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Normale und pathologische Anatomie und Physiologie der Inselzellen

  • Peter Hürter

Zusammenfassung

Konsequenz der durch autoimmunologische Prozesse unterhaltenen chronisch-persistierenden Entzündung der Inselzellen (Insulitis) ist das vollständige Erlöschen der Insulinbiosynthese und Sekretion. Die Erörterung der pathoanatomischen Veränderungen und pathophysiologischen Konsequenzen des Insulinmangels setzt die Kenntnis der normalen Anatomie und Physiologie der Inselzellen voraus. Die pathophysiologischen Folgen des Insulinmangels sind diabetische Ketoazidose und Coma diabetisum.

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Literatur

  1. Abel JJ (1926) Crystalline insulin. Proc Natl Acad Sci 12: 132PubMedCrossRefGoogle Scholar
  2. Banting GF, Best CH (1922) The internal secretion of the pancreas. J Lab Clin Med 7: 251Google Scholar
  3. Bardet S, Joseph MG, Maugendre D, Mattieu E, Chaillous L, Semana G, Limal JM, Allannic H, Charbonne B, Sai P (1993) Predictive valve of age-related response to glucose in subjects at risk for type 1 diabetes: results of a 6-year follow-up study from west-France. Diabete Metab 19: 372–380Google Scholar
  4. Bell GI, Pictet RL, Rutter WJ, Cordell B, Tischer E, Goodman HM (1980) Sequence of the human islet gene. Nature 284: 26PubMedCrossRefGoogle Scholar
  5. Bolaffi JL, Heldt A, Lewis LD, Grodsky GM (1986) The third phase of in vitro insulin secretion: evidence for glucose intensitivity. Diabetes 35: 37oGoogle Scholar
  6. Brazeau P, Vale W, Burguns R, Ling N, Butcher M, Rivier J, Guillemin R (1973) Hypothalamic polypeptide that inhibits the secretion of immunreactive pituitary growth hormone. Science 179: 77PubMedCrossRefGoogle Scholar
  7. Bromer WW, Sinn LG, Staub A, Behrens OK (1965) The amino acid sequence of glucagon. J Am Chem Soc 78: 3858CrossRefGoogle Scholar
  8. Cuatrecasas P (1972) Isolation of the insulin receptor of liver and fat cell membranes. Proc Natl Acad Sci USA 69: 318PubMedCrossRefGoogle Scholar
  9. Duckworth WC, Heinemann MA, Kitabchi AE (1972) Purification of insulin specific protease by affinity chromatography. Proc Natl Acad Sci USA 69: 3698PubMedCrossRefGoogle Scholar
  10. Faloona GR, Unger RH (1974) Glucagon. In: Jaffe BM, Behrmann HR (eds) Methods of hormone radioimmunoassay. Academic Press, New York, p 317Google Scholar
  11. Foa PP (1972) The secretion of glucagon. In: Steiner DF, Freinkel N (eds) Endocrine pancreas. Williams & Wilkins, Baltimore, p 261Google Scholar
  12. Frank BH, Chance RE (1983) Two routes for producing human insulin utilizing recombinant DNA technology. Munch Med Wochenschr 125 (Suppl 1): 14Google Scholar
  13. Goeddel DV, Kleid DG, Bolivar F et al. (1979) Expression in escherischia coli of chemically synthesized genes for human insulin. Proc Natl Sci (Wash) 76: 106CrossRefGoogle Scholar
  14. Institute of Biochemistry, Academia Sinica, Institute of Organic Chemistry, Academia Sinica, Department of Chemistry, Peking University (1966) The total synthesis of crystalline insulin. Kexue Tongbao 17: 241Google Scholar
  15. Jacobs S, Shechter Y, Bissell K, Cuatrecasas P (1977) Purification and proporties of insulin receptors from rat liver membranes. Biochem Biophys Res Commum 77: 981CrossRefGoogle Scholar
  16. Johnson IS (1983) Human insulin from recombinant DNA technology. Science 219: 632PubMedCrossRefGoogle Scholar
  17. Katsoyannis PG, Fukunda K, Tometsko A, Suzuki K, Tilak M (1964) Synthesis of the B-chain of insulin and its combination with natural or synthetic A-chain to generate insulin-activity. J Am Chem Soc 86: 930CrossRefGoogle Scholar
  18. Luft R, Efendic S, Hökfelt T, Johannsson O, Arimura A (1974) Immunohistochemical evidence for the localization of somatostatin-like-immunreactivity in a cell population of pancreatic islets. Med Biol 52: 428PubMedGoogle Scholar
  19. Markussen J (1982) Process for preparing esters of human insulin. US patent 4343898Google Scholar
  20. Meienhofer J, Schnabel E, Bremer H et al. (1963) Synthese der Insulinketten und ihre Kombination zu insulinaktiven Präparaten. Z Naturforsch 18 bal2oGoogle Scholar
  21. Mirsky IA (1957) Insulinase, insulinase inhibitors, and diabetes mellitus. Recent Prog Horm Res 13:429Google Scholar
  22. Müller MJ (1990) Glukosestoffwechsel. In: Hesch RD (Hrsg) Endokrinologie. Urban & Schwarzenberg, München, S 582Google Scholar
  23. Murlin JR, Clough HD, Gibbs CBF, Stokes AM (1923) Aqueous extracts of the pancreas. I. Influence on the carbohydrate metabolism of depancreatized animals. J Biol Chem 56: 253Google Scholar
  24. Obermeier R, Geiger R (1976) A new semisynthesis of human insulin. Hoppe Seylers Z Physiol Chem 357: 759PubMedCrossRefGoogle Scholar
  25. Orci L, Baetens D, Dubois MP, Rufener C (1975) Evidence for the D-cell of pancreas secreting somatostatin. Horm Metab Res 7: 40oGoogle Scholar
  26. Roth RA (1990) Insulin receptor structure. In: Cuatrecasas P, Jacobs S (eds) Insulin. Springer, Berlin Heidelberg New York Tokyo, p 169Google Scholar
  27. Sanger F, Thompson EOP, Kitai R (1955) The amino group of insulin. Biochem J 59509Google Scholar
  28. Sieber P, Kamber B, Hartmann A, Johl A, Riniker B,. Rittel W (1974) Totalsynthese von Humaninsulin unter gezielter Bildung der Disulfidbindungen. Helv Clin Acta 57: 2617Google Scholar
  29. Staub A, Sinn LG, Behrens OK (1953) Purification and crystallization of hyperglycemic-glycogenolytic factors ( HGF ). Science 117: 62Google Scholar
  30. Steiner DM, Clark JL, Nolan C, Rubinstein AH, Margoliash E, Aten B, Oyer PE (1969) Proinsulin and the biosynthesis of insulin. Recent Prog Horm Res 25: 207PubMedGoogle Scholar
  31. Steiner DF, Kemmler W, Clark JL, Oyer PE, Rubinstein AH (1972) The biosynthesis of insulin. In: Steiner DF, Freinkel N (eds) Endocrine pancreas. Williams & Wilkins, Baltimore, p 175Google Scholar
  32. Steiner DF (1990) The biosynthesis of insulin. in: Cuatrecasas P, Jacobs S (eds) Insulin. Springer, Berlin Heidelberg New York Tokyo, p 67Google Scholar
  33. Thim L, Hansen MT, Morris K et al (1986) Secretion and processing of insulin precursors in yeast. Proc Natl Acad Sci USA 83: 6766PubMedCrossRefGoogle Scholar
  34. Ullrich A, Shine J, Chirgwin J, Pictet RL, Tischer E, Rutter WJ, Goodman HM (1977) Rat insulin genes: construction of plasmids containing the coding sequences. Science 196: 1313PubMedCrossRefGoogle Scholar
  35. Von Meyenburg H (1940) Über „Insulitis“ bei Diabetes. Schweiz Med Wochenschr 70: 554Google Scholar
  36. Waldhäusl WK (1986) The physiological basis of insulin treatment - clinical aspects. Diabetologia 29: 837PubMedCrossRefGoogle Scholar
  37. Waldhäusl W, Bratusch-Marrain P, Kruse V, Jensen J, Nowotny P, Vierhappert H (1985) Effect of insulin antibodies on insulin pharmacokinetics and glucose utilization in insulin dependent diabetic patients. Diabetes 34x66Google Scholar
  38. Waldhäusl WK, Gasic S, Bratusch-Marrein P, Nowotny P (1983) The 75 g oral glucose tolerance test: effect on splanchnic metabolism of substrates and pancreatic hormone release in healthy man. Diabetologia 25: 489PubMedCrossRefGoogle Scholar
  39. Waldhäusl WK, Bratusch-Marrain P, Gasic S, Korn A, Nowotny P (1979) Insulin production rate following glucose ingestion estimated by splanchnic C-peptide output in normal man. Diabetologia 17: 221PubMedCrossRefGoogle Scholar
  40. Yalow RS, Berson SA (1960) Immunoassay of endogenous plasma insulin in man. J Clin Invest 39:1157Google Scholar
  41. Zahn H (1967) Struktur und Synthese von Insulin. Verh Dtsch Ges Inn Med 72: 800Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Peter Hürter
    • 1
  1. 1.HannoverDeutschland

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