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Growth Hormone Treatment Accelerates Growth of Short Children with Neural Tube Defects

  • Deborah Rotenstein
  • Donald H. Reigel
  • Lynda L. Flom

Abstract

Children with Open Neural Tube Defects have been noted to be short. To test the hypothesis that changes or growth hormone secretion may occur in Open Neural Tube Defects and contribute to this short stature, we assessed 12 hour Nocturnal and Clonidine stimulated Growth Hormone responses of 7 significantly short non obese pre-pubertal patients with Open Neural Tube Defects. Growth rate and Somatomedin responses to 6 months of treatment with Recombinant Human Growth Hormone were evaluated. Somatomedin C was measured via the Nicholas SMC RIA Kit. Growth Hormone was measured by a Hybritech Irma Kit. Recombinant Human Growth Hormone dose was .1 mg/kg SQ TIW. Statistical analysis utilized the non parametric Wilcoxon signed rank test. Controls were 33 pre-pubertal subjects whose Nocturnal Samples were assayed in the same laboratory.

Key words

Neural tube defects Growth hormone Hydrocephalus Short stature 

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Deborah Rotenstein
    • 1
    • 2
  • Donald H. Reigel
    • 1
    • 2
  • Lynda L. Flom
    • 1
    • 2
  1. 1.Department of Pediatrics and Division of Pediatric NeurosurgeryThe Medical College of PennsylvaniaPittsburghUSA
  2. 2.Department of Pediatric RadiologyWestern Pennsylvania HospitalPittsburghUSA

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