Skip to main content
SpringerLink
Log in

Pyridine nucleotide transhydrogenases

1.6.1.1 NADPH2:NAD oxidoreductase

  • Chapter
Book cover Enzyme

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

  • 55 Accesses

Abstract

The existence of enzymes which catalyze the direct transfer of hydrogen between TPNH and DPN was adumbrated by Ball 2 in 1941. 11 years later, Kaplan, Colowick and their collaborators1, 2 discovered such an enzyme in Pseudomonas fluorescens which they designated pyridine nucleotide transhydrogenase. Enzymes of this class have since been found in some animal3–9 and plant10 tissues, and in various micro-organisms1, 11. The pyridine nucleotide transhydrogenases of Pseudomonas fluorescens 1 and of spinach10 are soluble enzymes, while the animal transhydrogenases appear to be confined to the mitochondria and microsomes4, 5, 8, 9. The highest levels of transhydrogenase in animal tissues are located in the mitochondria of heart, kidney and liver4, 8.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 74.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Lang, K., u. H. Lang: B. Z. 329, 577 (1958).

    CAS  Google Scholar 

  2. Ball, E. G.; in: A Symposium on Respiratory Enzymes (O. Meyerhof, ed.), p. 40. University of Wisconsin Press, Madison, Wisconsin. 1941.

    Google Scholar 

  3. Colowick, S. P., N. O. Kaplan, E. F. Neufeld and M. M. Ciotti: J. biol. Ch. 195, 95 (1952).

    CAS  Google Scholar 

  4. Kaplan, N. O., S. P. Colowick and E. F. Neufeld: J. biol. Ch. 195, 107 (1952).

    CAS  Google Scholar 

  5. Kaplan, N. O., S. P. Colowick and E. F. Neufeld: J. biol. Ch. 205, 1 (1953).

    CAS  Google Scholar 

  6. Kaplan, N. O., M. N. Swartz, M. E. Frech and M. M. Ciotti: Proc. nat. Acad. Sci. USA 42, 481 (1956).

    Article  PubMed  CAS  Google Scholar 

  7. Stein, A. M., N. O. Kaplan and M. M. Ciotti: J. biol. Ch. 234, 979 (1959).

    CAS  Google Scholar 

  8. Vignais, P. V., and P. M. Vignais: J. biol. Ch. 229, 265 (1957).

    CAS  Google Scholar 

  9. Kiellet, W. W., and J. E. Bronk: J. biol. Ch. 230, 521 (1958).

    Google Scholar 

  10. Humphrey, G. F.: Biochem. J. 65, 546 (1957).

    PubMed  CAS  Google Scholar 

  11. Ball, E. G., and O. Cooper: Proc. nat. Acad. Sci. USA 43, 357 (1957).

    Article  PubMed  CAS  Google Scholar 

  12. Keister, D. L., and A. San Pietro: Biochem. biophys. Res. Comm. 1, 110 (1959).

    Article  CAS  Google Scholar 

  13. Mitsuhashi, S., and B. D. Davis: Biochim. biophys. Acta 15, 54 (1954).

    Article  PubMed  CAS  Google Scholar 

  14. Kaplan, N. O., S. P. Colowick, E. F. Neufeld and M. M. Ciotti: J. biol. Ch. 205, 17 (1953).

    CAS  Google Scholar 

  15. Kaplan, N. O., S. P. Colowick, L. J. Zatman and M. M. Ciotti: J. biol. Ch. 205, 31 (1953).

    CAS  Google Scholar 

  16. Shuster, L., and N. O. Kaplan: J, biol, Ch, 215, 183 (1955).

    CAS  Google Scholar 

  17. Kaplan, N. O., and M. M. Ciotti: J. biol. Ch. 221, 823 (1956).

    CAS  Google Scholar 

  18. Anderson, B. M., C. J. Ciotti and N. O. Kaplan: J. biol. Ch. 234, 1219 (1959).

    CAS  Google Scholar 

  19. Anderson, B. M., and N. O. Kaplan: J. biol. Ch. 234, 1226 (1959).

    CAS  Google Scholar 

  20. Kaplan, N. O., M. M. Ciotti and F. E. Stolzenbach: J. biol. Ch. 221, 833 (1956).

    CAS  Google Scholar 

  21. Weber, M. M., and N. O. Kaplan: J. biol. Ch. 225, 909 (1957).

    CAS  Google Scholar 

  22. Weber, M. M., N. O. Kaplan, A. San Pietro and F. E. Stolzenbach: J. biol. Ch. 227, 27 (1957).

    CAS  Google Scholar 

  23. Keister, D. L., A. San Pietro and F. E. Stolzenbach: J. biol. Ch. 235, 2989 (1960).

    CAS  Google Scholar 

  24. Strittmatter, P.: J. biol. Ch. 233, 748 (1958).

    CAS  Google Scholar 

  25. San Pietro, A., N. O. Kaplan and S. P. Colowick: J. biol. Ch. 212, 941 (1955).

    CAS  Google Scholar 

  26. Kaplan, N. O., S. P. Colowick and E. F. Neufeld: J. biol. Ch. 195, 107 (1952).

    CAS  Google Scholar 

  27. Stein, A. M., N. O. Kaplan and M. M. Ciotti: J. biol. Ch. 234, 979 (1959).

    CAS  Google Scholar 

  28. Hollmann, S., and O. Touster: J. biol. Ch. 225, 87 (1957).

    CAS  Google Scholar 

  29. Hers, H. G.: Biochim. biophys. Acta 22, 202 (1956).

    Article  PubMed  CAS  Google Scholar 

  30. Hers, H. G.: Biochim. biophys. Acta 37, 127 (1960).

    Article  PubMed  CAS  Google Scholar 

  31. Williams-Ashman, H. G., J. Banks and S. K. Wolfson jr.: Arch. Biochem. 72, 485 (1957).

    Article  PubMed  CAS  Google Scholar 

  32. Colowick, S. P., N. O. Kaplan, E. F. Neufeld and M. M. Ciotti: J. biol. Ch. 195, 95 (1952).

    CAS  Google Scholar 

  33. Holzer, H., u. S. Schneider: B. Z. 330, 240 (1958).

    CAS  Google Scholar 

  34. Navazio, F., B. B. Ernster and L. Ernster: Biochim. biophys. Acta 26, 416 (1957).

    Article  PubMed  CAS  Google Scholar 

  35. Talalay, P., and H. G. Williams-Ashman: Recent Progr. Hormone Res. 16, 1 (1960).

    PubMed  CAS  Google Scholar 

  36. Gordon, E. E., and C. A. Villee: J. biol. Ch. 216, 215 (1955).

    CAS  Google Scholar 

  37. Villee, C. A., and E. E. Gordon: J. biol. Ch. 216, 203 (1955).

    CAS  Google Scholar 

  38. Talalay, P., and H. G. Williams-Ashman: Proc. nat. Acad. Sci. USA 44, 15 (1958).

    Article  PubMed  CAS  Google Scholar 

  39. Villee, C. A., and D. D. Hagerman: J. biol. Ch. 233, 42 (1958).

    CAS  Google Scholar 

  40. Hollander, V. P., N. Hollander and J. D. Brown: J. biol. Ch. 234, 1678 (1959).

    CAS  Google Scholar 

  41. Talalay, P., and H. G. Williams-Ashman: Eecent Progr. Hormone Res. 16, 1 (1960).

    CAS  Google Scholar 

  42. Talalay, P., B. Hurlock and H. G. Williams-Ashman: Proc. nat. Acad. Sci. USA 44, 862 (1958).

    Article  PubMed  CAS  Google Scholar 

  43. Langer, L. J., and L. L. Engel: J. biol. Ch. 233, 583 (1958).

    CAS  Google Scholar 

  44. Jarabak, J., and P. Talalay: J. biol. Ch. 235, 2147 (1960).

    CAS  Google Scholar 

  45. Hagerman, D. D., and C. A. Villee: J. biol. Ch. 234, 2031 (1959).

    CAS  Google Scholar 

  46. Hagerman, D. D., and C. A. Villee: J. biol. Ch. 234, 2031 (1959).

    CAS  Google Scholar 

  47. Villee, C. A., D. D. Hagerman and P.B. Joel: Recent Progr. Hormone Res. 16, 48 (1960).

    Google Scholar 

  48. Jarabak, J., J. A. Adams, H. G. Williams-Ashman and P. Talalay: J. biol. Ch. 237, 345 (1962).

    CAS  Google Scholar 

  49. Talalay, P., and H. G. Williams-Ashman: Recent Progr. Hormone Ees. 16, 1 (1960).

    CAS  Google Scholar 

  50. Hurlock, B., and P. Talalay: J. biol. Ch. 233, 886 (1958).

    CAS  Google Scholar 

  51. Talalay, P.: Rec. chem. Progr. 18, 31 (1957).

    CAS  Google Scholar 

  52. Colowick, S. P., N. O. Kaplan, E. F. Neufeld and M. M. Ciotti: J. biol. Ch. 195, 95 (1952).

    CAS  Google Scholar 

  53. Kaplan, N. O., S. P. Colowick and E. F. Neufeld: J. biol. Ch. 205, 1 (1953).

    CAS  Google Scholar 

  54. San Pietro, A., and H. M. Lang: J. biol. Ch. 231, 211 (1958).

    CAS  Google Scholar 

  55. Keister, D. L., and A. San Pietro: Biochem. biophys. Res. Comm. 1, 110 (1959).

    Article  CAS  Google Scholar 

  56. Keister, D. L., A. San Pietro and F. E. Stolzenbach: J. biol. Ch. 235, 2989 (1960).

    CAS  Google Scholar 

  57. Humphrey, G. F.: Biochem. J. 65, 546 (1957).

    PubMed  CAS  Google Scholar 

  58. Kaplan, N. O., S. P. Colowick and E. F. Neufeld: J. biol. Ch. 205, 1 (1953).

    CAS  Google Scholar 

  59. Anderson, B. M., and N. O. Kaplan: J. biol. Ch. 234, 1226 (1959).

    CAS  Google Scholar 

  60. Colowick, S. P., N. O. Kaplan, E. F. Neufeld and M. M. Ciotti: J. biol. Ch. 195, 95 (1952).

    CAS  Google Scholar 

  61. Humphrey, G. F.: Biochem. J. 65, 546 (1957).

    PubMed  CAS  Google Scholar 

  62. Stein, A. M., N. O. Kaplan and M. M. Ciotti: J. biol. Ch. 234, 979 (1959).

    CAS  Google Scholar 

  63. Ball, E. G., and O. Cooper: Proc. nat. Acad. Sci. USA 43, 357 (1957).

    Article  PubMed  CAS  Google Scholar 

  64. Siebert, G., J. Dubuc, R. C. Warner and G. W. E. Plaut: J. biol. Ch. 226, 965 (1957).

    CAS  Google Scholar 

  65. Kaplan, N. O., S. P. Colowick, E. F. Neufeld and M. M. Ciotti: J. biol. Ch. 205, 17 (1953).

    CAS  Google Scholar 

  66. Kaplan, N. O., S. P. Colowick and E. F. Neufeld: J. biol. Ch. 205, 1 (1953).

    CAS  Google Scholar 

  67. Kornberg, A., and W. E. Pricer jr.: J. biol. Ch. 189, 123 (1951).

    CAS  Google Scholar 

  68. Kaplan, N. O., S. P. Colowick, E. F. Neufeld and M. M. Ciotti: J. biol. Ch. 205, 17 (1953).

    CAS  Google Scholar 

  69. Stein, A. M., N. O. Kaplan and M. M. Ciotti: J. biol. Ch. 234, 979 (1959).

    CAS  Google Scholar 

  70. Siegel, J. M., G. A. Montgomery and E. M. Bock: Arch. Biochem. 82, 288 (1959).

    Article  PubMed  CAS  Google Scholar 

  71. Kaplan, N. O., M. N. Swartz, M. E. Frech and M. M. Ciotti: Proc. nat. Acad. Sci. USA 42, 481 (1956).

    Article  PubMed  CAS  Google Scholar 

  72. Talalay, P., B. Hurlock and H. G. Williams-Ashman: Proc. nat. Acad. Sci. USA 44, 862 (1958).

    Article  PubMed  CAS  Google Scholar 

  73. Stein, A. M., N. O. Kaplan and M. M. Ciotti: J. biol. Ch. 234, 979 (1959).

    CAS  Google Scholar 

  74. Talalay, P., B. Hurlock and H. G. Williams-Ashman: Proc. nat. Acad. Sci. USA 44, 862 (1958).

    Article  PubMed  CAS  Google Scholar 

  75. Talalay, P., and H. G. Williams-Ashman: Proc. nat. Acad. Sci. USA 44, 15 (1958).

    Article  PubMed  CAS  Google Scholar 

  76. Kaplan, N. O., S. P. Colowick and E. F. Neufeld: J. biol. Ch. 205, 1 (1953).

    CAS  Google Scholar 

  77. Jarabak, J., J. A. Adams, H. G. Williams-Ashman and P. Talalay: J. biol. Ch. 237, 345 (1962).

    CAS  Google Scholar 

  78. Langer, L. J., and L. L. Engel: J. biol. Ch. 233, 583 (1958).

    CAS  Google Scholar 

  79. Hagerman, D. D., and C. A. Villee: J. biol. Ch. 234, 2031 (1959).

    CAS  Google Scholar 

  80. Adams, J. A., J. Jarabak and P. Talalay: J. biol. Ch. 237, 3069 (1962).

    CAS  Google Scholar 

  81. Hagerman, D. D., and C. A. Villee: J. biol. Ch. 234, 2031 (1959).

    CAS  Google Scholar 

  82. Villee, C. A., D. D. Hagerman and P. B. Joel: Recent Progr. Hormone Res. 16, 48 (1960).

    Google Scholar 

  83. Villee, C. A.: Kli. Wo. 39, 173 (1961).

    Article  CAS  Google Scholar 

  84. Hagerman, D. D., and C. A. Villee; in: Mechanism of Action of Steroid Hormones (C. A. Villee and L. L. Engel, eds.) Pergamon Press, New York, 1961, p. 169.

    Google Scholar 

  85. Kaufman, B., and N. O. Kaplan: J. biol. Ch. 236, 2133 (1961).

    CAS  Google Scholar 

  86. Stein, A. M., B. T. Kaufman and N. O. Kaplan: Biochem. biophys. Res. Comm. 2, 354 (1960).

    Article  Google Scholar 

  87. Veeger, C., and V. Massey: Biochim. biophys. Acta 37, 181 (1960).

    Article  PubMed  CAS  Google Scholar 

  88. Kaplan, N. O., M. N. Swartz, M. E. Frech and M. M. Ciotti: Proc. nat. Acad. Sci. USA 42, 481 (1956).

    Article  PubMed  CAS  Google Scholar 

  89. Stein, A. M., N. O. Kaplan and M. M. Ciotti: J. biol. Ch. 234, 979 (1959).

    CAS  Google Scholar 

  90. Ernster, L., and A. J. Glasky: Biochim. biophys. Acta 38, 168 (1960).

    Article  PubMed  CAS  Google Scholar 

  91. Ernster, L.: Biochim. biophys. Acta 38, 170 (1960).

    Article  PubMed  CAS  Google Scholar 

  92. Purvis, J. L.: Biochim. biophys. Acta 52, 148 (1961).

    Article  PubMed  CAS  Google Scholar 

  93. Vignais, P. V., and P. M. Vignais: Biochim. biophys. Acta 47, 515 (1961).

    Article  PubMed  CAS  Google Scholar 

  94. Pesch, L. A., K. Piros and G. Klatskin: Biochim. biophys. Acta 62, 602 (1962).

    Article  PubMed  CAS  Google Scholar 

  95. Pesch, L., K. Piros and R. Moquin: Fed. Proc. 22, 409 (1963).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Ben May Laboratory for Cancer Research and Department of Biochemistry, The University of Chicago, Chicago 37, Illinois, USA

    H. G. Williams-Ashman & Shutsung Liao

Authors
  1. H. G. Williams-Ashman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shutsung Liao
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

R. Abraham E. Balke K.-H. Bässler R. K. Bonnichsen H. Breuer T. Bücher F. C. Charalampous L. W. Cunningham G. E. Glock F. Heinz O. Hoffmann-Ostenhof S. Hollmann M. Klingenberg K. Krisch W. Lamprecht K. Lang A. L. Lehninger S. LeonhÄuser K. Leybold S. Liao W. Luh L. Lumper A. C. Maehly H. R. Mahler G. Mohn A. P. Nygaard D. Pette G. Pfleiderer W. J. Rutter K. A. Sack I. Schirrmacher-Göllner G. Siebert E. C. Slater H. Staudinger F. B. Straub H. Süllmann E. Werle J. N. Williams Jr. H. G. Williams-Ashman J. B. Wise

Rights and permissions

Reprints and permissions

Copyright information

© 1964 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Williams-Ashman, H.G., Liao, S. (1964). Pyridine nucleotide transhydrogenases. In: Abraham, R., et al. Enzyme. Handbuch der Physiologisch- und Pathologisch-Chemischen Analyse, vol 6 / a. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-11689-0_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-11689-0_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-11690-6

  • Online ISBN: 978-3-662-11689-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation