The Sorbent Suspension Reciprocating Dialyzer for Use in Peritoneal Dialysis

  • S. R. Ash
  • D. J. Carr
  • D. E. Blake
  • J. A. Thornhill


The greatest cost of peritoneal dialysis is in the preparation, packaging, and shipping of sterile dialysis fluid. CAPD and CCPD represent attempts to support patients on the minimal volumes of such dialysis fluid. Sorbent chemicals which regenerate dialysate could decrease the shipping weight of disposables, while allowing much higher dialysate flows.

A plate dialyzer with screen supports has been designed which can operate with a thick sorbent suspension on the screen side (SSRD). The sorbent suspension contains charcoal, covalently-bound urease, calcium-loaded zeolites, and hydrogen-loaded cation exchangers. Alteration in pressure of the sorbent suspension propels 200 ml of peritoneal dialysate into and out of the dialyzer (through a single central port), where it lies directly across the membrane from the sorbent suspension. In tests of the SSRD on dogs with BUN 50–60 mg/dl and plasma creatinine 6 mg/dl, the clearances, of urea and creatinine were 80–100 ml/min, phosphorus was 50, and K was 20 ml/min for 4 hours. These clearances are high enough to maintain low concentrations of urea, creatinine, phosphorus and K in the peritoneal dialysate. Protein is not removed, and calcium and bicarbonate are returned to the animal. Ultrafiltration ranged from 0.2–0.8 L/h. Protein removal is entirely avoided. The sorbent suspension need not be sterile. If sorbent components can be made at moderate cost, the SSRD may be a simple, cost effective method of intermittent peritoneal dialysis.


Peritoneal Dialysis Peritoneal Fluid Dialysis Fluid Peritoneal Catheter Loaded Zeolite 
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  1. 1.
    Barile RG, Wang NL, Blake DE, Belcastro PF, Gupta S, Regnier FE, Thornhill JA, Kessler DP, and Ash SR: A reciprocating, single-needle hemodialyzer with bidirectional flow of sorbent suspension. Artif Organs 6: 267, 1982PubMedCrossRefGoogle Scholar
  2. 2.
    Ash SR, Barile RG, Wilcox PG, Wright DL, Thornhill JA, Dhein CR, Kessler DP, and Wang NL: The sorbent suspension reciprocating dialyzer: A device with minimal sorbent saturation. asaio J 4: 28, 1981Google Scholar
  3. 3.
    Wang NHL, Kessler DP, and Ash SR: Mass transfer characteristics of a sorbent-based reciprocating dialyzer. Chem Eng Corn 5: 347, 1980CrossRefGoogle Scholar
  4. 4.
    Ash SR, Barile RG, Thornhill JA, Sherman JD, and Wang NHL: In vivo evaluation of calcium-loaded zeolites and urease for urea removal in hemodialysis. Trans Am Soc Artif Intern Organs 26: 111, 1980PubMedGoogle Scholar
  5. 5.
    Gordon A, Better OS, Greenbaum MA, Marantz LB, Gral T, and Maxwell MH: Clinical maintenance hemodialysis with a sorbent-based low-volume dialysate regeneration system. Trans Am Soc Artif Intern Organs 17: 253, 1971PubMedGoogle Scholar
  6. 6.
    Klein E, Holland FF, Eberle K, Morton SC, and Cabasso I: Sorbent-filled hollow fiber for hemopuri-Google Scholar
  7. fication. Trans Am Soc Artif Intern Organs 24: 127, 1978Google Scholar
  8. 7.
    Kablitz C, Stephen RL, Duffy DP, Jacobsen SC, Zelman A, and Kolff WJ: Technological augmentation of peritoneal urea clearance: Past, present and future. Dial Trans 9: 741, 1980Google Scholar
  9. 8.
    Banks G: Maintenance peritoneal dialysis as an alternative for the patient with end-stage renal failure. Clin Digest 6: 1, 1978Google Scholar
  10. 9.
    Maxwell MH, Gordon A, and Lewin AJ: Sorbentbased regenerative peritoneal dialysis system. Proc 11th Annu Contractors’ Conf Artificial Kidney Program, NIAMDD, DHEW Publ No (NIH) 79–1442, 1978, p 54Google Scholar
  11. 10.
    Ash SR, and Thornhill JA: Animal models of renal failure. CRC Press, 1984Google Scholar
  12. 11.
    Ash SR, Johnson H, Hartman J, Granger J, Koszuta JJ, Sell S, Dhein CR, Blevins W, and Thornhill JA: The column disc peritoneal catheter: A peritoneal access device with improved drainage. asaio J 3: 109, 1980Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • S. R. Ash
    • 1
  • D. J. Carr
    • 1
  • D. E. Blake
    • 1
  • J. A. Thornhill
    • 1
  1. 1.Ash Medical Systems, Inc., and the Small Animal Clinic, School of Veterinary MedicinePurdue UniversityWest LafayetteUSA

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