Zusammenfassung
Häufigkeit: Häufigste Tumorerkrankung in den westlichen Industrienationen. Von 1940–1980 bei Männern rasch steigende Inzidenz von 10 auf 70 pro 100000, seither Plateau der Erkrankungszahlen in den USA. Beim weiblichen Geschlecht seit 1965 permanent steigende Inzidenz von 5 auf 30 pro 100000. Ca. 90% der Patienten versterben an ihrer Erkrankung. Das Bronchialkarzinom ist daher die häufigste tumorbedingte Todesursache beim Mann und die zweithäufigste (nach dem Mammakarzinom) bei der Frau.
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Literatur
Albain K, Rusch V, Crowley Jet al. (1994) Concurrent cisplatin (DDP), VP16, and chest irradiation (RT) followed by surgery for stages IIIA and IIIB non small cell lung cancer (NSCLC): A Southwest Oncology Group (SWOG) Study (# 8805). Proc Am Soc Clin Oncol 13: 337 (p 1120 )
Ayesh R, Idle JR, Ritchie JC et al. (1984) Metabolic oxidation phenotypes as markers for susceptibility to lung cancer. Nature 312: 169–170
Bonomi PD, Finkelstein DM, Ruckdeschl JC et al. (1989) Combination chemotherapy versus single agents followed by combination chemotherapy in stage IV non-small cell lung cancer: A Study of the Eastern Cooperative Oncology Group. J Clin Oncol 7 (11): 1602–1613
Bulzebruck H, Bopp R, Drings P et al. (1992) New aspects in the staging of lung cancer. Cancer 70: 1102–1110
Burkes RL, Ginsberg RJ, Shepherd FA et al. (1992) Induction chemotherapy with mitomycin, vindesine, and cisplatin in for stage III unresectable non-small-cell lung cancer: Results of the Toronto phase II trial. J Clin Oncol 10: 580–586
Cellerino R, Tummarello D, Piga A (1990) Chemotherapy or not in advanced non-small cell lung cancer. Lung Cancer 6: 99–109
Charmack Holes E (1993) Postoperative chemotherapy for non small cell lung cancer. Chest 103: 30–34
Choy W, Akerley H, Safran H et al. (1994) Phase I trial of outpatient weekly paclitaxel and concurrent radiation therapy for advanced non small cell lung cancer. J Clin Oncol 12 (12): 2682–2688
Crino LM, Clerici F, Figoli F et al. (1995) Chemotherapy of advanced non small cell lung cancer. A comparison of three active regimens. A randomized trial of the Italian Oncology Group for Clinical Research ( G.O.I.R.C. ). Ann Oncol 6: 347–353
Dilimann RO, Seagren SL, Propert KJ et al. (1990) A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non small cell lung cancer. N Engl J Med 323: 940–945
Ebert W, Dienemann H, Fateh-Moghadam A, Scheulen M, Konietzko N, Schleich T, Bombardiere E (1994) CYTOKERTIN 19 fragment CYFRA 21–1 compared with carcinoembryonic antigen, squamous cell carcinoma antigen and neuron-specific enolase in lung cancer. Eur J Clin Chem Clin Biochem 32 (in press)
Gatzemeier U, Heckmayr M, Hossfeld DK et al. (1990) Chemotherapie des fortgeschrittenen nicht-kleinzelligen Bronchialkarzinoms mit Mitomycin-C/ Ifosfamid versus Mitomycin-C/Vindesin versus Cisplatin/Etoposid–Eine randomisierte Studie. Pneumologie 44: 91–674
Gatzemeier U, Shepherd F, Le Chevalier T et al. (1995) Activity of gemcitabine in patients with non small lung cancer. A multicentre, extended phase-II-study. Eur J Cancer (in press)
Ginsberg RJ (1993) Multimodality therapy for non small cell lung cancer: the role of surgery. Lung Cancer 9 (Suppl 2): 25–30
Holmes EG, Gail M (1986) Surgical adjuvant therapy for stage II and stage III adenocarcinoma and large cell undifferential carcinoma. J Clin Oncol 4: 710–715
Johnson DH, Einhorn LH, Bartolussi A et al. (1990) Thoracic radiotherapy does not prolong survival in patients with locally advanced, unresectable non small cell lung cancer. Ann Intern Med 113: 33–38
Kik K, Osinga J, Carritt B (1987) Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer. Nature 330: 578–581
Klatersky J et al. (1989) Cisplatin vs Cisplatin plus Etoposid an the treatment of advanced non small cell lung cancer. J Clin Oncol 7 (8): 1087–1092
Konietzko N, Ferlinz R, Loddenkemper R und die Arbeitsgemeinschaft „Diagnostik“ der „Deutschen Gesellschaft für Pneumologie und Tuberkulose” (1983) Präoperative Lungenfunktionsdiagnostik. Prax Klin Pneumol 37: 1199
Le Chevalier T, Arriagada R, Quoix E et al. (1991) Radiotherapy alone versus combined chemotherapy and radiotherapy in unresectable non small cell lung carcinoma. J Natl Cancer Inst 83: 417–423
Levine A, Momand J, Finaly C (1991) The p53 tumor suppressor gene. Nature 351: 453–456
Loddenkemper R (1983) Criteria of functional operability in patients with bronchial carcinoma: preoperative assessment of risk and prediction of postoperative function. J Thorac Cardiovasc Surg 31: 334
Manegold C, Fischer JR, Vogt-Moykopf I, Drings P (1994) Induction chemotherapy (ICT) in stage III A/B non-small cell lung cancer (NSCLC). J Cancer Res Clin Onkol 120 [Suppl]: 279
Martini N, Kries MG, Flehinger J et al. (1993) Preoperative chemotherapy for stage lIa (N2) lung cancer: The Sloan Kettering experience with 136 patients. Ann Thorac Surg 55: 1365–1374
Naruke T, Suemasu K, Ishikawa S (1978) Lymph node mapping and curability of various levels of metastases in resected lung cancer. J Thorax Cardiovasc Surg 76: 832–839
Rosell R, Gomez-Codina J, Camps C et al. (1994) A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non small cell lung cancer. N Engl J Med 330: 153–158
Rosso R et al. (1988) Etoposie +/- cisplatin in the treatment of advanced non small cell lung cancer (NSCLC): A fonicap randomized trial. Lung Cancer 4 (6):2.27:A 124
Roth JA, Fossella F, -Komaki R et al. (1994) A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non small cell lung cancer. J Natl Cancer Inst 86 (9):673–680
Ruckdeschel JC et al. (1986) A randomized trial of the four most active regimens for metastatic non small cell lung cancer. J Clin Oncol 4 (1): 14–22
Rudiger H, Schwartz U, Serrand E et al. (1989) Reduced 06-methylguanine repair in fibroblast cultures from patients with lung cancer. Cancer Res 49: 5623–5626
Schaake-Koning C, Van den Bogaert W, Dalesio O et al. (1992) Effects of concomitant cisplatin and radiotherapy on inoperable non small cell lung cancer. N Engl J Med 326: 524–530
Schildberg FW, Sunder-Plassmann L (1990) Chirurgische Therapie des Bronchial-carcinomas. Chirurg 61: 558–564
Schirren J, Krysa S, Trainer S, Bülzebruck H, Wassenberg D, Di Rienzo N, Branscheid D (1993) Die Technik der systematischen Lymphadenektomie beim Bronchialkarzinom unter besonderer Berücksichtigung am linken Hemithorax. Z Herz-Thorax-Gefäßchir 7: 178–183
Seidegard J Pero RW, Müller DG et al. (1986) A gluthathione transferase in human leucocytes as a marker for the susceptibility to lung cancer. Carcinogenesis 751–753
Smith ThJ, Hillner BE, Neigbors D et al. (1995) Economic evaluation of a randomized clinical trail comparing vinorelbine, vinorelbine plus cisplatin and vindesine plus cisplatin for non small cell lung cancer. J Clin Oncol 13: 2166–2173
Splinter TAW, Verhoeven G, Kho GS, Bos E, Zondervan P (1993) Neoadjuvant chemotherapy in stage 3 non small cell lung cancer (NSCLS): Evaluation of response. Proc ASCO 12: 359 (abs. 1213)
Stamatis G, Wilke H, Eberhardt W et al. (1994) Chirurgie des lokal fortgeschrittenen nicht-kleinzelligen Bronchialkarzinoms nach intensiver präoperativer Chemo-/Strahlentherapie. Chirurg 65: 42–47
Vogt-Moykopf I, Krysa S, Probst G et al. (1991) Die chirurgische Therapie des Bronchialkarzinoms. In: Drings P, Vogt-Moykopf I (Hrsg) Thoraxtumoren. Springer, Berlin Heidelberg New York Tokyo, S 170–186
Watanabe I, Shimizu J, Oda M (1991) Results of surgical treatment in patients with stage III-A non small cell lung cancer. J Thorac Cardiovasc Surg 39: 44–49
Weick JK, Crowley J, Natale RB et al. (1991) A randomized trial of five cisplatincontaining in patients with metastatic non small cell lung cancer: A Southwest Oncology Group Study. J Clin Oncol 9 (7): 1157–1162
Weitberg AB, Yashar J, Glicksman AS et al. (1993) Combined modality therapy for stage IIIA non small cell carcinoma of the lung. Eur J Cancer 29A /4: 511–515
Wilke H, Eberhardt W, Stamatis G et al. (1995) High efficacy of an intensive preoperative chemo-radiotherapy for locally far advanced (LAD) NSCLC. Proc Am Soc Clin Oncol 14 /371: 1142
Wolf M, Havemann K, Hans K et al. (1989— Spontaneous tumor growth as a selection criterium for chemotherapy in extensive stage non-small cell lung cancer (NSCLC). Proc ECCO 5, Lung Cancer 0–0006
Wolf M, Goerg C, Goerg K, Pfab R, Achterrath W, Havemann K (1992) Carboplatin and simultaneous radiation in the treatment of stage IIIA/B non small cell lung cancer. Oncology 49 [Suppl 11: 71–77
Wolf M, Merte H, Faoro C et al. (1995) Dose finding study of paclitaxel and simultaneous radiotherapy in stage III non small cell lung cancer NSCLC. Proc Am Soc Clin Oncol 14 /348: 10–52
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Wolf, M., Havemann, K., Schneider, P., Vogt-Moykopf, I., Budach, V. (1997). Nichtkleinzelliges Bronchialkarzinom. In: Schmoll, HJ., Höffken, K., Possinger, K. (eds) Kompendium Internistische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12175-7_28
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