Zusammenfassung
Definition: Die Mundhöhle reicht von der Schleimhautgrenze der Lippe bis zum Übergang vom harten zum weichen Gaumen (obere Begrenzung) sowie bis zur Linie der Papillae vallatae. Der Oropharynx beinhaltet den Zungengrund, die Tonsillen und die Rachenhinterwand. Die Epiglottis gehört nach der neuesten UICC-Einteilung zur Supraglottis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Ahsee KW, Cooke TG, Pickford IR et al. (1994) An allelotype of sqamous carcinoma of the head and neck using microsatelite markers. Cancer Res 54: 1617–1621
Ang KK, Peters LK, Maor MH, Morrison WH, Wendt CCD, Brown BW (1990) Concomitant boost radiotherapy schedules in in the treatment of carcinoma of the oropharynx and nasopharynx. Int J Radiat Oncol Biol Phys 19: 1339–1345
Ang KK, Kaanders JHAM, Peters LJ (eds) (1994) Radiotherapy for head and neck cancers: indications and techniques. Lea amp; Febiger, Philadelphia
Boyle JO, Hakim J, Koch W et al. (1993) The incidence of p53 mutations increases with progression of head and neck cancer. 53: 4477–4480
Burkhardt A, Maerker R (1978) Dyplasieklassifikation oraler Leukoplakien und Präkanzerosen. Bedeutung für Prognose und Therapie. Dtsch Z Mund Kiefer Gesichtschir 2: 199
Callender T, El-Nagger AK, Lee MS et al. (1994) PRAD-1 (CCBD 1)/cyclin D1 oncogene amplification in primary head and neck squamous cell carcinoma. Cancer 74: 152–158
Catimel G, Vermorken JB, Clavel M et al. (1994) A phase II study of Gemcitabine (LY 188011) in patients with advanced squamous cell carcinoma of the head and neck. Ann Oncol 5: 533–537
Catimel G, Verweij J, Mattijssen V et al. (1994) Docetaxele (Taxotere): An active drug for the treatment of patients with advanced squamous cell carcinoma of the head and neck. Ann Oncol 5: 533–537
Chicarilli ZN, Ariyan S (1987) Surgical management. In: Ariyan S (ed) Cancer of the head and neck. Mosby, St. Louis
Cowan JM, Beckett MA, Ahmed-Swan S, Weichselbaum RR (1992) Cytogenetic evidence of the multistep origin of head and neck squamous cell carcinomas. J Natl Cancer Inst 84: 793–796
De Andrés L, Brunet J, Lopez-Pousa A et al. (1995) Randomized trial of neoadjuvant cisplatin and fluorouracil versus carboplatin and fluorouracil in patients with stage IV-MO head and neck cancer. J Clin Oncol 13: 1493–1500
Decker DA et al. (1983) Adjuvant chemotherapy with cis-diamminedichloroplatinum II and 1–2-hour infusion 5-fluorouracil in stage III and IV squamous cell carcinoma of the head and neck. Cancer 51: 1353–1355
Foote RL, Parsons, JT, Mendenhall WM, Million RR, Cassisi NJ, Stringer ST (1990) Is interstitial implantation essential for successful radiotherapeutic treatment of base of tongue carcinoma? Int J Radiat Oncol Biol Phys 18: 1293–1298
Forastiere AA (1991) Randomized trials of induction chemotherapy: A critical review. Hematol Oncol Clin North Am 5: 725–736
Forastiere AA, Urba SG (1995) Single agent paclitaxel and paclitaxel plus infosfamide in the treatment of head and neck cancer. Semin Oncol 22: 24–27
Forastiere AA, Metch B, Schuller DE et al. (1992) Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck: A Southwest Oncology Group study. J Clin Oncol 10: 1245–1251
Gebbia V, Testa A, Valenza R et al. (1993) A pilot study of vinorelbine on a weekly schedule in recurrent and/or metastatic squamous cell carcinoma of the head and neck. Eur J Cancer 29A: 1358–1359
Gebbia V, Testa A, Valenza R et al. (1993) Vinorelbine plus cisplatin and 5fluorouracil in recurrent and/or metastatic squamous cell head and neck carcinoma. Proc Am Soc Clin Oncol 12: 283 (Abstr 917)
Goffinet DR et al. (1975) Irradiation of clinically uninvolved cervical lymph nodes. Can J Otolaryngol 4: 927
Head and Neck Contracts Program (1987) Adjuvant chemotherapy for advanced head and neck squamous carcinoma: Final report. Cancer 60: 301–311
Horiot JC, Le Fur R, N“Guyen T et al. (1992) Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy. Radiother Oncol 25: 231–241
Jacobs C, Makuch R (1990) Efficacy of adjuvant chemotherapy for patients with resectable head and neck cancer: A subset analysis of the Head and Neck Contracts Program. J Clin Oncol 8: 838–847
Jacobs C, Goffinet DR, Goffinet L et al. (1987) Chemotherapy as a substitute for surgery in the treatment of advanced resectable head and neck cancer. A report from the Northern California Oncology Group. Cancer 60: 1178–1183
Jacobs C, Lyman G, Valez-Garcia E et al. (1992) A phase III randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck. J Clin Oncol 10: 257–263
Jarez P, Fernandez PL. Campo E et al. (1994) PRAD-1/Cyclin D1 gene amplification correlates with mesenger RNA overexpression and tumor progression in human laryngeal carcinomas. Cancer Res 54: 4813–4817
Kalniens IK et al. (1977) Correlation between prognosis and degree of lymph node involvement in carcinoma of the oral cavity. Am J Surg 134: 450
Keus RB, Pontvert D, Brunin F, Jaulerry Ch, Bataini JP (1988) Results of irradiation in squamous cell carcinoma of the soft palate and uvula. Radiother Oncol 11: 311–317
Kristen K, Zöller J (1992) Tumoren im Kopf-und Halsbereich. In: Vinzenz K, Waclawiczek HW (Hrsg) Chirurgische Therapie von Kopf-Hals-Tumoren. Springer, Wien New York
Laramore GE, Scott CB, Al-Sarraf M et al. (1992) Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: Report on intergroup study. Int J Radiat Oncol Biol Phys 23: 705–713
Lefebvre JL, Sahmoud T, for the EORTC Head and Neck Cancer Cooperative Group (1994) Larynx preservation in hypopharynx squamous cell carcinoma: Peliminary results of a randomized study (EORTC 24891). Proc Am Soc Clin Oncol 13: 283 (Abstr 912)
Leone LA et al (1968) Treatment of carcinoma of the head and neck with intravenous methotrexate. Cancer 21: 828–837
Liverpool Head and Neck Oncology Group (1992) A phase III randomized trial of cisplatinum, methotrexate, cisplatinum + methotrexate and cisplatinum + 5-FU in end stage squamous carcinoma of the head and neck. Br J Cancer 61: 311–315
Lotan R, Xu XC, Lippman SM et al. (1995) Suppression of retinoic acid receptor-a in premaligmant oral lesions and its up-regulation by isotretinoin. N Engl J Med 332: 1405–1410
Mak-Kregar S, Hilgers FJM, Levendag PC et al. (1995) A nationwide study of the epidemiology, treatment and survival of oropharyngeal carcinoma in the Netherlands. Eur Arch Otorhinopharyngol 252: 133–138
Mashberg A, Meyers H (1976) Anatomical site and size of 222 early asymptomatic oral squamous carcinomas: A continuing prospective study of oral cancer. Cancer 37: 1149
Mazer TM, Robbins KT, Mc Murtrey MJ et al. (1988) Resection of pulmonary metastases from squamous carcinoma of the head and neck. Am J Surg 156: 238–242
Merlano M, Grimaldi A, Benasso M et al. (1988) Alternating cisplatin-5-fluorouracil and radiotherapy in head and neck cancer. Am J Clin Oncol 11: 538–542
Merlano M, Corvo R, Marganno G et al. (1991) Combined chemotherapy and radiation therapy in advanced inoperable squamous cell carcinoma of the head and neck: The final report of randomized trial. Cancer 67: 915–921
Merlano M, Vitale V, Rosso R et al. (1992) Treatment of advanced squamous cell carcinoma of the head and neck with alternating chemotherapy and radiotherapy. N Engl J Med 327: 1115–1121
Million RR, Cassisi NJ (eds) (1994) Management of head and neck cancer, 2nd edn. Lippincott, Philadelphia
Morton RP, Rugman F, Dorman EB et al. (1985) Cisplatinum and bleomycin for advanced or recurrent squamous cell carcinoma of the head and neck: A randomized factorial phase III controlled trial. Cancer Chemother Pharmacol 15: 282–289
Paccagnella A, Orlando A, Marcniori C et al. (1994) Phase III trial of initial chemotherapy in stage III or IV head and neck cancers: A study by the Gruppo di Studio sui Tumori della Testa e del Collo. J Natl Cancer Inst 86: 265–272
Parkin DM et al. (1988) Estimates of the worldwide frequency of sixteen major cancers in 1980. Int J Cancer 41: 184
Robert F, Wheller RH, Molthrop DC et al. (1994) Phase II study of topotecan in advanced head and neck cancer: Identification of an active new agent. Proc Am Soc Clin Oncol 13: 281 (Abstr 905)
Rudert H (1992) Maligne Tumoren der Lippen, der Mundhöhle und des Oropharynx. In: Naumann HH et al. (Hrsg) Otorhinolaryngologie in Klinik und Praxis, Bd 2. Thieme, Stuttgart, S 648–668
Schuller DE, Metch B, Stein DW et al. (1988) Preoperative chemotherapy in advanced resectable head and neck cancer: Final report of the Southwest Oncology Group. Laryngoscope 98: 1205–1211
Shanmugaratnam K (1991) Histologic typing of tumours of the upper respiratory tract and ear, 2nd edn. Springer, Berlin Heidelberg New York Tokyo
Shin DM, Kim J, Ro JY et al. (1994) Activation of p53 gene expression in pre-malignant lesions during head and neck tumorigenesis. Cancer Res 54: 321–326
Somers KD, Cartwright SL, Schechter GL (1990) Amplifications of the int-2 gene in human head and neck squamous cell carcinomas. Oncogene 5: 915–920
Stevens KR Jr, Britsch A, Moss WT et al. (1993) High-dose reirradiation of head and neck cancer with curative intent. Int J Radiat Oncol Biol Phys 29: 913
The Department of Veterans Affairs Laryngeal Cancer Study Group (1991) Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 324: 1685–1690
Van der Riet P, Nawroz H, Hruban RH et al. (1994) Frequent loss of chromosome 9p21–22 early in head and neck cancer progression. Cancer Res 54: 1156–1158
Van Dyke DL, Worsham MJ, Benninger MS et al. (1994) Recurrent cytogenetic abnormalities in squamous cell carcinoma of the head and neck region. Genet Chromosom Cancer 9: 192–206
Veronesi A, Zagonel V, Tirelli U et al. (1985) High-dose versus low-dose cisplatin in advanced head and neck squamous carcinoma: A randomized study. J Clin Oncol 3: 1105–1108
Verweij J, Alexiery-Figresch J, DeBoer MF (1988) Ifosfamide in advanced head and neck cancer. A phase II study of the Rotterdam Cooperative Head and Neck Cancer Study Group. Eur J Cancer Clin Oncol 24: 795–796
Vokes EE (1993) Flourouracil modulation in head and neck cancer. In Rustum YM (ed) Novel approaches to selective treatments of human solid tumors: Laboratory and clinical correlation. Plenum Press, New York, pp 197–208
Vokes EE, Athanasiadis I (1996) Chemotherapy for squamous carcinoma of head and neck: The future is now. Ann Oncol 7: 15–29
Vokes EE, Weichselbaum RR (1990) Concomitant chemoradiotherapy: Rationale and clinical experience in patients with solid tumors. J Clin Oncol 8: 911–934
Vokes EE, Rosenberg RK, Jahanzeb M et al. (1995) Multicenter phase II study of weekly oral vinorelbine for stage IV non-small cell lung cancer. J Clin Oncol 13: 637–644
Wang CC (1993) To reirradiate or not to reirradiate? Int J Radiat Oncol Biol Phys 29: 913
Wendt TG, Hartenstein RC, Wustrow TP et al. (1989) Cisplatin/fluorouracil with leucovorin enhancement, and synchronous accelerated radiotherapy in the management of locally advanced head and neck cancer: A phase II study. J Clin Oncol 7: 471–476
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Heermann, R., Lenarz, T., Schmoll, HJ. (1997). Lippen-, Mundhöhlen- und Oropharynx-Tumoren. In: Schmoll, HJ., Höffken, K., Possinger, K. (eds) Kompendium Internistische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12175-7_23
Download citation
DOI: https://doi.org/10.1007/978-3-662-12175-7_23
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-60830-1
Online ISBN: 978-3-662-12175-7
eBook Packages: Springer Book Archive