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The “endogenous cardiac glycoside”

  • W. Schoner
  • K. Moreth
  • R. Kuske
  • D. Renner

Abstract

Evidence is accumulating that, in addition to the second messengers of hormone action cAMP, Ca2+ and inositoltriphosphate, alterations of the intracellular Na+-concentration may also mediate hormonal effects on cellular processes (66). Provided this concept is right, the sodium pump must also be considered as a receptor of hormones and as a mediator of hormonal action (3). Alterations of the intracellular sodium concentration are considered to be involved in the mechanism of inotropy of the cardiac muscle cells (2) and in differentiation processes (66). With this in mind, it is not astonishing that a hormone of insects, which stimulates the differentiation of tissues (50), uses the sodium pump as a target in the follicle cells of the bug Rhodnius prolixus (28) (Fig. 1): isolated (Na++K+)-ATPase from follicle cells is activated below 10−8 M juvenile hormone but is inhibited above this concentration. The effect is specific for the follicle enzyme and is not seen with the brain enzyme of Rhodnius prolixus. Swelling of vitellogenic follicle cells is activated by juvenile hormone, but inhibited by ouabain (1). It is therefore likely that the juvenile hormone binds to the cardiac glycoside receptor site and that the activating effect of the juvenile hormone reflects the sometimes observable effect of a stimulation of (Na++K+)-ATPase by cardiac glycosides (18, 19, 42) at very low concentrations.

Keywords

Essential Hypertension Juvenile Hormone Follicle Cell Cardiac Glycoside Sodium Pump 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • W. Schoner
    • 1
    • 3
  • K. Moreth
    • 1
  • R. Kuske
    • 1
  • D. Renner
    • 2
  1. 1.Institut für Biochemie und EndokrinologieJustus-Liebig UniversitätGiessenWest Germany
  2. 2.Medizinische KlinikKrankenhauszweckverband AugsburgWest Germany
  3. 3.Institut für Biochemie und Endokrinologie des Fachbereichs VeterinärmedizinJustus-Liebig-Universität GiessenGiessenWest Germany

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