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Gene Therapy Strategies for Inhibition of HIV

  • Magnús Gottfredsson

Abstract

Most of the HIV proteins and virtually every stage in the HIV life cycle can be viewed as a potential site for inhibition. Several of the HIV proteins have been successfully inhibited in vitro and in T cell lines. However, challenging transduced primary T cells and macrophages with diverse strains of HIV is a more realistic system to test and compare the effectiveness of different gene therapy approaches. With several clinical trials planned or underway, the field of gene therapy research for HIV disease is very active, representing 18% of patients undergoing clinical gene therapy trials.1 These advances parallel the remarkable progress in stem cell biology in the past 2–3 years.2,3 In the future, once an ideal combination of anti-HIV genes has been identified, stem cells could be made resistant by one-time delivery of potent combinations of antiviral genes, thereby reconstituting an immune system durably protected from rampant viral multiplication. This chapter reviews different gene therapy approaches that have been taken to inhibit HIV replication, using either viral components or cellular proteins as targets.

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Type Human Immunodeficiency Virus Infection Human Immunodeficiency Virus Infected Patient Gene Therapy Strategy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1998

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  • Magnús Gottfredsson

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