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Release of Histamine from Mast Cells

  • Chapter
Book cover Histamine and Anti-Histaminics

Abstract

The mast cells are connective tissue cells characterized morphologically by the presence in their cytoplasm of numerous metachromatic granules and biochemically by their high content of heparin and histamine. The relationship between mast cells and histamine was firmly established by the fundamental papers of Riley. West and co-workers (Riley, 1953 a, b; Riley and West, 1953; Cass, Riley, West, Head and Stroud, 1954) and is dealt with in detail by Riley and West in this volume. Besides heparin and histamine, Benditt, Wong, Arase and Roeper (1955) showed that the mast cells contain also 5-hydroxytryptamine and Bhattacharya and Lewis (1956) showed that 5-hydroxytryptamine is released from rat tissues perfused with compound 48–80. It seems of interest to call attention to the fact that the role of histamine, heparin and 5-hydroxytryptamine is, up to now, completely unknown and that there is not yet any evidence that the mast cells deliver to the blood or tissues any of these substances under normal conditions. Notwithstanding, the papers referred to above, which suggest that the mast cells can act as a source of heparin, histamine and 5-hydroxytryptamine, have opened a wide field of approach to the study of mast cell physiology. In the present chapter, an attempt will be made to gather and analyze the many papers that have been published in the last years concerning the phenomenon of histamine liberation from the mast cells, with emphasis on the behavior of these cells in anaphylaxis. As we are concerned more with experimental details than with ideas, references will preferentially be made to original work rather than to reviews.

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  1. Ivan Mota
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Mauricio Rocha e Silva

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Mota, I. (1966). Release of Histamine from Mast Cells. In: Rocha e Silva, M. (eds) Histamine and Anti-Histaminics. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 18 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12016-3_21

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