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Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression pp 137–144Cite as

Corepressors and Retinoblastoma Protein Function

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 254))

Abstract

The retinoblastoma protein (Rb) is a ubiquitous transcriptional repressor and a negative regulator of the Gl-to-S phase transition in the eukaryotic cell cycle. Through this inhibitory activity, Rb plays a critical role in suppressing neoplastic transformation and is disrupted in most cancers, either by mutation of the Rb gene (Lee et al. 1988; Shew et al. 1989; Bookstein et al. 1990; Kubota et al. 1995), or by functional inactivation of Rb by hyperphosphorylation (Sherr 1996). DNA tumor viruses transform cells, at least in part, by expressing oncoproteins such as adenovirus Ela, SV40 large tumor antigen, and human papillomavirus (HPV) E7 which bind and inactivate Rb (Decaprio et al. 1988; Dyson et al. 1989). In addition, Rb plays an important role in development as underscored by the embryonic lethal phenotype of Rb(−) knockout mice (Clarke et al. 1992; Jacks et al. 1992; Lee et al. 1992). The transcriptional repression by Rb is dependent on interaction of Rb with various corepressors.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, Division of Molecular Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA

    J. W. Harbour

  2. Division of Molecular Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA

    D. C. Dean

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  1. J. W. Harbour
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  2. D. C. Dean
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Editors and Affiliations

  1. Section of Microbiology, Division of Biological Sciences, University of California at Davis, One Shields Avenue, 95616, Davis, CA, USA

    Martin L. Privalsky

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© 2001 Springer-Verlag Berlin Heidelberg

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Harbour, J.W., Dean, D.C. (2001). Corepressors and Retinoblastoma Protein Function. In: Privalsky, M.L. (eds) Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression. Current Topics in Microbiology and Immunology, vol 254. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10595-5_7

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  • DOI: https://doi.org/10.1007/978-3-662-10595-5_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-08709-7

  • Online ISBN: 978-3-662-10595-5

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