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Myothermal economy of rat myocardium, Chronic adaptation versus acute inotropism

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Controversial issues in cardiac pathophysiology

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Summary

By means of rapid planar Hill type antimony-bismuth thermopiles the initial heat liberated by papillary muscles was measured synchronously with developed tension for control (C), pressure-overload (GOP), and hypothyrotic (PTU) rat myocardium (chronic experiments) and after application of 10−6 M isoproterenol or 200 10−6 M UDCG-115. Economy of force production was analyzed by the ratio of initial heat versus developed tension-time integral. This ratio was found to be reduced by 34% in GOP and by 43% in PTU myocardium (P <0.01, respectively) indicating increased economy of force production. In contrast, isoproterenol increased initial heat versus tension-time integral by 70% (P<0.01) indicating reduced economy of force production. No change in this ratio was found for UDCG-115. The presented data indicates that long and short term modulation of myocardial energetic costs of force generation is possible. The basic mechanisms for these myocardial alterations are discussed.

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References

  1. Alpert NR, Mulieri LA (1977) The partitioning of altered mechanics in hypertrophied heart muscle between the sarcoplasmic reticulum and the contractile apparatus by means of myothermal measurements. Basic Res Cardiol 72: 153–159

    Article  PubMed  CAS  Google Scholar 

  2. Alpert NR, Mulieri LA (1982) The functional significance of altered tension dependent heat in thyrotoxic myocardial hypertrophy. Basic Res Cardiol 75: 153–159

    Google Scholar 

  3. Alpert NR, Mulieri LA (1984) The inhomogeneity and appropriateness of the myocardial response to stress. Hypertension 6 (Suppl III): 50–57

    Article  CAS  Google Scholar 

  4. Barclay JK, Gibbs CL, Loiselle DS (1979) Stress as an index of metabolic cost in papillary muscle in the cat. Basic Res Cardiol 54: 594–603

    Article  Google Scholar 

  5. Blanchard EM, Mulieri LA, Alpert NR (1984) The effect of 2,3-Butenedione monoxime (BDM) on the relation between initial heat and mechanical output and on the activity of the contractile apparatus of rat papillary muscle. Conference of Muscle Energetics, Burlington, Vermont

    Google Scholar 

  6. Coughlin P, Gibbs CL (1981) Cardiac energetics in short and long term hypertrophy induced by aortic coarctation. Cardiovasc Res 15: 623–631

    Article  PubMed  CAS  Google Scholar 

  7. Ebrecht G, Rupp H, Jacob R (1982) Alterations of mechanical parameters in chemically skinned preparations of rat myocardium as a function of isoenzyme pattern of myosin. Basic Res Cardiol 77: 220–234

    Article  PubMed  CAS  Google Scholar 

  8. Gibbs C, Loiselle D (1978) The energy output of tetanized cardiac muscle: species differences. Pflügers Arch 373: 31–38

    Article  PubMed  CAS  Google Scholar 

  9. Gibbs CL (1967) Role of catecholamines in heat production in the myocardium. Circ Res 21 (Suppl III): 223–230

    CAS  Google Scholar 

  10. Gibbs CL, Gibson WR (1969) Effect of oubain on the energy output of rabbit cardiac muscle. Circ Res 24: 951

    Article  PubMed  CAS  Google Scholar 

  11. Hoh, JFY, McGath PA, Hale PT (1977) Electrophoretic analysis of multiple forms of rat cardiac myosin: effects of hypophysectomy and thyroxine replacement. J Mol Cell Cardiol 10: 1053–1076

    Article  Google Scholar 

  12. Hoh JFY, Rosmanith HG (1983) Crossbridge dynamics in rat papillary muscles containing VI and V3 isomyosins: effects of adrenaline. J Mol Cell Cardiol 15 (Suppl 2): 65

    Article  Google Scholar 

  13. Holubarsch Ch, Alpert NR, Goulette R, Mulieri LA (1982) Heat production during hypoxic contracture of rat myocardium. Circ Res 51: 777–786

    Article  PubMed  CAS  Google Scholar 

  14. Holubarsch Ch, Goulette RP, Mulieri LA, Alpert NR (1985) The economy of isometric force development, myosin isoenzyme pattern and myofibrillar ATPase activity in normal and hypothyroid rat myocardium. Circ Res 56: 78–86

    Article  PubMed  CAS  Google Scholar 

  15. Holubarsch Ch, Goulette RP, Mulieri LA, Alpert NR (1983) Heat liberation in experimentally induced tetanic contractions of myocardium from normal and Goldblatt rats. In: Jacob R (ed) Cardiac Adaptation of Hemodynamic Overload, Training and Stress. Steinkopff Verlag, Darmstadt, pp 158–166

    Chapter  Google Scholar 

  16. Jacob R, Ebrecht G, Holubarsch Ch, Medugorac I (1980) Elastic and contractile properties of the myocardium in experimental cardiac hypertrophy in the rat. Methodological and pathophysiological considerations. Basic Res Cardiol 75: 253–261

    Article  PubMed  CAS  Google Scholar 

  17. Kretzschmar KMM, Wilkie DR (1972) A new method for absolute heat measurements, utilizing the Peltier effect. J Physiol (Lond) 224: 18p - 20 p

    CAS  Google Scholar 

  18. Litten RZ, Martin BJ, Low RB, Alpert NR (1982) Altered myosin isoenzyme pattern from pressure-overload and thyrotoxic hypertrophied rabbit hearts. Circ Res 50: 856–864

    Article  PubMed  CAS  Google Scholar 

  19. Loiselle DS, Wendt IR, Hoh JFY (1982) Energetic consequences of thyroid-modulated shifts in ventricular isomyosin distribution in the rat. J Muscle Res Cell Motil 3: 5–23

    Article  PubMed  CAS  Google Scholar 

  20. Loiselle DS, Gibbs CL (1979) Species differences in cardiac energetics. Am J Physiol 237: H90 - H98

    PubMed  CAS  Google Scholar 

  21. Mulieri LA, Luhr G, Trefry J, Alpert NR (1977) Metal-film thermopiles for use with rabbit right ventricular papillary muscles. Am J Physiol 233: C 136 - C156

    Google Scholar 

  22. Rüegg JC, Pfitzer G (1984) Myokardkontraktilität and Phosphorylierung der kontraktilen Proteine. In: Keul J, H-H Dickhuth (eds) Herzinsuffizienz. Pathophysiologie, Klinik and Therapie. Perimed Fachbuch-Verlagsgesellschaft, Erlangen, pp 53–56

    Google Scholar 

  23. Rupp H (1982) Polymorphic myosin as the common determinant of myofibrillar ATPase in different hemodynamic and thyroid states. Basic Res Cardiol 77: 34–46

    Article  PubMed  CAS  Google Scholar 

  24. Scheuer J, Malhotra A, Hirsch C, Capasso J (1982) Physiologic cardiac hypertrophy corrects contractile protein abnormalities associated with pathologic hypertrophy of rats. J Clin Invest 70: 1300–1305

    Article  PubMed  CAS  Google Scholar 

  25. Wikman-Coffelt J, Parmley WW, Mason DT (1979) The cardiac hypertrophy process. Analyses of factors determining pathological versus physiological development. Circ Res 45: 697–707

    Article  PubMed  CAS  Google Scholar 

  26. Winegrad S, Weisberg A, Lin LE, McClellan G (1986) Adrenergic regulation of myosin adenosine Friphosphatase activity. Circ Res 58: 83–95

    Article  PubMed  CAS  Google Scholar 

  27. Yasaki Y, Raben MS (1975) Effect of the thyroid state on the enzymatic characteristics of cardiac myosin. A difference in behavior of rat and rabbit cardiac myosin. Circ Res 36: 208–215

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Cardiology, Medizinische Universitätsklinik III, Freiburg, Germany

    G. Hasenfuss & H. Just

  2. Department of Physiology & Biophysics, University of Vermont, Burlington, Vermont, USA

    E. Blanchard, N. R. Alpert & L. A. Mulieri

  3. Department of Cardiology, Medizinische Universitätsklinik, Hugstetter Straße 55, D-7800, Freiburg, Germany

    Doz. Dr. Ch. Holubarsch

Authors
  1. Doz. Dr. Ch. Holubarsch
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  2. G. Hasenfuss
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  3. E. Blanchard
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  4. N. R. Alpert
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  5. L. A. Mulieri
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  6. H. Just
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R. Jacob

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© 1986 Springer-Verlag Berlin Heidelberg

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Holubarsch, C., Hasenfuss, G., Blanchard, E., Alpert, N.R., Mulieri, L.A., Just, H. (1986). Myothermal economy of rat myocardium, Chronic adaptation versus acute inotropism. In: Jacob, R. (eds) Controversial issues in cardiac pathophysiology. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-11374-5_10

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  • DOI: https://doi.org/10.1007/978-3-662-11374-5_10

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-11376-9

  • Online ISBN: 978-3-662-11374-5

  • eBook Packages: Springer Book Archive

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