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Differentiation of Gastric Cancer Cells: Analysis Using Immunohistochemistry and Mucin Histochemistry

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Digestive Disease Pathology

Abstract

Most, even all neoplasms are known to show variable degrees of cellular differentiation, not only biologically, but also morphologically.1 Thus, we pathologists can recognize the histological type of each tumor on the basis of morphological similarities to its normal or nonneoplastic counterparts. Carcinoma of the stomach, the most common cancer in Japan,2,3 shows a variety of histological appearances, although it has been roughly grouped into two types, diffuse carcinoma vs. adenoplastic carcinoma.4,5 The diffuse cancer is characterized by its scirrhous growth pattern and the occurrence of signet ring cells, a peculiar cancer morphology in the stomach. The histological heterogeneities of gastric cancer possibly reflect the fact that the gastric mucosa shows a bidirectional cell renewal pattern, (i.e., the generative (stem) cells differentiate upward to the foveolar epithelium and downward to the gastric gland).6–9 The frequent occurrence of intestinal metaplasia in the aged gastric mucosa2,10 makes the situation more complicated.

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Authors
  1. Yutaka Tsutsumi
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Editors and Affiliations

  1. Keio University School of Medicine, Tokyo, Japan

    Shaw Watanabe M.D. (Chief for Epidemiology Division, National Cancer Center Research Institute and Professor of Pathology) (Chief for Epidemiology Division, National Cancer Center Research Institute and Professor of Pathology)

  2. College of Physicians & Surgeons, Columbia University, New York, New York, USA

    Marianne Wolff M.D. (Professor of Clinical Surgical Pathology) & Sheldon C. Sommers M.D. (Clinical Professor of Pathology) (Professor of Clinical Surgical Pathology) &  (Clinical Professor of Pathology)

  3. Pathology Department, Morristown Memorial Hospital, Morristown, New Jersey, USA

    Marianne Wolff M.D. (Professor of Clinical Surgical Pathology) (Professor of Clinical Surgical Pathology)

  4. School of Medicine, University of Southern California, Los Angeles, California, USA

    Sheldon C. Sommers M.D. (Clinical Professor of Pathology) (Clinical Professor of Pathology)

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© 1988 Springer-Verlag Berlin Heidelberg

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Tsutsumi, Y. (1988). Differentiation of Gastric Cancer Cells: Analysis Using Immunohistochemistry and Mucin Histochemistry. In: Watanabe, S., Wolff, M., Sommers, S.C. (eds) Digestive Disease Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-11562-6_1

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  • DOI: https://doi.org/10.1007/978-3-662-11562-6_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-11564-0

  • Online ISBN: 978-3-662-11562-6

  • eBook Packages: Springer Book Archive

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