Cerebral Metabolism in Hydrocephalic Animals: Comparison of water, electrolytes and energy metabolism in brain tissues between congenital and acquired hydrocephalic rats
In order to assess cerebral metabolism, changes of water and electrolyte content, glycolytic metabolites and high energy Phosphates were examined in the brain tissues of rats with congenital and acquired hydrocephalus. As an experimental model of congenital hydrocephalus, 3-week-old LEW-HYR, which is a mutant rat with hydrocephalus breeding and maintained in our institute, was used. Acquired hydrocephalus was produced in adult rats by intracisternal injection of kaolin. The energy status of the brain was estimated by brain tissue lactate level, lactate/pyruvate (L/P) ratio, ATP/ADP ratio, total adenylates and adenylate energy charge.