Control of the G1/S Phase Transition in Tobacco BY-2 Cells

  • Masami Sekine
  • Atsuhiko Shinmyo
Part of the Biotechnology in Agriculture and Forestry book series (AGRICULTURE, volume 53)


The ability of cells to clonally replicate is central to life, and the co-ordinated regulation of cell division with cell growth and differentiation is required for the development of multicellular organisms. The cell division cycle consists of DNA replication and the allocation of identical genetic information to two daughter cells through mitosis and cell division. As in other eukaryotic cells, the plant cell cycle consists of four different phases representing DNA synthesis (S phase) and mitosis (M phase) separated by two gaps, the G1 and G2 phases, such that cells pass in order through M, G1, S, and G2 phases. Although progression through the cell cycle is regulated at both the G1/S and G2/M phase transitions, the major checkpoint of cell division commitment occurs at the G1 phase. Once cells have passed through this checkpoint, they become irreversibly committed to complete the cell cycle (Murray et al. 2001; Oakenful et al. 2002).


Proliferate Cell Nuclear Antigen Curr Opin Plant Biol Plant Cell Cycle Exhibit Transactivation Activity Geminivirus Replication Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Masami Sekine
    • 1
  • Atsuhiko Shinmyo
    • 1
  1. 1.Nara Institute of Science and Technology (NAIST)Graduate School of Biological SciencesIkoma, NaraJapan

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