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Changes of Muscarinic Cholinergic Receptors and Cholinergic Neurons in Experimental Acute Hydrocephalic Rat Brains

  • Takashi Sakamoto
  • Masahiro Kurisaka
  • Koreaki Mori

Abstract

Recently, the relationship between neurological disorders and neurotransmitters has received much attention. Many studies have been reported about the changes of neurotransmitters and their metabolites in cerebrospinal fluid (CSF) in hydrocephalus, and it is presumed that neurotransmitters may play a role in the regulation of CSF dynamics. In our last report, we had taken up acetylcholine (ACh) and had studied the changes in the number and distribution of muscarinic receptors of ACh in experimental hydrocephalic rat brains by binding assay and macroautoradiography. We reported that muscarinic receptors had been increased in acute hydrocephalus and tended to be normal in chronic hydrocephalus.

Key words

Acute hydrocephalus Muscarinic receptor Cholinergic neuron Microautoradiography 

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Takashi Sakamoto
    • 1
  • Masahiro Kurisaka
    • 1
  • Koreaki Mori
    • 1
  1. 1.Department of NeurosurgeryKochi Medical SchoolNankokuJapan

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