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Pathophysiologie

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Zusammenfassung

Im menschlichen Auge finden sich mit dem Alter vielfältige degenerative Veränderungen. Einige dieser strukturellen und funktionellen Veränderungen sowie physikalische und diätetische Einflüsse wurden als mögliche pathophysiologische Faktoren bei der Entstehung der altersabhängigen Makuladegeneration diskutiert. Obgleich sich viele der Veränderungen in nahezu jedem alternden Auge finden, entwickelt dennoch nur ein Teil der betroffenen Altersgruppe visusvermindernde Läsionen. Daher spielen offensichtlich andere individuelle Faktoren wie eine genetische Prädisposition oder spezifische Umwelteinflüsse eine Rolle.

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Literatur

  • Bellmann C, Holz FG, Otto TP, Wicker HE (1996) Topographie der Fundus-Autofluoreszenz mit einem konfokalen Laser-Scanning-Ophthalmoskop. Ophthalmologe 93: 71

    Google Scholar 

  • Boulton M, Marshall J (1986) Effects of increasing numbers of phagocytic inclusions on human retinal pigment epithelial cells in culture: a model for aging. Br J Opthalmol 70: 808

    Article  CAS  Google Scholar 

  • Boulton ME, MCKechnie NM, Breda J, Bayly M, Marshall J (1989) The formation of auto-fluorescent granules in cultured human RPE. Invest Ophthalmol Vis Sci 30: 83

    Google Scholar 

  • Boulton ME (1991) Ageing of the retinal pigment epithelium. In: Osborn NN, Chader GJ (eds.) Retinal Research. Pergamon Press, Oxford, pp 126

    Google Scholar 

  • Brunk U, Collins VP (1981) Lysosomes and age pigments in cultured cells. In: Sohal RS (ed) Age pigments. Elsevier/North-Holland Biomedical Press, pp 243

    Google Scholar 

  • Burns RP, Feeney-Burns L (1980) Clinicomorphologic correlations of Drusen of Bruch’s membrane. Trans Am Ophthalmol Soc 78: 206

    PubMed  CAS  Google Scholar 

  • Casswell AG, Kohen D, Bird AC (1985) Retinal pigment epithelial detachments in the elderly: classification and outcome. Br J Ophthalmol 69: 397

    Article  PubMed  CAS  Google Scholar 

  • Delori CD, Dorey CK, Staurenghi G, Arend O, Goger DG, Weiter JJ (1995) In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci 36: 718

    PubMed  CAS  Google Scholar 

  • Delori CD, Staurenghi G, Arend O, Dorey CK, Goger DG, Weiter JJ (1995) In vivo measurement of lipofuscin in Stargardt’s disease - fundus flavimaculaturs. Invest Ophthalmol Vis Sci 36: 718

    PubMed  CAS  Google Scholar 

  • Dorey CK, Wu G, Ebenstein D, Garsd A, Weiter JJ (1989) Cell loss in the aging retina: relationship of lipofuscin accumulation and macular degeneration Invest Ophthalmol Vis Sci 30a051

    Google Scholar 

  • Dorey CK, Staurenghi G, Delori FC (1993) Lipofuscin in aged and ARMD eyes. In: Holly-field JG et al. (eds) Retinal Degeneration. New York: Plenum Press, pp 3

    Chapter  Google Scholar 

  • Eagle RC Jr (1984) Mechanisms of maculopathy. Ophthalmology 91: 613

    PubMed  Google Scholar 

  • Eldred CE, Laskey MR (1993) Retinal age pigments generated by self-absorbing lysosomotropic detergents. Nature 361: 724

    Article  PubMed  CAS  Google Scholar 

  • Feeney L (1978) Lipofuscin and melanin of human retinal pigment eipthelium. Invest Ophthalmol Vis Sci 17: 583

    PubMed  CAS  Google Scholar 

  • Feeney-Burns L, Berman ER, Rothman H (1980) Lipofuscin of human retinal pigment epithelium. Am J Ophthalmol 90: 783

    PubMed  CAS  Google Scholar 

  • Feeney-Burns L, Hilderbrand ES, Eldridge S (1984) Aging human RPE: morphometric analy-sis of macular, equatorial and peripheral cells. Invest Ophthalmol Vis Sci 25: 195

    PubMed  CAS  Google Scholar 

  • Feeney-Burns L, Ellersieck MR (1985) Age-related changes in the ultrastructure of Bruch’s membrane. Am J Ophthalmol 100: 686

    PubMed  CAS  Google Scholar 

  • Fisher RF (1987) The influence of age on some ocular basement membranes. Eye 1: 184

    Article  PubMed  Google Scholar 

  • Flood M, Gouras P, Kjeldbye H (1980) Growth characteristics and ultrastructure of human retinal pigment epithelium in vitro. Invest Ophthalmol Vis Sci 19: 1309

    PubMed  CAS  Google Scholar 

  • Hayes KC (1974) Retinal degeneration in monkeys induced by deficiencies of vitamin E or A. Invest Ophthalmol 13: 499

    CAS  Google Scholar 

  • Hinsull SM, Bellamy D (1981) Tissue homeostasis and cell death. In: Bowen ID, Lockshin RA (eds) Cell biology in biology and pathology. Chapman and Hall, London, pp 123

    Chapter  Google Scholar 

  • Holz FG, Dorey CK, Sheraidah G, Bird AC (1994a) Lipofuscin fluorescence, Bruch’s membrane fluorescence and lipid deposits in aging donor eyes. Invest Ophthalmol Vis Sci 35: 1501

    Google Scholar 

  • Holz FG, Sheraidah G, Pauleikhoff D, Bird AC (1994 b) Analysis of lipid deposits extracted from human macular and peripheral Bruch’s membrane. Arch Ophthalmol 112: 402

    Google Scholar 

  • Holz FG, Owens S, Marks J, Haimovici R, Bird AC. Ultrastructural findings in autosomal-dominant drusen. Arch Ophthalmol (im Druck)

    Google Scholar 

  • Hopkins J, v Rückmann A, Fitzke FW, Bird AC (1996) Fundus autofluorescence in age-related macular disease. Invest Ophthalmol Vic Sci 37: S114

    Google Scholar 

  • Ishibashi T, Sorgente N, Patterson R, Ryan SJ (1986) Pathogenesis of drusen in the primate. Invest Ophthalmol Vis Sci 27: 184

    PubMed  CAS  Google Scholar 

  • Kliffen M, de Jong PTVM, Luider TM (1995) Protein analysis of human maculae in relationship to age-related maculopathy. Lab Invest 73: 267

    PubMed  CAS  Google Scholar 

  • Mann DM, Yates PO (1974) Lipofuscin pigments: their relationship to ageing in the human nervous system. I. The lipofuscin content of nerve cells. Brain 97: 481

    Google Scholar 

  • Mann DM, Yates PO, Stamp JE (1978) The relationship between lipofuscin pigment and ageing in the human nervous system. J Neurol Sci 37: 83

    Article  PubMed  CAS  Google Scholar 

  • Moore DJ, Hussain AA, Marshall J (1995) Age-related variation in the hydraulic conductivity of Bruch’s Membrane. Invest Ophthalmol Vis Sci 36: 1290

    PubMed  CAS  Google Scholar 

  • Olver J, Pauleikhoff D, Bird AC (1990) Morphometric analysis of age changes in the chorioicapillaris. Invest Ophthalmol Vis Sci (Suppl.) 31: 47

    Google Scholar 

  • Organisciak DT, Wang H, Li ZY, Tso MOM (1985) The protective effect of ascorbate in retinal light damage of rats. Invest Ophthalmol Vis Sci 26: 1580

    PubMed  CAS  Google Scholar 

  • Pauleikhoff D, Harper CA, Marshall J, Bird AC (1990) Aging changes in Bruch’s membrane. A histochemical and morphologic study. Ophthalmology 97: 171

    Google Scholar 

  • Pauleikhoff D, Zuels S, Sheraidah G, Bird AC (1992) Correlation between biochemical composition and fluorescein binding of deposits in Bruch’s membrane. Ophthalmology 99: 1548

    PubMed  CAS  Google Scholar 

  • Penfold PL, Killingsworth M, Sarks S (1985) Senile macular degeneration: The involvement of immunocompetent cells. Graefes Arch Clin Exp Ophthalmol 223: 69

    Google Scholar 

  • Ramratten RS, van der Schaft TL, Mooy CM, Bruijn WC, Mulder PGH, de Jong PTVM (1994) Morphometric analysis of Bruch’s membrane, the choriocapillaris and the choroid in aging. Invest Ophthalmol Vis Sci 35: 2857

    Google Scholar 

  • Rückmann A v, Fitzke FW, Bird AC (1995) Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Br J Ophthalmol 79: 407

    Article  PubMed  Google Scholar 

  • Sheraidah G, Steinmetz R, Maguire J, Pauleikhoff D, Marshall J, Bird AC (1993) Correlation between lipids extracted from Bruch’s membrane and age. Ophthalmology l00: 47

    CAS  Google Scholar 

  • Wing GL, Gordon CB, Weiter JJ (1978) The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium. Invest Ophthalmol Vis Sci 17: 601

    PubMed  CAS  Google Scholar 

  • Young RW (1987) Pathophysiology of age-related macaular degeneration. Sury Ophthalmol 31: 291

    Article  CAS  Google Scholar 

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© 1997 Springer-Verlag Berlin Heidelberg

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Holz, F.G., Pauleikhoff, D., Bird, A.C. (1997). Pathophysiologie. In: Holz, F.G., Pauleikhoff, D. (eds) Altersabhängige Makuladegeneration. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-11126-0_2

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  • DOI: https://doi.org/10.1007/978-3-662-11126-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-11127-7

  • Online ISBN: 978-3-662-11126-0

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