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α-Adrenoceptor Subtypes in the Coronary Circulation

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Adrenergic Mechanisms in Myocardial Ischemia

Summary

The pathophysiological role of sympathetic coronary innervation in myocardial ischemia is not clear, probably due to the complexities of adrenergic vascular control. In the canine coronary bed in vivo under β-adrenergic blockade, α1- as well as α2-adrenoceptor-mediated constrictions can be elicited with predominance of the former in the epicardial conductance arteries, and of the latter in coronary resistance vessels. However, this distribution of functional responsiveness cannot indicate distribution of receptor density and cannot remain unchanged under differing conditions. First, each of these two classes of α-adrenoceptors consists of a mixture of different, interacting subtypes; second, the smooth muscular responsiveness to these two classes of α-adrenoceptors is differently modulated by contractile preactivation, by β2-blockade, and by the influence of sympathetic cotransmitters; third, α-adrenoceptors on endothelial cells and on sympathetic nerve endings can substantially modulate sympathetic coronary constriction. Thus, this neuroge-nic coronary control possesses a great functional plasticity, which is not yet fully evaluated with the presently available pharmacological tools.

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  1. Institut für Angewandte Physiologie und Balneologie, Universität Freiburg, Hermann — Herder — Str. 7, 7800, Freiburg, Federal Republic of Germany

    Prof. Dr. med. J. Holtz

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Gerd Heusch John Ross Jr.

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Holtz, J. (1991). α-Adrenoceptor Subtypes in the Coronary Circulation. In: Heusch, G., Ross, J. (eds) Adrenergic Mechanisms in Myocardial Ischemia. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-11038-6_7

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  • DOI: https://doi.org/10.1007/978-3-662-11038-6_7

  • Publisher Name: Steinkopff, Heidelberg

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