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Hochmaligne nodale Non-Hodgkin-Lymphome, lymphoblastische und Burkitt-Lymphome

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Kompendium Internistische Onkologie

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Zusammenfassung

Inzidenz: Bei einer Gesamtinzidenz der Non-Hodgkin-Lymphome (NHL) von ca. 6/100000 pro Jahr sind nach den Daten des Kieler Lymphknotenregisters in etwa 30% der Fälle Erkrankungen an hochmalignen NHL zu erwarten. Die Inzidenz liegt für Männer generell etwas höher als für Frauen, wobei der Quotient für die einzelnen NHL-Entitäten variiert.

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Literatur

  • Armitage JO (1993) Treatment of non-Hodgkin’s lymphoma. N Engl J Med 328: 1023 - 1030

    Article  PubMed  CAS  Google Scholar 

  • Cabanillas F, Hagemeister FB, Bodey GP, Freireich EJ (1982) IMVP-16 An effective regimen for patients with lymphoma who have relapsed after initial combination chemotherapy. Blood 60: 693 - 697

    PubMed  CAS  Google Scholar 

  • Coleman NC, Picozzi VR jr, Cox RS et al. (1986) Treatment of lymphoblastic lymphoma in adults. J Clin Oncol 4: 1628 - 1637

    PubMed  CAS  Google Scholar 

  • Engelhard M, Meusers P, Brittinger G et al. (1991) Prospective multicenter trial for the response-adapted treatment of high-grade malignant non-Hodgkin’s lymphomas: Updated results of the COP-BLAM/IMVP-16 protocol with randomized adjuvant radiotherapy. Ann Oncol 2 [Suppl 2]: 177 - 180

    Article  PubMed  Google Scholar 

  • Engelhard M, Löffler M (1993) Klinisch relevante Prognosefaktoren maligner Lymphome. Internist 34: 127 - 131

    PubMed  CAS  Google Scholar 

  • Engert A, Engelhard M, Scheulen M et al. (1993) Phase-II study of idarubicin, ifosfamide, and VP-16 (IIVP-16) in patients with relapsed aggressive non-Hodgkin’s lymphoma. Ann Hematol 67 [Supp]: A30 (Abstr 117)

    Google Scholar 

  • Fisher RI, Gaynor ER, Dahlberg Set al. (1993) Comparison of a standard regimen ( CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin’s lymphoma. N Engl J Med 328: 1002-1006

    Google Scholar 

  • Gerhartz HH, Walther J, Bunica O et al. (1992) Clinical hematological and cytokine response to interleukin 3 (IL-3) supported chemotherapy in resistant lymphomas: A phase II study. Proc Am Soc Clin Oncol 11: 329 (Abstr 1123)

    Google Scholar 

  • Gerhartz HH, Engelhard M, Meusers P et al. (1993) Randomized, double-blind, placebo-controlled, phase III study of recombinant human granulocyte-macrophage colony-stimulating factor as adjunct to induction treatment of high-grade malignant non-Hodgkin’s lymphomas. Blood 82: 2329 - 2339

    PubMed  CAS  Google Scholar 

  • Gordon LI, Harrington D, Andersen J et al. (1992) Comparison of a second-generation combination chemotherapeutic regimen (m-BACOD) with a standard regimen ( CHOP) for advanced diffuse non-Hodgkin’s lymphoma. N Engl J Med 327: 1342-1349

    Google Scholar 

  • Gribben JG, Goldstone AH, Linch DC et al. (1989) Effectiveness of high-dose combination chemotherapy and autologous bone marrow transplantation for patients with non-Hodgkin’s lymphomas who are still responsive to conventional-dose chemotherapy. J Clin Oncol 7: 1621 - 1629

    PubMed  CAS  Google Scholar 

  • Grogan TM, Miller TP (1993) Immunobiologic correlates of prognosis in lymphoma. Semin Oncol 20 [Suppl 5]: 58 - 74

    PubMed  CAS  Google Scholar 

  • Haioun C, Lepage E, Gisselbrecht C et al. (1992) Autologous bone marrow transplantation (ABMT) versus sequential chemotherapy in first complete remission aggressive non-Hodgkin’s lymphoma (NHL): first interim analysis on 370 patients (LNH87 protocol). Proc Am Soc Clin Oncol 11: 316 (Abstr 1071)

    Google Scholar 

  • Havemann K, Köppler H, Brittinger G, Steinke B (1993) Therapiestrategien für hochmaligne Non-Hodgkin-Lymphome. Internist 34: 139 - 145

    PubMed  CAS  Google Scholar 

  • Ho AD, Del Valle F, Haas R et al. (1990) Sequential studies on the role of mitoxantrone, high-dose cytarabine, and recombinant human granulocyte-macrophage colony-stimulating factor in the treatment of refractory non-Hodgkin’s lymphoma. Semin Oncol 17 [Suppl 10]: 14 - 19

    PubMed  CAS  Google Scholar 

  • Hoelzer D, Thiel E, Löffler H et al. (1984) Intensified therapy in acute lymphoblastic leukemia in adults. Blood 64: 38 - 47

    PubMed  CAS  Google Scholar 

  • Hoelzer D, Thiel E, Ludwig WD et al. for the German Adult ALL Study Group (1992) The German multicentre trials for treatment of acute lymphoblastic leukemia in adults. Leukemia 6 [Suppl 2]:175-177

    Google Scholar 

  • Jones SE, Fuks Z, Kaplan HS, Rosenberg SA (1973) Non-Hodgkin’s lymphomas: V. Results of radiotherapy. Cancer 32: 682-691

    Google Scholar 

  • Jones SE, Miller TP, Conners JM (1989) Long-term follow-up and analysis for prognostic factors for patients with limited-stage diffuse large cell lymphoma treated with initial chemotherapy with or without adjuvant radiotherapy. J Clin Oncol 7: 1186 - 1191

    PubMed  CAS  Google Scholar 

  • Kath R, Höffken K, Günzel K et al. (1990) Chemotherapie des nichtendemischen Burkitt-Lymphoms. Dtsch Med Wochenschr 115: 1219 - 1226

    Article  PubMed  CAS  Google Scholar 

  • Köppler H (1993) Early dose intensification with autologous hematopoetic stem cell support for poor prognosis high grade non-Hodgkin’s lymphomas (HL). Ann Hematol 67 [Suppl]: A67 (Abstr 263)

    Google Scholar 

  • Köppler H, Pflüger KH, Eschenbach I et al. (1991) Sequential versus alternating chemotherapy for high-grade non-Hodgkin’s lymphomas: A randomzed multicentre trial. Hematol Oncol 9: 217-223

    Google Scholar 

  • Köppler H, Pflüger KH, Klausmann M, Havemann K (1992) High-dose cyclophosphamide, etoposide, and BCNU with non-cryopreserved autologous bone marrow transplantation for poor prognosis malignant lymphoma. Leukemia Lymphoma 6: 219 - 225

    Article  Google Scholar 

  • Köppler H, Pflüger KH, Eschenbach I et al. (1994) Randomised comparison of CHOEP versus alternating hCHOEP/IVEP for high-grade non-Hodgkin’s lymphomas: Treatment results and prognostic factor analysis in a multi-centere trial. Ann Oncol 5: 49-55

    Google Scholar 

  • Lennert K, Feller AC (1992) Histopathology of non-Hodgkin’s lymphomas. Springer, Berlin Heidelberg New York Tokyo

    Book  Google Scholar 

  • Linch DC, Vaughan Hudson G, Anderson L (1993) Comparison of CHOP vs. PACEBOM in diffuse and large cell lymphomas with an analysis of outcome in poor prognosis younger patients: A BNLI randomised trial. Proc Fifth Int Conf on malignant lymphoma, Lugano: 55 (Abstr 69)

    Google Scholar 

  • Longo DL, De Vita VT Jr, Duffey PL et al. (1991) Superiority of ProMACE-CytaBOM over ProMACE-MOPP in the treatment of advanced diffuse aggressive lymphoma: Results of a prospective randomized trial. J Clin Oncol 9: 25-38

    Google Scholar 

  • McKelvey EM, Gottlieb JA, Wilson HE et al. (1976) Hydroxydaunomycin (adriamycin) combination chemotherapy in malignant lymphoma. Cancer 38: 1484 - 1493

    Article  PubMed  CAS  Google Scholar 

  • Meyer RM, Hryniuk WM, Goodyear MDE (1991) The role of dose intensity in determining outcome in intermediate-grade non-Hodgkin’s lymphoma. J Clin Oncol 9: 339 - 347

    PubMed  CAS  Google Scholar 

  • Meyer RM, Quirt IC, Skillings JR et al. (1993) Escalated as compared with standard doses of doxorubicin in BACOP therapy for patients with non-Hodgkin’s lymphoma. N Engl. J Med 329: 1770-1776

    Google Scholar 

  • Musshoff K, Schmidt-Vollmer H (1975) Prognosis of non-Hodgkin’s lymphomas with special emphasis on the staging classification. Z Krebsforsch 83: 323 - 341

    Article  CAS  Google Scholar 

  • O’Connell MJ, Harrington DP, Earle JD et aI. (1988) Chemotherapy followed by consolidation radiation therapy for the treatment of clinical stage II aggressive histologic type non-Hodgkin’s lymphoma. Cancer 61: 1754 - 1758

    Google Scholar 

  • Pettengell R, Crowther D (1994) Haemopoetic growth factors and dose intensity in high-grade and intermediate grade lymphoma. Ann Oncol 5 [Supp 2]: 133 - 141

    Article  PubMed  Google Scholar 

  • Pettengell R, Gurney H, Radford JA et al. (1992) Granulocyte colony-stimulating factor to prevent dose-limiting neutropenia in non-Hodgkin’s lymphoma. A randomized controlled trial. Blood 80: 1430-1436

    Google Scholar 

  • Rizzoli V, Almici C, Philip T, Bron D, Gughielmi C, Coiffier C (1993) The Parma International Randomized Prospective Study in relapsed non-Hodgkin’s lymphoma: First interim analysis in 153 patients. In: Zander AR, Barlogie B (eds) Autologous bone marrow transplantation for non-Hodgkin’s lymphoma and multiple myeloma. Springer, Berlin Heidelberg New York Tokyo, pp 35 - 39

    Google Scholar 

  • Sack H, Budach V, Stuschke M, Hoederath A (1992) Non-Hodgkin lymphomas (NHL) - Early stages: Interim results of a multi-centre trial. Cancer Res Clin Oncol 118 [Suppl]: R115

    Google Scholar 

  • Salles G, Shipp MA, Coiffier B (1994) Chemotherapy of non-Hodgkin[s aggressive lymphomas. Semin Hematol 31: 46 - 69

    PubMed  CAS  Google Scholar 

  • Somers R, Carde P, Thomas J et al. (1994) EORTC study of non-Hodgkin’s lymphoma: Phase III sudy comparing CHVmP-VB and ProMACE-MOPP in patients with stage II, II, and IV intermediate and high grade lymphoma. Ann Oncol 5 [Suppl 2]: 85 - 89

    Article  PubMed  Google Scholar 

  • Shepherd JD, Phillips GL (1993) High-dose therapy for lymphoma. Curr Op Oncol 5: 797 - 804

    Article  CAS  Google Scholar 

  • Steinke B, Bross K, Reinold HM et al. (1992) Cyclic alternating chemotherapy of high-grade malignant non-Hodgkin lymphomas with VIM-Bleo and CHOP. Eur J Cancer 28: 100 - 104

    Article  PubMed  CAS  Google Scholar 

  • Steinke B, Manegold C, Freund M et al. (1992) G-CSF for treatment intensification in high-grade malignant non-Hodgkin’s lymphomas. Onkologie 15: 46 - 50

    Article  Google Scholar 

  • Sweetenham JW, Proctor SJ, Blaise D et al. (1994) High dose therapy and autologous bone marrow transplantation in first complete remission for adult patients with high grade non-Hodgkin lymphoma: The EBMT experience. Ann Oncol 5 [Suppl 2]: 155 - 160

    Article  PubMed  Google Scholar 

  • The International Non-Hodgkin’s Lymphoma Prognostic Factors Project (1993) A predictive model for aggressive non-Hodgkin’s lymphoma. N Engl J Med 329: 987 - 994

    Article  Google Scholar 

  • Tondini C, Zanini M, Lombardi F et al. (1993) Combined modality treatment with primary CHOP chemotherapy followed by locoregional irradiation in stage I or II histologically aggressive non-Hodgkin’s lymphomas. J Clin Oncol 11: 720725

    Google Scholar 

  • Trümper L, Renner C, Nahler M et al. (1993) Intensification of the CHOEP regimen for high-grade non-Hodgkin’s lymphomas by G-CSF: Feasability of a 14-day regimen. Onkologie 17: 69 - 71

    Article  Google Scholar 

  • Velasquez WS, Cabanillas F, Salvator P (1988) Effective salvage therapy for lymphoma with cisplatin in combination with high-dose Ara-C and dexamethasone. Blood 71: 117 - 122

    PubMed  CAS  Google Scholar 

  • Velasquez WS, Hagemeister F, McLaughlin P et al. (1992) E-SHAP: An effective treatment for refractory and relapsing lymphoma. A long follow-up. Proc Am Soc Clin Oncol 11: 326 (Abstr. 1111)

    Google Scholar 

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Authors
  1. M. Engelhard
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  2. K.-H. Pflüger
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  3. H. Sack
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Editor information

Editors and Affiliations

  1. Klinik und Poliklinik, Innere Medizin IV, Abteilung Hämatologie/Onkologie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Straße 40, D-06120, Halle/Saale, Deutschland

    Hans-Joachim Schmoll (Direktor) (Direktor)

  2. Klinik und Poliklinik für Innere Medizin II, Klinikum der Friedrich-Schiller-Universität Jena, Erlanger Allee 101, D-07740, Jena, Deutschland

    Klaus Höffken (Direktor) (Direktor)

  3. Medizinischen Klinik II, Schwerpunkt Onkologie und Hämatologie, Humboldt-Universität, Universitätsklinikum Charité, Schumannstraße 20/21, D-10117, Berlin, Deutschland

    Kurt Possinger (Direktor) (Direktor)

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© 1997 Springer-Verlag Berlin Heidelberg

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Engelhard, M., Pflüger, KH., Sack, H. (1997). Hochmaligne nodale Non-Hodgkin-Lymphome, lymphoblastische und Burkitt-Lymphome. In: Schmoll, HJ., Höffken, K., Possinger, K. (eds) Kompendium Internistische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12175-7_14

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  • DOI: https://doi.org/10.1007/978-3-662-12175-7_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60830-1

  • Online ISBN: 978-3-662-12175-7

  • eBook Packages: Springer Book Archive

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