• P. Schöffski
  • C.-H. Köhne-Wömpner
  • H.-J. Schmoll


Häufigkeit: Gut- und bösartige Neubildungen des Dünndarms sind vergleichsweise selten und machen lediglich 5–10% aller gastrointestinalen Tumoren aus. Zwei Drittel dieser Tumoren sind maligne, entsprechend einem Anteil von nur 0,1–0,3% aller bösartigen Erkrankungen. In den USA werden jährlich 2100–2400 Neuerkrankungen registriert.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abe M, Takahashi M, Yabumoto E (1980) Clinical experience with intraoperative radiotherapy of locally advanced cancer. Cancer 45: 40–48PubMedCrossRefGoogle Scholar
  2. Baigrie R J (1991) Seven different primary cancers in a single patient. A case report and review of multiple primary malignant neoplasia. Eur J Surg Oncol 17; 8183Google Scholar
  3. Barnhill M, Hess E, Guccion JG, Nam LH, Bass BL, Patterson RH (1994) Tripartite differentiation in a carcinoma of the duodenum. Cancer 73: 266–272PubMedCrossRefGoogle Scholar
  4. Barquist E, Zinner M (1993) Neoplasms of the small intestine, vermiform appendix and peritoneum. In: Holland JF, Frei E, Bast RC, Kufe DW, Morton DL, Weichselbaum RR (eds) Cancer medicine. Lea and Febiger, Philadelphia London, pp 1485–1493Google Scholar
  5. Bastug DF, Cochran RC, Caldwell R, Foster D (1991) Adenocarcinoma of the small intestine in Crohn’s disease: a unique finding. W V Med J 87: 295–298PubMedGoogle Scholar
  6. Bugra D, Alper A, Goksen Y, Emre A (1991) Villous tumors of the duodenum. Hepatogastroenterology 38: 84–85PubMedGoogle Scholar
  7. Coit GC (1993) Cancer of the small intestine. In: De Vita VT, Hellman S, Rosenberg SA (eds) Cancer: Principles and practice of oncology. J. B. Lippincott, Philadelphia, pp 915–928Google Scholar
  8. Dannenberg A, Godwin T, Rayburn J, Goldin H, Leonard M (1989) Multifocal adenocarcinoma of the proximal small intestine in a patient with celiac sprue. J Clin Gastroenterol 11: 73–76PubMedCrossRefGoogle Scholar
  9. Del Vecchio R, La Torre P, Cotugno M, Costarelli L (1989) Adenocarcinoma of the duodenum associated with skin neurofibromatosis and Caroli’s disease. Minerva Chir 44: 2421–2426PubMedGoogle Scholar
  10. Donohue JH, Kelly KA (1991). Cancers of the small intestine. In: Moossa AR, Schimpff SC, Robson MC (eds) Comprehensive textbook of oncology. Williams and Wilkins, Baltimore, pp 892–903Google Scholar
  11. Dozois RR, Judd ES, Dahlin DC (1969) The Peutz-Jeghers syndrome: Is there a predisposition to the development of intestinal malignancy? Arch Surg 98: 509–517PubMedCrossRefGoogle Scholar
  12. Dupont Lampert V, Landmann J (1989) Tubulo-villous adenoma of the duodenum: case report and review of the literature. Schweiz Med Wochenschr 119: 1057–1059Google Scholar
  13. Fielding JR, Prior P, Waterhouse JA, Cooke WT (1972) Malignancy in Crohn’s disease. Scand J Gastroenterol 7: 3–7PubMedCrossRefGoogle Scholar
  14. Good CA (1963) Tumors of the small intestine. Am J Roentgenol 89: 685–705Google Scholar
  15. Hart R, Levin B (1993) Neoplasms of the small bowel. In: Calabresi P, Schein PS(eds) Medical oncology. Basic principles and clinical management of cancer. Mc Graw-Hill, New York, pp 741–747Google Scholar
  16. Jigyasu D, Bedikian AY, Stroehlein JR (1984) Chemotherapy for primary adenocarcinoma of the small bowel. Cancer 53: 23–25PubMedCrossRefGoogle Scholar
  17. Jones MA, Griffith LM, West AB (1989) Adenocarcinoid tumor of the periampullary region: a novel duodenal neoplasm presenting as biliary tract obstruction. Hum Pathol 20: 198–200PubMedCrossRefGoogle Scholar
  18. Kaminsky N, Shahm D, Eliakim R (1993) Primary tumours of the duodenum. Postgrad Med J 69: 136–138CrossRefGoogle Scholar
  19. Kusumoto H, Kumashirso R, Kido K, Inutsuka S (1991) Simultaneous adenocarcinoma of the stomach and fourth portion of the duodenum: case report and review of the literature. Radiat Med 9: 223–228PubMedGoogle Scholar
  20. Laurent F, Raynaud M, Biset JM, Boisserie-Lacroix M, Grelet P, Drouilliard J (1991) Diagnosis and categorization of small bowel neoplasms: Role of computed tomography. Gastrointest Radiol 16: 115–119Google Scholar
  21. Lehnert T, Deschner EE, Karmali RA, DeCosse JJ (1990) Effect of fluriprofen and 16,16-dimethyl prostaglandin E2 on gastrointestinal tumorigenesis induced by N-methyl-N-nitro-N-nitrosoguanidin in rats: glandular epithelium of stomach and duodenum. Cancer Res 50: 381–384PubMedGoogle Scholar
  22. Lillemoe KD, Sauter PK, Pitt HA, Yeo CJ, Cameron JL (1993) Current status of surgical palliation of periampullary carcinoma. Surg Gynecol Obstet 176: 1–10PubMedGoogle Scholar
  23. Lioe TF, Biggart JD (1990) Primary adenocarcinoma of the jejunum and ileum: clinicopathological review of 25 cases. J Clin Pathol 43: 533–536PubMedCrossRefGoogle Scholar
  24. Lowell JA, Rossi RL, Munson JL, Braasch JW (1992) Primary adenocarcinoma of third and fourth portions of duodenum. Favourable prognosis after resection. Arch Surg 127: 557–560Google Scholar
  25. Lowenfels AB, Sonni A (1977) Distribution of small bowel tumors. Cancer Lett 3: 83–86PubMedCrossRefGoogle Scholar
  26. Lynch HT, Smyrk TC, Lynch PM et al. (1989) Adenocarcinoma of the small bowel in Lynch syndrome II. Cancer 64: 2178–2183PubMedCrossRefGoogle Scholar
  27. Michelassi F, Erroi F, Dawson PJ, Pietrabissa A, Noda S, Handcock M, Block GE (1989) Experience with 647 consecutive tumors of the duodenum, ampulla, head of the pancreas, and distal common bile duct. Ann Surg 210: 544–554PubMedCrossRefGoogle Scholar
  28. Ohkusa T, Ohtomo K, Yamamoto N, Fujimoto H (1991) Primary adenocarcinoma of duodenal bulb benefitted by chemotherapy. Dig Dis Sci 36: 1653–1656PubMedCrossRefGoogle Scholar
  29. Panday SC, Go IH, Mravunac M, Koning RW de (1993) Obstructive jejunal adenocarcinoma in the Muir-Torre syndrome. Neth J Med 43: 116–120PubMedGoogle Scholar
  30. Poon MA, O’Connell MJ, Wieand HS, Krook JE, Gerstner JB, Tschetter LK, Levitt R, Kardinal CG, Mailliard JA (1991) Biochemical modulation of fluorouracil with Leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. J Clin Oncol 9 (11): 1967–1972PubMedGoogle Scholar
  31. Reddy VB, Husain AN, Gattuso P, Abraham K, Castelli MJ (1990) Synchronous adenocarcinomas of jejunum and cecum following transverse colon carcinoma. A case study. Mt Sinai J Med 57: 34–36Google Scholar
  32. Rösch T, Lorenz R, Zenker K et al. (1992) Local staging and assessment of resectability in carcinoma of the esophagus, stomach, and duodenum by endoscopic ultrasonography. Gastrointest Endosc 38: 460–467PubMedCrossRefGoogle Scholar
  33. Rotman N, Pezet D, Fagniez PL, Cherqui D, Celicout B, Lointier P (1994) Adenocarcinoma of the duodenum: factors influencing survival. Br J Surg 81: 83–85PubMedCrossRefGoogle Scholar
  34. Sheldon CD, Hodson ME, Carpenter LM, Swerdlow AJ (1993) A cohort study of cystic fibrosis and malignancy. Br J Cancer 68: 1025–1028PubMedCrossRefGoogle Scholar
  35. Sindelar WF, Hoekstra HJ, Kinsella TJ (1989) Surgical approaches and techniques in intraoperative radiotherapy for intra-abdominal, retroperitoneal, and pelvic neoplasms. Surgery 103: 247–256Google Scholar
  36. Surveillance, Epidemiology, and End Results Data (1987) J Natl Cancer Inst 78: 653Google Scholar
  37. Verhulst ML, Dur AH, Driessen WM (1993) Two sisters with coeliac disease and jejunal cancer: just a coincidence? Neth J Med 432: 16–20Google Scholar
  38. Wagner A, Waitz W (1990) Intratumorale Injektion von Mitomycin beim Adenokarzinom des Duodenums. Dtsch Med Wochenschr 115: 757PubMedGoogle Scholar
  39. Weiss NS, Yang C (1987) Incidence of histologic types of cancer of the small intestine. J Natl Cancer Inst 78: 653–656PubMedGoogle Scholar
  40. Yeung RS, Weese JL, Hoffmann JP et al. (1993) Neoadjuvant chemoradiation in pancreatic and duodenal carcinoma. A phase II study. Cancer 72: 2124–2133Google Scholar
  41. Zucchetti F, Bellantone R, Frontera D, Crucitti A, Bilanzone M, Crucitti F (1991) Adenocarcinoma of the small intestine. Int Surg 76: 230–234PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • P. Schöffski
  • C.-H. Köhne-Wömpner
  • H.-J. Schmoll

There are no affiliations available

Personalised recommendations