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Opsonically-Active Proteins in CAPD Fluid

  • V. M. A. Yewdall
  • D. N. Bennett-Jones
  • J. S. Cameron
  • C. S. Ogg
  • D. G. Williams

Summary

Concentrations of albumin, transferrin, IgG, C3 and α 2 macroglobulin were measured by radial immunodiffusion in serum and dialysate of patients treated by CAPD. Fibronectin and CH50 were also measured by nephelometry and dialysate opsonic activity was determined. Transport of proteins into peritoneal dialysate was low, varied considerably from patient to patient, and showed little discrimination according to protein size. The dialysate protein level correlated with in vitro opsonic activity.

Keywords

Peritoneal Dialysate Protein Ratio Radial Immunodiffusion Chronic Peritoneal Dialysis Opsonic Activity 
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References

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    Verbrugh HA, Keane WF, Hoidal JR, Freiberg MR, Elliott GR, and Peterson PK: Peritoneal macrophages and opsonins: Antibacterial defense in patients undergoing chronic peritoneal dialysis. J Infect Dis 147: 1018, 1983PubMedCrossRefGoogle Scholar
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    Weir DM: Handbook of experimental immunology, Vol 1. Oxford: Blackwell Scientific Publications, 1973, p 5. 10Google Scholar
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    Peterson PK, Verhoef J, Schmelling D, and Quie PG: Kinetics of phagocytosis and bacterial killing by human polymorphonuclear leukocytes and monocytes. J Infect Dis 136: 502, 1977PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • V. M. A. Yewdall
    • 1
  • D. N. Bennett-Jones
    • 1
  • J. S. Cameron
    • 1
  • C. S. Ogg
    • 1
  • D. G. Williams
    • 1
  1. 1.Renal UnitGuy’s HospitalLondonUK

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