Regulation of SMRT and N-CoR Corepressor Function

  • M. L. Privalsky
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 254)


This review will describe how the functions of transcriptional corepressors are regulated in cells. I will focus primarily on the SMRT (Silencing Mediator of Retinoic acid and Thyroid hormone receptors) and N-CoR (Nuclear hormone receptor Co-Repressor) complexes that mediate repression by the nuclear hormone receptors (Chen and Evans 1995; Hörlein et al. 1995; Sande and Privalsky 1996). Given that these same corepressors also participate in transcriptional repression by a variety of other transcriptional factors, including PLZF, BCL-6, Myo D, CBF-1/RBP-Jk, and ETO, this review will also touch on aspects of transcriptional regulation by non-receptor transcription factors (Dhordain et al. 1997; Hong et al. 1997; Gelmetti et al. 1998; Grignani et al. 1998; Guidez et al. 1998; He et al. 1998; Kao et al. 1998; Lin et al. 1998; Lutterbach et al. 1998; Wong and Privalsky 1998a; Bailey et al. 1999).


Nuclear Receptor Thyroid Hormone Receptor Nuclear Hormone Receptor Corepressor Complex Nuclear Receptor Corepressor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • M. L. Privalsky
    • 1
  1. 1.Section of Microbiology, Division of Biological SciencesUniversity of California at DavisDavisUSA

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