Abstract
In homothallic (self-compatible) strains of the yeasts Saccharomyces cerevisiae and Schizosac-charomyces pombe, individual cells switch their mating type (MT) in a programmed manner. In contrast, the cells of heterothallic (self-incompatible) strains have a stable MT. These are called a and a in S. cerevisiae and h + and h - in S. pombe. Only cells of opposite MT can copulate. This chapter will deal with the intriguing process of MT switching, also termed MT interconversion.
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References
Arcangioli B, Klar AJS (1991) A novel switch-activating site (SAS1) and its cognate binding factor (SAP1) required for efficient matl switching in Schizosaccharo-mycespombe. EMBO J 10:3025–3032
Beach DH (1983) Cell type switching by DNA transposition in fission yeast. Nature 305:682–688
Beach DH, Klar AJS (1984) Rearrangements of the trans-posable mating-type cassettes of fission yeast. EMBO J 3:603–610
Bernstein H, Hopf FA, Michod RE (1987) The molecular basis of the evolution of sex. Adv Genet 24:323–370
Carr AM, Sheldrick KS, Murray JM, Al-Harithy R, Watts FZ, Lehmann AR (1993) Evolutionary conservation of excision repair in Schizosaccharomycespombe: evidence for a family of sequences related to the Saccharomyces cerevisiae RAD2 gene. Nucleic Acids Res 21:1345–1349
Egel R (1977) Frequency of mating type switching in homothallic fission yeast. Nature 266:172–174
Egel R (1984a) Two tightly linked silent cassettes in the mating-type region of Schizosaccharomyces pombe. Curr Genet 8:199–203
Egel R (1984b) The pedigree pattern of mating-type switching in Schizosaccharomyces pombe. Curr Genet 8:205–210
Egel R (1989) Mating-type genes, meiosis and sporulation. In: Nasim A, Young P, Johnson BF (eds) Molecular biology of the fission yeast. Academic Press, London, pp 31–73
Egel R, Gutz H (1981) Gene activation by copy transposition in mating-type switching of a homothallic fission yeast. Curr Genet 3:5–12
Egel R, Kohli J, Thuriaux P, Wolf K (1980) Genetics of the fission yeast Schizosaccharomyces pombe. Annu Rev Genet 14:77–108
Egel R, Beach DH, Klar AJS (1984) Genes required for initiation and resolution steps of mating-type switching in fission yeast. Proc Natl Acad Sci USA 81:3481–3485
Egel R, Willer M, Nielsen O (1989) Unblocking of meiotic crossing-over between the silent mating-type cassettes of fission yeast, conditioned by the recessive, pleiotropic mutant rikl. Curr Genet 15:407–410
Ekwall K, Nielsen O, Ruusala T (1991) Repression of a mating-type cassette in the fission yeast by four DNA elements. Yeast 7:745–755
Engelke U, Grabowski L, Gutz H, Heim L, Schmidt H (1987) Molecular characterization of h~ mutants of Schizosaccharomyces pombe. Curr Genet 12:535–542
Fleck O, Heim L, Gutz H (1990) A mutated swi4 gene causes duplications in the mating-type region of Schizosaccharomyces pombe. Curr Genet 18:501–509
Fleck O, Michael H, Heim L (1992) The swi4 + gene of Schizosaccharomyces pombe encodes a homologue of mismatch repair enzymes. Nucleic Acids Res 20: 2271–2278
Game JC (1983) Radiation-sensitive mutants and repair in yeast. In: Spencer JFT, Spencer DM, Smith ARW (eds) Yeast genetics. Springer, Berlin Heidelberg New York, pp 109–137
Gutz H, Angehrn P (1968) Lethal mutations in the mating-type region of Schizosaccharomyces pombe (Abstr). Genetics 60:186
Gutz H, Schmidt H (1985) Switching genes in Schizosaccharomyces pombe. Curr Genet 9:325–331
Gutz H, Schmidt H (1990) The genetic basis of homothallism and heterothallism in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Semin Dev Biol 1:169–176
Gutz H, Heslot H, Leupold U, Loprieno N (1974) Schizosaccharomyces pombe. In: King RC (ed) Handbook of genetics, vol 1. Plenum Press, New York, pp 395–446
Haber JE (1983) Mating-type genes of Saccharomyces cerevisiae. In: Shapiro JA (ed) Mobile genetic elements. Academic Press, New York, pp 559–619
Haber JE (1992) Mating-type gene switching in Saccharomyces cerevisiae. Trends Genet 8:446–452
Herskowitz I (1988) The Hawthorne deletion twenty-five years later. Genetics 120:857–861
Herskowitz I (1989) A regulatory hierarchy for cell specialization in yeast. Nature 342:749–757
Herskowitz I, Oshima Y (1981) Control of cell type in Saccharomyces cerevisiae: Mating type and mating-type interconversion. In: Strathern JN, Jones EW, Broach JR (eds) The molecular biology of the yeast Saccharomyces. Life cycle and inheritance. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp 181–209
Herskowitz I, Rine J, Strathern J (1992) Mating-type determination and mating-type interconversion in Saccharomyces cerevisiae. In: Jones EW, Pringle JR, Broach JR (eds) The molecular and cellular biology of the yeast Saccharomyces. Gene expression. Cold Spring Harbor Laboratory Press, Plainview, NY, pp 583–656
Kelly M, Burke J, Smith M, Klar A, Beach D (1988) Four mating-type genes control sexual differentiation in the fission yeast. EMBO J 7:1537–1547
Klar AJS (1989) The interconversion of yeast mating type: Saccharomyces cerevisiae and Schizosaccharomyces pombe. In: Berg DE, Howe MM (eds) Mobile DNA. American Society for Microbiology, Washington, DC, pp 671–691
Klar AJS (1992a) Molecular genetics of fission yeast cell type: Mating type and mating-type interconversion. In: Jones EW, Pringle JR, Broach JR (eds) The molecular and cellular biology of the yeast Saccharomyces. Gene expression. Cold Spring Harbor Laboratory Press, Plainview, NY, pp 745–777
Klar AJS (1992b) Developmental choices in mating-type interconversion in fission yeast. Trends Genet 8:208–213
Klar AJS, Miglio LM (1986) Initiation of meiotic recombination by double-strand DNA breaks in S. pombe. Cell 46:725–731
Klar AJS, Strathern JN, Hicks JB (1984a) Developmental pathways in yeast. In: Losick R, Shapiro L (eds) Microbial development. Cold Spring Habor Laboratory, Cold Spring Harbor, NY, pp 151–195
Klar AJS, Strathern JN, Abraham JA (1984b) Involvement of double-strand chromosomal breaks for mating-type switching in Saccharomyces cerevisiae. Cold Spring Harbor Symp Quant Biol 49:77–88
Klar AJS, Bonaduce MJ, Cafferkey R (1991) The mechanism of fission yeast mating-type interconversion: seal/ replicate/cleave model of replication across the double-stranded break site at matl. Genetics 127:489–496
Kostriken R, Strathern JN, Klar AJS, Hicks JB, Heffron F (1983) A site-specific endonuclease essential for mating-type switching in Saccharomyces cerevisiae. Cell 35: 167–174
Leupold U (1950) Die Vererbung von Homothallie und Heterothallie bei Schizosaccharomyces pombe. C R Trav Lab Carlsberg Sér Physiol 24:381–480
Leupold U (1955) Methodisches zur Genetik von Schizosaccharomyces pombe. Schweiz Z allg Pathol Bakteriol 18:1141–1146
Lindegren CC, Lindegren G (1943) A new method for hybridizing yeast. Proc Natl Acad Sci USA 29:306–308
Lorentz A, Heim L, Schmidt (1992) The switching gene swi6 affects recombination and gene expression in the mating-type region of Schizosaccharomyces pombe. Mol Gen Genet 233:436–442
Lorentz A, Ostermann K, Fleck O, Schmidt H (1994) Switching gene swi6, involved in repression of silent mating-type loci in fission yeast, encodes a homologue of chromatin-associated proteins from Drosophila and mammals. Gene (in press)
Michael H (1992) Charakterisierung des L-Bereichs der Paarungstyp-Region von Schizosaccharomyces pombe. Dissertation, Technische Universität Braunschweig, Braunschweig, Germany
Miller AM, Nasmyth KA (1984) Role of DNA replication in the repression of silent mating-type loci in yeast. Nature 312:247–251
Miyata H, Miyata M (1981) Mode of conjugation in homothallic cells of Schizosaccharomyces pombe. J Gen Appl Microbiol 27:365–371
Nasmyth KA (1982) Molecular genetics of yeast mating type. Annu Rev Genet 16:439–500
Nielsen O, Egel R (1989) Mapping the double-strand breaks at the mating-type locus in fission yeast by genomic sequencing. EMBO J 8:269–276
Oeser H (1962) Genetische Untersuchungen über das Paarungstypverhalten bei Saccharomyces und die Maltose-Gene einiger untergäriger Bierhefen. Arch Mikrobiol 44:47–74
Ostermann K, Lorentz A, Schmidt H (1993) The fission yeast rad22 gene, having a function in mating-type switching and repair of DNA damages, encodes a protein homolog to Rad52 of Saccharomyces cerevisiae. Nucleic Acids Res 25:5940–5944
Raveh D, Hughes SH, Shafer BK, Strathern JN (1989) Analysis of the HO-cleaved MAT DNA intermediate generated during the mating-tpye switch in the yeast Saccharomyces cerevisiae. Mol Gen Genet 220:33–42
Rödel C, Kirchhoff S, Schmidt H (1992) The protein sequence and some intron positions are conserved between the switching gene swilO of Schizosaccharomyces pombe and the human excision repair gene ERCC1. Nucleic Acids Res 20:6347–6353
Schlake C, Ostermann K, Schmidt H, Gutz H (1993) Analysis of DNA repair pathways of Schizosaccharomyces pombe by means of swi-rad double mutants. Mutat Res 294: 59–67
Schmidt H (1987) Strains of Schizosaccharomyces pombe with a disrupted swil gene still show some mating-type switching. Mol Gen Genet 210:485–489
Schmidt H (1993) Effective long-range mapping in Schizosaccharomyces pombe with the help of swi5. Curr Genet 24:271–273
Schmidt H, Kapitza P, Gutz H (1987) Switching genes in Schizosaccharomyces pombe: their influence on cell viability and recombination. Curr Genet 11:303–308
Schmidt H, Kapitza-Fecke P, Stephen ER, Gutz H (1989) Some of the swi genes of Schizosaccharomyces pombe also have a function in the repair of radiation damage. Curr Genet 16:89–94
Singh J, Klar AJS (1993) DNA polymerase-α is essential for mating-type switching in fission yeast. Nature 361: 271–273
Sipiczki M (1989) Taxonomy and phylogenesis. In: Nasim A, Young P, Johnson BF (eds) Molecular biology of the fission yeast. Academic Press, London, pp 431–452
Strathern JN (1988) Control and execution of homothallic switching in Saccharomyces cerevisiae. In: Kucherlapati R, Smith GR (eds) Genetic recombination. American Society for Microbiology, Washington, DC, pp 445–464
Strathern JN, Herskowitz I (1979) Asymmetry and directionality in production of new cell types during clonal growth: the switching pattern of homothallic yeast. Cell 17:371–381
Strathern JN, Klar AJS, Hicks JB, Abraham JA, Ivy JM, Nasmyth KA, McGill C (1982) Homothallic switching of yeast mating-type cassettes is initiated by a double-stranded cut in the MAT locus. Cell 31:183–192
Styrkársdóttir U, Egel R, Nielsen O (1993) The smt-0 mutation which abolishes mating-type switching in fission yeast is a deletion. Curr Genet 23:184–186
Szostak JW, Orr-Weaver TL, Rothstein RJ (1983) The double-strand-break repair model for recombination. Cell 33:25–35
Takano I, Kusumi T, Oshima Y (1973) An a mating-type allele insensitive to the mutagenic action of the homothallic gene system in Saccharomyces diastaticus. Mol Gen Genet 126:19–28
Thon G, Klar AJS (1992) The clrl locus regulates the expression of the cryptic mating-type loci of fission yeast. Genetics 131:287–296
Thon G, Klar AJS (1993) Directionality of fission yeast mating-type interconversion is controlled by the location of the donor loci. Genetics 134:1045–1054
Weeda G, Hoeijmakers JHJ, Bootsma D (1993) Genes controlling nucleotide excision repair in eukaryotic cells. Bio Essays 15:249–258
Weiffenbach B, Haber JE (1981) Homothallic mating-type switching generates lethal breaks in rad52 strains of Saccharomyces cerevisiae. Mol Cell Biol 6:522–534
Weiler KS, Broach JR (1992) Donor locus selection during Saccharomyces cerevisiae mating-type interconversion responds to distant regulatory signals. Genetics 132: 929–942
White CI, Haber JE (1990) Intermediates of recombination during mating-type switching in Saccharomyces cerevisiae. EMBO J 9:663–673
Winge Ö (1935) On haplophase and diplophase in some Saccharomycetes. C R Trav Lab Carlsberg Sér Physiol 21:77–111
Winge Ö, Roberts C (1949) A gene for diploidization in yeasts. C R Trav Lab Carlsberg Sér Physiol 24:341–346
Yarrow D (1984) Saccharomyces. In: Kreger-van Rij NJW (ed) The yeasts, 3rd edn, Elsevier, Amsterdam, pp 379–395
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Schmidt, H., Gutz, H. (1994). The Mating-Type Switch in Yeasts. In: Wessels, J.G.H., Meinhardt, F. (eds) Growth, Differentiation and Sexuality. The Mycota, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-11908-2_16
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DOI: https://doi.org/10.1007/978-3-662-11908-2_16
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