Zusammenfassung
Die Definition und Dokumentation von Nebenwirkungen ist nicht nur wesentlicher Bestandteil jeder klinischen Studie, sondern auch Voraussetzung für ihr frühzeitiges Erkennen und ihre Behandlung.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Abrams J, Rayner A, Wiernik P, Parkinson D (1989) High dose Interleukin-2 without lymphokine activated killer cells: inactive in advanced renal call cancer. Proc Am Soc Clin Oncol 30: 380
Aso Y, Tazaki H, Umeda T, Marumo K (1991) Treatment of advanced renal cell carcinoma by systemic low-dose recombinant interleukin-2. In: Debruyne FMJ, Bukowski RM, Pontes JE, deMulder PHM (eds) Immunotherapy of renal cell carcinoma. Springer, Berlin Heidelberg New York Tokyo, pp 91–103
Atkins MB, Mier JW, Parkinson DR, Gould JA, Berkman EM, Kaplan MM (1988) Hypothyroidism after treatment with Interleukin-2 and lymphokine-activated killer cells. N Engl J Med 318: 1557–1563
Atzpodien J, Kirchner H (1990) Cancer, cytokines, and cytotoxic cells: interleukin-2 in the immunotherapy of human neoplasms. Klin Wochenschr 68:1–11
Atzpodien J, Körfer A, Kirchner H (1991) Interleukin-2 and interferon alpha in renal cell carcinoma: the European experience. The second international symposium: immunobiology of renal cell carcinoma. Oct 21 and 22, 1991. Cleveland, Ohio/USA
Belldegrun A, Webb DE, Austin HA, Steinberg SM, White DE, Linehan WM, Rosenberg SA (1987) Effects of Interleukin-2 on renal function in patients receiving immunotherapy for advanced cancer. Ann Intern Med 106:817–822
Braley-Mullen H, Johnson M, Sharp GC, Kyriakos M (1985) Induction of experimental autoimmune thyroiditis in mice with in vitro activated splenic T cells. Cell Immunol 93:132–143
Bruns P (1888) Die Heilwirkung des Erysipels auf Geschwülste. Beitr Klin Chir 3:443–466
Bukowski RM, Goodman P, Crawford ED, Sergi JS, Redman BG, Whitehead RP (1990) Phase II trial of high-dose intermittent Interleukin-2 in metastatic renal cell carcinoma: Southwest Oncology Group Study. Reports 82:143–146
Busch (1868) Verhandlungen ärztlicher Gesellschaften. Berl Klin Wochenschr 12:137–138
Buzaid AC, Robertone A, Kisala C, Salmon SE (1987) Phase II study of recombinant interferon alfa-2a (Roferon-A) in metastatic renal cell carcinoma. J Clin Oncol 5:1083–1089
Coley WB (1891) Contribution to the knowledge of sarcoma. Ann Surg 14:199–220
Creagan ET, Kovach JS, Moertel CG, Frytak S, Kvols LK (1988) A phase I clinical trial of recombinant human tumor necrosis factor. Cancer 62:2467–2471
DeKernion JB, Sarna G, Figlin R, Lindner A, Smith RB (1983) The treatment of renal cell carcinoma with human leukocyte alpha-interferon. J Urol 130:1063–1066
Dinarello CA (1989) Interleukin-1 and its biologically related cytokines. Adv. Immunol 44:153–205
Dutcher J (1991) Clinical results with high dose interleukin-2 in the United States. The second international symposium: immunobiology of renal cell carcinoma, October 21 and 22, Cleveland, Ohio/USA
Fossa SD (1991) Further experience with high dose interferon alpha and prednisone in metastatic renal cell carcinoma. The second international symposium: immunobiology of renal cell carcinoma, Oct 21 and 22, Cleveland, Ohio/USA
Galligioni E, Sorio R, Sacco C et al. (1991) Recombinant Interleukin-2 (rIL2) by continuous infusion in patients with advanced renal cell cancer. The second international symposium: immunobiology of renal cell carcinoma, Oct 21 and 22, Cleveland, OH, USA, p 135
Herr HW, Pinsky CM, Whitmore WF, Sogani PC, Oettgen HF, Melamed MR (1986) Long-term effect of intravesical bacillus calmette-guerin on flat carcinoma in situ of the bladder. J Urol 135:265–267
Hermann F, Mertelsmann R (1989) Tumornekrosefaktor. Dtsch Med Wochenschr 114:312–316
Herrmann F (1990) Die Stellung der Interferone in der Zytokinkaskade. In: Niederle N, von Wussow P (Hrsg) Interferone — Präklinische und klinische Befunde. Springer, Berlin Heidelberg New York Tokyo, S 53–64
Huland E (1992) IL-2 Inhalation beim pulmonal metastasierten Nierenzell-Ca. Symposium: Immuntherapie in der Uro-Onkologie. 6.–8. Februar 1992, Essen
Jacobs SJ, Sullivan LM, Salfi M, Grossberg H, Spiegel RJ, Leibowitz PJ, Oden EM, Kelsey DK, Treuhaft MW (1988) Minimal antigenicity of Intron A in human recipients demonstrated by three analytical methods. J Biol Response Mod 7:447–456
Jacobsen H (1990) Struktur und Wirkung von Interferonen. In: Niederle N, von Wussow P (Hrsg) Interferone — Präklinische und klinische Befunde. Springer, Berlin Heidelberg New York Tokyo, S 1–44
Jakubowski AA, Casper ES, Gabrilove JL, Templeton M-A, Sherwin SA, Oettgen HF (1989) Phase I trial of intramuscularly administered tumor necrosis factor in patients with advanced cancer. J Clin Oncol 7:298–303
Khanna OMP, Son DL, Mazer H et al. (1990) Multicenter study of superficial bladder cancer treated with intravesical bacillus calmette-guerin or adriamycin. Urology 35:101–108
Kirkwood JM, Harris JE, Vera R et al. (1985) A randomized study of low and high doses of leukocyte alpha-interferon in metastatic renal cell carcinoma: the American Cancer Society collaborative trial. Cancer Res 45:863–871
Kragel AH, Travis MD, Feinberg L et al. (1990) Pathologic findings associated with Interleukin-2-based immunotherpy for cancer: A postmortem study of 19 patients. Hum Pathol 21:493–502
Krown SE, Einzig Al, Abramson JA (1983) Treatment of advanced renal cell cancer with recombinant leukocyte alpha interferon. Proc Am Soc Clin Oncol 2:58
Kummer G, Kloke O, Niederle N (1990) Interferonrezeptoren: Charakterisierung und mögliche klinische Bedeutung. In: Niederle N, von Wussow P (Hrsg) Interferone. Präklinische und klinische Befunde. Springer, Berlin Heidelberg New York Tokyo, S 65–78
Lamm DL, Stogdill VD, Stogdill BJ, Crispen RG (1986) Complications of Bacillus Calmette Guérin immunotherapy in 1278 patients with bladder cancer. J Urol 135:272–274
Lamm DL, Steg A, Boccon-Gibod L et al. (1989) Complications of Bacillus Calmette-Guérin immunotherapy: review of 2602 patients and comparison of chemotherapy complication. In: Debruyne FMJ, Denis L, van der Meijden APM (eds) BCG in superficial bladder cancer. Riss, New York, PP 335–355
Lee RE, Lotze MT, Skibber JM et al. (1989) Cardiorespiratory effects of immunotherapy with Interleukin-2. J Clin Oncol 7:7–20
Maase H von der, Geertsen P, Thatcher N et al. (1991) Recombinant interleukin-2 in metastatic renal all carcinoma — a European multicenter phase II study. Eur J Cancer 27:1583–1589
Margolin KA, Rayner AA, Hawkins MJ et al. (1989) Interleukin-2 and lymphokineactivated killer cell therapy of solid tumors: analysis of toxicity and management guidelines. J Clin Oncol 7: 486–498
Marumo K, Murai M, Hayakawa M, Tazaki H (1984) Human lymphoblastoid interferon therapy for advanced renal cell carcinoma. Urology 6:567–571
Marumo K, Muraki J, Ueno M et al. (1989) Immunologic study of human recombinant Interleukin-2 (low-dose) in patients with advanced renal cell carcinoma. Urology 33:219–225
Morales A, Eidinger D, Bruce AW (1976) Intracavitary Bacillus Calmette-Guérin in the treatment of superficial bladder tumors. J Urol 116:180–183
Muss HB, Costanzi JJ, Leavitt R et al. (1987) Recombinant alfa interferon in renal cell carcinoma: a randomized trial of two routes of administration. J Clin Oncol 5:286–291
Neidhart JA, Gagen MM, Young D, Tuttle R, Melink TJ, Ziccarrelli A, Kisner D (1984) Interferonalpha therapy of renal cancer. Cancer Res 44:4140–4143
O’Garra A (1989a) Interleukins and the immune system 1. Lancet 1:943–946
O’Garra A (1989b) Interleukins and the immune system 2. Lancet 1:1003–1005
Orihuela E, Herr HW, Pinsky CM, Whitmore WF (1987) Toxicity of intravesical BCG and its management in patients with superficial bladder tumors. Cancer 60:326–333
Puri RK, Travis WD, Rosenberg SA (1989) Decrease in interleukin 2-induced vascular leakage in the lungs of mice by administration of recombinant interleukin-i alpha in vivo. Cancer Res 49: 969–976
Quesada JR, Swanson DA, Trindade A, Gutterman JU (1983) Renal cell carcinoma: anti tumor effects of leukocyte interferon. Cancer Res 43:940–943
Quesada JR, Rios A, Swanson D, Trown P, Gutterman JU (1985a) Antitumor activity of recombinant-derived interferon alpha in metastatic renal cell carcinoma. J Clin Oncol 3:1522–1528
Quesada JR, Swanson DA, Gutterman JU (1985b) Phase II study of interferon alpha in metastatic renal cell carcinoma: a progress report. J Clin Oncol 3:1086–1092
Reid I, McDevitt SJ, Emmons MR, Tanner WA, Monson JRT (1991) Thyroid dysfunction can predict response to immunotherapy with interleukin-2 and interferon-2 alpha. Cancer 64: 915–918
Richards JM, Barker E, Latta J, Ramming K, Vogelzang NJ (1988) Phase I study of weekly 24-hours infusions of recombinant human interleukin-2. J Natl Cancer Inst 80:1325–1328
Rombis V, Gaganakis J, Salfigides G, Hafalamfous S, Anastasiadis G (1989) The treatment of metastatic renal cell carcinoma with alpha-interferon. J 16th Int Cong Chemotherapy, p 14
Rosenberg SA, Lotze MT, Muul LM (1987) A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N Engl J Med 316:889–897
Rosenberg SA, Lotze MT, Yang JC, Uebersold PM, Linehan WM, Seipp CA, White DE (1989) Experience with the use of high-dose Interleukin-2 in the treatment of 652 patients. Ann Surg: 474–485
Rosenthal FM, Lindemann A, Herrmann F, Mertelsmann R (1991) Zytokine in der Tumortherapie. Die Gelben Hefte 31:51–60
Samlowski WE, Ward JH, Craven CM, Freedman RA (1989) Severe myocarditis following high-dose Interleukin-2 administration. Arch Pathol Lab Med 113:838–841
Schwarz JA (1990) Vorschlag für einen Standardprüfplan und eine Patienteneinverständniserklärung. In: Witte PU, Schenk J, Schwarz JA, Kori-Lindner C (Hrsg) Ordnungsgemäße klinische Prüfung. Habrich, Fürth, S 11–50
Shinka T, Hirano Y, Uekado I, Kyoku I, Aoshi H, Ohkawa T (1989) Intravesical bacillus calmette-guerin treatment for superficial bladder tumours. Br J Urol 63:610–615
Sosman JA, Kohler PC, Hank J, Moore KH, Bechhofer R, Storer B, Sondel PM (1988) Repetitive weekly cycles of recombinant human interleukin-2: responses of renal carcinoma with acceptable toxicity. J Natl Cancer Inst 80:60–63
Steineck G, Strander H, Carbin BE et al. (1989) Recombinant leukocyte interferon alpha-2A and medroxyprogesterone in advanced renal cell carcinoma. Acta Oncol 29:155–162
Steis RG, Smith JW, Urba WJ et al. (1988) Resistance to recombinant interferon alfa-2a in hairy-cell leukemia associated with neutralizing antunterferon antibodies. N Engl J Med 318:1409–1413
Umeda T, Niijima T (1986) Phase II study of alpha interferon on renal cell carcinoma. Cancer 58: 1231–1235
Vetto JT, Papa MZ, Lotze MT, Chang AE, Rosenberg SA (1987) Reduction of toxicity of Interleukin-2 and lymphokine-activated killer cells in humans by the administration of corticosteroids. J Clin Oncol 5:496–503
Vugrin D, Hood L, Taylor W, Laszlo J (1985) Phase II study of human lymphoblastoid interferon in patients with advanced renal carcinoma. Cancer Treat Rep 69:817–820
Whitehead RP, Ward D, Hemingway L, Hemstreet GP, Bradley E, Konrad M (1990) Subcutaneous recombinant interleukin 2 in a dose escalating regimen in patients with metastatic renal cell adenocarcinoma. Cancer Res 50:6708–6715
Wiedenmann B, Reichard P, Räth U et al. (1989) Phase-I trial of intravenous continuous infusion of tumor necrosis factor in advanced metastatic carcinomas. J Cancer Res Clin Oncol 115:189–192
Wong GG, Witek-Giannotti JS, Temple TA (1988) Stimulation of murine hemopoietic colony formation by human IL-6. Immunol 140:3040–3044
Wussow P von, Jakschies D (1990) Interferon-Antikörper — Phantasie oder Faktum. In: Niederle N, von Wussow P (Hrsg) Interferone. Präklinische und klinische Befunde. Springer, Berlin Heidelberg New York Tokyo, S 79–91
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Ebert, T., Vögeli, T., Schmitz-Dräger, B.J. (1997). Immuntherapie urologischer Tumoren — Nebenwirkungen und ihre Behandlung. In: Rübben, H. (eds) Uroonkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10731-7_16
Download citation
DOI: https://doi.org/10.1007/978-3-662-10731-7_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-10732-4
Online ISBN: 978-3-662-10731-7
eBook Packages: Springer Book Archive