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Secretory IgA and Mucosal Immune Responses

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Digestive Disease Pathology

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Abstract

Mucosal immunity is charascterized predominantly by a secretory antibody response, involving immunoglobulins of the IgA class. They provide an immunological barrier to foreign matter by preventing absorption of such materials into the mucosal epithelium and penetration into the body. The humoral responses in nonmucosal sites are largely of the IgG class. The cell-mediated immune mechanism is also distinctive in mucosal and nonmucosal lymphoid organs. During the past decade, significant advances have been made in understanding the mucosal immune system. Ontological and physiological relationships between immunocompetent cells in mucosal and nonmucosal sites have been characterized, and the postulation of a common mucosal immune system1,2 involving the intestinal tract, biliary tract, mammary glands, salivary glands, lacrimal glands, and female genital tract has led to new insights.

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Authors
  1. H. Nagura M.D.
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  2. Y. Sumi M.D.
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Editors and Affiliations

  1. Keio University School of Medicine, Tokyo, Japan

    Shaw Watanabe M.D. (Chief for Epidemiology Division, National Cancer Center Research Institute and Professor of Pathology) (Chief for Epidemiology Division, National Cancer Center Research Institute and Professor of Pathology)

  2. College of Physicians & Surgeons, Columbia University, New York, New York, USA

    Marianne Wolff M.D. (Professor of Clinical Surgical Pathology) & Sheldon C. Sommers M.D. (Clinical Professor of Pathology) (Professor of Clinical Surgical Pathology) &  (Clinical Professor of Pathology)

  3. Pathology Department, Morristown Memorial Hospital, Morristown, New Jersey, USA

    Marianne Wolff M.D. (Professor of Clinical Surgical Pathology) (Professor of Clinical Surgical Pathology)

  4. School of Medicine, University of Southern California, Los Angeles, California, USA

    Sheldon C. Sommers M.D. (Clinical Professor of Pathology) (Clinical Professor of Pathology)

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Nagura, H., Sumi, Y. (1988). Secretory IgA and Mucosal Immune Responses. In: Watanabe, S., Wolff, M., Sommers, S.C. (eds) Digestive Disease Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-11562-6_9

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  • DOI: https://doi.org/10.1007/978-3-662-11562-6_9

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