Ätiopathogenese des Typ-I-Diabetes

  • Peter Hürter


Genetische Faktoren, Virusinfektionen und andere exogene Faktoren sowie autoimmunologische Prozesse wirken bei der Entstehung des Typ-I-Diabetes in bisher nicht vollständig geklärter Weise zusammen.


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  1. Åkerblom HK, Savilahti E, Saukkonen TT, Paganus A, Virtanen SM, Teramo K, Knip M, Ilonen J, Reijonen H, Karjalainen J,Vaarala O, Reunanen A (1993) The case for elimination of cow’s milk in early infancy in the prevention of type I diabetes: The Finnish Experience. Diab metabol Rev 9: 269–278Google Scholar
  2. Atkinson MA, Bowman MA, Kao KJ, Campbell L, Dush PJ, Shah SC, Simell O, MacLaren NK (1993) Lack of immune responsiveness to bovine serum albumine in insulin-dependent diabetes. N Engl J Med 329x853–1858Google Scholar
  3. Atkinson MA, MacLaren NK, Lichetta R (199o) Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy. Diabetes 39: 933–937Google Scholar
  4. Baekkeskov S, Aanstoot HJ, Christgav S, Reetz A, Solimena M, Cascalbo M, Folli F, Richter-Olesen H, Camilli PD (1990) Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347: 151–156PubMedCrossRefGoogle Scholar
  5. Baekkeskov S, Nielsen JH, Marner B, Bilde T, Ludvigsson J, Lenmark A (1982) Autoantibodies in newly diagnosed diabetic children immuno-precipitate human pancreatic islet cell protein. Nature 298: 167PubMedCrossRefGoogle Scholar
  6. Bardet S, Joseph MG, Maugendre D, Mattieu E, Chaillous L, Semana G, Limal JM, Allannic H, Charbonne B, Sai P (1993) Predictive value of age-related response to glucose in subjects at risk for type 1 diabetes: results of a 6-year follow-up study from west-France. Diabet Metab 19: 372–380Google Scholar
  7. Barnett AH, Eff C, Leslie RDG, Pyke DA (1981) Diabetes in identical twins. A study of loo pairs. Diabetologia 20: 87Google Scholar
  8. Bertrams J, Sodomann P, Gries FA, Sachse B, Jahnke K (1981) Die HLA-Assoziation des insulinpflichtigen Diabetes mellitus Typ I. Dtsch Med Wochenschr 106: 927PubMedCrossRefGoogle Scholar
  9. Bertrams J (1994) Genetik des Typ-I-Diabetes. Diab Stoffw 3: 283–290Google Scholar
  10. Blom L, Dahlquist G, Nystrom L, Sandstrom A, Wall S (1989) The Swedish Childhood Diabetes Study: social and perinatal determinants for diabetes in childhood. Diabetologia 32: 7–13PubMedCrossRefGoogle Scholar
  11. Bonifazio E, Bingley PJ, Shattock M, Dean BM, Dunger D, Gale EAM, Botazzo GF (1990) Quantification of islet cell antibodies and prediction of insulin-dependent diabetes. Lancet 335: 147–149CrossRefGoogle Scholar
  12. Borch-Johnsen K, Zachau-Christiansen B, Mandrup-Poulsen T, Joner G, Christy M, Katrup K, Nerup J (1984) Relation between breast-feeding and incidence rates of insulin-dependent diabetes mellitus: a hypothesis. Lancet II: 1083–1086Google Scholar
  13. Botazzo GF, Florin-Christensen A, Doniach D (1974) Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet II: 1279Google Scholar
  14. Botazzo GF, Mann JI, Thorogood M, Baum JD, Doniach D (1978) Autoimmunity in juvenile diabetes and their families. Br Med J II: 165Google Scholar
  15. Botazzo GF, Doniach D (1976) Pancreatic autoimmunity and HLA antigens. Lancet I I: 88oGoogle Scholar
  16. Botazzo GF, Dean BM, Gorsuch AN, Cudworth AG, Doniach D(198o) Complement-fixing islet-cellantibodies in type I diabetes: possible monitors of active beta cell damage. Lancet 1:1668 Buschard K, Madsbad S, Rygaard J (1980) Depressed suppressor cell activity in patients with newly diagnosed insulin dependent diabetes mellitus. Clin Exp Immunol 42: 25Google Scholar
  17. Cavender DE, Wagner DK, Rabin BS et al. (1984) The Pittsburgh insulin-dependent diabetes mellitus study. HLA-antigens and haplotypes as risk factors for the development of IDDM in IDDM patients and their siblings. J Chron Dis 37: 555Google Scholar
  18. Cobb WE, Molitich M, Reichlin S (1980) Levamisole in insulin-dependent diabetes mellitus. N Engl J Med 303: 1065PubMedGoogle Scholar
  19. Cudworth AG (1978) Type I diabetes mellitus. Diabetologia 14: 281PubMedCrossRefGoogle Scholar
  20. Cudworth AG (1979) Type 2 (insulin-independent) diabetes, fibres and flushers. Diabetologia 17:67 Cudworth AG, Woodrow JC (1974) HLA-antigens and diabetes mellitus. Lancet 1L•1153Google Scholar
  21. Dahlquist G, Kallen B (1992) Maternal-child blood-group incompatibility and other perinatal events increase the risk for early-onset type 1 (insulin-dependent) diabetes mellitus. Diabetologia 35: 671–675PubMedCrossRefGoogle Scholar
  22. Deaizpurea HK, Harrison LC, Cram DS (1992) An ELISA for antibodies to recombinant glutamic acid decarboxylase in IDDM. Diabetes 41: 1182–1187CrossRefGoogle Scholar
  23. Degnobl B, Green A (1978) Diabetes mellitus among first-and second-degree relatives of early onset diabetes. Ann Hum Genet 42: 25CrossRefGoogle Scholar
  24. Deschamps I, Lestradet H, Busson M, Hors J (1986) Effect of HLA genotype, age and birth order on empirical risk estimated for insulin-dependent diabetes in siblings of diabetic children. An actuarialy evaluation. Diab Res 3: 391Google Scholar
  25. Dulin WE, Syse BM, Kalamazoo MS (1969) Studies on the ability of compounds to block the diabetogenic activity of streptozotocin. Diabetes 18:459–466Google Scholar
  26. Eisenbarth BS, Srikanta S, Jackson R (1983) Immunotherapy of recent onset type I diabetes mellitus. Clin Res 31: 500Google Scholar
  27. Elliott RB, Chase HP (1991) Prevention or delay of type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide. Diabetologia 34: 362–365PubMedCrossRefGoogle Scholar
  28. Elliott RB, Crossley JR, Berryman CC, James AG (1981) Partial preservations of pancreatic B-cell function in children with diabetes. Lancet II: 1Google Scholar
  29. Füchtenbusch M, Ziegler AG (1995) Umweltfaktoren in der Pathogenese des Typ-I-Diabetes. Diab Stoffw 4: 369–377Google Scholar
  30. Gamble DR, Taylor KW (1969) Seasonal incidence of diabetes mellitus. Br Med J 3: 631PubMedCrossRefGoogle Scholar
  31. Gepts W (1983) Role of cellular immunity in the pathogenesis of type I diabetes. In: Kolb H, Schernthaner G, Gries FA (eds) Diabetes and immunology: Pathogenesis and immunotherapy. Huber, Bern, p 86Google Scholar
  32. Gerstein HC (1994) Cow’s milk exposure and type r diabetes mellitus. Diabetes Care 17:13–19 Gleichmann H, Botazzo GF (1987) Progress towards standardisation of cytoplasmatic islet cell antibody assay. Diabetes 36:578Google Scholar
  33. Gorsuch AN, Spencer KL, Lister J, Wolf E, Botazzo GF, Cudworth AG (1982) Can future type I diabetes be predicted? A study on families of affected children. Diabetes 31: 862PubMedCrossRefGoogle Scholar
  34. Gorsuch AN, Spencer KM, Lister J, McNally JM, Dean BM, Botazzo CF, Cudworth AG (1981) The natural history of type I (insulin-dependent) diabetes mellitus: evidence for a long pre-diabetic period. Lancet II: 1363Google Scholar
  35. Gotfreden CF, Buschard K, Frandsen EK (1985) Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals. Diabetologia 28:933–935Google Scholar
  36. Harris H (1950) The familial distribution of diabetes mellitus. Ann Eugen (Lond) 15: 95CrossRefGoogle Scholar
  37. Harris HF (1899) A case of diabetes mellitus quickly following mumps. Boston Med Surg J 140:465 Horowitz S, Borcherding W, Bargmann G (1981) Suppressor T-cell-function in diabetes mellitus, Lancet II: 1291Google Scholar
  38. Irving WJ, MacCallum CJ, Grax RS et al. (1977) Pancreatic islet-cell antibodies in diabetes mellitus correlated with the duration and type of diabetes, coexistent autoimmune disease, and HLA-type. Diabetes 26: 138CrossRefGoogle Scholar
  39. Jackson RA, Morris MA, Haynes BF, Eisenbarth GS (1982) Increased circulating Ia-antigen-bearing T cells in type I diabetes mellitus. N Engl J Med 306: 785PubMedCrossRefGoogle Scholar
  40. Karjalainen J, Martin JM, Knip M, Ilonen J, Ronbinson BH, Savilahti E, Akerblom HK, Dosch HM (1992) A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N Engl J Med 327: 302–307PubMedCrossRefGoogle Scholar
  41. Keller RF, Eisenbarth GS, Jackson RA (1993) Insulin prophylaxis in individuals at high risk of type I diabetes. Lancet 341: 927–928PubMedCrossRefGoogle Scholar
  42. Kiess W, Worgall S, Rascher W (1996) Ätiopathogenese des Typ-I-Diabetes. Monatsschr Kinderheilkd 143: (Suppl 1) 2–11Google Scholar
  43. Klinghammer A (1995) Diagnose and Therapie des Prä-Typ-I-Diabetes. Monatschr Kinderheilkd 143:26–32Google Scholar
  44. Koivisto V, Aro A, Cantell K et al. (1984) Remissions in newly diagnosted type I (insulin-dependent) diabetes: Influence of interferon as an adjunct to insulin therapy. Diabetologia 27: 193Google Scholar
  45. Kolb H (1989) Register of published immune intervention trials in type I diabetes with complete addresses of authors. In: Adreani D, Kolb H, Pozzilli P (eds) Immunotherapy of type I diabetes. Wiley and Sons, New York Chichester, p 221Google Scholar
  46. Kolb H, Kantwerk G, Treichel U, Kürner T, Kiesel U, Hoppe T, Kolb-Bachofen V (1986) Prospective analysis of islet lesions in BB rats. Diabetologia 29:559 AGoogle Scholar
  47. Kolb H, Kolb-Bachofen V (1992) Type 1 (insulin dependent) diabetes mellitus and nitric oxide. Diabetologia 35: 796–797PubMedGoogle Scholar
  48. Krolewski AS, Warram JH, Rand LI, Krahn CR (1987) Epidemiologic approach to the etiology of type I diabetes mellitus and its complications. N Engl J Med 317: 1390PubMedCrossRefGoogle Scholar
  49. Kuglin B, Bertrams J, Kolb H, Gries FA (1989) Früherkennung des Typ-I-Diabetes. Grenzen, Möglichkeiten and Perspektiven. Dtsch Med Wochenschr 114: 762Google Scholar
  50. Kyvik KO, Green A, Svendsen A, Mortensen K (1992) Breast feeding and the development of type 1 diabetes mellitus. Diabetic Med 9: 233–235Google Scholar
  51. La Porte RE, Orchard TJ, Kuller LH, Wagener DK, Drash AL, Schneider BB, Fishbein HA (1981) The Pittsburgh insulin-dependent diabetes mellitus registry: the relationship of insulin-dependent diabetes mellitus incidence to social class. Am J Epidemiol 114: 379–384Google Scholar
  52. Lazarow A (1947) Protection against alloxan diabetes. Anat Rec 97: 353PubMedGoogle Scholar
  53. Lederman MM, Ellner JJ, Rodman HM (1981) Defective suppressor cell generation in juvenile onset diabetes. J Immunol 127: 2051PubMedGoogle Scholar
  54. Lendrum R, Walker, G, Cudworth AG, Theophanides C, Pyke D, Bloom A, Gamble DR (1976) Islet cell antibodies in diabetes mellitus. Lancet I1: 1273CrossRefGoogle Scholar
  55. Lendrum R, Walker G, Gamble DR (1975) Islet-cell antibodies in juvenile diabetes mellitus of recent onset. Landet I: 88oGoogle Scholar
  56. Lernmark A (1990) Pankreas. In: Hesch RD (Hrsg) Endokrinologie. Urban and Schwarzenberg, München, S 802Google Scholar
  57. Lernmark A, Möller C, Kockum I, Sanjeevi C (1993) Autoimmune endocrinopathies 3: islet cell autoimmunity. J Int Med 234: 361–369CrossRefGoogle Scholar
  58. Lernmark A, Freedman ZR, Hofmann C et al. (1978) Islet cell surface antibodies in juvenile diabetes. N Engl J Med 299: 375PubMedCrossRefGoogle Scholar
  59. Leslie RDG, Pyke DA (1980) Immunosuppression of acute insulin dependent diabetics. In: Irvine WJ (ed) Immunology of diabetes. Teviot, Scientific Publications, Endinburgh, p 345Google Scholar
  60. Like AA, Weringer EJ (1988) Autoimmune diabetes in the BioBreeding/Worchester rat. in: Le Fébvre PJ, Pipleers DG (eds) The pathology of the endocrine pancreas in diabetes. Springer, Berlin Heidelberg New York Tokyo, p 269CrossRefGoogle Scholar
  61. Ludvigsson J, Heding L, Lieden G, Marner B, Lernmark A (1983) Plasmapheresis in the initial treatment of insulin dependent diabetes mellitus in children. Br Med J 286: 176CrossRefGoogle Scholar
  62. Mandrup-Poulsen T, Egeberg J, Nerup J, Bentzen K, Nielsen JH, Dinarello CA (1987) Ultrastructural study of time-course and cellular specifrty of interleukin-i mediated islet cytotoxicity. Acta Pathol Microbil Immunol Scand 95: 55Google Scholar
  63. Mayer EJ, Hamman RF, Gay EC, Lezotte DC, Savitz DA, Klingensmith GJ (1988) Reduced risk of IDDM among breast-fed children: The Colorado IDDM registry. Diabetes 37: 1625–1632Google Scholar
  64. McDevitt HO, Bodmer WF (1974) HL-A, immune response genes and disease. Lancet I: 1269Google Scholar
  65. McLaren NK, Huang SW (1980) Cell mediated immunity in insulin dependent diabetes. In: Irvine WJ (ed) Immunology of diabetes. Teviot Scientific Publications, Endinburgh, p 174Google Scholar
  66. Metcalfe MA, Baum JD (1992) Family characteristics and insulin-dependent diabetes. Arch Dis Child 67: 731–736PubMedCrossRefGoogle Scholar
  67. Michelsen B, Lernmark A (1987) Molecular cloning of a polymorphic DNA endonuclease fragment associates insulin-dependent diabetes mellitus with HLA-dQ, J Clin Invest 79: 1144PubMedCrossRefGoogle Scholar
  68. Neel JV (1976) Diabetes mellitus — a geneticists nightmare. In: Creutzfeldt W, Köbberling J, Neel JV (eds) The genetics of diabetes mellitus. Springer, Berlin Heidelberg New YorkGoogle Scholar
  69. Nerup J (1989) Rationale of immune intervention in type I diabetes. In: Andreani D, Kolb H, Pozzilli P (eds) Immunotherapy of type I diabetes. Wiley and Sons, New York Chichester, p 5Google Scholar
  70. Nerup J, Anderson O, Bendixen G, Egeberg, J, Poulsen JE (1971) Antipancreatic cellular hypersensitivity in diabetes mellitus. Diabetes 2o: 424Google Scholar
  71. Nerup J, Mandrup-Poulsen T, Molvig, Helquist S, Wogensen L, Egeberg J (1988) Mechanism of pancreatic 13-cell destruction in type I diabetes. Diabetes Care is (Suppl s): 16Google Scholar
  72. Nerup J (1981) Etiology and pathogenesis of insulindependent diabetes mellitus: Present views and future developments. In: Martin JM, Ehrlich RM, Holland FJ (eds) Etiology and pathogenesis of insulin-dependent diabetes mellitus. Raven, New York, p 275Google Scholar
  73. Nerup J, Platz P, Ortved-Andersen O et al. (1974) HLA-antigens and diabetes mellitus. Lancet A:864 Palmer JP, Asplin M, Clemens P, Lyen K, Talpati O, Raghu PK, Paquette TL (1983) Insulin autoantibodies in insulin dependent diabetics before insulin treatment. Science 222: 1337Google Scholar
  74. Palmer JP (1994) Predicting IDDM. Diabetes Rev I: 104–115Google Scholar
  75. Papadopoulos G, Lernmark KA (1984) Islet cell antibodies and cellular immunity in human diabetes. Behring Inst Mitt 75: 5oGoogle Scholar
  76. Patterson CC, Carson DJ, Hadden DR, Waugh NR, Cole SK (1994) A case-control investigation of perinatal risk factors for childhood IDDM in Northern Ireland and Scotland. Diabetes Care 17: 376–381Google Scholar
  77. Penrose LS, Watson EM (1945) A sex-linked tendency in familial diabetes. Proc Am Diab Assoc 5:163 Pincus G, White P (1933) On the inheritance of diabetes mellitus. Am J Med Sci 186: 1Google Scholar
  78. Platz P, Jacobsen BK, Morling N et al. (1981) HLA-D and DR antigens in genetic analysis of insulin-dependent diabetes mellitus. Diabetologia 21: 108PubMedCrossRefGoogle Scholar
  79. Position Statement: Prevention of type I diabetes mellitus (1990). Diabetes Care 13: 1026–1027Google Scholar
  80. Pozzilli P, Sensi M, Gorsuch A, Botazzo GF, Cudworth AG (1979) Evidence for raised K-cell levels in type-I-diabetes. Lancet IIa73Google Scholar
  81. Pujol-Borell R, Todd I, Doski M et al (1987) HLA class II induction in human islet cells by interferony-plus tumor necrosis factor or lymphotoxin. Nature 326: 304CrossRefGoogle Scholar
  82. Pyke DA (1977) Genetics of diabetes. Clin Endocrinol Metab 6: 285PubMedCrossRefGoogle Scholar
  83. Riley WJ, MacLaren NK, Krischer J, Spillar RP, Silverstein JH, Schatz D, Schwartz S, Malone J, Shah S, Vadheim C, Rotter J (1990) A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes. N Engl J Med 323: 1167–1172PubMedCrossRefGoogle Scholar
  84. Rimoin DL (1970) The genetics of diabetes mellitus. In: Ellenberg M, Rifken H (eds) Diabetes mellitus. Theory and practice. McGraw-Hill, New YorkGoogle Scholar
  85. Rimoin DL, Schimke RN (1971) Disorders of the endocrine glands. Mosby, St. LouisGoogle Scholar
  86. Roep BO, Kallan AA, Hazenbos WW, Bruining GJ, Bailyes EM, Arden SD, Hutton JC, De Vries RRP (1991) T-cell reactivity to 38 kD insulin secretory-granule protein in patients with recent onset of type 1 diabetes. Lancet 337: 1439–1441PubMedCrossRefGoogle Scholar
  87. Rossini AA (1983) Immunotherapy for insulin-dependent diabetics? N Engl Med. 308: 333CrossRefGoogle Scholar
  88. Rotter JI, Rimoin DL (1978) Heterogeneity in diabetes mellitus-update. Evidence for further genetic heterogeneity within juvenile-onset insulin-dependent diabetes mellitus. Diabetes 27: 599Google Scholar
  89. Rotter JI, Landaw EM, McClaren N et al. (1983) The use of family HLA haplotype data for risk assessment and estimation of genetic contribution of the HLA genes to IDDM. Diabetes 32 (Suppl 1):7o Rubinstein P, Suciu-Foca N, Nicholson JF (1977) Close genetic linkage of HLA and juvenile diabetes mellitus. N Engl J Med 297x036Google Scholar
  90. Schernthaner G (1982) The relationship between clinical, immunological and genetic factors in insulin-dependent diabetes. In: Köbberling J, Tattersall R (eds) The genetics of diabetes mellitus. Academic Press, London, p 109Google Scholar
  91. Schwertner R, Engelberger I, Rabl W, Ziegler AG (1994) Prophylactic intermittent insulin administration in prediabetic children and adolescents-A-controlled trial. Horm Res 41: 130Google Scholar
  92. Scott FW (1990) Cow’s milk and insulin dependent diabetes mellitus: is there a relationship? Am J Clin Nutr 51:489–491Google Scholar
  93. Sensi M, Pozzilli P, Gorsuch AN, Botazzo GF, Cudworth AG (1981) Increased killer cell activity in insulin dependent (type I) diabetes mellitus. Diabetologia zoao6Google Scholar
  94. Siemiatycki J, Colle E, Campbell S, Dewar R, Aubert B, Belmonte MM (1988) Incidence of IDDM in Montreal by ethnic group and by social class and comparisons with ethnic groups living elsewhere. Diabetes 37: 1096–1102PubMedCrossRefGoogle Scholar
  95. Simpson NE (1964) Multifactorial inheritance: a possible hypothesis for diabetes. Diabetes 13:462 Simpson NE (1968) Diabetes in the families of diabetics. Can Med Assoc J 98: 427Google Scholar
  96. Soeldner JS (1982) The etiology of diabetes. In: Kozak GP (ed) Clinical diabetes mellitus. Saunders, Philadelphia, p 21Google Scholar
  97. Steinberg AG (1959) The genetics of diabetes mellitus. Ann NY Acad Med 82:197Google Scholar
  98. Stiller CR, Laupacis A, Dupré J, Jenner MR, Keown, PA, Rodger W, Wolfe BMJ (1983) Cyclosporin for treatment of early type I diabetes: preliminary results. N Engl J Med 308: 1226PubMedGoogle Scholar
  99. Svejgaard A, Platz P, Ryder LP (1980) Insulin-dependent diabetes mellitus (Joint Report). In: Terasaki PI (ed) Histocompatibility testing. University of California Press, Los Angeles, p 638Google Scholar
  100. Tan AC, Janice TM, Dean BM, Ingram D, Schwarz G, Botazzo GF, Gale EAM (1988) Predicting insulindependent diabetes. Lancet I: 845Google Scholar
  101. Ten Berg H (1939) The genetic aspect of diabetes mellitus. JAMA 112:1091Google Scholar
  102. The Canadian-European randomized control trial group (1988) Cyclosporin-induced remission of IDDM after early intervention. Diabetes 37: 1574CrossRefGoogle Scholar
  103. Virtanen SM, Räsänen L, Ylönen K, Aro A, Clyton D, Langholz B, Pitkäniemi J, Savilahr E, Lounoman R, Toumiletho J, Akerblom HK and the Childhood Diabetes in Finland Study Group (1993) Early introduction of diary products associated with increased risk of IDDM in Finnisch children. Diabetes 42: 1786–1789Google Scholar
  104. Von Kries J (1953) Beitrag zur Genetik des Diabetes mellitus. Z Menschl Vererb Konstit Lehre 31:406Google Scholar
  105. Warram JH, Krolewski AS, Gottlieb MS, Krahn CR (1984) Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. N Engl J Med 311:149Google Scholar
  106. Warram JH, Martin BC, Krolewski AS (1991) Risk of IDDM in children of diabetic mothers decreases with increasing maternal age at pregnancy. Diabetes 4o: 1679–1684CrossRefGoogle Scholar
  107. Yoon JW, Austin M, Oroderea T, Notkins AL (1979) Virus-induced diabetes mellitus: Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 300: 1173Google Scholar
  108. Ziegler AG, Ziegler R, Wardi P, Jackson RA, Soeldner JS, Eisenbarth GS (1989) Life table analysis of progression to diabetes of anti-insulin-autoantibody positive relatives of type I diabetics. Diabetes 38: 1320–1325PubMedCrossRefGoogle Scholar
  109. Ziegler AG (1993) Prä-Typ-I-Diabetes: Diagnostik and mögliche Therapie. Diab Stoffw 2:27–32Google Scholar

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© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Peter Hürter
    • 1
  1. 1.HannoverDeutschland

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