Non-Hodgkin’s Lymphomas of the Gastrointestinal Tract: A Review with Special Reference to the Gut-associated Lymphoid Tissue

  • P. van der Valk
  • J. Lindeman
  • C. J. L. M. Meijer


Non-Hodgkin’s lymphomas (NHL) are intriguing tumors for several reasons. First, they show a marked variety of histological pictures. Second, though most common in the lymphoid tissues, they can be found in any tissue or organ of the body; and third, they are related to the immune system, as lymphocytes are the cells composing that system. Our knowledge concerning NHL has increased enormously in the last 20 years, due largely to technical advances, such as immunohistochemistry with monoclonal antibodies and electron microscopy. Basic to our present insights is the realization that normal lymphocyte physiology can be seen mirrored in NHL. Malignant lymphoid cells resemble normal lymphocytes in some state of their development, both morphologically and functionally. As lymphocytes are engaged in reactions in the immune response and malignant lymphoid cells mimic normal lymphocytes in morphology and behavior, NHL can be regarded as neoplastic counterparts of the immune reactions. This concept1,2,3,4 is the basis of proper understanding of NHL and is reflected in the classification schemes according to Lukes and Collins2 & Kiel.3


Migration Lymphoma Oncol Sarcoma Diarrhea 


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© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • P. van der Valk
  • J. Lindeman
  • C. J. L. M. Meijer

There are no affiliations available

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