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Cardiac Energetics pp 369–376Cite as

Heterogeneous regulatory changes in cell surface membrane receptors coupled to a positive inotropic response in the failing human heart

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Summary

The failing human ventricular myocardium undergoes heterogeneous changes at the receptor level that have some impact on the ability of the failing myocardium to respond to inotropic stimuli. In the failing human ventricular myocardium the β l-adrenergic receptor is profoundly down-regulated, the β 2-adrenergic receptor is only slightly decreased, α l-adrenergic receptors are unchanged and VIP receptors appear to be increased in density or affinity. These changes have implications for therapeutic strategies for heart failure and for the natural history and pathogenesis of heart muscle disease.

Supported by NIH Grant HL 13108.

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Authors and Affiliations

  1. Cardiology Division, University of Utah, School of Medicine, Salt Lake City, USA

    M. R. Bristow M.D. Ph.D., R. Ginsburg, E. M. Gilbert & R. E. Hershberger

  2. Cardiology Division, 4A-100, University of Utah Medical Center, 50 Medical Drive, Salt Lake City, UT, 84132, USA

    M. R. Bristow M.D. Ph.D.

Authors
  1. M. R. Bristow M.D. Ph.D.
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  2. R. Ginsburg
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  3. E. M. Gilbert
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  4. R. E. Hershberger
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Editor information

R. Jacob Hj. Just Ch. Holubarsch

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© 1987 Springer-Verlag Berlin Heidelberg

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Bristow, M.R., Ginsburg, R., Gilbert, E.M., Hershberger, R.E. (1987). Heterogeneous regulatory changes in cell surface membrane receptors coupled to a positive inotropic response in the failing human heart. In: Jacob, R., Just, H., Holubarsch, C. (eds) Cardiac Energetics. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-11289-2_36

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  • DOI: https://doi.org/10.1007/978-3-662-11289-2_36

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-11291-5

  • Online ISBN: 978-3-662-11289-2

  • eBook Packages: Springer Book Archive

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