A Comparison of Glucose Polymer and Dextrose as Osmotic Agents in CAPD
Dialysis solutions containing a mixture of glucose oligosaccharides (average molecular mass 710 daltons) derived from starch, were compared with 1.5% or 4.25% dextrose-containing dialysis fluids in single exchanges in 88 patients on continuous ambulatory peritoneal dialysis (CAPD). Dialysis fluid osmolality, net ultrafiltration and dialysate-to-plasma solute ratios for urea and creatinine were determined during a single 2 L exchange over 1 to 10 hours dwell time. In addition, absorption of the dextrose and oligosaccharides was investigated. Net ultrafiltration (mean ± SEM) was comparable for an 8 hour dwell time (1086 ± 169 ml for 4.25% dextrose solution and 1081 ± 100 ml for 8% polymer solution). In addition, clearances of urea and creatinine were nearly identical for the 4.25% dextrose and 8% glucose polymer solutions, as were the dialysate-toplasma concentration ratios for urea and creatinine. Both dextrose and glucose oligosaccharides were absorbed within 2 hours of starting dialysis. Although few adverse effects were observed during glucose polymer single exchanges, absorbed oligosacçharides were eliminated slowly from the blood (half-life of 20 hours) suggesting a limited use for this particular preparation of glucose oligosaccharides for CAPD.
KeywordsPeritoneal Dialysis Dwell Time Continuous Ambulatory Peritoneal Dialysis Dialysis Solution Osmotic Agent
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