Skip to main content
SpringerLink
Log in

Immunozytom (lymphoplasmozytisches/lymphoplasmozytoides Lymphom)

  • Chapter
Kompendium Internistische Onkologie

  • 13 Accesses

Zusammenfassung

Morphologische und immunhistochemische Kriterien führen innerhalb der Kiel-Klassifikation zur Differenzierung zwischen der chronischen lymphatischen Leukämie (B-CLL) und dem Immunozytom (Lennert u. Feller 1992). Für die klinische und prognostische Bedeutung dieser Unterteilung sprechen die Ergebnisse einer prospektiven, multizentrischen Beobachtungsstudie (Brittinger et al. 1984, 1985; Engelhard et al. 1991). Das Immunozytom subsumiert die früher als nosologische Einheit betrachtete Makroglobulinämie Waldenström sowie Erkrankungsformen, die vor der Erarbeitung der Kiel-Klassifikation klinisch-prognostisch als „atypische“ chronische lymphatische Leukämie imponierten.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Bagley CM, DeVita jr VT, Berard CW, Canellos GP (1972) Advanced lyphosarcoma: Intensive cyclical combination chemotherapy with cyclophosphamide, vincristine, and prednisone. Ann Intern Med 76: 227-234

    Google Scholar 

  • Barlogie B, Smith L, Alexanian R (1984) Effective treatment of advanced multiple myeloma refractory to alkylating agents. N Engl J Med 310: 1353 - 1356

    Article  PubMed  CAS  Google Scholar 

  • Beutler E (1994) New chemotherapeutic agents: 2-Chlorodeoxyadenosine. Semin Hematol 31: 40 - 45

    PubMed  CAS  Google Scholar 

  • Binet JL (1993) Treatment of chronic lymphocytic leukaemia. In: Bailliére’s Clinical Haematology. International Practice and Research, vol 6/no 4. Bailliéere Tindall, London Philadelphia Sydney Tokyo Toronto, pp 867 - 878

    Google Scholar 

  • Binet JL, Catovsky D, Chandra P, Dighiero G, Montserrat E, Rai KR, Sawitsky A (1981) Chronic lymphocytic leukaemia: Proposals for a revised prognostic staging system. Report from the International Workshop on CLL. Br J Haematol 48: 365-367

    Google Scholar 

  • Brittinger G, Bartels H, Common H et al. (1984) Clinical and prognostic relevance of the prospective multicenter study by the Kiel Lymphoma Study Group. Hematol Oncol 2: 269 - 306

    Article  PubMed  CAS  Google Scholar 

  • Brittinger G, Meusers P, Musshoff K, Gyenes T (1985) Non-Hodgkin-Lymphome und Plasmozytom. In: Gross R, Schmidt CG (Hrsg) Klinische Onkologie. Thieme, Stuttgart New York, pp 41.0-41. 81

    Google Scholar 

  • Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M (1971) Report of the committee on Hodgkin’s disease staging classification. Cancer Res 31: 1860 - 1861

    PubMed  CAS  Google Scholar 

  • Carde P, Burger JMV, Glabbeke M van, Hayat M, Cosset JM, Somers R (1984) Combined radiotherapy for early stages non-Hodgkin’s lymphoma: The 1975-1980 EORTC controlled lymphoma trial. Radiother Oncol Biol Phys 6: 125 - 134

    Google Scholar 

  • Chabner BA, Bates SE, Fojo AT, Spolyar M, Wilson WH (1994) Drug resistance in adult lymphomas. Semin Hematol 31: 70 - 87

    PubMed  CAS  Google Scholar 

  • Cheson BD, Bennett JM, Rai KR et al. (1988) Guidelines for clinical protocols for chronic lymphocytic leukemia: Recommendations of the National Cancer Institute-sponsored Working Group. Am J Hematol 29: 152-163

    Google Scholar 

  • Cooperative Group for the Study of Immunoglobulin in Chronic Lymphocytic Leukemia (1988) Intravenous immunoglobulin for the prevention of infection in chronic lymphocytic leukemia. A randomized, controlled clinical trial. N Engl J Med 319: 902 - 907

    Article  Google Scholar 

  • Dillman RO (1994) A new chemotherapeutic agent: Deoxycoformycin (pentostatin). Semin Hematol 31: 16 - 27

    PubMed  CAS  Google Scholar 

  • Dimopoulos MA, O’Brien S, Kantarjian H et al. (1993) Fludarabine therapy in Waldenström’s macroglobulinemia. Am J Med 95: 49 - 52

    Article  PubMed  CAS  Google Scholar 

  • Engelhard M, Brittinger G, Heinz R et al. (1991) Chronic lymphocytic leukemia (BCLL) and immunocytoma (LP-IC): Clinical and prognostic relevance of this distinction. Leukemia and Lymphoma [Suppl]: 161 - 173

    Google Scholar 

  • Epelbaum R, Kuten A, Coachman NM et al. (1992) Stage I-II low grade non-Hodgkin’s lymphoma: Prognostic factors and treatment results. Strahlenther Onkol 168: 66-72

    Google Scholar 

  • French Cooperative Group on Chronic Lymphocytic Leukaemia (1986) Effectiveness of „CHOP” regimes in advanced untreated chronic lymphocytic leukaemia. Lancet I: 1346 - 1349

    Google Scholar 

  • Gale RP, Montserrat E (1993) Intensive therapy of chronic lymphocytic leukaemia. In: Bailliére’s Cliniucal Haematology. International Practice and Research, vol6/no 4. Bailliére Tindall, London Philadelphia Sydney Tokyo Toronto, pp 879 - 885

    Google Scholar 

  • Gandhi V, Kemena A, Keating MJ, Pluinkett W (1992) Fludarabine infusion potentiates arabinosylcytosine metabolism in lymphocytes of patients with chronic lymphocytic leukemia. Cancer Res 52: 897 - 903

    PubMed  CAS  Google Scholar 

  • Grossbard ML, Press OW, Appelbaum FR, Bernstein ID, Nadler LM (1992) Monoclonal antibody-based therapies of leukemia and lymphoma. Blood 80: 863 - 878

    PubMed  CAS  Google Scholar 

  • Karnofsky DA, Burchenal JH (1948) The evaluation of chemotherapeutic agents against neoplastic disease. Cancer Res 8: 388 - 389

    Google Scholar 

  • Keating MJ, O’Brien S, Plunkett W et al. (1994) Fludarabine phosphate: A new active agent in hematologic malignancies. Semin Hematol 31: 28-39

    Google Scholar 

  • Kempin S, Lee BH III, Thaler HT et al. (1982) Combination chemotherapy of advanced chronic lymphocytic leukemia. The M-2 protocol (vincristine, BCNU, cyclophosphamide, melphalan and prednisone ). Blood 60: 1110-1121

    Google Scholar 

  • Knospe WH, Loeb jr V, Huguley jr CM (1974) Biweekly chlorambucil treatment of chronic lymphocytic leukemia. Cancer 33: 555 - 562

    Article  PubMed  CAS  Google Scholar 

  • Landys KE (1987) Mitoxantrone in combination with prednimustine in treatment of unfavorable non-Hodgkin’s lymphoma. Blut 55: 328

    Google Scholar 

  • Lawrence TS, Urba WJ, Steinberg SM, Sundeen JT, Cossman J, Young RC, Glatstein E (1988) Retrospective analysis of stage I and II indolent lymphomas at the National Cancer Institute. Int J Radiat Oncol Biol Phys 14: 417 - 424

    Article  PubMed  CAS  Google Scholar 

  • Lennert K, Feller AC (eds) (1992) Histopathology of non-Hodgkin’s lymphomas (based on the updated Kiel classifikation), 2nd edn. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • McKelvey EM, Gottlieb JA, Wilson HE et al. (1976) Hydroxyldaunomycin (adriamycin) combination chemotherapy in malignant lymphoma. Cancer 38: 1484 - 1493

    Article  PubMed  CAS  Google Scholar 

  • Montserrat E, Alcala A, Parody R et al. (1985) Treatment of chronic lymphocytic leukemia in advanced stages: A randomized trial comparing chlorambucil plus prednisone versus cyclophosphamide, vincristine and prednisone. Cancer 56: 2369-2375

    Google Scholar 

  • Musshoff K, Schmidt-Vollmer H (1975) Prognosis of non-Hodgkin’s lymphomas with special emphasis on the staging classification. Z Krebsforsch 83: 323 - 341

    Article  CAS  Google Scholar 

  • Paule B, Cosset JM, Le Bourgois JP (1985) The possible role of radiotherapy in chronic lymphocytic leukaemia: A critical review. Radiother Oncol 4: 45-54

    Google Scholar 

  • Piro LD, Carrera CJ, Beutler E, Carson DA (1988) Chlorodeoxyadenosine. An effective new agent for the treatment of chronic lymphatic leukemia. Blood 72: 1069-1073

    Google Scholar 

  • Rabinowe SN, Grossbard ML, Nadler LM (1993) Innovative treatment strategies for chronic lymphocytic leukemia: Monoclonal antibodies, immunoconjugates, and bone marrow transplantation. In: Cheson BD (ed) Chronic lymphocytic leukemia: Scientific advances and clinical developments. Dekker, New York, pp 337 - 367

    Google Scholar 

  • Rai KR, Rabinowe SN (1993) Chronic lymphocytic leukemia. In: Holland IF, Frei III E, Bart RC, Kufe DW, Morton DL, Weichselbaum RR (eds) Cancer medicine, vol II, 3rd edn. Lea & Febiger, Philadelphia London, pp 1971 - 1988

    Google Scholar 

  • Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS (1975) Clinical staging of chronic lymphocytic leukemia. Blood 46: 219 - 234

    PubMed  CAS  Google Scholar 

  • Sawitsky A, Rai KR, Glidewell O et al. (1977) Comparison of daily versus intermittent chlorambucil and prednisone therapy in the treatment of patients with chronic lymphocytic leukemia. Blood 50: 1049 - 1059

    PubMed  CAS  Google Scholar 

  • Taylor RE, Allan SG, McIntyre MA, Kerr GR, Talor AJ, Ritchie GL, Leonard RCF (1988) Low grade stage I and II non-Hodgkin’s lymphoma: Results of treatment and relapse pattern following therapy. Clin Radiol 39: 287-290

    Google Scholar 

  • Theml H, Burger A, Keiditsch E et al. (1977) Beobachtungen zur Charakterisierung des splenomegalen Immunozytoms. Med Klin 72: 1019 - 1032

    PubMed  CAS  Google Scholar 

  • Yahalom J, Varsos G, Fuks Z, Myers J, Clarkson BD, Straus DJ (1993) Adjuvant cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy after radiation therapy in stage I low-grade and intermediate-grade non-Hodgkin lymphoma. Results of a prospectice randomized study. Cancer 71: 2342-2350

    Google Scholar 

Download references

Authors
  1. P. Meusers
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Brittinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Bamberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinik und Poliklinik, Innere Medizin IV, Abteilung Hämatologie/Onkologie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Straße 40, D-06120, Halle/Saale, Deutschland

    Hans-Joachim Schmoll (Direktor) (Direktor)

  2. Klinik und Poliklinik für Innere Medizin II, Klinikum der Friedrich-Schiller-Universität Jena, Erlanger Allee 101, D-07740, Jena, Deutschland

    Klaus Höffken (Direktor) (Direktor)

  3. Medizinischen Klinik II, Schwerpunkt Onkologie und Hämatologie, Humboldt-Universität, Universitätsklinikum Charité, Schumannstraße 20/21, D-10117, Berlin, Deutschland

    Kurt Possinger (Direktor) (Direktor)

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Meusers, P., Brittinger, G., Bamberg, M. (1997). Immunozytom (lymphoplasmozytisches/lymphoplasmozytoides Lymphom). In: Schmoll, HJ., Höffken, K., Possinger, K. (eds) Kompendium Internistische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12175-7_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-12175-7_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60830-1

  • Online ISBN: 978-3-662-12175-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation