Zusammenfassung
Das Mammakarzinom galt bis in die 60er Jahre des letzten Jahrhunderts als eine lokoregionäre Erkrankung, die in der Brust entsteht und primär in die Lymphbahnen der Axilla, des Mediastinums und parasternal entlang der A. mammaria interna metastasiert. Diese sog. Halsted-Theorie (Halsted 1894) hat die Behandlung des Mammakarzinoms während 70 Jahren bestimmt, indem immer radikalere Operationen mit dem Ziel der Heilung zur Anwendung kamen (➔ Tabelle 32.1).
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Literatur
Ahr A, Kahn T, Solbach C, Seiter T, Strelhardt K, Holtrich H, Kaufmann M (2002) Identification of high risk breast cancer patients by gene expression profiling. Lancet 359: 131–133
Batson OV (1967) The vertebral system of veins as a means for cancer dissemination. Prog Clin Cancer 3: 1–18
Beatson GT (1896) On the treatment of inoperable cases of carcinoma of the mamma: suggestion for a new method of treatment, with illustrative cases. Lancet II (104): 162
Black MM, Speer FD (1957) Nuclear structure in cancer tissues. Surg Gynecol Obstet ío 5: 97–105
Bloom HJG, Richardson WW (1957) Histological grading and prognosis in breast cancer. A study of 1049 cases, of which 359 have been followed 15 years. Br J Cancer 11: 359–377
Boyd NF, Martin LJ, Noffel M, Lockwood GA, Trichler DL (1993) A meta-analysis of studies of dietary fat and breast cancer risk. Br J Cancer 68 (3): 627–636
Boyle P, Zheng T (2001) Environmental features influencing the epidemiology of breast cancer. The Breast 10 (S3): 1–8
Braun S, Pantel K, Muller P et al. (2000). Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med 342 (8): 525–533
Carter CL, Jones DY, Schatzkin A, Brinton LA (1989) A prospective study of reproductive, familial and socioeconomic risk factors for breast cancer using NHANES I data. Public Health Rep 104 (1): 45–50
De Larco JE, Reynolds R, Carlberg K, Engle C, Todaro GJ (1980) Sarcoma growth factor from mouse sarcoma virus-transformed cells. Purification by binding and elution from epidermal growth factor receptor-rich cells. J Biol Chem 255 (8): 3685–3690
Early Breast Cancer Trialists’ Collaborative Group (1998) Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet 351 (9114): 1451–1467
Fisher B (1979) Sounding board. Breast cancer management: alternatives to radical mastectomy. N Engl J Med 301 (6): 326–328
Fisher B, Slack NH, Bross ID (1969) Cancer of the breast: size of neoplasm and prognosis. Cancer 24 (5): 1071–1080
Fisher B, Slack N, Katrych D, Wolmark N (1975) Ten year follow-up results of patients with carcinoma of the breast in a cooperative clinical trial evaluating surgical adjuvant chemotherapy. Surg Gynecol Obstet 140 (4): 528–534
Goldhirsch A, Glick JH, Gelber RD, Coates AS, Senn HJ (2001) Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer. Seventh International Conference on Adjuvant Therapy of Primary Breast Cancer. J Clin Oncol 19 (18): 3817–3827
Haagensen CD (1986) Diseases of the Breast, 3rd ed. Philadelphia: Saunders
Halsted W (1894) The results of operations for cure of cancer of the breast performed at John Hopkins Hospital. Johns Hopkins Hosp Bull 4: 497–507
Harris JR, Hellman S (1996) Natural History of breast cancer. In: Harris JR, Lippman ME, Morrow M, Hellman S (eds) Diseases of the Breast. Philadelphia: Lippincott-Raven Publishers
Houston SJ, Plunkett TA, Barnes DM, Smith P, Rubens RD, Miles DW (1999) Overexpression of c-erbB2 is an independent marker of resistance to endocrine therapy in advanced breast cancer. Br J Cancer 79: 1220–1226
Jordan VC (2001) Oestrogen receptors, growth factors and the control of breast cancer. The Breast 10 (S3): 27–35
Kaufmann M, Jonat W, von Minckwitz G (20oí) Aktuelle Empfehlungen zur Therapie primärer Mammakarzinome. Dt Ärztebl 98 (33): A2121–A2123
Key TJ, Allen NE (2001) Nutrition and breast cancer. The Breast 10 (S 3): 9–13
Muller A, Homey B, Soto H et al. (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410 (6824): 50-56
Paget S (1889) The distribution of secondary growth in cancer of the breast. Lancet I: 571–573
Prenzel N, Fischer OM, Streit S, Hart S, Ullrich A (2001) The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocrine-related Cancer 8: 11–31
Revillion F, Bonneterre J, Peyrat JP (1998) ERBB2 oncogene in human breast cancer and its clinical significance. Eur J Cancer 34: 791–808
Rozan S, Vincent-Salomon A, Zafrani B et al. (1998) No significant predictive value of c-erbB-2 or p53 expression regarding sensitivity to primary chemotherapy or radiotherapy in breast cancer. Int J Cancer 79: 27–33
Rudolph P, Olsson H, Bonatz G, Ratjen V, Bolte H, Baldetorp B, Ferno M, Parwaresch R (1999) Correlation between p53, cerbB-2, and topoisomerase II alpha expression, DNA ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinomas: prognostic implications. J Pathology 187: 207–216
Scharl A, Costa SD, von Minckwitz G, Kaufmann M (1998) Neuere Entwicklungen und operative Möglichkeiten bei der Behandlung von Brustkrebs. Forschung Frankfurt 4: 54–66
Tetu B, Brisson J, Plante V, Bernard P (1998) p53 and c-erbB-2 as markers of resistance to adjuvant chemotherapy in breast cancer. Mod Pathol 823–830)
Thiersch C (1865) Der Epithelialkrebs namentlich der Haut. Leipzig: Engelmann
Thor AD, Berry DA, Budman DR et al. (1998) erbB-2, p53, and efficacy of adjuvant therapy in lymph node-positive breast cancer. J Natl Cancer Inst 9o: 1346–1360
Thor AD, Liu S, Moore DH 2nd, Edgerton SM (1999) Comparison of mitotic index, in vitro bromodeoxyuridine labeling, and MIB-1 assays to quantitate proliferation in breast cancer. J Clin Onco117: 470–477
Valagussa P, Bonadonna G, Veronesi U (1978) Patterns of relapse and survival following radical mastectomy. Cancer 41: 1170–1178
Varmus HE, Vogt PK, Bishop JM (1973) Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts. Proc Natl Acad Sci USA 70 (11): 3067–3071
Veronesi U, Rilke F, Luini A et al. (1987) Distribution of axillary lymph node metastases by level of invasion: An analysis of 539 cases. Cancer 59: 682–687
Veronesi U, Saccozzi R, Del Vecchio M et al. (1981) Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med 305 (1): 6–11
von Minckwitz G, Sinn HP, Raab G, Blohmer JU, Graf E, Kaufmann M (2000) Evaluation of predictive factors in a randomized trial of preoperative dose-intensified adriamycin-docetaxel +I- tamoxifen in primary operable breast cancer. Breast Cancer Res Treat 64 (1): 303
Waldeyer W (1872) Die Entwicklung der Carcinome. Virchows Arch Path Anat 55: 67–159
Yu Q, Geng Y, Sicinski P (2001) Specific protection against bre- ast cancers by cyclin Di ablation. Nature 411: 1017–1021
Breast Cancer Linkage Consortium (1997) Pathology of familial breast cancer: differences between breast cancers in carriers of BRCAI or BRCA2 mutations and sporadic cases. Lancet 349 (9064): 1505–1510
Cuzick J (1998) Continuation of the International Breast Cancer Intervention Study (IBIS). Eur J Cancer 34 (11): 1647–1648
Cummings SR, Eckert S, Krueger KA, Grady D et al. (1999) The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation. JAMA 281 (23): 2189–2197
Fisher B, Costantino JP, Wickerham DL et al. (1998) Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 90 (18): 1371–1388
Ford D, Easton DF, Stratton M et al. (1999) Genetic heterogeneity and penetrance analysis of the BRCAI and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. Am J Hum Genet 62 (3): 676–689
Hartmann LC, Schaid DJ, Woods JE et al. (1999) Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer. N Engl J Med 340 (2): 77–84
Jernstrom H, Lerman C, Ghadirian P et al. (1999) Pregnancy and risk of early breast cancer in carriers of BRCAI and BRCA2. Lancet 354 (9193): 1846–1850
National Institutes of Health Consensus Development Statement (1997) Breast Cancer Screening for women ages 40–49.
Osin P, Gusterson BA, Philp E, Waller J, Bartek J, Peto J, Crook T (1998) Predicted anti-oestrogen resistance in BRCA-associated familial breast cancers. Eur J Cancer 34 (11): 1683–1686
Powles T, Eeles R, Ashley S, Easton D, Chang J, Dowsett M, Tidy A, Viggers J, Davey J (1998) Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomised chemoprevention trial. Lancet 352 (9122): 98–101
Rebbeck TR, Levin AM, Eisen A et al. (1999) Breast cancer risk after bilateral prophylactic oophorectomy in BRCAI mutation carriers. J Natl Cancer Inst 91 (17): 1475–1459
Smart CR, Hendrick RE, Rutledge III JH, Smith RA (1997) Benefit of Mammography Screening in Women Ages 40–49; Current Evidences from Randomized Controlled Trials. In: NIH Consensus Development Conference. Breast Cancer Screening for Women Ages 40–49. Abstract book: 83–90
Veronesi U, Maisonneuve P, Costa A, Sacchini V, Maltoni C, Robertson C, Rotmensz N, Boyle P (1998) Prevention of breast cancer with tmoxifen: preliminary findings from the Italian randomised trial among hysterectomised women. Italian Tamoxifen Prevention Study. Lancet 352 (9122): 93–97
Minckwitz G, Kaufmann M (1997) Mammographie-Screening für Frauen zwischen 4o and 49. Dtsch Ärzteblatt 94 A: 1436–1438
Davidson N, O’Neill A, Vukov A, Osborne CK, Martino S, White D, Abeloff MD for ECOG, SWOG, and CALGB (1999) Effect of chemohormonal therapy in premenopausal, node+, receptor+ breast cancer. An Eastern Cooperative Oncology Group Phase III Intergroup trial (E51288, INT-oio1). Proc ASCO 18: 67a
Early Breast Cancer Trialists’ Collaborative Group (1996) Ovarian ablation in early breast cancer: overview of the randomised trials. Lancet 348: 1189–1196
Early Breast Cancer Trialists’ Collaborative Group (1998b) Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet 351: 1451–1467
Early Breast Cancer Trialists’ Collaborative Group (1998b) Polychemotherapy for early breast cancer: an overview of the randomised trials. Lancet 352: 930–942
Fisher B, Brown A, Mamounas E et al. (1997) Effect of Preoperative Chemotherapy on Local-Regional Disease in Women With Operable Breast Cancer: Findings From National Surgical Adjuvant Breast and Bowel Project B-18. J Clin Onco115: 2483–2493
Goldhirsch A, Gelber RD, Simes RJ, Glasziou P, Coates AS (1989) Costs and benefits of adjuvant therapy in breast cancer: a quality-adjusted survival analysis. J Clin Oncol 7 (1): 36–44
Goldhirsch A, Glick JH, Gelber RD, Coates AS, Senn HJ (2001) Meeting highlights: international consensus panel on the treatment of primary breast cancer. J Clin Oncol 19 (18): 3817–3827
Henderson IC, Berry D, Demetri G et al. for CALGB, ECOG, SWOG, and NCCTG (1998) Improved disease-free and overall survival from the addition of sequential Paclitaxel but not from the escalation of Doxorubicin dose level in the adjuvant chemotherapy of patients with node positive breast cancer. Proc ASCO 17: 390A
Honkoop AH, Wagstaff J, Pinedo HM (1998) Management of stage III breast cancer. Oncology 55: 218–227
Houghton J, Baum M, Rutqvist L, Nordensjkold B, Nicolucci A, Sawyer W (2001) The ZIPP trial of adjuvant Zoladex in premenopausal patients with early breast cancer: An update at five years. Proc ASCO 19: 93a
Jakesz R, Hausmaninger H, Samonigg H (1999) Comparison of adjuvant therapy with tamoxifen and goserelin vs CMF in premenopausal stage I and II hormone-responsive breast cancer patients: four year results of ABCSG trial 5. Proc ASCO 18: 67a
Kaufmann M, Jonat W, Abel U (1993) Adjuvant randomized trials of doxorubicin/cyclophosphamide versus doxorubicin/ cyclophosphamide/tamoxifen and CMF chemotherapy versus tamoxifen in woman with node-positive breast cancer. J Clin Oncol 11: 454–46o
Kaufmann M, Jonat W, von Minckwitz G (2001) Aktuelle Empfehlungen zur Therapie primärer Mammakarzinome. Dt. Ärzteblatt 98: A-2121-A-2123
Kaufmann M, von Minckwitz G (1996) Das primäre Mammakarzinom. Vorschläge und aktuelle Aspekte zur adjuvanten systemischen Therapie. Dt. Ärzteblatt 93: A-755-A-758
Kaufmann M, von Minckwitz G (2001) Bericht über die NIH Consensus Development Conference zur adjuvanten Therapie von Mammakarzinomen. Onkologie 24: 190–192
Kaufmann M, von Minckwitz G for the German Adjuvant Breast Cancer Study Group (GABG) (2001) The emerging role of hormonal ablation as adjuvant therapy in node+ and node-pre-/perimenopausal patients. The Breast 10 (Suppl 3): 123–129
Mamounas EP (2000) Evaluating the use of paclitaxel following doxorubicin/cyclophosphamide in patients with breast cancer and positive axillary nodes. NIH Consensus Development Conference on adjuvant therapy for breast cancer. Bethesda
Minckwitz G, Costa SD, Eiermann W, Blohmer JU, Tulusan AH, Jackisch C, Kaufmann M (1999) Maximized Reduction of Primary Breast Tumor Size Using Preoperative Chemotherapy with Adriamycin and Docetaxel. J Clin Oncol 17: 1999–2005
Minckwitz G, Costa SD, Kaufmann M (1998a) Hochdosis Chemotherapie beim Mammakarzinom. Schlusswort. Dt Ärzteblatt 95: B-674-B-677
Minckwitz G, Costa SD, Kaufmann M (1998b) Allgemeine Chemotherapie In: Wulf KH, Schmidt-Mathiesen H (Hrsg) Klinik der Frauenheilkunde und Geburtshilfe. Allgemeine gynäkologische Onkologie, 4. Aufl. München: Urban and Schwarzenberg
Biganzoli B, Cufer T, Bruning P et al. (2000) Doxorubicin (A)/Taxol (T) Versus Doxorubicin/Cyclophosphamide (C) as First Line Chemotherapy in Metastatic Breast Cancer (MBC): A Phase III Study. Proc ASCO 19: 282
Bloomfield DJ (1998) Should bisphosphonates be part of the standard therapy of patients with multiple myeloma or bone metastases from other cancers? An evidence-based review. J Clin Oncol 16 (3): 1218–1225
Bonneterre J, Thurlimann B, Robertson JF et al. (2000) Anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: results of the Tamoxifen or Arimidex Randomized Group Efficacy and Tolerability study. J Clin Onco118 (22): 3748–3757
Buzdar AU, Jonat W, Howell A et al. (1998) Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma: results of a survival update based on a combined analysis of data from two mature phase III trials. Arimidex Study Group. Cancer 83 (6): 1142–1152
Carmichael J (2oo1) UKCCCR trial of epirubicin and cyclophosphamide vs epirubicin and taxol in the first line treatment of women with metastatic breast cancer. Proc ASCO 20: 84
Chan S, Noel D, Pintér T et al. (1999) on behalf of the entire 303 study group. Prospective Randomized Trial of Docetaxel versus Doxorubicin in Patients with Metastatic Breast Cancer. J Clin Oncol 17: 2341–2354
Clemons M, Hamilton T, Goss P (2001) Does treatment at the time of locoregional failure of breast cancer alter prognosis? Cancer Treat Rev 27 (2): 83–97
Dalberg K, Mattsson A, Sandelin K, Rutqvist LE (1998) Outcome of treatment for ipsilateral breast tumor recurrence in early-stage breast cancer. Breast Cancer Res Treat 49 (1): 69–78
Dirix L, Piccart M, Lohrisch C et al. (2001) Efficacy of and tolerance to exemestane versus tamoxifen in 151 line hormone therapy of postmenopausal metastatic breast cancer patients: A European Organisation for the Research and Treatment of Cancer ( EORTC Breast Group) phase II trial with Pharmacia and Upjohn. Proc ASCO 20: 114
Dombernowsky P, Smith I, Falkson G et al. (1998) Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate. J Clin Oncol 16 (2): 453–461
Fossati R, Confalonieri C, Torri V et al. (1998) Cytotoxic and hormonal treatment for metastatic breast cancer: a systematic review of published randomisid trials involving 31,510 women. J Clin Onco116: 3439–3460
Hortobagyi GN (1998) Treatment of breast cancer. N Engl J Med 339: 974–984
Kaufmann M, Henderson IC, Enghofer E (1989) Consensus development in cancer therapy 1. Therapeutic management of metastatic breast cancer. Walter de Gruyter, Berlin, New York
Kaufmann M, Jonat W, Kleeberg U et al. (1989) Goserelin, a depot gonadotropin-releasing hormone agonist in the treatment of premenopausal patients with metastatic breast cancer. German Zoladex Trial Group. J Clin Oncol 7: 1113–1119
Kaufmann M, von Minckwitz G (1999) Systemische Therapie metastasierter Mammakarzinome. Deutsches Ärzteblatt 96: A-2509-A-2512
Kaufmann M, Bajetta E, Dorix LY et al. (2000) Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal woman with advanced breast cancer: Results of a phase III randomized double-blind trial. J Clin Oncol 18: 1399–1411
Klijn JG, Blarney RW, Boccardo F, Tominaga T, Duchateau L, Sylvester R (2001) Combined Hormone Agents Trialists’ Group and the European Organization for Research and Treatment of Cancer. Combined tamoxifen and luteinizing hormone-releasing hormone (LHRH) agonist versus LHRH agonist alone in premenopausal advanced breast cancer: a meta-analysis of four randomized trials. J Clin Oncol 19 (2): 343–353
Konecny G, Thomssen C, Pegram M et al. (2001) Here/neu gene amplification and response to paclitaxel in patients with metastatic breast cancer. Proc ASCO 20: 88
Kretzler A, Molls M (1997) Grundlagen der Radiotherapiebehandlung ossärer Metastasen. In: Böttcher HD et al. (Hrsg) Klinik der Skelettmetastasen-Grundlagen, Diagnostik und Therapie. Zuckschwerdt
Lohrisch C, di Leo A, Piccart M (2001) Optimal adjuvant cytotoxic therapy for breast cancer. ASCO Educational Book: 61–70
Lück HJ, Thomssen C, Untch M et al. (2000) Multicentric Phase III Study in First Line Treatment of Advanced Metastatic Breast Cancer (ABC). Epirubicin/Paclitaxel (ET) vs Epirubicin/Cyclophosphamide (EC). A Study of the Ago Breast Cancer Group. Proc ASCO 19: 280
Nabholtz JM, Buzdar A, Pollak M et al. (2000) Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North Arnerican multicenter randomized trial. Arimidex Study Group. J Clin Oncol 18 (22): 3758–3767
Nabholtz JM, Falkson G, Campos D et al. (1999) on behalf of the international TAX3o6 study group. A Phase III Trial Comparing Doxorubicin (A) and Docetaxel (T) (AT) to Doxorubicin and Cyclophosphamide ( AC) as First Line Chemotherapy for MBC. Proc ASCO 18: 485
Nabholtz JA, Paterson A, Dirix L et al. (2001) A Phase III randomized trial comparing docetaxel, doxorubicin and cyclophosphamide to FAC as first line chemotherapy for patients with metastatic breast cancer. Proc ASCO 20: 83
Oberhoff C, Kieback DG, Wurstlein R et al. (2001) Topotecan chemotherapy in patients with breast cancer and brain metastases: results of a pilot study. Onkologie 24 (3): 256–260
Pienkowski T, Fumeleau P, Eiermann W et al. (2001) Taxotere, Cisplatin and Herceptin (TCH) in first line Her positive metastatic breast cancer patients. A phase II pilot study by the Breast Cancer International Research Group. Proc ASCO 20: 2030
Sinn HP, Anton HW, Magener A, von Fournier D, Bastert G, Otto HF (1998) Extensive and predominant in situ component in breast carcinoma: their influence on treatment results after breast-conserving therapy. Eur J Cancer 34 (5): 646–653
Slamon DJ, Leyland-Jones B, Shak S et al. (2001) Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344 (11): 783–792
Vogel C, Cobleigh M, Tripathy D, Mass R, Murphy M, Stewart SJ (2001) Superior outcomes with herceptin (trastuzumab) in fluorescence in situ hybridisation-selected patients. Proc ASCO 20: 86
Voogd AC, Nielsen M, Peterse JL et al. (2001) Danish Breast Cancer Cooperative Group. Breast Cancer Cooperative Group of the European Organization for Research and Treatment of Cancer. Differences in risk factors for local and distant recurrence after breast-conserving therapy or mastectomy for stage I and II breast cancer: pooled results of two large European randomized trials. J Clin Oncol 19 (6): 1688–1697
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Kaufmann, M., von Minckwitz, G., Costa, S.D. (2003). Mammakarzinom. In: Kaufmann, M., Costa, S.D., Scharl, A. (eds) Die Gynäkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-11496-4_32
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