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Trockene Haut — Barrierestörungen im kosmetischen Bereich

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Zusammenfassung

Normale Haut ist definiert als Zustand ohne sichtbare Läsionen und ohne Empfindungen des Unwohlseins [4]. Dieser Zustand resultiert aus einem Gleichgewicht diverser physiologischer Parameter einschließlich Feuchtigkeitsgehalt, Talgproduktion, Verhornung und Abschuppung. Trockene Haut (Xerosis cutis) ist durch einen Feuchtigkeitsmangel in der Hornschicht der Haut charakterisiert. Somit betrifft der Zustand einer trockenen Haut anatomisch lediglich die obersten, nicht mehr stoffwechselaktiven Anteile der Epidermis, das Stratum corneum. Ein normales Stratum corneum speichert etwa 10 bis 20% Wasser, bei niedrigerem Wassergehalt kommt es zur subjektiven Empfindung einer trockenen Haut [14]. Es existieren prinzipiell zwei Faktoren, die an der Entwicklung der Xerosis cutis beteiligt sind: 1. Dehydratation der Hornschicht durch eine gestörte epidermale Barrierefunktion mit erhöhtem transepidermalen Wasserverlust (TEWL) und 2. Störungen der Verhornung von Keratinozyten. Die epidermale Barriere kann z. B. durch eine unphysiologische Quantität und/oder Zusammensetzung der Hautlipide (z. B. bestimmter Ceramide) in ihrer Integrität gestört sein.

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Literatur

  1. Aioi A, Okuda M, Matsui M, Tonogaito H, Ramada K (2001) Effect of high population density environment on skin barrier function in mice. J Dermatol Sci 25: 189–197

    Article  PubMed  CAS  Google Scholar 

  2. Akimoto K, Yoshikawa N, Higaki Y, Kawashima M, Imokawa G (1993) Quantitative analysis of stratum corneum lipids in xerosis and asteatotic eczema. J Dermatol 20: 1–6

    PubMed  CAS  Google Scholar 

  3. Baumann L (2002) Cosmetic Dermatology -Principles and Practice. Mc Graw Hill, New York

    Google Scholar 

  4. Black D, Diridollou S, Lagarde JM, Gall Y (1998) Skin care products for normal, dry and greasy skin. In: Baran R, Maibach HI (eds) Textbook of Cosmetic Dermatology (2nd edn), Martin Dunitz, London 125–151

    Google Scholar 

  5. Böni R, Burg G (2000) Altershaut: physiologische Grundlagen, prophylaktische Massnahmen and Therapieansätze. Schweiz Med Wochenschr 130: 1272–1278

    PubMed  Google Scholar 

  6. Bouwstra JA, Gooris GS, Dubbelaar FE, Ponec M (2002) Phase behavior of stratum corneum lipid mixtures based on human ceramides: the role of natural and synthetic ceramide. 1. J Invest Dermatol 118: 606–617

    Article  PubMed  CAS  Google Scholar 

  7. Carlomusto M, Pillai S, Rawlings AV (1996) Human keratinocytes in vitro can utilize exogenously supplied sphingosine analogues for sphingolipid biosynthesis. J Invest Dermatol 106: 871

    Google Scholar 

  8. Chernosky ME (1976) Clinical aspects of dry skin. J Soc Cosmet Chem 65: 365–376

    Google Scholar 

  9. Davies A, Verdejo P, Feinberg C, Rawlings AV (1996) Increased stratum corneum ceramide levels and improved barrier function following topical treatment with tetraacetylphytosphingosine. J Invest Dermatol 106: 918

    Google Scholar 

  10. Denda M, Koyama J, Hori J, Horii I, Takahashi M, Hara M, Tagami H (1993) Age-and sex-dependent change in stratum corneum sphingolipids. Arch Dermatol Res 285: 415–417

    Article  PubMed  CAS  Google Scholar 

  11. Di Nardo A, Wertz P, Giannetti A, Seidenari S (1998) Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol 78: 27–30

    Article  PubMed  Google Scholar 

  12. Downing DT, Stewart ME, Wertz PW, Colton SW, Abraham W, Strauss JS (1987) Skin lipids: an update. J Invest Dermatol 88 (Suppl 3): 2–6

    Article  Google Scholar 

  13. Downing DT, Stewart ME, Strauss JS (1989) Changes in sebum secretion and the sebaceous gland. Clin Geriatr Med 5: 109–114

    PubMed  CAS  Google Scholar 

  14. Draelos ZD (2000) Therapeutic moisturizers. Dermatol Clin 18: 597–607

    Article  PubMed  CAS  Google Scholar 

  15. Elias PM, Cooper ER, Korc A, Brown BE (1981) Percutaneous transport in relation to stratum corneum structure and lipid composition. J Invest Dermatol 76: 297–301

    Article  PubMed  CAS  Google Scholar 

  16. Elias PM, Menon GK (1991) Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv Lipid Res 24: 1–26

    PubMed  CAS  Google Scholar 

  17. Feingold KR, Man MQ, Menon GK, Cho SS, Brown BE, Elias PM (1990) Cholesterol synthesis is required for cutaneous barrier function in mice. J Clin Invest 86: 1738–1745

    Article  PubMed  CAS  Google Scholar 

  18. Feingold KR, Man MQ, Proksch E, Menon GK, Brown BE, Elias PM (1991) The lovastatin-treated rodent: a new model of barrier disruption and epidermal hyperplasia. J Invest Dermatol 96: 201–209

    Article  PubMed  CAS  Google Scholar 

  19. Fritsch P (1998) Dermatologie und Venerologie. Springer, Berlin Heidelberg, pp 3–97

    Google Scholar 

  20. Gloor M, Gehring W (2003) Eigenwirkungen von Emulsionen auf die Hornschichtbarriere und -hydratation. Hautarzt 54: 324–330

    PubMed  CAS  Google Scholar 

  21. Gougerot A, Enjolras O (1992) Améliorer les peaux sèches pathologiques. Rev Eur Dermatol MST 4: 75–82

    Google Scholar 

  22. Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G (2000) High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis. J Invest Dermatol 115: 406–413

    Article  PubMed  CAS  Google Scholar 

  23. Held E, Sveinsdóttir S, Agner T (1999) Effect of long-term use of moisturizer on skin hydration, barrier function and susceptibility to irritants. Acta Derm Venereol 79: 49–51

    Article  PubMed  CAS  Google Scholar 

  24. Hollmann J, Melnik BC, Lee MS, Hofmann U, Plewig G (1991) Stratum-corneum-und Nagel-lipide bei Patienten mit atopischer Dermatitis. Hautarzt 42: 302–306

    PubMed  CAS  Google Scholar 

  25. Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A (1991) Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 96: 523–526

    Article  PubMed  CAS  Google Scholar 

  26. Lampe MA, Burlingame AL, Whitney J, Williams ML, Brown BE, Roitman E, Elias PM (1983) Human stratum corneum lipids: characterization and regional variations. J Lipid Res 24: 120–130

    PubMed  CAS  Google Scholar 

  27. Mahe A (2002) Peau sèche et Peau noire: quelles sont les données? Ann Dermatol Venereol 129: 152–157

    PubMed  CAS  Google Scholar 

  28. Man MQ, Feingold KR, Elias PM (1993) Exogenous lipids influence permeability barrier recovery in acetone-treated murine skin. Arch Dermatol 129: 728–738

    Article  PubMed  CAS  Google Scholar 

  29. Man MQ M, Feingold KR, Thornfeldt CR, Elias PM (1996) Optimization of physiological lipid mixtures for barrier repair. J Invest Dermatol 106: 1096–1101

    Article  Google Scholar 

  30. Mazereeuw J, Bonafe JL (2002) La xérose [Xerosis] Ann Dermatol Venereol 129: 137–142

    CAS  Google Scholar 

  31. Melnik B, Braun-Falco 0 (1996) Bedeutung der Ölbäder für die adjuvante Basistherapie entzündlicher Dermatosen mit trockener, barrieregestörter Haut. Hautarzt 47: 665–672

    CAS  Google Scholar 

  32. Murata Y, Ogata J, Higaki Y, Kawashima M, Yada Y, Higuchi K, Tsuchiya T, Kawainami S, Imokawa G (1996) Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency? J Invest Dermatol 106: 1242–1249

    Article  PubMed  CAS  Google Scholar 

  33. Nappé C, Delesalle G, Jansen A, de Rigal J, Camus C (1993) Decrease in ceramide II in skin xerosis. J Invest Dermatol 100: 530

    Google Scholar 

  34. Norlen L, Nicander I, Lundh Rozell B, Ollmar S, Forslind B (1999) Inter-and intra-individual differences in human stratum corneum lipid content related to physical parameters of skin barrier function in vivo. J Invest Dermatol 112: 72–77

    Article  PubMed  CAS  Google Scholar 

  35. Pilgram GS, Vissers DC, van der Meulen H, Pavel S, Lavrijsen SP, Bouwstra JA, Koerten HK (2001) Aberrant lipid organization in stratum corneum of patients with atopic dermatitis and lamellar ichthyosis. J Invest Dermatol 117: 710–717

    Article  PubMed  CAS  Google Scholar 

  36. Prottey C (1976) Essential fatty acids and the skin. Br J Dermatol 94: 579–585

    Article  PubMed  CAS  Google Scholar 

  37. Prottey C (1977) Investigation of functions of essential fatty acids in the skin. Br J Dermatol 97: 29–38

    Article  PubMed  CAS  Google Scholar 

  38. Rawlings A, Hope J, Rogers J, Mayo A, Watkinson A, Scott I (1993) Skin dryness–What is it? J Invest Dermatol 100: 510–517

    Google Scholar 

  39. Rogers J, Harding C, Mayo A, Banks J, Rawlings A (1996) Stratum corneum lipids: the effect of ageing and the seasons. Arch Dermatol Res 288: 765–770

    Article  PubMed  CAS  Google Scholar 

  40. Saint-Leger D, Francois AM, Leveque JL, Stoudemayer TJ, Kligman AM, Grove G (1989) Stratum corneum lipids in skin xerosis. Dermatologica 178: 151–155

    Article  PubMed  CAS  Google Scholar 

  41. Swartzendruber DC, Wertz PW, Kitko DJ, Madison KC, Downing DT (1989) Molecular models of the intercellular lipid lamellae in mammalian stratum corneum. J Invest Dermatol 92: 251–257

    Article  PubMed  CAS  Google Scholar 

  42. Sybert VP, Dale BA, Holbrook KA (1985) Ichthyosis vulgaris: Identification of a defect in synthesis of filaggrin correlated with an absence of keratohyaline granules. J Invest Dermatol 84: 191–194

    Google Scholar 

  43. Wildnauer RH, Bothwell JW, Douglas AB (1971) Stratum corneum biomechanical properties:I. Influence of relative humidity on normal and extracted human stratum corneum. J Invest Dermatol 56: 72–78

    Google Scholar 

  44. Yoshikawa N, Imokawa G, Akimoto K, Jin K, Higaki Y, Kawashima M (1994) Regional analysis of ceramides within the stratum corneum in relation to seasonal changes. Dermatology 188: 207–214

    Article  PubMed  CAS  Google Scholar 

  45. Zouboulis CC, Boschnakow A (2001) Chronological ageing and photoageing of the human sebaceous gland. Clin Exp Dermatol 26: 600–607

    Article  PubMed  CAS  Google Scholar 

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© 2004 Springer-Verlag Berlin Heidelberg

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Kerscher, M. (2004). Trockene Haut — Barrierestörungen im kosmetischen Bereich. In: Dermatokosmetik. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-11456-8_3

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  • DOI: https://doi.org/10.1007/978-3-662-11456-8_3

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-11457-5

  • Online ISBN: 978-3-662-11456-8

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