. 2.
    Watanabe, A. and Taketa, K. (1973). Actinomycin D-insensitive induction of rat liver glucose-6-phosphate dehydrogenase by carbon tetrachloride injury, J. Biochem, Tokyo, Vol. 73, pp. 771–779.Google Scholar
  3. 3.
    Taketa, K., Watanabe, A. and Kosaka, K. (1973). Biochemical mechanisms of increased AFP production by injured livers, Tumor Res, Vol. 8 pp. 108–113.Google Scholar
  4. 4.
    Ueda, M., Taketa, K. and Kosaka, K. (1975). Hexokinase isozyme pattern in CC14-injured rat liver, Clin Chim Acta, Vol. 60, pp. 77–84.PubMedCrossRefGoogle Scholar
  5. 5.
    Taketa, K., Watanabe, A. and Kosaka, K. (1975). Different mechanisms of increased a-fetoprotein production in rats following CC14 intoxication and partial hepatectomy, Ann N.Y.Acad Sci, Vol. 259, pp. 80–84.PubMedCrossRefGoogle Scholar
  6. 6.
    Taketa, K., Tanaka, A., Watanabe, A., Takesue, A., Aoe, H. and Kosaka, K. (1976). Undifferentiated patterns of key carbohydrate metabolizing enzymes in injured livers, I. Acute carbon tetrachloride intoxication of rat, Enzyme, Vol. 21, pp. 158–173.PubMedGoogle Scholar
  7. 7.
    Watanabe, A., Taketa, K., Kosaka, K. and Miyazaki, M. (1976). Mechanisms of increased alpha-fetoprotein production by hepatic injury and its pathophysiological significance, Onco-Developmental Gene Expression, W. H. Fishman and S. Sell, eds., Academic Press, New York, pp. 209–217.Google Scholar
  8. 8.
    Taketa, K, Watanabe, A. and Kosaka, K. (1976). Undifferentiated gene expression in liver injuries, Onco-Developmental Gene Expression, W.H. Fishman and S. Sell, eds., Academic Press, New York, pp. 219–226.Google Scholar
  9. 9.
    Taketa, K., Shimamura, J., Mori, O., Watanabe, A., Ueda, M., Kobayashi, M. and Nagashima, H. (1979). Onco-fetal proteins in liver injuries and preneoplastic livers-Alteration of carbohydrate-metabolizing key isozymes, Oncofetal Protein, Particularly on Hepatoma, H. Hirai and Y. Tsukada, eds., Nankoudou Publisher, Tokyo, pp. 308–322 (Japanese).Google Scholar
  10. 10.
    Kobayashi, M. (1978). Studies of liver phosphorylase in hepatic injuries II. Alteration in isozyme pattern, Acta Med Okayama, Vol. 32, pp. 319–330.PubMedGoogle Scholar
  11. 11.
    Taketa, K., Shimamura, J., Takesue, A., Tanaka, A. and Kosaka, K. (1976). Undifferentiated patterns of key carbohydrate-metabolizing enzymes in injured livers, II. Human viral hepatitis and cirrhosis of the liver, Enzyme, Vol. 21, pp. 200–210.PubMedGoogle Scholar
  12. 12.
    Ueda, M. (1975). Hexokinase isozyme in human liver: altered isozyme distribution among liver diseases, Acta Hepatol Jpn, Vol. 16, pp. 503–510 (Japanese).Google Scholar
  13. 13.
    Nishi, S. and Hirai, H. (1973). Radioimmunoassay of a-fetoprotein in hepatoma, other liver diseases, and pregnancy, Gann Monogr Cancer Res, Vol. 14, pp. 79–87.Google Scholar
  14. 14.
    Ishiguro, T., Taketa, K. and Gatti, R.A. (1986). Tissue of origin of elevated alpha fetoprotein in ataxia-telangiectasia, Disease Markers, Vol. 4, pp. 293–297.PubMedGoogle Scholar
  15. 15.
    Watanabe, A., Miyazaki, M. and Taketa, K. (1976). Differential mechanisms of increased a1-fetoprotein production in rats following carbon tetrachloride injury and partial hepatectomy, Cancer Res, Vol. 36, pp. 2171–2175.PubMedGoogle Scholar
  16. 16.
    Kinoshita, T., Tashiro, K. and Nakamura, T. (1989). Marked increase of HGF mRNA in non-parenchymal liver cells of rats treated with hepatotoxins, Biochem and Biophys Res Communs, Vol. 165, pp. 1229–1234.CrossRefGoogle Scholar
  17. 17.
    Okajima, A., Miyazawa, K. and Kitamura, N. (1990). Primary structure of rat hepatocyte growth factor and induction of its mRNA during liver regeneration following hepatic injury, Eur J. Biochem, Vol. 193, pp. 375–381.PubMedCrossRefGoogle Scholar
  18. 18.
    Ito, T., Hayashi, N., Horimoto, M., Sasaki, Y., Tanaka, Y., Kaneko A., Fusamoto, H. and Kamada, T. (1993). Expression of the c-met/hepatocyte growth factor receptor gene during rat liver regeneration induced by carbon tetrachloride, Biochem Biophys Res Communs, Vol. 190, pp. 870–874.CrossRefGoogle Scholar
  19. 19.
    Alpert, E. and Feller E.R. (1978). a-Fetoprotein (AFP) in benign liver disease: evidence that normal liver regeneration does not induce AFP synthesis, Gastroenterology, Vol. 74, pp. 856–858.Google Scholar
  20. 20.
    Karvountizis, G.G. and Redeker, A.G. (1974). Relation of alpha-fetoprotein in acute hepatitis to severity and prognosis, Ann Intern Med, Vol. 80, pp. 156160.Google Scholar
  21. 21.
    Collazos, J., Genolla, J. and Ruibal, A. (1992). Preliminary study of alphafetoprotein in nonmalignant liver diseases. A clinicobiochemical evaluation, Int J Biol Markers, Vol. 7, pp. 97–102.PubMedGoogle Scholar
  22. 22.
    Taketa, K. and Sekiya, C. (1993). Liver injury marker (9), Tumor marker, Practical Gastroenterology, A. Okub, eds., Bunkou-dou Publisher, Tokyo, pp. 144–147 (Japanese).Google Scholar
  23. 23.
    Taketa, K., Shimamura, J., Ueda, M., Shimada, Y. and Kosaka, K. (1988). Profiles of carbohydrate-metabolizing enzymes in human hepatocellular carcinomas and preneoplastic livers, Cancer Research, Vol. 48, pp. 467–474.PubMedGoogle Scholar
  24. 24.
    Taketa, K. (1990): a-Fetoprotein: reevaluation in hepatology, Hepatology, Vol. 12, pp. 1420–1432.Google Scholar
  25. 25.
    Taketa, K., Sekiya, C., Namiki, M., Akamatsu, K., Ohta, Y. and Endo, Y. (1990). Lectin-reactive profiles of alpha fetoprotein characterizing hepatocellular carcinoma and related conditions, Gastroenterology, Vol. 99, pp. 508–518.PubMedGoogle Scholar
  26. 26.
    Taketa, K., Ikeda, S., Sekiya, C. and Shimamura, J. (1994). a-fetoprotein, KanTan-Sui, Vol. 29, pp. 621–627 (Japanese).Google Scholar
  27. 27.
    Du, M.Q., Hutchinson, W.L., Johnson, P.J. and Williams, R. (1991). Differential alpha fetoprotein lectin binding in hepatocellular carcinoma, Diagnostic utility at low serum levels, Cancer, Vol. 67, pp. 476–480.PubMedCrossRefGoogle Scholar
  28. 28.
    Szpirer, C., Riviere, M., Cortese, R., Nakamura, T., Islam, M.Q., Levan, G. and Szpirer, J. (1992). Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNFI/LFB1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF), Genomics, Vol. 13, pp. 293–300.PubMedCrossRefGoogle Scholar
  29. 29.
    Tronche, F. and Yaniv, M. (1992). HNFI, a homeoprotein member of the hepatic transcription regulatory network, Bioessays, Vol. 14, pp. 579–587.PubMedCrossRefGoogle Scholar
  30. 30.
    Cuif, M.H., Porteu, A., Kahn, A. and Vaulont, S. (1993). Exploration of a liver-specific, glucose/insulin-responsive promoter in transgenic mice, J Biol Chem, Vol. 268, pp. 13769–13772.PubMedGoogle Scholar
  31. 31.
    Wu, K.J., Wilson, D.R., Shih, C. and Darlington, G.J. (1994). The transcription factor HNFI acts with C/EBP alpha to. synergistically activate the human albumin promoter through a novel domain, J Biol Chem, Vol. 269, pp. 1177–1182.PubMedGoogle Scholar
  32. 32.
    Nagy, P., Bisgaard, H.C. and Thorgeirsson, S.S. (1994). Expression of hepatic tracscription factors during liver development and oval cell differentiation, J Cell Biol, Vol. 126, pp. 223–233.PubMedCrossRefGoogle Scholar
  33. 33.
    Stumpf, H., Senkel, S., Rabes, H.M. and Ryffel, G.U. (1995). The DNA binding activity of the liver transcription factors LFBI (HNF1) and HNF4 varies coordinately in rat hepatocellular carcinoma, Carcinogenesis, Vol. 16, pp. 143–145.PubMedCrossRefGoogle Scholar
  34. 34.
    Yasuda, H., Mizuno, A., Tamaoki, T. and Morinaga, T. (1994). ATBF1, a multiple-homeodomain zinc finger protein, selectively down-regulates AT-rich elements of the human alpha-fetoprotein gene, Mol Cell Biol, Vol. 14, pp. 1395–1401.PubMedGoogle Scholar
  35. 35.
    Panduro, A., Shalaby, F. and Shafritz, D.À. (1987). Liver-specific gene expression in various pathophysiologic states, Hepatology, Vol. 7, pp. 10S - 18S.PubMedCrossRefGoogle Scholar
  36. 36.
    Watanabe, A. and Taketa, K. (1972). Actinomycin D-insensitive induction of rat liver glucose-6-phosphate dehydrogenase by carbon tetrachloride injury, J Biochem, Vol. 73, pp. 771–779.Google Scholar
  37. 37.
    Briborowicz, J. and Mackiewicz, A. (1989). Affinity electrophoresis for diagnosis of cancer and inflammatory conditions, Electrophoresis, Vol. 10, pp. 568–573.CrossRefGoogle Scholar
  38. 38.
    Hansen, J.E.S., Brpg-Hansen, T.C., Pedersen, B. and Neland, K. (1989). Microheterogeneity of orosomucoid in pathological conditions, Electrophoresis, Vol. 10, pp. 574–578.PubMedCrossRefGoogle Scholar
  39. 39.
    Mackiewicz, A., Rose, J.S., Schooltink, H., Laciak, M., Gorny, A. and Heinrich, P.C. (1992). Soluble human interleukin-6-receptor modulates interleukin-6dependent N-glycosylation of al-protease inhibitor secreted by HepG2 cells, Febs Lett, Vol. 306, pp. 257–261.Google Scholar
  40. 40.
    Hanasaki, K., Varki, A., Stamenkovic, I. and Bevilacqua, M.P. (1994). Cytokine-induced ß-galactoside a2,6-sialyltransferase in human endothelial cells mediates a2,6-sialylation of adhesion molecules and CD22 ligands, J Biol Chem, Vol. 269, pp. 10637–10643.PubMedGoogle Scholar
  41. 41.
    Okada, K., Shimizu, Y., Tsukishiro, T., Minemura, M., Nishimori, H., Higuchi, K. and Watanabe, A. (1994). Serum interleukin-8 levels in patients with hepatocellular carcinoma, Int Hepatol Commun, Vol. 2, pp. 178–182.CrossRefGoogle Scholar
  42. 42.
    Nakabayashi, H., Taketa, K., Miyano, K., Yamane, T. and Sato, J. (1982). Growth of human hepatoma cell lines with differentiated functions in chemically defined medium, Cancer Res, Vol. 42, pp. 3858–3863.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Kazuhisa Taketa
    • 1
  1. 1.Department of Public HealthOkayama University Medical SchoolOkayamaJapan

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