Corepressor Proteins and Control of Transcription in Yeast

  • J. R. Bone
  • S. Y. Roth
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 254)


The identity and function of a eukaryotic cell are defined to a large extent by the complex program of gene expression that each cell undertakes. The importance of maintaining tight regulation over the expression of the eukaryotic genome is intuitively obvious on many levels. From a competitive standpoint, it is important to reduce the metabolic load on a cell by keeping genes encoding synthetic or catabolic functions silent until such time as nutritional and environmental conditions warrant their expression. From a functional standpoint, certain processes in the cell must be temporally regulated, as many processes are contingent upon the completion of previous ones. Developmentally, the ectopic expression of a cell fate determinant can drastically alter the identity of a cell. Thus, the proper control over transcription is critical for nearly all aspects of cell function.


Histone Acetylation Histone Gene Transcriptional Corepressor Corepressor Complex Basal Transcription Machinery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • J. R. Bone
    • 1
  • S. Y. Roth
    • 1
  1. 1.Department of Biochemistry and Molecular BiologyUniversity of Texas, M.D. Anderson Cancer CenterHoustonUSA

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