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A Na+,K+-ATPase inhibitor isolated from pig kidney

  • Conference paper
Book cover Cardiac Glycosides 1785–1985

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Summary

Pig kidney alcoholic extracts contain various substances which cross-react with antibodies for cardiac glycosides. Further fractions were found which inhibited Na+,K+-ATPase activity, displaced 3H-ouabain binding and had a positive inotropic effect on guinea-pig left atria.

The Na+,K+-ATPase inhibitory factors did not correlate with cardiac glycoside antibody cross-reactivity.

One fraction A4, which was radioimmunologically inert and extremely lipophilic, was not significantly contaminated with ions, showed a potent inhibition of the Na+,K+-ATPase, displaced 3H-ouabain binding and increased cardiac contractile force.

A further fraction, B1, was radioimmunologically active, but was found to inhibit the Na+,K+-ATPase, displace 3H-ouabain binding and increase contractile force due to a contamination with a significant amount of calcium.

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References

  1. Akera T, Fox AAL, Greeff K (1981) In: Greeff K (ed) Cardiac Glycosides Part 1. Experimental Pharmacology Handbook. Exp Pharm 56: 459, Springer-Verlag, Berlin

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  3. Fox AAL, Greeff K (1981) Biochem Pharmacol 30: 611

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Author information

Authors and Affiliations

  1. Institut für Pharmakologie, Universität Düsseldorf, Düsseldorf, Germany

    A. A. L. Fox, H. Strobach & K. Greeff

  2. Institut für Pharmakologie der Universität, Moorenstraße 5, D-4000, Düsseldorf 1, West Germany

    M. Krekler

Authors
  1. M. Krekler
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  2. A. A. L. Fox
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  3. H. Strobach
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  4. K. Greeff
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Editor information

Editors and Affiliations

  1. Medizinische Klinik I, Klinikum Großhadern der Universität München, Marchioninistraße 15, 8000, München 70, West Germany

    Erland Erdmann

  2. Institut für Pharmakologie, Universität Düsseldorf, Moorenstraße 5, 4000, Düsseldorf, West Germany

    K. Greef

  3. Biophysik Institut, Aarhus Universitet, Universitetparken, 8000, Aarhus, Denmark

    J. C. Skou

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© 1986 Springer-Verlag Berlin Heidelberg

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Krekler, M., Fox, A.A.L., Strobach, H., Greeff, K. (1986). A Na+,K+-ATPase inhibitor isolated from pig kidney. In: Erdmann, E., Greef, K., Skou, J.C. (eds) Cardiac Glycosides 1785–1985. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-11292-2_22

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  • DOI: https://doi.org/10.1007/978-3-662-11292-2_22

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-11294-6

  • Online ISBN: 978-3-662-11292-2

  • eBook Packages: Springer Book Archive

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