Multiples Myelom (Plasmozytom)

  • F. J. Giles
  • B. G. M. Durie


Es wurde über eine statistische Assoziation zwischen HLA-CwA und HLA-Cw2 und der Entwicklung eines Myeloms berichtet. Der Nachweis einer Translokation t(8,14) (q24; q32) ist mit Expression des IgA-Paraproteins assoziiert; Abberationen am Chromosom 14 treten bei 1/3 der Patienten mit zytogenetischen Abnormalitäten auf. Die Bedeutung einer Expression von bcl-1 und bcl-2 ist ungeklärt. Gelegentlich findet sich eine Überexpression des c-myc Protoonkogens.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • F. J. Giles
  • B. G. M. Durie

There are no affiliations available

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