Skip to main content
SpringerLink
Log in
Book cover

Transfusionsmedizin pp 163–172Cite as

Alloantigene von Thrombozyten

  • Chapter

Zusammenfassung

Thrombozyten besitzen, wie alle anderen zellulären Elemente des Blutes, eine dreischichtige Plasmamembran („unit membrane“), der ein etwa 150–200 Å dicker, äußerer Mantel aufliegt. Dieser enthält adsorbierte Plasmaproteine, spezifische Glykoproteine und verschiedene Enzyme, die eine wichtige Rolle in der Hämostase spielen [77]. Er ist möglicherweise auch für die Adsorption von Antigenen von Bedeutung. Die Plasmamembran trägt die meisten der heute bekannten Thrombozytenantigene.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Ando B, Ibayashi H (1986) Indentification of anti-Lea by platelet compelement fixation. Vox Sang 50:169–173.

    Article  PubMed  CAS  Google Scholar 

  2. Aster RH (1965) Effect of anticoagulant and ABO incompatibility on recovery of transfused human platelets. Blood 26:732.

    PubMed  CAS  Google Scholar 

  3. Aster RH, Szatkowski N, Liebert M, Duquesnoy RJ (1977) Expression of HLA-B12, HLA-B8, w4, and w6 on platelets. Transplant Proc 9:1695–1696.

    PubMed  CAS  Google Scholar 

  4. Blanke H, Leschke M, Strauer BE (1987) Hepa-rin-induzierte Thrombopenie. Dtsch Med Wo-chenschr 112:96–99.

    Article  CAS  Google Scholar 

  5. Blumberg N, Masel D, Mayer T, Horan P, Heal J (1984) Removal of HL α-A, B antigens from platelets. Blood 63:448–450.

    PubMed  CAS  Google Scholar 

  6. Boizard B, Wautier J-L (1984) Leka, a new platelet antigen absent in Glanzmann’s thrombasthenis. Vox Sang 46:47–54.

    Article  PubMed  CAS  Google Scholar 

  7. Borne AEGKr von dem, Plas-van Dalen CM van der (1985) Further observations on post-transfusion purpura (PTP). Br J Haematol 61:374–375.

    Article  Google Scholar 

  8. Borne AEGKr von dem, Riesz E von, Verheugt FWA, Cate JWten, Koppe JG, Engelfriet CP, Ni-jenhuis LE (1980) Baka, a new platelet-specific antigen involved in neonatal allo-immune thrombocytopenia. Vox Sang 39:113–120.

    Article  Google Scholar 

  9. Cartron JP, Nurden AT (1979) Galactosyltrans-ferase and membrane glycoprotein abnormality in human platelets from Tn-syndrome donors. Nature 282:621–623.

    Article  PubMed  CAS  Google Scholar 

  10. Cartron JP, Nurden AT, Blanchard D, Lee H, Dupuis D, Salmon C (1980) The Tn-receptors of human red cells and platelets. Blood Transf Haematol 23:613–628.

    CAS  Google Scholar 

  11. Cines DB, Schreiber AD (1979) Effect of anti-PlA1 antibody on human platelets. I. The role of complement. Blood 53:567–577.

    PubMed  CAS  Google Scholar 

  12. Colombani J, Colombani M (1976) Transplantation antigens studied by complement-fixation methods. In: Rose NR, Friedman H (eds) Blood, American Society for Microbiology, Washington, pp 805–810.

    Google Scholar 

  13. Cruz WO, Faro JM (1954) Forssman antigen in platelets. Am J Clin Pathol 24:735–739.

    PubMed  CAS  Google Scholar 

  14. Dautigny A, Bernier I, Colombani J, Joliès P (1973) Purification and characterization of HL-A antigens from human platelets, solubilized by the non-ionic detergent NP-40. Biochim Biophys Acta 298:783–789.

    Article  PubMed  CAS  Google Scholar 

  15. Degos L, Colombani J, Kissmeyer-Nielsen F, Svej-gaard A, Mueller-Eckhardt C, Rood JJ van, Lee-uwen A van, Oliver RTD (1975) Joint report on platelet complement fixation workshop. In: Kissmeyer-Nielsen F (eds) Histocompatibility Testing, Munksgaard, Copenhagen, pp 348–349.

    Google Scholar 

  16. Dunstan RA (1986) The expression of ABH antigens during in vitro megakaryocyte maturation: origin of heterogeneity of antigen density. Br J Haematol 62:587–593.

    Article  PubMed  CAS  Google Scholar 

  17. Dunstan RA, Simpson MB (1985) Heterogeneous distribution of antigens on human platelets demonstrated by fluorescence flow cytometry. Br J Haematol 61:603–609.

    Article  PubMed  CAS  Google Scholar 

  18. Dunstan RA, Simpson MB, Rosse WF (1984) Erythrocyte antigens on human platelets, absence of Rhesus, Duffy, Kell, Kidd and Lutheran antigens. Transfusion 24:243–246.

    Article  PubMed  CAS  Google Scholar 

  19. Dunstan RA, Simpson MB, Knowles RW, Rosse WF (1985) The origin of ABH antigens on human platelets. Blood 65:615–619.

    PubMed  CAS  Google Scholar 

  20. Feuerstein N, Monos DS, Cooper HL (1985) Phor-bol ester effect in platelets, lymphocytes, and leukemic cells (HL-60) is associated with enhanced phosphorylation of class IHLA antigens. Biochem Biophys Res Commun 126:206–213.

    Article  PubMed  CAS  Google Scholar 

  21. Friedman JM, Aster RH (1985) Neonatal alloimmune thrombocytopenic purpura and congenital in two siblings associated with a „new“ maternal antiplatelet antibody. Blood 65:1412–1415.

    PubMed  CAS  Google Scholar 

  22. Furihata K, Nugent DJ, Bissonette A, Aster RH, Kunicki TJ (1987) On the assocation of the platelet-specific alloantigen, Pena, with glycoprotein IIIa. Evidence for heterogeneity of glycoprotein IIIa. J Clin Invest 80:1624–1630.

    Article  PubMed  CAS  Google Scholar 

  23. Glöckner WM, Kaulen HD, Uhlenbruck G (1978) Immunochemical detection of the Thomsen-Frie-denreich antigen (T-antigen) on platelet plasma membranes.Thromb Haemost 39:186–192.

    PubMed  Google Scholar 

  24. Gockerman JP, Jacob W (1979) Purification and characterization of papain-solubilized HLA-anti-gens from human platelets. Blood 53:838–850.

    PubMed  CAS  Google Scholar 

  25. Hakomori S (1981) Blood group ABH and Ii: Antigens of human erythrocytes: chemistry, polymorphism, and their developmental change. Se-min Hematol 18:39–62.

    CAS  Google Scholar 

  26. Harrington WJ, Spraque CC, Minnich V, Moore CV, Aulvin RC, Dubach R (1953) Immunologic mechanisms in idiopathic and neonatal thrombocytopenic purpura. Ann Intern Med 38:433–469.

    Article  PubMed  CAS  Google Scholar 

  27. Haynes WDG, Jones JV, Cumming JCO (1974) HLA-antigens on circulating platelets. Transplantation 18:81–86.

    Article  PubMed  CAS  Google Scholar 

  28. Heinrich D, Mueller-Eckhardt C, Voigtmann R, Uhlenbruck G (1973) Action of different enzymes on HL-A receptors of platelets. In: Gerlach E, Moser K, Deutsch E, Wilmanns W (eds) Erythrocytes, Thrombocytes, Leukocytes, Georg Thieme, Stuttgart, pp 244–247.

    Google Scholar 

  29. Hysell JK, Hysell JW, Nicholls ME, Leonardi RG, Marsh WL (1976) In vivo and vitro activation of T-antigen receptors on leukocytes and platelets. Vox Sang 31:9–15.

    Article  PubMed  CAS  Google Scholar 

  30. Keimowitz RM, Collins J, Davis K, Aster RH (1986) Post-transfusion purpura associated with alloimmunization against the platelet-specific antigen Bak(a). Am J Hematol 21:79–88.

    Article  PubMed  CAS  Google Scholar 

  31. Kickler TS, Furihata K, Kunicki TJ, Herman JH, Aster RH (1986) A new platelet alloantigen allelic to Bak(a) and its assocation with posttransfusion purpura. Blood 68(Suppl 1):111a.

    Google Scholar 

  32. Kiefel V, Santoso S, Katzmann B, Mueller-Eckhardt C (1988) A new platelet-specific alloantigen Br(a). Report of four cases with neonatal alloimmune thrombocytopenia. Vox Sang 54:101–106.

    Article  PubMed  CAS  Google Scholar 

  33. Kornecki E, Chung S-Y, Holt JC, Cierniewski CS, Tuszynski GP. NiewiarowskiS (1985) Identification of P1A1 alloantigen domain on a 66 kDa protein derived from glycoprotein IIIa of human platelets. Biochim Biophys Acta 818:285–290.

    Article  PubMed  CAS  Google Scholar 

  34. Kunicki TJ, Aster RH (1978) Deletion of platelet-specific alloantigen P1A1 from platelets in Glanz-mann’s thrombasthenia. J Clin Invest 61:1225–1231.

    Article  PubMed  CAS  Google Scholar 

  35. Kunicki TJ, Aster RH (1979) Isolation and immunologic characterization of the human platelet isoantigen P1(A1). Mol Immunol 16:353–360.

    Article  PubMed  CAS  Google Scholar 

  36. Kunicki TJ, Pidard D, Cazenave JP, Nurden AT, Caen JP (1981) Inheritance of the human platelet alloantigen P1A1 in type-I Glanzmann’s thrombasthenia. J Clin Invest 67:717–724.

    Article  PubMed  CAS  Google Scholar 

  37. Lalezari P, Driscoll AM (1982) Ability of thrombocytes to acquire HLA specificity from plasma. Blood 59:167–170.

    PubMed  CAS  Google Scholar 

  38. Langenscheidt F, Kiefel V, Santoso S, Mueller-Eckhardt C (1988) Platelet transfusion refractoriness due to two rare platelet-specific alloanti-bodies (anti-Baka and anti-PlA2) associated with multiple HL A antibodies. Transfusion (im Druck).

    Google Scholar 

  39. Lansdorp PM, Oosterhof F, Astaldi GCB, Zeu-lemaker WP (1982) Detection of HLA antigens on blood platelets and lymphocytes by means of monoclonal antibodies in an ELISA technique. Tissue Antigens 19:11–19.

    Article  PubMed  CAS  Google Scholar 

  40. Leeuwen EF van, Borne AEGKr von dem, Riesz LE von, Nijenhuis LE, Engelfriet CP (1981) Absence of platelet-specific alloantigens in Glanz-mann’s thrombasthenia. Blood 57:49–54.

    PubMed  Google Scholar 

  41. Leeuwen EF van, Leeksma OC, Mourik JA van, Engelfriet CP, Borne AEGKr von dem (1984) Effect of the binding of anti-Zwa antibodies on platelet function. Vox Sang 47:280–289.

    Article  PubMed  Google Scholar 

  42. Liebert M, Aster RH (1979) Expression of HLA-B12 on platelets, on lymphocytes and in serum: a quantitative study. Tissue Antigens 9:199–208.

    Article  Google Scholar 

  43. Loghem JJ van, Dorfmeijer H, Hart M van der (1959) Serological and genetical studies on a pla-teled antigen (Zw). Vox Sang 4:161–169.

    Article  Google Scholar 

  44. Marcelli-Barge A, Poirier JC, Dausset J (1973) Allo-antigens and allo-antibodies of the Ko system, serological and genetic study. Vox Sang 24:1–11.

    Article  PubMed  CAS  Google Scholar 

  45. McFarland JG, Aster RH (1985) Clinical significance of platelet-specific antigens. In: McCarthy LJ, Menitove JE (eds) Immunologic aspects of platelet transfusion, American Association of Blood Banks, Arlington, VA, pp 55–69.

    Google Scholar 

  46. Moulinier J (1958) Iso-immunisation maternelle anti-plaquettaire et pupura neonatal le systeme de groupe plaquettaire Duzo. Proceedings of the 6th Congress of the European Society of Haemato-logy, Karger, Basel, pp 817–820:1–11.

    Google Scholar 

  47. Mueller-Eckhardt C (1986) Posttransfusion Purpura. Br J Haematol 64:419–424.

    Article  PubMed  CAS  Google Scholar 

  48. Mueller-Eckhardt C, Küenzlen E (1984) Alloim-mune thrombocytopenia of the newborn. In: Engelfriet CP, Loghem JJ van, Borne AEGKr von dem (eds) Immunohematology, Elsevier Science Publishers, B.V, Amsterdam, pp 166–177.

    Google Scholar 

  49. Mueller-Eckhardt C, Sachs V (1966) Untersuchungen zum Nachweis antithrombozytärer He-teroantikörper durch Immunfluoreszenz. Throm-bos Diathes Haemorrh 16:412–419.

    Google Scholar 

  50. Mueller-Eckhardt C, Heinrich D, Rothenberg V (1972) Studies on cross reactive HL-A antibodies by elution with platelets. Tissue Antigens 2:436–446.

    Article  PubMed  CAS  Google Scholar 

  51. Mueller-Eckhardt C, Heinrich D, Mersch-Bau-mert K, Czitrom A, Walker P (1974) A critical evaluation of HL-A phenotype and genotype frequencies in a large German population determined by platelet complement fixation and lymphocyto-toxicity. Humangenetik 24:319–324.

    Article  PubMed  CAS  Google Scholar 

  52. Mueller-Eckhardt C, Mueller-Eckhardt G, May-ser B, Colombani J (1977) Definition of HLA-B8 by platelet complement fixation. In: Bodmer WF, Batchelor JR, Bodmer JG, Festenstein H, Morris PJ (eds) Histocompatibility Testing, Munksgaard, Copenhagen, pp 449–463.

    Google Scholar 

  53. Mueller-Eckhardt C, Marks H-J, Baur MP, Mueller-Eckhardt G (1982) Immunogenetic studies of the platelet-specific P1A1 (Zwa). Immunobiol 160:375–381.

    Article  CAS  Google Scholar 

  54. Mueller-Eckhardt G, Hauck M, Kayser W, Mueller-Eckhardt C (1980) HLA-C antigens on platelets. Tissue Antigens 16:91–94.

    Article  PubMed  CAS  Google Scholar 

  55. Mueller-Eckhardt C, Becker T, Weisheit M, Witz C, Santoso S (1986) Neonatal alloimmune thrombocytopenia due to fetomaternal Zwb incompatibility. Vox Sang 50:94–96.

    Article  PubMed  CAS  Google Scholar 

  56. Mulder A, Leeuwen EF van, Veenboer GJM, Tet-teroo PAT, Borne AEGKr von dem (1984) Immunochemical characterization of platelet-specific alloantigens. Scand J Haematol 33:267–274.

    Article  PubMed  CAS  Google Scholar 

  57. Nurden AT, Dupuis D, Pidard D, Kieffer N, Ku-nicki TJ, Cartron JP (1982) Surface modifications in the platelets of a patient with alpha-N-acetyl-D-galactosamine residues, the Tn-syndrome. J Clin Invest 70:1281–1291.

    Article  PubMed  CAS  Google Scholar 

  58. Pfueller SL (1985) Immunology of the platelet surface. In: George JN, Nurden AT, Phillips DR (eds) Platelet Membrane Glycoproteins, Plenum Press, New York, pp 327–355.

    Chapter  Google Scholar 

  59. Pollack MS, Zaroulis CG, Klainbard J, Leiderman IZ, Dupont B (1980) Retention of HLA antigens on previously frozen human platelets. Transfusion 20:458–461.

    Article  PubMed  CAS  Google Scholar 

  60. Ramsey G, Salamon DJ (1986) Frequency of P1(A1) in blacks. Transfusion 26:531–532.

    Article  PubMed  CAS  Google Scholar 

  61. Santoso S, Mueller-Eckhardt G, Santoso Susanti, Kiefel V, Mueller-Eckhardt C (1986) HLA antigens on platelet membranes: in vitro and in vivo studies. Vox Sang 51:327–333.

    Article  PubMed  CAS  Google Scholar 

  62. Santoso S, Shibata Y, Kiefel V, Mueller-Eckhardt C (1987) Identification of the Yuk(b) allo-antigen on platelet glycoprotein IIIa. Vox Sang 53:48–51.

    Article  PubMed  CAS  Google Scholar 

  63. Santoso S, Kiefel V, Mueller-Eckhardt C (1987) Immunochemical characterization of the new platelet-specific alloantigen Bra. Blood 70 (Suppl 1): 360 a (abstract).

    Google Scholar 

  64. Saunders PWG, Durack BE, Narang HK (1985) Zwa antigen distribution on the human platelet: an electron microscope study using a colloidal gold labelled marker. Br J Haematol 59:209–219.

    Article  PubMed  CAS  Google Scholar 

  65. Schoot CE van der, Wester M, Borne AEGKr von dem, Huisman HG (1986) Characterization of platelet-specific alloantigens by immunoblotting: localization of Zw and Bak antigens. Br J Haematol 64:715–723.

    Article  PubMed  Google Scholar 

  66. Shibata Y, Matsuda I, Miyaji T, Ichikawa Y (1986) Yuka, a new platelet antigen involved in two cases of neonatal alloimmune thrombocytopenia. Vox Sang 50:177–180.

    Article  PubMed  CAS  Google Scholar 

  67. Shibata Y, Miyaji T, Ichikawa Y, Matsuda I (1986) A new platelet antigen system, Yuka/Yukb. Vox Sang 51:334–336.

    Article  PubMed  CAS  Google Scholar 

  68. Shulman NR, Marder VJ, Hiller MC, Collier EM (1964) Platelet and leucocyte iso-antigens and their antibodies: serologic, physiologic and clinical studies. In: Moore CV, Brown EB (eds) Progress in Hematology, Grune & Stratton, New York, pp 222–304.

    Google Scholar 

  69. Shulman NR, Moor-Jankowski J, Hiller MC (1965) Platelet and leukocyte iso-antigens common to man and other animals. In: Jensen KG, Killmann S-A (eds) Histocompatibility Testing 1965 (Series Haemat. Vol. 11), Munksgaard, Copenhagen, pp 113–122.

    Google Scholar 

  70. Shulman NR, Jordan JV (1982) Platelet immunology. In: Colman RW, Hirsh J, Marder VJ, Salzman EW (eds) Hemostasis and Thrombosis, B. Lippincott, Philadelphia Toronto, pp 274–342.

    Google Scholar 

  71. Simon T, Collins J, Kunicki T, Furihata K, Smith K, Aster RH (1986) Post-transfusion purpura with antiplatelet antibody specific for the platelet antigen Pen (a). Blood 68 (Supp. l):117a.

    Google Scholar 

  72. Skinnider LF, Taylor D (1981) The in vitro effect of anti-A and anti-AB alloantibodies on group A and AB platelets. Tranfusion 21:706–708.

    Article  CAS  Google Scholar 

  73. Soulier JP, A Patereau (1976) Groupage et detection d’anticorps dans le systeme PIA (plaquettaire). Application a l’etude des thrombopenies neonatales par allo-immunisation foeto-maternelle P1A1. Rey Fr Transfus Immunohematol 19:431–448.

    Article  CAS  Google Scholar 

  74. Svejgaard A (1969) Iso-antigenic systems of human blood platelets. A survey. In: Jensen KG, Killmann S-A (eds) Pathology, Munksgaard, Copenhagen.

    Google Scholar 

  75. Szatkowski N. Duquesnoy RJ, Aster RH (1978) Further studies of the expression of Bw4, Bw6 and other antigens of the HLA-B locus on human platelets. Transplant Proc 10:739–740.

    PubMed  CAS  Google Scholar 

  76. Szatkowski NS, Aster RH (1980) HLA antigens of platelets. IV. Influence of „private“ HLA-B locus specificities on the expression of Bw4 and Bw6 on human platelets. Tissue Antigens 15:361–368.

    Article  PubMed  CAS  Google Scholar 

  77. Taaning E, Morling N, Ovesen H., Svejgaard A (1985) Post transfusion purpura and anti-Zwb (-P1A2). Tissue Antigens 26:143–146.

    Article  PubMed  CAS  Google Scholar 

  78. Vainchenker W, Testa U, Deschamps JF, Henri A, Titeux M, Breton-Gorius J, Rochant H, Lee D, Cartron JP (1982) Clonal expression of the Tn antigen in erythroid and granulocyte colonies and ists application to determination of the clonality of the human megakaryocyte colony assay. J. Clin Invest 69:1081–1091.

    Article  PubMed  CAS  Google Scholar 

  79. Weerdt C M van der (1965) Platelet antigens and iso-immunization. Thesis, Drukkerij Amstelstad, Amsterdam.

    Google Scholar 

  80. Weerdt C M van der, Veenhoven-von Riesz LE, Nijenhuis LE, Loghem JJ van (1963) The Zw blood group system in platelets. Vox Sang 8:513–530.

    Article  Google Scholar 

  81. White JG (1983) Platelet morphology and function. In: Williams WJ, Beutler E, Erslev AJ, Licht-man MA (eds) Hematology, 3rd edn. McGraw-Hill, New York, p 1121.

    Google Scholar 

Download references

Authors
  1. C. Mueller-Eckhardt
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Klinische Immunologie und Transfusionsmedizin, Langhansstraße 7, D-6300, Gießen, Deutschland

    Christian Mueller-Eckhardt

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Mueller-Eckhardt, C. (1988). Alloantigene von Thrombozyten. In: Mueller-Eckhardt, C. (eds) Transfusionsmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10601-3_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-10601-3_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-10602-0

  • Online ISBN: 978-3-662-10601-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation