Pathophysiologie des Schocks

  • K. Werdan
  • U. Müller-Werdan

Zusammenfassung

Die Betrachtung der hämodynamischen Schockauswirkungen muß neben dem arteriellen Schenkel und der Mikrozirkulation auch den venösen Schenkel des Kreislaufsystems miteinbeziehen (Abb. 33-2a-c).

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Literatur zu Sektion VI Kap.33

  1. Ahnefcld I’W, Barth J, Dick W et al (1994) Akuttherapie anaphylaktoider Reaktionen. Antisthesisl 43: 211–222Google Scholar
  2. Alpert JS, Becker RC (1993) Mechanisms and management of cardiogenic shock.Crit Care (din 9: 205–218Google Scholar
  3. American College of Cardiology/American I(cart Association ‘task Force on PracticeCuidclines (Committee on (.valuation:Ind Management of Ilcart Failure) (1995) ((tot-felines tor the cvaliiaiion and management u1 heart failure. Circulation 92:2764–2784Google Scholar
  4. Anderson It Oilman IfM, Holmes I(k et al, for the GUSTO- I Investigators (1997) Use id intraaorlic ballon countcrpulsation in patients presenting with cardiogenic shock: ohservations tronc the GUSTO I study. J Am Cull Cardiol 11: 708–715Google Scholar
  5. Anonymus (1999) Vergessene Therapie des akuten Myokardinfarkts wiederentdeckt? Arzneimittelbrief 33: 28–29Google Scholar
  6. Antoniucci D, Valenti R, Santoro GM et al (1998) Systematic direct angioplasty and stent-supported direct angioplasty therapy for cardiogenic shock complicating acute myocardial infarction: In-hospital and long-term survival. J Am Coll Cardiol 31: 294–300Google Scholar
  7. Argenziano M, Choudhri AF, Moazami N et al (1998) Randomized, double-blind trial of inhaled nitric oxide in LVAD recipients with pulmonary hypertension. Ann Thorac Surg 65: 340–345PubMedGoogle Scholar
  8. Artigas A, Bernard GR, Carlet J et al, and the Consensus Committee (1998) The American-European Consensus Conference of ARDS, Part 2. Am J Respir Grit Care Med 157: 1332–1347Google Scholar
  9. Austin SM, Barooah B, Kim CS (1984) Reversible acute cardiac injury during cefoxitin-induced anaphylaxis in a patient with normal coronary arteries. Am J Med 77: 729–732PubMedGoogle Scholar
  10. Badesch DB (1997) Clinical trials in pulmonary hypertension.Annu Rev Med 48: 399–408Google Scholar
  11. Bahrami S, Redl H, Schlag G (1998) Der Darm als Ursache von Sepsis and Multiorganversagen. Wien Klin Wochenschr uo ISuppl 11: 2–10Google Scholar
  12. Baker CH, Wilmoth FR, Sutton ET, Price JM (1988) Microvascular responses of intact and adrenal medullectomized rats to hemorrhagic shock. Circ Shock 26: 203–218PubMedGoogle Scholar
  13. Bakker J, Coffemils M, Leon M et al (1992) Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest 99: 956–962Google Scholar
  14. Ballal RS, Sanyal RS, Nanda NC, Mahan EF III (1993) Usefulness of transesophageal echocardiography in the diagnosis of ventricular septal rupture secondary to acute myocardial infarction. Am J Cardiol 71: 367–370PubMedGoogle Scholar
  15. Barton P, Garcia J, Kouatli A et al (1996) Hemodynamic effects of iv milrinone lactate in pediatric patients with septic shock–a prospective, double-blinded, randomized, placebo-controlled, interventional study. Chest 109: 1302–1312PubMedGoogle Scholar
  16. Bates ER, Topol EJ (1991) Limitations of thrombolytic therapy for acute myocardial infarction complicated by congestive heart failure and cardiogenic shock. J Am Coll Cardiol 18: 1077–1084PubMedGoogle Scholar
  17. Baumert J-H, Roissant R (1998) Mechanische Kreislaufunterstützung in der kardiochirurgischen Intensivmedizin. lntensivmed 35565–573Google Scholar
  18. Beerthuizen GIJM (1993) Response of the microcirculation: tissue oxygenation. In: Schlag G, Redl H (eds) Pathophysiology of Shock, Sepsis and Organ Failure. Springer, Berlin Heidelberg New York Tokyo, pp 230–241Google Scholar
  19. Behringer W, Kittler H, Sterz F et al (1998) Cumulative epinephrine dose during cardiopulmonary resuscitation and neurologic outcome. Ann Intern Med 129:450–456. Editorial (Cummins RO, Hazinski MF) (1998) 129: 501–502Google Scholar
  20. Beilman GJ, Groehler KE, Lazaron V, Ortner JP (1999) Near-infrared spectroscopy measurement of regional tissue oxyhemoglobin saturation during hemorrhagic shock. Shock 12: 196–200PubMedGoogle Scholar
  21. Berger PB, Holmes DR jr, Stebbins AL et al, for the GUSTO-I Investigators (1997) Impact of an aggressive invasive catheterization and revascularization strategy on mortality in patients with cardiogenic shock in the global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries ( GUS’T’O-I) Trial - An observational study. Circulation 96: 122–127Google Scholar
  22. Berger 11B, Tuttle RH, Holmes DR et al, for the GUSTO-I Investigators (1999) One-year survival among patients with acute myocardial infarction complicated by card iogenic shock, and its relation to early revascularization–Results from the GUSTO-I Trial. Circulation 99: 873–878Google Scholar
  23. Bernard GR, Artigas A, Brigham KI, et al and the Consensus Committee 0991) The American-European Consensus conference on ARI)S. A J Respir Crit Care Meni 149: 818–824Google Scholar
  24. Bertcl O, Slraumann P., Balnielli N, Nilgeli li (1998) Der kardiogenc Schock. Schweiz Med Wochenschr 128:1428–1435Google Scholar
  25. Bhakdi S, Moldy M, Mannhardt U, Arvand M, Hugo I (1989) Baleterielle Pxotoxine and ihre Relevanz (Br die Pathogenese des seplischen Schocks. Intensivnoed 20 (Stipp) 1): 10–15Google Scholar
  26. Bihari D, Smithies M,Cinson A et al (1987) The clfects of vasodilation with prostacyclin on oxygen delivery and uptake in critically ill patients. N I:ngl J Med 317: 397–403Google Scholar
  27. Blumberg N, Heal JM (1998) Blood transfusion immunomodulati- on–The silent epidemic. Arch Pathol Lab Med 122: 117–119PubMedGoogle Scholar
  28. Boekstegers P, Weidenhöfer S, Kapsner T, Werdan K (1994) Skeletal muscle partial pressure of oxygen in patients with sepsis. Crit Care Med 22: 640–650PubMedGoogle Scholar
  29. Böker KHW, Manns MP (1998) Akutes Leberversagen. Internist 39: 442–452PubMedGoogle Scholar
  30. Bond RF (1993) Peripheral macro-and microcirculation. In: Schlag G, Redl H (eds) Pathophysiology of Shock, Sepsis and Organ Failure. Springer, Berlin Heidelberg New York Tokyo, pp 893–907Google Scholar
  31. Bond RF, Johnson G III (1985) Vascular adrenergic interactions during hemorrhagic shock. Fed Proc 44: 281–289PubMedGoogle Scholar
  32. Bone RC (1994) Gram-positive organisms and sepsis. Arch Intern Med 154: 26–34PubMedGoogle Scholar
  33. Booth BH, Patterson R (1970) Electrocardiographic changes in human anaphylaxis. JAMA 211: 627PubMedGoogle Scholar
  34. Bower RH (1993) Nutrition during critical illness and sepsis. New Horiz 1: 348–352PubMedGoogle Scholar
  35. Bowers TR, O’Neill WW, Grines C et al (1998) Effect of reperfusion on biventricular function and survival after right ventricular infarction. N Engl J Med 338: 933–940PubMedGoogle Scholar
  36. Bowton DL, Bertels NH, Prough DS, Stump DA (1989) Cerebral blood flow is reduced in patients with sepsis syndrome. Grit Care Med 17: 399–403Google Scholar
  37. Braat SH, de Zwaan C, Brugada P, Coenegracht JM, Wellens HJ (1984) Right ventricular involvement with acute inferior wall myocardial infarction identifies high risk of developing atrioventricular nodal conduction disturbances. Am Heart J 107: 1183–1187.PubMedGoogle Scholar
  38. Briegel J, Forst H, Haller M et al (1999) Stress doses of hydrocortisone reverse hyperdynamic septic shock: A prospective, randomized, double-blind, single-center study. Grit Care Med 27: 723–732Google Scholar
  39. Calvo FE, Figueras J, Cortadellas J, Soler JS (1997) Severe mitral regurgitation complicating acute myocardial infarction. Clinical and angiographic differences between patients with and without papillary muscle rupture. Eur Heart J 18: 1606–1610Google Scholar
  40. Camhi SL, Lee P, Choi AMK (1995) The oxidative stress response. New Horiz 3x70–182Google Scholar
  41. Campion HR, Sacco WJ, Copes WJ et al (1989) A revision of the trauma score. J Trauma 29: 623–629Google Scholar
  42. Carlson RW, Schaeffer RC, Puri VK et al (1981) Hypovolemia and permeability pulmonary edema associated with anaphylaxis. Crit Care Med 9: 883PubMedGoogle Scholar
  43. Cheifetz IM, Craig DM, Kern FH et al (1996) Nitric oxide improves transpulmonary vascular mechanics but does not change intrinsic right ventricular contractility in an acute respiratory distress syndrome model with permissive hypercapnia. Grit Care Med 24: 1554–1561Google Scholar
  44. Chernow B (1994) The pharmacologic approach to the critically ill patient, 3rd edn. Williams 00000 Wilkins, BaltimoreGoogle Scholar
  45. Claussen MS, Landercasper J, Coghill TH (1992) Acute adrenal insufficiency presenting as shock after trauma and surgery: three cases and review of the literature. J Trauma 32: 94–100PubMedGoogle Scholar
  46. Clemens MG, Bauer M, Pannen BHJ (1995) Heterogeneity of hepatic perfusion in shock. In: Vincent JL (ed) Yearbook of Intensive Care and Emergency Medicine 1995. Springer, Berlin Heidelberg New York Tokyo, pp 767–776Google Scholar
  47. Cohen TI, Goldner BG, Maccaro PC, Ardito AP,’Crazzera S, Cohen B, Bibs SR (1993) A comparison of active compression-decompression cardiopulmonary resuscitation with standard cardiopulmonary resuscitation for cardiac arrests occurring in the hospital. N Engl J Med 329: 1918–1921Google Scholar
  48. Conrad SA, Finkelstein JI., Madden MR, Burk I, Goodwin CW (1990) Cardiovascular dysfunction in multiple organ failure.ln: I)eiich EA (ed) Multiple Organ Failure–Pathophysiology and Basic Concepts of Therapy. Thierne, New York, pp 172–191Google Scholar
  49. Cooper 1)1, Walley KR, Wiggs 13R, Russell JA (1990) Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis: a prospective, controlled clinical study. Ann Intern Med 112: 492–498Google Scholar
  50. Cox EE, Morshuis WJ, Plokker IIW’I et al (1990) Early mortality at ter surgical repair of poslintarct ion ventricular septal rupture importance of rupture location. Ann Thorac Surg 61:1752-r, 58Google Scholar
  51. Cribier A, Letac B (1994) Percutaneous balloon aortic valvuloplasty: the European experience. In: Topol EJ (ed) Textbook of Interventional Cardiology. Saunders, Philadelphia, pp 1243–1252Google Scholar
  52. Cummings RG, Califf R, Jones RN et al (1997) Correlates of survival in patients with postinfarction ventricular septal defect. Ann Thorac Surg 63: 1508–1509Google Scholar
  53. Cuthbertson BH, Dellinger P, Dyar 01 et al (1997) UK guidelines for the use of inhaled nitric oxide therapy in adult ICUs. Intensive Care Med 23: 1212–1218PubMedGoogle Scholar
  54. Davis JM, Stevens JM, Peitzman A et al (1983) Neutrophil migrato- ry activity in severe hemorrhagic shock. Circ Shock 10: 199PubMedGoogle Scholar
  55. DeMaria EJ, Lilly MP, Gann DS (1987) Potentiated hormonal re- sponses in a model of traumatic injury. J Surg Res 43: 45–51PubMedGoogle Scholar
  56. Deutsche Gesellschaft für Kardiologie - Herz- und Kreislaufforschung, bearbeitet von Erbel R et. al. (1997) Richtlinien der interventionellen Koronartherapie. Z Kardiol 86a04o-1063Google Scholar
  57. Dhainaut JF, Dall’Ava J, Mira JP (1993) Coronary hemodynamics and myocardial metabolism in sepsis and septic shock. In: Schlag G, Redl H (eds) Pathophysiology of Shock, Sepsis and Organ Failure. Springer, Berlin Heidelberg New York Tokyo, pp 882–892Google Scholar
  58. Druml W (1997) Prävention und Therapie des akuten Nierenversagens. In: Lasch HG, Lenz K, Seeger W (Hrsg) Lehrbuch der Internistischen Intensivtherapie. Schattauer, Stuttgart, S 511–521Google Scholar
  59. Dunham C, Siegel J, Weireter L (1991) Oxygen debt and metabolic acidemia as quantitative predictors of mortality and the severity of the ischemia insult in hemorrhagic shock. Grit Care Med 19: 231–234Google Scholar
  60. Expertenforum Intensivmedizin 1995 (aus der Ständigen Kornmission „Intensivmedizin“ der DGaI) (1995) Kontinuierliche Nierenersatzverfahren: Indikationen, Anwendung, Nutzen und Grenzen. Intensivmed 32:580–617Google Scholar
  61. Fang XM, Schröder S, Hoeft A, Stüber F (1999) Comparison of two polymorphisms of the interleukin-1 gene family: Interleukin-i receptor antagonist polymorphism contributes to susceptibility to severe sepsis. Crit Care Med 27: 1330–1334Google Scholar
  62. Ferguson ND, Stewart TE, Etchells EE (1999) Human albumin administration in critically ill patients. Intensive Care Med 25323–325Google Scholar
  63. Ferrari M, Scholz KH, Figulla R (1996) PTCA with the use of cardiac assist devices: Risk stratification, short-and long-term results. Catheter Cardiovasc Diagn 38: 242–248Google Scholar
  64. Ferrari M, Wittmann G, Neumann S, Panzer W, Figulla HR (1998) Die perkutan implantierbare Herz-Lungen-Maschine erweitert die therapeutischen und diagnostischen Möglichkeiten bei therapierefraktärem Kreislaufstillstand–Fallpräsentation und Übersicht. Intensivmed 35: 56–61Google Scholar
  65. Fiddian-Green RG, Haglund U, Gutierrez G, Shoemaker WG (1993) Goals for the resuscitation of shock. Grit Care Med 21: 525 - S31Google Scholar
  66. Fullerton DA, Daggers J, Wollmering MM et al (1997) Variable response to inhaled nitric oxide after cardiac surgery. Ann Thorac Surg 63: 1251–1256PubMedGoogle Scholar
  67. Gattinoni L, Brazzi 1., Pelosi P, Latini R, Tognoni G, Pesenti A, Fuma-galli R, for the SVO, Collaborative Group (1995) A trial of goal-oriented hemodynamic therapy in critically ill patients. N Engl J Med 333: 1025–1032Google Scholar
  68. Gawaz M, Fateh-Moghadam S, Pilz G, Gurland H-1, Werdan K (1995) Severity of multiple organ failure ( MOE) but not of sepsis correlates with irreversible platelet degranulation. Infection 23: 16–23Google Scholar
  69. Gellerich EN, Trumbeckaite S, Hertel K et al (1999) Impaired energy metabolism in hearts of septic baboons: diminished activities of complex I and complex Il of the mitochondrial respiratory chain. Shock 11: 336–341PubMedGoogle Scholar
  70. Genoni M, Segesser L von, Niederhäuser U et al (1990) Herzchirurgie beim akuten Herzinfarkt: Indikationen und Resultate. Schweiz Med Wschr 126: 682–687Google Scholar
  71. Godin PI, Buchman TG (1990) Uncoupling of biological oscillators: A enmplemcntary hypothesis concerning the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med _4: 1107–1110.Google Scholar
  72. Goldberg RI, Gore J NI, Alpert IS et al (1991) Cardiogenic shock after acute myocardial infarction: incidence and mortality from.1 community-wide perspective N Engl 1 Med 325: 11–1122Google Scholar
  73. Goldberger M, Tabak StW, Shah PK (1986) Clinical experience with intraaortic balloon counterpulsation in 112 consecutive patients. Am Heart J 111: 497–502PubMedGoogle Scholar
  74. Gregory JS, Flancbaum L, Townsend MC et al (1991) Incidence and timing of hypothermia in trauma patients undergoing surgery. J Trauma 31: 795–798PubMedGoogle Scholar
  75. Groeneveld ABJ, Thijs LG (1995) Hypovolemic Shock. In: Parrillo JE, Bone RC (eds) Critical Care Medicine. Mosby-Year Book, St. Louis, MO, pp 387–418Google Scholar
  76. Gueugniaud P-Y, Mols P, Goldstein P et al, for the European Epinephrine Study Group (1998) A comparison of repeated high doses and repeated standard doses of epinephrine for cardiac arrest outside the hospital. N Engl J Med 339;1595–601. 340:1763–1765 (Correspondence 1999 )Google Scholar
  77. GUSTO Investigators (1993) An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med 329: 673–682Google Scholar
  78. Gutierrez G, Brown SD (1993) Response of the macrocirculation. In: Schlag G, Redl H (eds) Pathophysiology of Shock, Sepsis and Organ Failure. Springer, Berlin Heidelberg New York Tokyo, pp 215–229Google Scholar
  79. Guyton K, Bond R, Romeo C, Southern R, Cochran J, Teti G, Cook JA (1999) Endotoxin-induced cross-tolerance to Gram-positive sepsis. J Endotoxin Res 5: 119–126Google Scholar
  80. Haglund U (1993) Hypoxic damage. In: Schlag G, Redl H (eds) Pathophysiology of Shock, Sepsis and Organ Failure. Springer, Berlin Heidelberg New York Tokyo, pp 314–321Google Scholar
  81. Hallström S, Koidl B, Müller U et al (1993) Cardiodepressant factors. In: Schlag G, Redl H (eds) Pathophysiology of Shock, Sepsis and Organ Failure. Springer, Berlin Heidelberg New York Tokyo, pp 200–214Google Scholar
  82. Hamberger B, Fredholm BB, Farnebo LO (1980) Anaphylaxis and plasma catecholamines. Life Sci 26: 1465–1471PubMedGoogle Scholar
  83. Hanashiro PK, Weil MH (1967) Anaphylactic shock in man: report of two cases with detailed hemodynamic and metabolic studies. Arch Intern Med 119: 129–140PubMedGoogle Scholar
  84. Haupt MT (1995) Anaphylaxis and anaphylactic shock. In: Parrillo JE, Bone RC (eds) Critical Care Medicine. Mosby-Year Book, St. Louis, MO, pp 433–447Google Scholar
  85. Hayes MA, Timmins AC, Yau EHS, Palazzo M, Hinds CJ, Watson D (1994) Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 330: 1717–1722PubMedGoogle Scholar
  86. Hearse I)J, Bolli R (1991) Reperfusion-induced injury–manifestations, mechanisms and clinical relevance. Trends Cardiovasc Med 1: 233–240Google Scholar
  87. Hebert P, Wells G, Blajchman MA et al (1999) A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 340: 409–417PubMedGoogle Scholar
  88. Heeg K, Miethke T, Wagner H (1995) Neue Perspektiven zur Pathophysiologie der grampositiven Sepsis. Dtsch Arztebl 92:A-1177-n8oGoogle Scholar
  89. Heinroth KM, Kuhn C, Stache N et al (1999) Eingeschränkte Herzfrequenzvariabilität bei Patienten mit septischem and nichtseptischem Multiorgan-Dysfunktions-Syndrom. Intensivmed 36436–445Google Scholar
  90. Held AC, Cole PI., Lipton B et al (1988) Rupture of the interventricular septum complicating acute myocardial infarction: a multicenter analysis of clinical findings and outcome. Am Heart J 116: 1330–1336PubMedGoogle Scholar
  91. Hochman JS, Boland J, Sleeper LA et al (1995) Current spectrum of cardiogenic shock and effect of early revascularization on mortality. Results of an international registry. Circulation 91: 873–881Google Scholar
  92. Hochman JS, Sleeper LA, Webb JG et al, for the SHOCK Investigators (1999) Carly revascularization in acute myocardial infarctions complicated by cardiogenic shock. N Engl J Med 341: 625 634Google Scholar
  93. Hochman JS, Talley JI), Webb JC et al (1997) Ventricular septal rupture causing cardiogenic shock: Clinical profile, tinting and outcome. Circulation 96: 1–749Google Scholar
  94. Holmes DR, Dore KM, Williams 1)0, Kent KM, King SB Ill, Yeh W, Steenkiste A (1993) Long-term outcome of patients with depressed left ventricular [unction undergoing percutaneous transluminal coronary angioplasty.’Ehe NIII.Ii1 PTCA registry. (Jr, illation 87: 21 29Google Scholar
  95. Hoogenberg K, Smit AJ, Girbes ARJ (1998) Effects of low-dose dopamine on renal and systemic hemodynamics during incremental norepinephrine infusion in healthy volunteers. Crit Care Med 26: 260–265PubMedGoogle Scholar
  96. Hotchkiss RS, Swanson PE, Freeman BD et al (1999) Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27a 230–1251Google Scholar
  97. Hudson LD (1998) Protective ventilation for patients with acute respiratory distress syndrome. N Engl J Med 338: 385–387PubMedGoogle Scholar
  98. Ibelgaufts H (1995) Dictionary of Cytokines. Editiones Roche, BaselGoogle Scholar
  99. Johnson PC (1986) Autoregulation of blood flow. Circ Rev 59: 483Google Scholar
  100. Jörres A, Frei U (1995) Extrakorporale Behandlungsverfahren in der Intensivmedizin. Intensivmed 32: 78–85Google Scholar
  101. Juste RN, Panikkar K, Soni N (1998) The effects of low-dose dopamine infusions on haemodynamic and renal parameters in patients with septic shock requiring treatment with noradrenaline. Intensive Care Med 24: 564–568PubMedGoogle Scholar
  102. Kato S, Morimoto S-I, Hiramitsu S et al (1999) Use of percutaneous cardiopulmonary support of patients with fulminant myocarditis and cardiogenic shock for improving prognosis. Am J Cardiol 83: 623–625PubMedGoogle Scholar
  103. Katz ES, Tunik PA, Kronzon K (1992) Observations of coronary flow augmentation and balloon function during intraaortic balloon counterpulsation using transesophageal echocardiography. Am J Cardiol 69: 1635–1639PubMedGoogle Scholar
  104. Kern MJ, Aguirre F, Bach R, Donohue T, Siegel RT, Segal J (1993b) Augmentation of coronary blood flow by intra-aortic balloon pumping in patients after coronary angioplasty. Circulation 87: 500–511PubMedGoogle Scholar
  105. Kern MJ, Aguirre FV, Tatineni S, Penick D, Serota H, Donohue T, Walter K (1993a) Enhanced coronary blood flow velocity during intraaortic balloon counterpulsation in critically ill patients. J Am Coll Cardiol 21: 359–368PubMedGoogle Scholar
  106. Killen DA, Piehler JM, Borkon AM, Gorton ME, Reed WA (1997) Early repair of postinfarction ventricular septal rupture. Ann Thorac Surg 63: 138–142PubMedGoogle Scholar
  107. Kloeck W, Cummins RO, Chamberlain D et al (1997a) The Universal Advanced Life Support Algorithm. An Advisory Statement from the Advanced Life Support Working Group of the International Liaison Committee on Resusciation. Circulation 95: 2180–2182Google Scholar
  108. Kloeck W, Cummins RO, Chamberlain D et al (1997b) Early defibrillation. An Advisory Statement from the Advanced Life Support Working Group of the International Liaison Committee on Resusciation. Circulation 95: 212183–2184Google Scholar
  109. Kloeck W, Cummins RO, Chamberlain D et al (1997e) Special Resusciation Situations. An Advisory Statement from the Advanced Life Support Working Group of the International Liaison Committee on Resusciation. Circulation 95: 2196–2210Google Scholar
  110. Knaus WA, Draper EA, Wagner DP, Zimmermann JE (1985) APACHE II: A severity of disease classification system. Crit Care Med 13: 818–829Google Scholar
  111. König G, Guggenberger M, Bommersbach B (1996) 4ojähriger Patient ohne Vorerkrankung mit akuter Schocksymptomatik and schwerer Verbrauchskoagulopathie. Internist 37: 74–77Google Scholar
  112. Kovack PJ, Rasak MA, Bates ER, Ohman EM, Stomel RJ (1997) Thrombolysis plus aortic counterpulsation: Improved survival in patients who present to community hospitals with cardiogenic shock. J Am Coll Cardiol 29: 1454–1458Google Scholar
  113. Kreimeier U, Christ F, Frey I, et al (1997) Small-volume Resuscitation beim hypovolämischen Schlock–Konzeption, experimentelle and klinische Ergebnisse–eine Standortbestimmung. Anästhesist 46: 309–328Google Scholar
  114. Kreimeier U, Priickner St (1998) Volumentherapie hei Hypovolämie and Schock. No t fall Rettungsmed 1: 119–129Google Scholar
  115. Kuhlen B, Roissant R (1999) I?ntwöhnung von der Beat mu 1g: Standardisierte Protokolle erfolgreicher als Arzte? Intensivmed 36: 415–416Google Scholar
  116. Kumar A, Parrillo JE. (1995a) Shock: Classification, Pathophysiology and Approach to Management. In: Parrillo IF., Bone RC (eds) Critical Care Medicine–Principles of Diagnosis and Management. Mosby, St. Louis MO, pp 291–339Google Scholar
  117. Kumar A, Parrillo JE (1995b) Nitric oxide and the heart in sepsis. In: Fink MP, Payen D (eds) Role of Nitric Oxide in Sepsis and ARDS (Update in Intensive Care and Emergency Medicine 24 ). Springer, Berlin Heidelberg New York Tokyo, pp 73–99Google Scholar
  118. Lasch HG, Heene DL, Huth K, Sandritter W (1967) Pathophysiology, clinical manifestations and therapy of consumption coagulopathy („Verbrauchskoagulopathie“). Am J Cardiol 20: 381PubMedGoogle Scholar
  119. Lee L, Erbel R, Brown TM et al (1991) Multicenter registry of angioplasty therapy of cardiogenic shock: initial and long-term survival. J Am Coll Cardiol 17: 599–603PubMedGoogle Scholar
  120. Lemery R, Smith HC, Fiuliani ER, Gersh BJ (1992) Prognosis in rupture of the ventricular septum after acute myocardial infarction and role of early surgical intervention. Am J Cardiol 70: 147–151PubMedGoogle Scholar
  121. Lindenfeld JA (1998) Safety and effectiveness of inhaled nitric oxide and tirofiban for acute coronary syndromes–A report from the Cardiovascular and Renal Advisory Panel of the Food and Drug Administration. Circulation 98: 1829–1830PubMedGoogle Scholar
  122. Lindner A, Kappen K, Zierz S (1998) Akute Enzephalopathie, Polyneuropathie and Myopathie des kritisch Kranken. Internist 39: 485–492Google Scholar
  123. Livingston DH, Mosenthal AC, Deitch EA (1995) Sepsis and multiple organ dysfunction syndrome: a clinical-mechanistic overview. New Horiz 3: 257–266PubMedGoogle Scholar
  124. Loebe M, Müller J, Hetzer R (1999) Ventricular assistance for recovery of cardiac failure. Curr Opin Cardiol 14: 234–248PubMedGoogle Scholar
  125. Loppnow H, Flad HD, Rietschel ET, Brade H (1993) The active principle of bacterial lipopolysaccharides (endotoxins) for cytokine induction. In: Schlag G, Redl H (eds) Pathophysiology of Shock, Sepsis and Organ Failure. Springer, Berlin Heidelberg New York Tokyo, pp 405–416Google Scholar
  126. Lorente JA, Landin L, Renes E et al (1993) Role of nitric oxide in the hemodynamic changes on sepsis. Crit Care Med 21: 759–767PubMedGoogle Scholar
  127. Lu P-P, Shee J-J, Chen H-M, Lin C-C, Shyr M-H (1999) Spinal nitric oxide participates in the control of the blood pressure during graded hemorrhage in the conscious rat. Shock 12: 222–226PubMedGoogle Scholar
  128. Luce JM (1998) Acute lung injury and the acute respiratory distress syndrome. Crit Care Med 26: 369–376PubMedGoogle Scholar
  129. Madler C, Jauch K-W, Werdan K (1999) Das NAW Buch - Praktische Notfallmedizin, 2. Aufl. Urban 00000 Schwarzenberg, MünchenGoogle Scholar
  130. Mailman D, Self A, Henry M (1999) Time-and surgery-dependent effects of lipopolysaccharide on gut, cardiovascular and nitric oxide functions. Shock 12: 208–214PubMedGoogle Scholar
  131. Maynard N, Bihari D, Beale R et al (1993) Assessment of splanchnic oxygenation by gastric tonometry in patients with acute circulatory failure. JAMA 270: 1203–1210PubMedGoogle Scholar
  132. McCord JM (1985) Oxygen-derived free radicals in postischemic injury. N Engl J Med 312: 159–163PubMedGoogle Scholar
  133. McDonough KH, Giaimo ME, Miller HI (1995) Effects of endotoxin on the guinea pig heart response to ischemia reperfusion injury. Shock 4: 139–142PubMedGoogle Scholar
  134. McInnes GT (1989) The value of therapeutic drug monitoring to the practising physician–a hypothesis in need of testing. Br J Clin Pharmacol 27: 281–284PubMedGoogle Scholar
  135. Meßmer K (1982) Rheologische Grundlagen der modernen Schocktherapie. Internist 23: 445–449PubMedGoogle Scholar
  136. Meßmer K, Zeintl H, Kreimeier U, Schoenberg M (1986) Neue Trends in der Schockforschung. In: Eigler FW, Peiper H], Schildberg FW, Witte J, Zumtobel V (Hrsg) Stand and Gegenstand chirurgischer Forschung. Springer, Berlin Heidelberg New York Tokyo, S 58Google Scholar
  137. Meyer DM, Thal ER, Weigelt JA et al (1989) Evaluation of computed tomography and diagnostic peritoneal lavage in blunt abdominal trauma. J ‘Irannia 29: 1168–1170Google Scholar
  138. Meyer J, Merx W, Dörr R, Lambertz H, Bethge C, Effert 5 (1982) Successful treatment of acute myocardial infarction shock by combined percutaneous transluminal coronary reca nali zat ion and percutaneous coronary angioplasty. Am Heart J 103: 132–134Google Scholar
  139. Michic II R, Manogue KR, Spriggs DR et al (1988) Detection ofcirculating tumor necrosis factor after endotoxin administration. N Engl J Med 318: 1481–1486Google Scholar
  140. Mohr E, Englisch L, Roth A, Burchardi H, Zielmann S (1997) Ettects of early treatment with inununoglobulin on critical illness polyneuropathy following multiple organ failure and gram-negative sepsis. Intensive Care Med 23: 1144–1149PubMedGoogle Scholar
  141. Moldawer LL (1999) Organ apoptosis in the septic patient: A potential therapeutic target? Crit Care Med 27: 1381–1382PubMedGoogle Scholar
  142. Moss J, Fahmy NR, Sunder N, Beaven MA (1981) Hormonal and hemodynamic profile of an anaphylactic reaction in man. Circulation 63: 210–213PubMedGoogle Scholar
  143. Mullane K (1991) Neutrophil and endothelial changes in reperfusion injury. Trends Cardiovasc Med 1: 282–289PubMedGoogle Scholar
  144. Müller-Werdan U, Reithmann C, Werdan K (1996) Cytokines and the Heart - Molecular Mechanisms of Septic Cardiomyopathy. Landes, Aust in USAGoogle Scholar
  145. Müller-Werdan U, Schuster H-P (2000) Abriß der Pathophysiologie als Grundlage der Therapie. In: Schuster H-P, Werdan K (Hrsg) Intensivtherapie bei Sepsis und Multiorganversagen, 3. Aufl. Springer, Berlin Heidelberg New York Tokio, S. 27–72Google Scholar
  146. Müller-Werdan U, Werdan K (1997) Der anaphylaktische Schock. Anästhesist 46: 549–563Google Scholar
  147. Müller-Werdan U, Werdan K (1999) Septic cardiomyopathy. Curr Opin Crit Care 5: 415–420Google Scholar
  148. Müller-Werdan U, Werdan K (2000) Prophylaxe und Therapie der akuten septischen Kardiomyopathie. In: Schuster H-P, Wer-dan K (Hrsg) Intensivtherapie bei Sepsis und Multiorganversagen, 3. Aufl. Springer, Berlin Heidelberg New York Tokio, S. 333–396Google Scholar
  149. Müller-Werdan U, Werdan K, Schuster H-P (1999) Monitoring von kritisch Kranken mit Sepsis, Multiorgandysfunktionssyndrom und Herz-Kreislauf-Erkrankungen. Intensiv Notfallbeh 24: 10–24Google Scholar
  150. Myles PS, Buckland MR, Schenk NJ, Cannon GB, Langley M, Davis BB, Weeks AM (1993) Effect of „renal-dose“ dopamine on renal function following cardiac surgery. Anaesth Intensive Care 21: 56–61PubMedGoogle Scholar
  151. Natanson C, Hoffman W, Parrillo JE (1995) Septic Shock and Multiple Organ Failure. In: Parrillo JE, Bone RC (eds) Critical Care Medicine–Principles of Diagnosis and Management. Mosby, St. Louis MO, pp 355–374Google Scholar
  152. Nelson JB, Bresticker MA, Nahrwold DL (1992) Computer tomography in the initial evaluation of patients with blunt trauma. J Trauma 33: 722–727PubMedGoogle Scholar
  153. Overlie PA, Walter PD, Hurd HP II (1994) Emergency cardiopulmonary support with circulatory support devices. Cardiology 84: 231–237PubMedGoogle Scholar
  154. Packman MI, Rackow EC (1983) Optimum left heart filling pressure during fluid resuscitation of patients with hypovolemic and septic shock. Crit Care Med 11: 465Google Scholar
  155. Pannen BHJ, Robotham JL (1995) The acute-phase response. New Horiz 3: 183–197PubMedGoogle Scholar
  156. Pappert D, Roissant R (1996) Lungenersatzverfahren. Intensiv Notfallbeh 21: 36–41Google Scholar
  157. Park GR (1993) Pharmacokinetics and pharmacodynamies in the critically ill patient. Xenobiotica 23: 1195–1230PubMedGoogle Scholar
  158. Parker TE (1995) Molecular biology of myocardial hypertrophy and failure: gene expression and trophic signalling. New Horiz 3: 288–300PubMedGoogle Scholar
  159. Parratt JR, Stoclet JC (1995) Vascular smooth muscle function under conditions of sepsis and endotoxemia. In: Fink MP, Payen D (eds) Role of Nitric Oxide in Sepsis and ARDS (Update in Intensive Care and Emergency Medicine 24 ). Springer, Berlin Heidelberg New York Tokyo, pp 44–61Google Scholar
  160. Patel JJ, Kopisyansky C, Boston B et al (1995) Prospective evaluation of complications associated with percutaneous intraaortic balloon counterpulsation. Ani J Ca rdiol 76: 1205–120;Google Scholar
  161. Pellicane JV, DeMaria EJ, Abd-Elfattah A et al (1993) Interleukin-1 receptor antagonist improves survival and preserves organ ATP after hemorrhagic shock. Surgery 114: 278–284PubMedGoogle Scholar
  162. Pennington DD, Swartz MT (1992) Assisted circulation and mechanical hearts. In: Braunwald E (ed) Heart Disease–A Textbook of Cardiovascular Medicine. Saunders, Philadelphia, pp 535–150Google Scholar
  163. Peter K, Lawin P, Bein T (Hrsg) Intensivmedizin 1992; Intensivmedizin Notfallmedizin Anästhesiologie Bd 81. Thieme Stuttgart New York, S 89–118Google Scholar
  164. Petros A, Bennett 1), Valance P (1991) Effect of nitric oxide SV tie inhibitors on hypotension in patients with septic shock. Lancet 338: 1557 1558Google Scholar
  165. Pilz G, McGinn P, Boekstegers P, Käb S, Weidenhöfer S, Werdan K (1994) Pseudomonas sepsis does not cause more severe cardiovascular dysfunction in patients than non-Pseudomonas sepsis. Circ Shock 42: 174–182PubMedGoogle Scholar
  166. Plaisance P, Lurie KG, Vicaut E et al. (1999) A comparison of standard cardiopulmonary resucitation and active compression-decompression resuscitation for out-of-hospital cardiac arrest. N Engl J Med 341: 569–575PubMedGoogle Scholar
  167. Poderoso JJ, Boversi A, Jorge MA et al (1978) Function mitochondrial et shock septico. Medicinal (Firenze) 38x71–377Google Scholar
  168. Pokieser H (1995) Röntgendiagnostik, Ultraschall and Computertomographie. In: Benzer H, Burchardi H, Larsen R, Suter PM (Hrsg) Intensivmedizin. Springer, Berlin Heidelberg New York Tokyo, S 209–266Google Scholar
  169. Prielipp RC, MacGregor DA, Butterworth JF et al (1996) Pharmacodynamics and pharmacokinetics of milrinone administration to increase oxygen delivery in critically ill patients. Chest 109x291–1301Google Scholar
  170. Pulmonary Artery Consensus Conference Participants (1997) Pulmonary artery consensus conference: Consensus statement. Crit Care Med 25: 910–925Google Scholar
  171. Putterman C (1989) The Swan-Ganz catheter: a decade of hemorrhagic monitoring. J Crit Care 4: 127Google Scholar
  172. Puybasset L, Rouby JJ (1996) Inhalation of nitric oxide in acute respiratory distress syndrome. Intensivmed 33: 140–152Google Scholar
  173. Rackow EC, Falk JL, Fein IA et al (1983) Fluid resuscitation in circulatory shock: A comparison of the cardiorespiratory effects of albumin, hetastarch and saline solutions in patients with hypovolemic and septic shock. Crit Care Med 11: 839–850Google Scholar
  174. Rao RH, Vagnucci AH, Amico JH (1989) Bilateral massive adrenal hemorrhage: early recognition and treatment. Ann Intern Med 110: 227–235PubMedGoogle Scholar
  175. Raper R, Sibbald W], Driedger AA, Gerow K (1989) Relative myocardial depression in normotensive sepsis. J Crit Care 4:9–18 Raper RF, Fisher MMD (1988) Profound reversible myocardial depression after anaphylaxis. Lancet 1: 386–388Google Scholar
  176. Raper RF, Sibbald WJ (1988) The effects of coronary artery disease on cardiac function in nonhypotensive sepsis. Chest 94507–511Google Scholar
  177. Redl G, Germann P, Plattner H, Hammerle A (1993) Right ventricular function in early septic shock states. Intensive Care Med 19: 3–7PubMedGoogle Scholar
  178. Redling F, Neumann I, Zerkowski H-R (1998) Herzverletzungen. Intensiv Notfallbeh 23: 85–95Google Scholar
  179. Reines HD, DeMaria EJ (1995) Traumatic Shock: Nonsurgical Management. In: Parrillo JE, Bone RC (eds) Critical Care Medicine. Mosby-Year Book, St. Louis MO, pp 419–432Google Scholar
  180. Reithmann C, Hallström S, Pilz G, Kapsner T, Schlag G, Werdan K (1993) Desensitization of rat cardiomyocyte adenylyl cyclase stimulation by plasma of noradrenaline-treated patients with septic shock. Circ Shock 41: 48–59PubMedGoogle Scholar
  181. Reithmann C, Werdan K (1995) Klinische Ergebnisse der einzelnen therapeutischen Prinzipien: Katecholamine. In: Griebenow R, Gülker H, Dominiak P, Piper HM (Hrsg) Autonomes Nervensystem and Herzinsuffizienz. Thieme, Stuttgart New York, S 214–229Google Scholar
  182. Riecker G (1968) Störungen des Wasser-and Elektrolytstoffwechsels bei Nierenkrankheiten. In: Schwiegk H (Hrsg) Handbuch der Inneren Medizin, 5. Aufl, Bd 8/1. Springer, Berlin Heidelberg New York, S 760Google Scholar
  183. Riess H (1998) Hämostasestörungen im Umfeld von Sepsis and SIRS. Internist 39: 479–484PubMedGoogle Scholar
  184. Roberts JS, Bratton SL (1998) Colloid volume expanders–Problems, pitfalls and possibilities. Drugs 55: 621–630PubMedGoogle Scholar
  185. Russell IA, Zwass MS, Fineman JR et al (1998) The effects of inhaled nitric oxide on congenital heart disease. Anesth Analg 87: 46–51PubMedGoogle Scholar
  186. Ryan TJ (1999) Early revascularization in cardiogenic shock–a positive view of a negative trial. N Engl J Med 341: 687–688PubMedGoogle Scholar
  187. Sack JB, Kesselbrenner MB, Bregman D (1992a) Survival from in hospital cardiac arrest with interposed abdominal counterpulsation during cardiopulmonary resusciation. JAMA 267: 379–385PubMedGoogle Scholar
  188. Sack JB, Kesselbrenner MB, Jarrad A (19926) Interposed abdominal compression: Cardiopulmonary resuscitation and resuscitation outcome during asystole and electromechanical dissociation. Circulation 86: 1692–1700Google Scholar
  189. Scheidt S, Ascheim R, Killip T (197o) Shock after acute myocardial infarction: a clinical and hemodynamic profile. Am J Cardiol 26: 556–564Google Scholar
  190. Schierhout G, Roberts I (1998) Fluid resusciation with colloid or crystalloid solutions in critically ill patients: a systematic review of randomized trials. BMJ 316: 961–964PubMedGoogle Scholar
  191. Schlag G, Redl H (eds) (1993) Pathophysiology of Shock, Sepsis and Organ-Failure. Springer, Berlin Heidelberg New York TokyoGoogle Scholar
  192. Schmidt H, Heinroth K, Werdan K (1999) Autonomic dysfunction in critically ill patients. In: Vincent J-L (ed) Yearbook of intensive care and emergency medicine 1999. Springer, Berlin Heidelberg New York Tokyo, pp 519–536Google Scholar
  193. Schmidt W, Nottrott M, Desel H (1998) Lebensbedrohliche akute Intoxikationen durch kardio- und vasotoxisch wirkende Medikamente und Drogen. Intensiv Notfallbeh 23: 27–49Google Scholar
  194. Schölmerich J (1998) Akute Pankreatitis nach Schock, Ischämie, Reperfusion, Trauma und Sepsis. Internist 39: 453–458PubMedGoogle Scholar
  195. Scholz KH, Dubois-Rande J-L, Urban P et al (1998) Clinical experience with the percutaneous hemopump during high-risk coronary angioplasty. Am J Cardiol 82: 1507–1510Google Scholar
  196. Scholz KH, Figulla HR, Schröder T et al (1995) Pulmonary and left ventricular decompression by artificial pulmonary valve incompetence during percutaneous cardiopulmonary bypass support in cardiac arrest. Circulation 91: 2664–2668PubMedGoogle Scholar
  197. Scholz KH, Saathoff H, Tebbe U (1989) Intraaortale Ballongegenpulsation bei akutem Myokardinfarkt, ischämischer Linksherzinsuffizienz und therapierefraktärer Angina pectoris. Dtsch Med Wochenschr 114: 1821–1827PubMedGoogle Scholar
  198. Schroeder S, Reck M, Hoeft A, Stüber F (1999) Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 7o genes in patients with severe sepsis. Crit Care Med 27: 1265–1270PubMedGoogle Scholar
  199. Schumann RR, Rietschel ET (1995) Endotoxin–structure, recognition, cellular response and septic shock. Antiinfective Drugs and Chemotherapy 13: 115–524Google Scholar
  200. Schuster H-P, Müller-Werdan U (2000) Systematik der Therapie bei Sepsis und Multiorganversagen. In: Schuster H-P, Werdan K (Hrsg) Intensivtherapie bei Sepsis und Multiorganversagen, 3. Aufl. Springer, Berlin Heidelberg New York Tokio, S. 87–504Google Scholar
  201. Schuster H-P, Schuster FP, Ritschel P, Wilts S, Bodmann KF (1997) The ability of the Simplified Acute Physiology Score ( SAPS II) to predict outcome in coronary care patients. Intens Care Med 23: 381–384Google Scholar
  202. Seeger W, Suttorp N, Grimminger F, Bhakdi S (1993) Bacterial exotoxins and vascular injury. In: Schlag G, Redl H (eds) Pathophysiology of Shock, Sepsis and Organ Failure. Springer Berlin Heidelberg New York Tokyo, pp 427–446Google Scholar
  203. Seeger W, Walmrath D, Grimminger F (1995) ARDS–Intensivtherapie des akuten Lungenversagens. Internist 36: 785–801PubMedGoogle Scholar
  204. Seige M, Werdan K (1999) Allgemeine Intensivtherapie. In: Paumgartner G (Hrsg) Therapie innerer Krankheiten, 9. Aufl. Springer, Berlin Heidelberg New York Tokio, S. 1452–1508Google Scholar
  205. Shawl FA, Quyyumi AA, Bajaj S, Hoff SB, Dougherty KG (1996) Per-cutaneous cardiopulmonary bypass-supported coronary angioplasty in patients with unstable angina pectoris or myocardial infarction and a left ventricular ejection fraction _ 25%. Am J Cardiol 77x4–19Google Scholar
  206. Shears LL, Biliar TR (1995) Biochemistry and synthesis of NO in sepsis. In: Fink MP, Payen D (eds) Role of Nitric Oxide in Sepsis and ARDS (Update in Intensive Care and Emergency Medicine 24). Springer Berlin Heidelberg New York Tokyo, pp 14–28Google Scholar
  207. Sherman JC, Dalaurier GA, Hawkins ML et al (1989) Percutaneous peritoneal lavage in blunt abdominal trauma: a safe and accurate diagnostic method. J Trauma 29: 801–804PubMedGoogle Scholar
  208. Shimamoto H, Kawazoe K, Kito Y, Ohara K, Kosakai Y, Kito H, Fujita T (1992) Effects of intraaortic balloon pumping on mitral flow dynamics in patients with coronary artery bypass operations. Am Heart J 123x229–1236Google Scholar
  209. Silverman HJ, Penaranda R, Orens JB, Lee NH (1993) Impaired ß-adrenergic receptor stimulation of cyclic adenosine mono-phosphate in human septic shock: association with myocardial hyporesponsiveness to catecholamines. Crit Care Med 21: 31–39PubMedGoogle Scholar
  210. Silverman HJ, Van Hook C, Haponik EF (1984) Hemodynamic changes in human anaphylaxis. Am J Med 77: 341–343PubMedGoogle Scholar
  211. Simon TL, Alverson DC, AuBuchon J et al (1998) Practice Parameter for the Use of Red Blood Cell transfusions–Developed by the Red Blood Cell Administration Practice Guidelines Development Task Force fo the College of American Pathologists. Arch Pathol Lab Med 122: 130–138PubMedGoogle Scholar
  212. Simoons ML, Serruys PW, van der Brand M et al (1985) Improved survival after early thrombolysis in acute myocardial infarction. Lancet 2: 578–582PubMedGoogle Scholar
  213. Song W, Furman BL, Parratt JR (1994) Attenuation by dexamethasone of endotoxin protection against ischaemia-induced ventricular arrhythmias. Br J Pharmacol 113: 1083–1084PubMedGoogle Scholar
  214. Spiegel T, von (1999) Monitoring des kardiovaskulären Systems. Intensiv Notfallbeh 24: 25–32Google Scholar
  215. St. John J, Barbee RW, Sonin N, Clemens MG, Watts JA (1999) Inhibition of Poly(ADP-ribose) synthetase improves vascular contractile responses following trauma-hemorrhage and resuscitation. Shock 12:188–195Google Scholar
  216. Stacpoole PW, Wright EC, Baumgartner TG et al (1992) A controlled trial of dichloroacetate for treatment of lactic acidosis in adults. N Engl J Med 327: 1564–1569PubMedGoogle Scholar
  217. Stallmach A, Zeitz M (1998) Der Darm als immunologisches Organ. Wien Klin Wochenschr 110: 72–78PubMedGoogle Scholar
  218. Stokkers P, Camoglio L, Deventer SJH van (1996) Cytokine gene polymorphism in infectious and inflammatory disease. In: Vincent J-L (ed) Yearbook of intensive care and emergency medicine 1996. Springer, Berlin Heidelberg New York Tokyo, pp 73–82Google Scholar
  219. Stüber F, Petersen M, Bokelmann F, Schade U (1996) A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-a concentrations and outcome of patients with severe sepsis. Crit Care Med 24: 381–384PubMedGoogle Scholar
  220. Suffredini AF, Fromm RE, Parker MM, Brenner M, Kovacs JA, Wesly RA, Parrillo JE (1989) The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 321: 280–287PubMedGoogle Scholar
  221. Sullivan TJ (1982) Cardiac disorders in penicillin-induced anaphylaxis. JAMA 248: 2161–2162PubMedGoogle Scholar
  222. Szabo C, Thiemermann C (1994) Invited opinion: Role of nitric oxide in hemorrhagic, traumatic and anaphylactic shock and thermal injury. Shock 2: 145–155Google Scholar
  223. Taniguchi T, Koido y, Aiboshi J et al (1999) Change in the ratio of interleukin-6 to interleukin-io predicts a poor outcome in patients with systemic inflammatory response syndrome. Crit Care Med 27: 1262–1264PubMedGoogle Scholar
  224. Task Force of the American College of Critical Care Medicine, Society of Critical Care Medicine (1999) Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Crit Care Med 27: 639–660Google Scholar
  225. Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology (1996) Acute myocardial infarction: pre-hospital and in-hospital management. Eur Heart J 17: 43–63Google Scholar
  226. Tcheng JE, Jackman JD, Nelson CL et al (1992) Outcome of patients sustaining acute ischemic mitral regurgitation during myocardial infarction. Ann Intern Med 117: 18–24PubMedGoogle Scholar
  227. Tebbe U, Carlsson J (1998) Kardiopulmonale Reanimation–Darstellung and Kommentar aktueller Richtlinien. Internist 39: 179–187PubMedGoogle Scholar
  228. Teirstein PS, Vogel RA, Dorros G et al (1993) Prophylactic versus standby cardiopulmonary coronary angioplasty. J Am Coll Cardiol 21: 590–596PubMedGoogle Scholar
  229. Thiemermann C (1995) Inhibition of nitric oxide synthase activity in circulatory shock: friend or foe? In: Fink MP, Payen D (eds) Role of Nitric Oxide in Sepsis and ARDS (Update in Intensive Care and Emergency Medicine 24 ). Springer, Berlin Heidelberg New York Tokyo, pp 201–216Google Scholar
  230. Thijs LG, Groeneveld ABJ (1988) Peripheral circulation in septic shock. Appl Cardiopulm Pathol 2: 203Google Scholar
  231. Thompson BT, Cockrill BA (1994) Renal-dose dopamine: a Siren song? Lancet 344: 7–8PubMedGoogle Scholar
  232. Tommaso CL (1998) Current status of percutaneously inserted cardiopulmonary bypass in the cardiac catheterization laboratory. Catheterization Cardiovascular Diagnosis 45oa2o-121Google Scholar
  233. Tommaso CL, Vogel RA (1994) National registry for supported angioplasty; results and follow-up of three years of supported and standby supported angioplasty in high-risk patients. Cardiology 84: 238–244PubMedGoogle Scholar
  234. Tresadern JC, Threlfall CJ, Wilford K et al (1988) Muscle adenosine 5`triphosphate and creatine phosphate concentrations in relation to nutritional status and sepsis in man. Clin Sci 75: 233–242PubMedGoogle Scholar
  235. Villa LM, Salas E, Darley-Usmar VM, Radomski MW, Moncada S (1994) Peroxynitrite induces both vasodilation and impaired vascular relaxation in the isolated perfused rat heart. Proc Natl Acad Sci USA 91: 12383–12387PubMedGoogle Scholar
  236. Vincent J-L, Moreno R, Takala J et al, on behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine (1996) The SOFA ( Sepsis-related Organ Failure Assessment) score to describe organ dysfunction. Intensive Care Med 22: 707–710Google Scholar
  237. Vincent JL, Thijs LG (eds) (1987) Septic Shock–European View; Update in Intensive Care and Emergency Medicine 4. Springer, Berlin Heidelberg New York Tokyo, S 186–196Google Scholar
  238. Vogel RA (1994) Supported angioplasty. In: Topol EJ (ed) Textbook of Interventional Cardiology. Saunders, Philadelphia, pp 495–501Google Scholar
  239. Wagenknecht B, Hug M, Hübner G, Werdan K (1989) Myokardiale Wirkungen von Mediatoren. Intensivmed 26 (Supp11) 32–40Google Scholar
  240. Waldenberger FR, Borges A, Schubel J, Baumann G, Konertz W (1998) Haemodynamic changes in patients undergoing high-risk PTCA under protection of transfemoral heart-lung machine support with centrifugal pumps. Int J Artif Organs 21: 809–813PubMedGoogle Scholar
  241. Walmrath H-D, Grimminger F (1997) Lungenödem und akutes respiratorisches Distreß-Syndrom des Erwachsenen. In: Lasch HG, Lenz K, Seeger W (Hrsg) Lehrbuch der Internistischen Intensivtherapie. Schattauer, Stuttgart New York, S 366–391Google Scholar
  242. Wampler RK, Baker BA, Wright WM (1994) Circulatory support of cardiac interventional procedures with the hemopumpfiM cardiac assist system. Cardiology 84x94–201Google Scholar
  243. Wang P, Hauptman JG, Chaudry IH (1990) Hemorrhage produces depression in microvascular blood flow which persists despite fluid resuscitation. Circ Shock 32: 307–318PubMedGoogle Scholar
  244. Webb JB, Thompson CR,Abel JG et al (1997) Characteristics and outcome when severe mitral regurgitation causes post MI shock: Report from the SHOCK registry. Circulation 96: I - 749Google Scholar
  245. Weil MH, Nakagawa Y, Tang W et al (1999) Sublingual capnometry: A new noninvasive measurement for diagnosis and quantitation of severity of circulatory shock. Crit Care Med 27: 1225–1229Google Scholar
  246. Werdan K (1995a) Myocardial energy metabolism. In: Böhles H, Hofstetter R, Sewell AC (eds) Metabolic cardiomyopathy. Wissenschaftliche Verlagsgesellschaft, Stuttgart, pp 17–49Google Scholar
  247. Werdan K (1999) Notfalltherapie der akuten Herzinsuffizienz. Dtsch Med Wochenschr 124: 53–63Google Scholar
  248. Werdan K, Boekstegers P, Müller U et al (1991) Akute septische Kardiomyopathie: Bestandteil des Multiorganversagens in der Sepsis? Med Klin 86: 526–534Google Scholar
  249. Werdan K, Kuhn C, Müller-Werdan U, Prondzinsky R (1999) Kornplikationen: Sepsis. In: Zerkowski, Baumann (Hrsg) HerzAkutMedizin. Steinkopff, Darmstadt, S. 555–604Google Scholar
  250. Werner GS, Sold G,Andreas S, Wiegand V, Kreuzer H (1990) Dopplerechokardiographische Beurteilung der Ventrikelfunktion während intraaortaler Ballongegenpulsation. Z Kardiol 79: 8–14Google Scholar
  251. Williams G, Giroir BP (1995) Regulation of cytokine gene expression: tumor necrosis factor, interleukin-s and the emerging biology of cytokine receptors. New Horiz 3: 276–287PubMedGoogle Scholar
  252. Witthaut R, Werdan K, Schuster H-P (1998) Multiorgandysfunktionssyndrom und Multiorganversagen - Diagnose, Prognose und Therapiekonzepte. Internist 39: 493–501Google Scholar
  253. Wollert KC, Drexler H (1998) Kardiogener Schock nach Myokard- infarkt–Aktuelle Therapieansätze. Intensivmed 35: 535–542Google Scholar
  254. Yao Z, Auchampach JA, Pieper GM, Gross GJ (1993) Cardioprotective effects of monophosphoryl lipid A, a novel endotoxin analogue in the dog. Cardiovasc Res 27: 832–838PubMedGoogle Scholar
  255. Zehender M, Kasper W, Kauder E et al (1993) Right ventricular infarction as an independent predictor of prognosis after acute inferior myocardial infarction. N Engl J Med 328: 981–988PubMedGoogle Scholar
  256. Zell R, Geck P,Werdan K, Boekstegers P (1997) TNF-a and IL-1Œ inhibit both pyruvate dehydrogenase activity and mitochondrial function in cardiomyocytes: evidence for primary impairment of mitochondrial function. Mol Cell Biochem 177: 61–67PubMedGoogle Scholar
  257. Zotz RJ, Dohmen G, Genth S, Erbel R, Meyer J (1993) Diagnosis of papillary muscle rupture after acute myocardial infarction by transthoracic and transesophageal echocardiography. Clin Cardio116: 665–670Google Scholar
  258. Zweier JL, Wang P, SamouilovA, Kuppusami P (1995) Enzyme-independent formation of nitric oxide in biological tissues. Nature Med 1:804–809; letter to the editor: 1103Google Scholar

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  • K. Werdan
  • U. Müller-Werdan

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