Summary
As a result of gradual coronary occlusion, coronary collaterals are stimulated to develop. This maturation process involves not only dilatation of the vessel, but the development of new vascular smooth muscle. Experiments have been performed to examine vasomotor characteristics of mature coronary collaterals from dogs 3 to 6 months following ameroid constrictor placement. Studies in Langendorff blood-perfused hearts have shown that transcollateral resistance does not change during either the administration of α1-or α2-adrenergic agonists. Isolated collateral vessels studied as rings in organ chambers do not constrict to either α1- or α2-adrenergic agonists. These studies show that mature collateral vessels are not likely to possess functioning α-adrenergic receptors. Subsequent experiments using a cover slip autoradiographic ligand-binding approach have demonstrated a population of β-adrenergic receptors on mature coronary collaterals. Studies of isolated collaterals have demonstrated β-adrenoceptor-mediated relaxation that appears due to a population of mixed β1- and β2-adrenergic receptors.
Subsequent studies have demonstrated that mature collateral vessels are hyperresponsive to the vasoconstrictor effects of Vasopressin and that concentrations of Vasopressin which may be encountered in pathophysiologic conditions can markedly attenuate coronary collateral perfusion. Finally, the microcirculation of the collateral-dependent myocardium develops endothelial cell dysfunction. This results in impaired endothelium-dependent relaxations to adenosine diphosphate and acetylcholine and enhanced vasoconstriction to Vasopressin. These alterations of the coronary circulation may have important implications regarding neurohumoral regulation of myocardial perfusion in collateral-dependent myocardium.
Dr. Harrison is an established investigator of the American Heart Association. Supported by NIH grants HL32717, HL39006, Ischemic SCOR HL32295, and a Merit Review Grant from the Veterans Administration.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Bache RJ, Schwartz JS (1983) Myocardial blood flow during exercise after gradual coronary occlusion in the dog. Am J Physiol 245:H131–H138
Beller BM, Trevino A, Uban E (1971) Pitressin-induced myocardial injury and depression in a young woman. Am J Med 51, 675–679
Cohen MV, Sonnenblick EH, Kirk ES (1976) Coronary steal: Its role in detrimental effect of isoproterenol after acute coronary occlusion in dogs. Am J Cardiol 38, 880–888
Eng C, Patterson RE, Horowitz SF, Halgash DA, Pichard AD, Midwall J, Herman MV, Gorlin R (1982) Coronary collateral function during exercise. Circulation 66, 309–316
Feldman RD, Christy JP, Paul ST, Harrison DG (1989) β-Adrenergic receptors on canine coronary collateral vessels: characterization and function. Am J Physiol 257:H1634–H1639
Harrison DG, Chapman MP, Christy JP, Marcus ML (1986) Studies of functional site of origin of native coronary collaterals. Am J Physiol 241:H1217–H1224
Harrison DG, Chilian WM, Marcus ML (1986) Absence of functioning α-adrenergic receptors in mature canine coronary collaterals. Circ Res 59, 133–142
Hautamaa PV, Dai X-Z, Homans DC, Robb JF, Bache RJ (1987) Vasomotor properties of immature canine coronary collateral circulation. Am J Physiol 252:H1105–H1111
Kelly KJ, Stang JM, Mekhjian HS (1980) Vasopressin provocation of ventricular dysrhythmia. Ann Intern Med 92, 205–206
Maruoka Y, McKirnan D, Engler R, Longhurst JC (1987) Functional significance of α-adrenergic receptors in mature coronary collateral circulation of dogs. Am J Physiol 253:H582–590
Mills MD, Burchell HB, Parker RL, Kirklin BR (1949) Myocardial infarction and sudden deaths following the administration of pitressin; additional electrocardiographic study of 100 patients given pitressin for cholecystography. Staff Meetings of the Mayo Clinic, Rochester, Minnesota, pp 254–258
Muntz KH, Olson EG, Lariviere GR, D’Souza S, Mukherjee A, Willerson JT, Buja LM (1984) Autoradiographic characterization of beta adrenergic receptors in coronary blood vessels and myocytes in normal and ischemic myocardium of the canine heart. J Clin Invest 73, 349–357
Peters KG, Marcus ML, Harrison DG (1989) Vasopressin and the mature coronary collateral circulation. Circulation 79, 1324–1331
Quillen JE, Sellke FW, Brooks LA, Harrison DG (1990) Ischemia-reperfusion impairs endothelium-dependent relaxation of coronary microvessels while not affecting large arteries. Circulation 82, 586–594
Ruskin A (1947) Pitressin test of coronary insufficiency. Am Heart J 30, 569–579
Schaper W (1971) The Collateral Circulation of the Heart. Amsterdam, North Holland Publishing Co
Schaper W, Vandesteen R (1967) The rate of growth of interarterial anastomoses in chronic coronary artery occlusion. Life Sci 6, 1673–1680
Schaper W (Ed) (1979) The Pathophysiology of Myocardial Perfusion. Elsevier /North-Holland Biomedical Press
Sellke FW, Armstrong ML, Harrison DG (1990) Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates. Circulation 81, 1586–1593
Sellke FW, Quillen JE, Brooks LA, Harrison DG (1990) Endothelial modulation of the coronary vasculature in vessels perfused via mature collaterals. Circulation 81, 1938–1947
Simonetti I, Cooper SM, Harrison DG (1987) Dependence of native coronary collateral perfusion on normal zone resistance. Circulation 76 suppl IV:IV–327 (abstr.)
Simonetti I, Cooper SM, Harrison DG (1988) Effect of diltiazem on precollateral resistances. Circulation 78 suppl II:II–18 (abstr.)
Slotnik KL, Teigland JD (1951) Cardiac accidents following Vasopressin injection (pitressin). JAMA 146, 1126–1129
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Harrison, D.G., Sellke, F.W., Quillen, J.E. (1991). Neurohumoral Regulation of Coronary Collateral Vasomotor Tone. In: Heusch, G., Ross, J. (eds) Adrenergic Mechanisms in Myocardial Ischemia. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-11038-6_10
Download citation
DOI: https://doi.org/10.1007/978-3-662-11038-6_10
Publisher Name: Steinkopff, Heidelberg
Print ISBN: 978-3-662-11040-9
Online ISBN: 978-3-662-11038-6
eBook Packages: Springer Book Archive