α-Adrenergic Regulation of Myocardial Performance in the Exercising Dog: Evidence for Both Presynaptic α1- and α2-Adrenoceptors

  • Brian D. Guth
  • E. Thaulow
  • G. Heusch
  • R. Seitelberger
  • J. RossJr.
Conference paper


New evidence supporting both presynaptic α1- and α2-adrenoceptors playing a role in the regulation of myocardial contractile performance in the exercising dog is reviewed. Studies utilized chronically instrumented dogs having sonomicrometers for the measurement of regional wall thickening and transducers for the measurement of left ventricular and systemic hemodynamics. During steady state exercise, either the selective α1-adrenoceptor blocker prazosin (80μg/kg) or the selective α2-adrenoceptor blocker idazoxan (80μg/kg) was infused into the left atrium while exercise continued. Immediately following the administration of either α-adrenoceptor blocking agent, there were substantial increases in heart rate, left ventricular dP/dt and regional contractile function as assessed using sonomicrometers, and norepinephrine release by the myocardium increased substantially. β-adrenergic blockade prevented the heart rate and contractile effects of either α1 - or α2-adrenoceptor blocker whereas norepinephrine release was further enhanced. These effects could not be attributed to baroreceptor unloading. In dogs studied under resting conditions with norepinephrine infusion to produce an increase in dP/dt similar to that observed during treadmill exercise, no sympathetic augmentation was observed following either α-blocker. Together, these studies provide evidence that both α1- and α2-adrenoceptors participate in the modulation of sympathetic neuronal norepinephrine release in the canine myocardium.


Left Atrium Coronary Sinus Norepinephrine Release Negative Feedback Mechanism Exercise Heart Rate 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Brian D. Guth
    • 1
  • E. Thaulow
    • 1
  • G. Heusch
    • 1
  • R. Seitelberger
    • 1
  • J. RossJr.
    • 1
  1. 1.Seaweed Canyon Laboratory, Department of MedicineUniversity of CaliforniaLa JollaUSA

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