Skip to main content
SpringerLink
Log in

Toxicity of Histamine: Lethal Doses

  • Chapter
Histamine and Anti-Histaminics

  • 224 Accesses

Abstract

For a substance, such as histamine, whose normal physiological role has not been completely established (Feldberg, 1954; Gaddum, 1948; Jancso, 1947; Kahlson, 1960; Parrot and Reuse, 1954; Rocha e Silva, 1955; Schayer, 1961), it is difficult to delimit when the effects should be considered toxic. On the other hand, there is no problem in qualifying as toxic the effects when represented by histological alterations or irreversible biochemical reactions, which ultimately produce death.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature

  • Ambrus, J. L., C. M. Ambrus and J. Jacob: Histamine desensitization in the guinea pig and the rat. Experientia (Basel) 6, 272 (1950).

    Article  CAS  Google Scholar 

  • Ambrus, J. L., C. M. Ambrus, and J. W. E. Harrison: Mode of action of histamine desensitization. Amer. J. Physiol. 167, 268 (1951 a).

    Google Scholar 

  • Ambrus, J. L., C. M. Ambrus, and J. W. E. Harrison, Effect of histamine desensitization on histamine induced gastric secretion of guinea pigs. Gastroenterology 18, 249 (1951 b).

    Google Scholar 

  • Ambrus, J. L., LE. W. Packman, G. V. Rossi, C. M. Ambrus and J. W. E. Harrison: The antagonism and synergism of histamine and antihistamines in mice. J. Pharm. Pharmacol. 4, 466 (1952). Handb. d. exp. Pharmakol. Erg. W. Bd. Xviii/1

    Google Scholar 

  • Angelakos, T. E., and E. R. LoEw: Histamine toxicity in mice and rats following treatment with histaminase inhibitors. J. Pharmacol. exp. Ther. 119, 444 (1957).

    PubMed  CAS  Google Scholar 

  • Arunlakshana, O., J. L. Mongar and H. O. Schild: Potentiation of pharmacological effects of histamine by histaminase inhibitors. J. Physiol. (Lond.) 123, 32 (1954).

    CAS  Google Scholar 

  • Banting, F. G., and S. Gairns: Suprarenal insufficiency. Amer. J. Physiol. 77, 100 (1926).

    CAS  Google Scholar 

  • Barger, G., and H. H. Dale: Beta-imidazol-ethyl-amine and other active principles of ergot. J. Chem. Soc. 97, 2592 (1910a).

    Article  CAS  Google Scholar 

  • Barger, G., and H. H. Dale: Chemical structure and sympathomimetic action of amines. J. Physiol. (Lond.) 41, 19 (1910b).

    CAS  Google Scholar 

  • Best, C. H., and E. W. Machenry: The inactivation of histamine. J. Physiol. (Lond.) 70, 349 (1930).

    CAS  Google Scholar 

  • Best, C. H., and E. W. Machenry: Histamine. Physiol. Rev. 11, 371 (1931).

    CAS  Google Scholar 

  • Carlsten, A., and D. R. Wood: Restoration of normal lymph histaminase in adrenalectomized cats by adrenocortical extract. J. Physiol. (Lond.) 111, 8 P (1950).

    Google Scholar 

  • Clark, R.: The paralytic action of histamine on the ruminal musculature. J. S. Afr. vet. med. Ass. 21, 13 (1950).

    Google Scholar 

  • Cordier, D., et M. Cordier: Troubles de la phosphorolyse du glycogène hépatique au cours de l’intoxication histaminique. J. Physiol. (Paris) 47, 141 (1955).

    CAS  Google Scholar 

  • Cordier, D., et A. Duveau: Sensibilité à l’adrénaline et à l’acétylcholine de l’intestin grêle du rat intoxiqué par l’histamine. C. R. Soc. Biol. (Paris) 150, 1954 (1956).

    CAS  Google Scholar 

  • Cordier, D., et G. PÉRhs: Troubles de la protidémie au cours de l’intoxication histaminique. J. Physiol. (Paris) 49, 107 (1957).

    CAS  Google Scholar 

  • Crane, J. T., S. Lindway and N. E. Dailey: An attempt to prevent histamine induced ulcers in guinea pigs with Benadryl. Amer. J. Digest. Dis. 14, 56 (1947).

    Article  CAS  Google Scholar 

  • Crivellari, C. A.: Sensitivity of adrenalectomized rats to the action of some toxic substances. Rev. Soc. argent. Biol. 2, 448 (1926).

    Google Scholar 

  • Crivellari, C. A.: Sensibilité des rats décapsulés à l’égard de la nicotine, du cyanure, de l’acétylcholine et de l’histamine. C. R. Soc. Biol. (Paris) 96, 223 (1927).

    CAS  Google Scholar 

  • Dale, H. H.: Conditions which are conducive to the production of shock by histamine. Brit. J. exp. Path. 1, 103 (1920).

    CAS  Google Scholar 

  • Crivellari, C. A. and P. P. Laidlaw: The physiological action of beta-iminazolyl-ethyl-amine. J. Physiol. (Lond.) 41, 318 (1911).

    Google Scholar 

  • Crivellari, C. A. and P. P. Laidlaw: Histamine shock. J. Physiol. (Loud.) 52, 355 (1919).

    Google Scholar 

  • Decourt, M. J., et J. L. Parrot: Les bases physiologiques et physiopathologiques de la médication antihistaminique. Presse méd. 66 764 (1947). (Rapport au 26e Congrès Français de Médecine).

    Google Scholar 

  • Delaunois, A. L., R. Kordecki, H. Polet and J. Ryzewski: Cardiac output, arterial blood pressure and pulmonary arterial pressure in histamine shock. Arch. in Pharmacodyn. 120, 114 (1959).

    Google Scholar 

  • Deutsch, S., and E. R. LoEw: Failure of antihistamine drugs to antagonize lethal effects of histamine in mice. Fed. Proc. 13, 348 (1954).

    Google Scholar 

  • Domenjoz, R., u. R. Jaques: Über Synopen, ein nues Antihistaminicum. Schweiz. med. Woch. 21, 476 (1949).

    Google Scholar 

  • Dougherty, R. W.: A study of drugs affecting the motility of the bovine rumen. Cornell Vet. 32, 269 (1942).

    CAS  Google Scholar 

  • Eichler, O.: Pharmakologie des Veritols. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharm. 187, 433 (1937).

    Google Scholar 

  • Eichler, O., u. H. Killian • Versuche zur Histaminwirkung am Kaninchen. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 159, 606 (1931).

    Google Scholar 

  • Eichler, O., u. H. MtiGge: Mechanismus der Histaminwirkung beim Kaninchen. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharm, 159, 633 (1931).

    Article  Google Scholar 

  • Elliot, T. R.: The control of the suprarenal glands by the splachnic nerves. J. Physiol. (Lond.) 44, 374 (1912).

    Google Scholar 

  • Essex, H. E., and B. T. Horton: Observations on development of resistance to histamine in the guinea pig. Proc. Mayo Clin. 16, 603 (1941).

    CAS  Google Scholar 

  • Fabinyi, M., and J. Szebehelyi • The mechanism of desensitization with histamine. Acta allerg. (Kbh.) 2, 233 (1949).

    CAS  Google Scholar 

  • Feinberg, S. M.: Histamine and antihistaminic agents; their experimental and therapeutic status. J. Amer. med. Ass. 132, 702 (1946).

    Article  CAS  Google Scholar 

  • Feldberg, W.: The action of histamine on the blood vessels of the rabbit. J. Physiol. (Lond.) 63, 211 (1927).

    CAS  Google Scholar 

  • Feldberg, W.: On some physiological aspects of histamine. J. Pharm. Pharmacol. 6, 281 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Feldberg, W., and A. A. Miles: Regional variations of increased permeability of skin capillaries induced by histamine liberation and their relation to the histamine content of the skin. J. Physiol. (Lond.) 120, 205 (1953).

    CAS  Google Scholar 

  • Flury, F.: In: Abderhalden’s Handb. biol. Arbeitsmethoden. 4, 7 b, 1354 (1925).

    Google Scholar 

  • FÜHner, H.: Beiträge zur vergleichenden Pharmakologie; die giftigen und tödlichen Gaben einiger Substanzen für Frösche und Mäuse. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 166, 437 (1932).

    Google Scholar 

  • Gabe, M.: Données histophysiologiques sur l’intoxication histaminique aiguë par voie gastrique. Arch. Mal. Appar. dig. 41, 10 (1952).

    PubMed  CAS  Google Scholar 

  • Gaddum, J. H.: Histamine. Brit. med. J. 1948 I, 867.

    Article  Google Scholar 

  • Gaddum, J. H.: The origin of histamine in the body. In: Histamine (Ciba Foundation Symposium), Little, Brown and Co. Publish. 285 (1956).

    Google Scholar 

  • Geiger, E.: Role of histamine in poisoning with spoiled fish. Science 121, 865 (1955).

    Google Scholar 

  • Goodman, L. S., and A. Gilman • The pharmacological basis of therapeutics. 2nd. ed. New York, N. Y.: The Macmillan Co., Publ. 1955.

    Google Scholar 

  • Graham, J. D. P.: A comparison of some antihistamine substances. Brit. J. Pharmacol. 91, 193 (1947).

    Google Scholar 

  • Gross, F.: Die Beeinflussung des Histaminschockes durch Desoxycorticosteron und Antihistaminica am nebennierenlosen Meerschweinchen. Hefe. physiol. pharmacol. Acta 6, 114 (1948).

    CAS  Google Scholar 

  • Halpern, B. N.: Les antihistaminiques de synthèse. Essai de chimiotherapie des états allergiques. Arch. int. Pharmacodyn. 68, 339 (1942).

    CAS  Google Scholar 

  • Halpern, B. N.: Experimental research on a new series of chemical substances with powerful antihistaminic activity: the thiodiphenylamine derivatives. J. Allergy 18, 263 (1947).

    Article  PubMed  CAS  Google Scholar 

  • Halpern, B. N.: Recherches sur une nouvelle série chimique de corps doués de propriétés antihistaminiques et anti-anaphylactiques: les dérivés de la thiodiphénylamine. Arch. in Pharmacodyn. 74, 314 (1947 b).

    Google Scholar 

  • Halpern, B. N.: Sur le mécanisme d’action des antihistaminiques de synthèse. Presse méd. 65, 949 (1949).

    Google Scholar 

  • Halpern, B. N., et M. Briot: Action des antihistaminiques de synthèse sur la température chez le rat normal et chez le rat surrénalectomisé. C. R. Soc. Biol. (Paris) 143, 633 (1950).

    Google Scholar 

  • Halpern, B. N., et L. Chmel: Etude de l’action de quelques antihistaminiques de synthèse sur la température du lapin. C. R. Soc. Biol. (Paris) 143, 636 (1949).

    CAS  Google Scholar 

  • Halpern, B. N., and J. Hamburger: A new synthetic antihistamine substance derived from phenothiazine (Phenergan, 3.277 RP). Canad. med. Ass. J. 59, 322 (1948).

    CAS  Google Scholar 

  • Halpern, B. N., et D. Woon: Mise en évidence de l’action antitoxique d’un antihistaminique de synthèse vis-à-vis de l’histamine chez la souris par la surrénalectomie. C. R. Acad. Sci. (Paris) 230, 138 (1950).

    CAS  Google Scholar 

  • Hay, L. M., R. L. Varco, C. F. Code and O. H. Wangensteen: The experimental production of gastric and duodenal ulcers in laboratory animals by the intramuscular injection of histamine in beeswax. Surg. Gynec. Obstet. 75, 170 (1942).

    CAS  Google Scholar 

  • Hirano, T.: Non-importance of medulla in the susceptibility to histamine of suprarenalectomized rabbits. Tohoku J. exp. Med. 37, 322 (1939).

    Google Scholar 

  • Horton, B. T.: Histamine cephalgia: differential diagnosis and treatment. Proc. Mayo Clin. 31, 325 (1956).

    CAS  Google Scholar 

  • Houssay, R. H.: The adrenals in the hypoxia and the histamine intoxication. Buenos Aires: El Ateneo Publis. 1951.

    Google Scholar 

  • Houssay, R. H.: Protection par les corticostéroïdes ou la cortisone contre l’intoxication histaminique. C. R. Soc. Biol. (Paris) 148, 907 (1954).

    CAS  Google Scholar 

  • Ingle, J.: Resistance of the rat to histamine shock after destruction of the adrenal medulla. Amer. J. Physiol. 118, 57 (1937).

    CAS  Google Scholar 

  • Jancso, M.: Histamine as a physiological activator of the reticuloendothelial system. Nature (Lond.) 160, 227 (1947).

    Article  CAS  Google Scholar 

  • Jones, L. M.: Veterinary pharmacology and therapeutics. 2nd. Ed., The Iowa State College Press, 1957.

    Google Scholar 

  • Kahlson, G.: Histamine in normal physiology. Lancet 1960I, 67.

    Google Scholar 

  • Karady, S.: Changes in the total blood volume in histamine and surgical shock in normal rabbits and in those pretreated with histaminase. Amer. J. Physiol. 123, 194 (1938).

    Google Scholar 

  • Karady, S., B. Rose and J. S. L. Browne: Decrease of histaminase in tissue by adrenalectomy and its restoration by cortico-adrenal extracts. Amer. J. Physiol. 130, 539 (1940).

    CAS  Google Scholar 

  • Kellaway, C. H., and S. J. Cowell: The antagonism between histamine and adrenaline. J. Physiol. (Lond.) 56, 20 (1922a).

    Google Scholar 

  • Kellaway, C. H., and S. J. Cowell: On the concentration of the blood and the effects of histamine in adrenal insufficiency. J. Physiol. (Lond.) 57, 82 (1922b).

    CAS  Google Scholar 

  • Kendall, E. C.: Hormones. Ann. Rev. Biochem. 10, 298 (1941).

    Article  Google Scholar 

  • Kimata, M., and A. Kawai: Production of histamine by bacteria causing spoilage in fish. Bull. Res. Inst. Food Sci. Kyoto Univ. 13, 29 (1953).

    Google Scholar 

  • LA Barre, J.: Sur les causes des variations de la glycémie au cours des chocs anaphylactique, histaminique et peptonique. Arch. int. Méd. exp. 3, 42 (1927).

    Google Scholar 

  • Lands, A. M., J. O. Hoppe, O. H. Siegmund and F. P. Luduena: The pharmacological properties of three new antihistaminic drugs. J. Pharmacol. exp. Ther. 95, 45 (1949).

    PubMed  CAS  Google Scholar 

  • Lands, A. M., F. P. Luduena, J. I. Grant and E. J. Ananenxo: The pharmacologic action of some analogs of 1-(3,4-dihydroxyphenyl)-2-amino-1-butanol (Ethylnorepinephrine). J. Pharmacol. exp. Ther. 99, 45 (1950).

    PubMed  CAS  Google Scholar 

  • Lands, A. M., V. L. Nash, H. M. Mccarthy, H. R. Granger and B. L. Dertinger: The pharmacology of N-alkyl homologues of epinephrine. J. Pharmacol. exp. Ther. 90, 110 (1947).

    PubMed  CAS  Google Scholar 

  • Lehmann, G.: Pharmacological properties of a new antihistaminic, 2-methyl-9-phenyl-2,3,4,9tetrahydro-1-pyridindene (thephorin) and derivatives. J. Pharmacol. exp. Ther. 92, 249 (1948).

    PubMed  CAS  Google Scholar 

  • Lehmann, G., and J. W. Young: The antihistamine activity of diethylamino-ethyl-dihydroanthracencarboxilate and other substances. J. Pharmacol. exp. Ther. 83, 90 (1945).

    CAS  Google Scholar 

  • Lindell, S. E., and H. Westling: Potentiation of histamine effects by an antihistaminase. Acta physiol. stand. 32, 230 (1954).

    Article  CAS  Google Scholar 

  • Lish, P. M., J. R. Albert, E. L. Peters and L. E. Alien: Pharmacology of methdilazine (tacaryl). Arch. int. Pharmacodyn. 129, 77 (1960).

    CAS  Google Scholar 

  • Lucas, G. H. W.: Blood and urine findings in desuprarenalized dogs. Amer. J. Physiol. 77, 114 (1926).

    CAS  Google Scholar 

  • Mac Kay, E. M., and W. G. Clark: Effect of histamine pretreatment upon adrenalectomized rats. Proc. Soc. exp. Biol. (N. Y.) 39, 56 (1938).

    Google Scholar 

  • MalmÉJac, J., A. Gross et G. Neverre: Histamine et adrénalino-sécrétion. C. R. Soc. Biol. (Paris) 144, 704 (1951).

    Google Scholar 

  • Marmorston-Gottesman, J., and J. Gottesman: The use of histamine as a standard test for diminished resistance in suprarenalectomized rats. J. exp. Med. 47, 503 (1928).

    Article  PubMed  CAS  Google Scholar 

  • Mongar, J. L., and H. O. Schild: Potentiation of action of histamine by semicarbazide. Nature (Lond.) 167, 232 (1951).

    Article  CAS  Google Scholar 

  • Naranjo, P.: Bronchospasm and emphysema. An experimental study. Gaceta Méd. 6, 200 (1951).

    Google Scholar 

  • Naranjo, P.: Bronchodilator amines. Chemical structure and selectivity. Terapia 11, 8 (1954).

    Google Scholar 

  • Naranjo, P.: Protection of the experimental asthma by sympathomimetic and anticholinergic drugs. In: Proceedings of the IV Congress of Medicine, Vol. I, 457, Ed. Impta. Municipal Guayaquil (1953d).

    Google Scholar 

  • Naranjo, P., and E. Banda DE Naranjo: Hista-3 a new antihistamine combination. In: Proceedings of the IV Congress of Medicine, Vol. I, 432, Ed. Impta. Municipal, Guayaquil(1953a).

    Google Scholar 

  • Naranjo, P., and E. Banda DE Naranjo: Inactivation of the antihistaminic drugs in the liver and in the gastrointestinal tract. J. Allergy 24, 442 (1953b).

    Article  PubMed  CAS  Google Scholar 

  • Naranjo, P., and E. Banda DE Naranjo: Studies of the combined action of some antihistamine agents. Ann. Allergy 11 699 (1953 c).

    Google Scholar 

  • Naranjo, P., and E. Banda DE Naranjo: Pressor effect of histamine in the rabbit. J. Pharmacol. exp. Ther. 123, 16 (1958).

    PubMed  CAS  Google Scholar 

  • Naranjo, P., and E. Banda DE Naranjo: Erworbene Antigentoleranz und Anaphylaxie. Allergie u. Asthma 7, 259 (1961).

    CAS  Google Scholar 

  • Ni, T. G.: On the inverse change between the concentration of glucose and chloride in the blood. Amer. J. Physiol. 78, 158 (1926).

    CAS  Google Scholar 

  • Noble, R. L., and J. B. Collip: The response of normal, hypophysectomized and adrenal ectomized rats to histamine administration. Amer. J. Physiol. 133, 623 (1941).

    CAS  Google Scholar 

  • Oehme, C.: Über die Wirkungsweise des Histamins. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharm. 72, 76 (1913).

    Google Scholar 

  • Oikawa, K.: The susceptibility of doubly suprarenalectomized rabbits to nicotine, histamine ephedrine and typhoid vaccine. Tohoku J. exp. Med. 18, 27 (1931).

    CAS  Google Scholar 

  • Papacostas, C. A., P. Mozden and E. R. LoEw: Influence of histamine and histamine liberator, compound 48/80, on blood glucose of unanesthetized animals. Fed. Proc. 15, 466 (1956).

    Google Scholar 

  • Parfentjev, I. A., and M. A. Goodline: Histamine shock in mice sensitized with Haemophilus pertussis vaccine. J. Pharmacol. exp. Ther. 92, 411 (1948).

    PubMed  CAS  Google Scholar 

  • Parrot, J. L., et J. Reuse: Rôle physiologique et physiopathologique de l’histamine. J. Physiol. (Paris) 46, 99 (1954).

    CAS  Google Scholar 

  • Perla, D.: Effect of anterior hypophysis emulsion on natural resistance of hypophysectomized and normal rats to histamine poisoning. Proc. Soc. exp. Biol. (N. Y.) 33, 121 (1935).

    CAS  Google Scholar 

  • Perla, D., and J. Marmorston-Gottesman: Natural resistance and clinical medicine. Boston: Little., Brown and Co. 1941.

    Google Scholar 

  • Pickering, G. W.: Observations on mechanism of headache produced by histamine. Clin. Sci. 1, 77 (1933).

    CAS  Google Scholar 

  • Reuse, J. J.: Histamine, antihistaminiques de synthèse et système circulatoire du Lapin. J. Physiol. (Paris) 40, 289 (1948).

    Google Scholar 

  • Robinson, B. W.: Histaminic cephalgia. Medicine 37, 161 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Rocha E Silva, M.: Histamine, its role in anaphylaxis and allergy. Springfield, Ill.: Charles C. Thomas. Publish. 1955.

    Google Scholar 

  • Rose, B., and J. S. L. Browne: The distribution and rate of disappearance of intravenously injected histamine in the rat. Amer. J. Physiol. 124, 412 (1938).

    CAS  Google Scholar 

  • Rose, B., and J. S. L. Browne: The effect of adrenalectomy on the histamine content of the tissues of the rat. Amer. J. Physiol. 131, 589 (1941).

    CAS  Google Scholar 

  • Roth, F. E., and W. M. GovIer: Comparative pharmacology of chlorpheniramine (chlortrimeton) and its optical isomers. J. Pharmacol. exp. Ther. 124, 347 (1958).

    PubMed  CAS  Google Scholar 

  • Satow, J.: A measure to alter the glycaemic effect of histamine and peptone. Tohoku J. exp. Med. 32, 239 (1938).

    Google Scholar 

  • Schayer, R. W.: The origin and fate of histamine in the body. In: Histamine (Ciba Foundation Symposium), Little, Brown and Co. Publish., 183 (1956a).

    Chapter  Google Scholar 

  • Schayer, R. W., The origin of histamine in the body. In: Histamine (Ciba Foundation Symposium), Little, Brown and Co. Publish. 299 (1956b).

    Google Scholar 

  • Schayer, R. W., Histamine metabolism. Iii. Congrès international d’allergologie, Paris, 377 (1958).

    Google Scholar 

  • Schayer, R. W., Significance of induced synthesis of histamine in physiology and pathology. Chemotherapia 3, 128 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Schayer, R. W., K. Y. T. Wu, and R. L. Smiley• Sources of urinary histamine in the rat. Amer J Physiol. 179, 481 (1954).

    PubMed  CAS  Google Scholar 

  • Schmidt, G. W., u. A. STÄHelin • Histaminempfindlichkeit und anaphylaktische Reaktionen. Z. Immun.-Forsch. 60, 222 (1929).

    CAS  Google Scholar 

  • Scott, W. J. M.: The effect of histamine in sublethal suprarenal insufficiency. Arch. Path. Lab. Med. 4, 491 (1927).

    Google Scholar 

  • Shifrine, M., L. E. Ousterhotjt, C. R. Grau and R. H. Vaughn: Toxicity to chicks of histamine formed during microbial spoilage of tuna. Appl. Microbiol. 7, 45 (1959).

    PubMed  CAS  Google Scholar 

  • Spencer, P. S. J., and G. B. West: Sensitivity of the hyperthyroid and hypothyroid mouse to histamine and 5-hydroxytryptamine. Brit. J. Pharmacol. 17, 137 (1961).

    PubMed  CAS  Google Scholar 

  • Stead, E. A., and J. V. Warren: The effect of injection of histamine into the brachial artery on the permeability of capillaries in the forearm and hand. J. Clin. Invest. 23, 279 (1944).

    Article  PubMed  CAS  Google Scholar 

  • Suzuki, T.: Adrenaline load of the suprarenal glands of rabbits in histamine poisoning. Tohoku J. exp. Med. 54, 289 (1951).

    CAS  Google Scholar 

  • Tabor, H.: The fate of histamine in the body. In: Histamine (Ciba Foundation Symposium), Boston: Little, Brown and Co. Publish. 318 (1956).

    Chapter  Google Scholar 

  • Takita, S.: Contribution to glycemic effect of histamine in dogs and rabbits. Tohoku J. exp. Med. 53, 145 (1950).

    CAS  Google Scholar 

  • Trendelenburg, U.: The pressor response of the cat to histamine and pilocarpine. J. Pharmacol. exp. Ther. 131, 65 (1961).

    PubMed  CAS  Google Scholar 

  • Wada, M., F. KeizO, S. Hatiro, S. Huminciko and M. C. LI: The action of histamine upon the epinephrine secretion from the suprarenal gland in non-anaesthetized dogs. Tohoku J. exp. Med. 37, 442 (1940).

    CAS  Google Scholar 

  • Walpole, S. H., R. L. Varco, C. F. Code and O. H. Wangensteen: Production of gastric and duodenal ulcers in the cat by intramuscular implantation of histamine. Proc. Soc. exp. Biol. (N. Y.) 44, 619 (1940).

    CAS  Google Scholar 

  • Wells, J A, J S Gray and C. A. Dragstedt: An investigation of the question of histamine tolerance. J. Allergy 13, 77 (1941).

    Article  CAS  Google Scholar 

  • Wilson, A.: The effect of adrenalectomy on the blood histamine of rabbits. J. Physiol. (Lond.) 99, 241 (1941).

    CAS  Google Scholar 

  • Woodbury, R. A., and W. F. Hamilton: Effect of histamine on pulmonary blood pressure of various animals with and without anesthesia. J. Pharmacol. exp. Ther. 71, 293 (1941).

    CAS  Google Scholar 

  • Wyman, L. C.: Studies on suprarenal insufficiency. II. The relative importance of cortex and medulla in the susceptibility to histamine of suprarenalectomized rats. Amer. J. Physiol. 87, 20 (1928).

    Google Scholar 

  • Zeller, E. A.: The fate of histamine in the body, with particular reference to the enzymology of histamine oxidation. In: Histamine (Ciba Foundation Symposium), Boston, Little, Brown and Co. Publish., 339 (1956).

    Chapter  Google Scholar 

Download references

Authors
  1. Plutarco Naranjo
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Mauricio Rocha e Silva

Rights and permissions

Reprints and permissions

Copyright information

© 1966 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Naranjo, P. (1966). Toxicity of Histamine: Lethal Doses. In: Rocha e Silva, M. (eds) Histamine and Anti-Histaminics. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 18 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12016-3_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-12016-3_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-12018-7

  • Online ISBN: 978-3-662-12016-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation