Biological Determination of Histamine in Living Tissues and Body Fluids

  • I. Vugman
  • M. Rocha e Silva
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 18 / 1)


The amounts of histamine that can be extracted from tissues and mammalian blood can be so small and the earliest methods of extraction and purification so laborious that they could not allow a satisfactory recovery for a quantitative chemical titration. Therefore, up to very recent times, the only accepted method for histamine estimation was the biological assay. By choosing appropriate conditions, the preparation could be rendered highly discriminative to estimate histamine in presence of other pharmacologically active principles which might contaminate the extracts.


Biological Assay Perfusion Fluid Tyrode Solution Histamine Content Ciba Foundation Symposium 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1966

Authors and Affiliations

  • I. Vugman
  • M. Rocha e Silva

There are no affiliations available

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