Intracellular turnover and cardiac hypertrophy

  • U. Pfeifer
  • J. Dämmrich
Conference paper


Ultrastructural evidence is presented that intracellular autophagic degradation of cytoplasmic constituents is reduced during perssure induced hypertropy of left ventricular myocardium after supravalvular aortic constriction in rats. This anti-catabolic reaction has to be considered as an important mechanism for shifting the balance between synthesis and degradation to the positive side. Short term studies after administration of isoproterenol suggest a close functional relationship between work load on the one hand and the anti-catabolic reaction on the other.

Key words

cellular autophagy protein turnover hypertrophy aortic constriction isoproterenol electron microscopy morphometry 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • U. Pfeifer
    • 2
  • J. Dämmrich
    • 1
  1. 1.Pathologisches InstitutUnviersität WürzburgWürzburgGermany
  2. 2.Pathologisches InstitutUniversität WürzburgWürzburgGermany

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